Healthcare & Life Sciences

Effects of Clinical Pilates on Pain and Quality of Life in Women With Dyspareunia

A clinical study on dyspareunia has been registered on ClinicalTrials.gov under identifier NCT07540195. The study will investigate the effects of clinical Pilates exercises on pain, self-esteem, body image, depression, and quality of life in women with dyspareunia. The research evaluates pelvic floor-focused clinical Pilates interventions as an approach to treatment.

Evuzamitide PET-CT Imaging for Detection of Cardiac Amyloidosis in Patients With Inconclusive Nuclear Scans

NIH has posted an observational clinical trial (NCT07538518) evaluating whether PET-CT imaging using evuzamitide can detect transthyretin cardiac amyloidosis in patients whose standard nuclear imaging results are inconclusive but who have elevated TAD1 blood levels. Eligible participants will receive a single PET-CT scan with evuzamitide and will be monitored for approximately 28 days for safety and clinical data collection. The trial is registered on ClinicalTrials.gov as an informational study record with no direct compliance obligations for external parties.

CAIX PET/CT Guided Radiation Therapy for Recurrent Clear Cell Renal Cell Carcinoma

This is a prospective, single-arm clinical trial (NCT07540260) investigating CAIX-targeted PET/CT imaging combined with stereotactic ablative radiotherapy (SABR) for adults with recurrent or metastatic clear cell renal cell carcinoma (ccRCC). Participants will receive standard systemic therapy (targeted therapy plus anti-PD-1 immunotherapy) and undergo dual PET/CT imaging (FDG and CAIX-targeted) to map disease sites, with PET/CT-visible lesions treated when feasible. The study plans to enroll approximately 70 participants and will evaluate progression-free survival, local control of treated lesions, and treatment-related adverse events.

Assessment of Climate Change Related Heat Stress Among Workers in Upper Egypt: Impact of Intervention Program on Physiological Responses

NIH registered clinical trial NCT07538778, a study assessing climate change-related heat stress among workers in Upper Egypt and evaluating the impact of a Heat Stress Awareness Program (HSAP) on physiological responses. The study focuses on occupational health effects associated with rising temperatures and climate change. Registration is informational; no regulatory obligations are imposed by this entry.

Clinical & Radiographic Evaluation of CGF With Auto Transplanted Closed Apex Teeth

NIH ClinicalTrials.gov has registered a clinical study (NCT07538921) evaluating Concentrated Growth Factors (CGF) in autotransplantation of closed apex teeth. The study will assess clinical outcomes including tooth stability, periodontal health, and radiographic bone healing over a defined follow-up period, with completion anticipated April 20, 2026. CGF, as an advanced generation of platelet concentrates, may enhance tissue regeneration and improve the success rate of transplanted teeth.

tTIs Brain Stimulation Trial for Consciousness Disorders

NIH has registered clinical trial NCT07539740 evaluating theta-burst patterned temporal interference stimulation (tTIs) versus sham stimulation for improving awareness in patients with disorders of consciousness (DoC). The randomized controlled study involves 10 sessions over 5 days with EEG monitoring and a 6-month follow-up period.

Effect of Social Support During Labor, Jordan, NCT07539376

NIH ClinicalTrials.gov registered a randomized controlled trial (NCT07539376) titled 'Effect of Social Support During Labor' conducted in Jordan. The study examines whether a supportive companion present during labor improves maternal and neonatal outcomes in governmental hospitals. This is described as the first study of its kind in Jordan, with investigators citing prior evidence linking social support to reduced anxiety, improved uterine contractions, and faster labor progress.

Gonadotropin Therapy Trial for Azoospermia

The NIH has registered a new clinical trial (NCT07540611) under the APHRODITE Group to evaluate whether short-term gonadotropin therapy (hCG + FSH) can increase sperm availability for ICSI in men with idiopathic non-obstructive azoospermia and hypogonadism. The randomized controlled trial will compare hormonal optimization with standard-of-care and assess outcomes including sperm retrieval success and reliance on micro-TESE through Week 16.

Effect of Acoustic Conditions on 6-Minute Walk Test Performance and Recovery

NIH ClinicalTrials.gov registered an observational study (NCT07540455) examining the acute effects of three auditory conditions—metronome, binaural beats, and silent control—on 6-Minute Walk Test performance, post-exercise recovery physiology, and perceived exertion in healthy young adults aged 18-35. The randomized cross-over study will expose all participants to all three conditions on separate days to assess how rhythmic auditory stimuli and cortical neural entrainment affect walking efficiency and recovery.

SBD111 Probiotic Dosing Frequency Trial in Healthy Adults NCT07538167

NIH has registered a new clinical trial (NCT07538167) sponsored by Sōlaria Biō to evaluate whether a modified formulation and dosing schedule of SBD111 results in similar gut probiotic levels compared with the current formulation. SBD111 is a probiotic medical food used for dietary management of postmenopausal bone loss. Participants will be assigned to once-daily or twice-daily capsule dosing over 28 days, with stool sample collection at baseline, Week 1, and Week 4 for microbiome analysis.

Trauma Advisory Council Data and PI Subcommittee Meeting - Apr. 23, 2026

The South Carolina Department of Public Health announces a meeting of the Trauma Advisory Council Data and Performance Improvement (PI) Subcommittee on Thursday, April 23, 2026 at 1 p.m. The meeting will be held at the State of South Carolina Health Campus, Conference Room B228, 400 Otarre Parkway, Cayce. A virtual viewing link and full agenda are available on the meeting event page.

Whitmer Proclaims April Child Abuse Prevention Month

Governor Whitmer proclaimed April 2026 as Child Abuse Prevention Month in Michigan. MDHHS recognized the critical role of prevention programs in keeping children safe and strengthening families, highlighting the Keep Kids Safe Action Agenda, the CSA teaming model, and various prevention initiatives including MI Parenting Resource, Michigan Home Visiting, MiFamily Together, and Children Trust Michigan programs.

Boil Water Advisory Issued for City of Fort Scott Bourbon County

KDHE has issued a boil water advisory for the City of Fort Scott, Bourbon Co RWD 2C, and City of Uniontown public water supply systems in Bourbon County, Kansas, effective April 18, 2026. The advisory was triggered by a waterline break causing loss of pressure in Fort Scott's distribution system, which may have compromised chlorine residuals and allowed bacterial contamination. Affected customers are advised to boil water for one minute before drinking or food preparation, or use bottled water.

VR Reduces Pain Anxiety During Arteriovenous Fistula Surgery

NIH registered a new interventional clinical trial (NCT07538687) investigating virtual reality (VR) as an adjunctive tool for patients undergoing arteriovenous fistula (AVF) surgery. The single-arm study hypothesizes that intraoperative VR immersion will reduce anesthetic doses, decrease patient anxiety and pain, and receive favorable acceptance from surgeons and anesthetists. The trial targets adult patients with end-stage renal disease on dialysis.

Superselective Renal Artery Embolization for Renal Angiomyolipoma Observational Study NCT07538908

NIH ClinicalTrials.gov has registered a new observational study (NCT07538908) evaluating superselective renal artery embolization as a treatment for renal angiomyolipoma. The prospective study will assess changes in serum creatinine and hemoglobin levels post-procedure, technical success rates, and complication incidence. Enrollment criteria include radiologically confirmed angiomyolipoma based on CT/MRI findings with clinical indications for embolization.

Effect of RECAST-H Reverse Case Studies on Nursing Student Professional Readiness

NIH registered a new clinical study (NCT07539363) examining whether reverse case studies based on the heutagogy educational approach improve professional readiness among final-year nursing students. The randomized controlled trial will compare an intervention group receiving the RECAST-H program with a waiting-list control group, measuring professional readiness, career adaptability, professional socialization, and psychological capital as outcomes. The study has an anticipated start date of April 20, 2026.

VCS Device Trial for Irritable Bowel Syndrome

NIH has registered a prospective interventional pilot trial (NCT07540312) to evaluate the safety and effectiveness of the Variable Compression System (VCS) device for treating moderate to severe Irritable Bowel Syndrome. The trial will enroll 20 subjects required to wear the device for a minimum of 6 hours daily, with follow-up assessments at 21 days, 8 weeks, and 6 months post-device administration.

OBESE-HFpEF: Towards Preventing Obesity Related HFpEF, Netherlands

The Netherlands Heart Foundation has registered an observational study (NCT07539766) in ClinicalTrials.gov examining how obesity contributes to heart failure with preserved ejection fraction (HFpEF). The study will enroll approximately 250 participants with obesity in South Limburg, using echocardiography and blood/tissue tests to identify early HFpEF markers, with follow-up at 1 and 2 years. Results may inform future treatment strategies for patients with obesity-related HFpEF.

Serratus Block vs Intrathecal Morphine for Thoracoscopic Surgery, Opioid Consumption 24h

A new clinical trial registration (NCT07540104) has been published on ClinicalTrials.gov for a prospective, randomized, controlled, single-center study based in the US. The trial will enroll adult patients undergoing elective video-assisted thoracoscopic surgery and randomly assign them to receive either serratus posterior superior intercostal plane block or intrathecal morphine prior to general anesthesia. The primary endpoint is cumulative opioid consumption at 24 postoperative hours measured in intravenous morphine milligram equivalents. Secondary endpoints include pain scores, time to first analgesic request, quality of recovery, and postoperative complications.

Phase 2 Study of Rina-S Monotherapy in Advanced Gastrointestinal Cancers

The NIH has registered a Phase 2 clinical trial (NCT07539311) evaluating Rina-S monotherapy in approximately 160 participants with advanced gastrointestinal cancers. The single-arm study has no placebo arm; all participants receive active drug. The expected average participant duration is 22 months, including a 12-month treatment period with cycles of 21 days and 1-5 clinic visits per cycle.

Phase 2 Trial of XH-02 for Hypoparathyroidism

NIH has registered a Phase 2 clinical trial (NCT07540286) for XH-02, an mRNA nucleic acid drug designed to express parathyroid hormone (PTH) in the body following subcutaneous injection for the treatment of hypoparathyroidism. The study will further validate the safety and efficacy of subcutaneously administered XH-02 in an expanded patient cohort. Prior clinical studies demonstrated preliminary safety and efficacy results for subcutaneous XH-02 administration.

Iparomlimab and Tuvonralimab Plus Chemotherapy Before Surgery for Stage III Lung Cancer

NIH ClinicalTrials.gov has registered a Phase II single-arm study (NCT07538193) evaluating iparomlimab and tuvonralimab (QL1706) combined with platinum-based chemotherapy as neoadjuvant treatment for resectable stage III-N2b non-small cell lung cancer. The study will enroll 28 patients across approximately 4 centers in China, with an anticipated completion date of April 20, 2026.

HSA Charges 21-Year-Old for Etomidate Vaporiser Pod Trafficking

The Health Sciences Authority (HSA) in Singapore has charged 21-year-old Brandon Loke Jo Kit in court on 20 April 2026 for alleged trafficking of etomidate vaporiser pods. HSA officers seized 21 vaporisers, 116 pods, and cash during an enforcement operation at the defendant's Kovan residence on 19 April 2026. Laboratory testing confirmed the seized pods contained etomidate. Under the enhanced penalties framework effective 1 September 2025, importers of etomidate vaporisers face 3 to 20 years' imprisonment and 5 to 15 strokes of the cane, while sellers and distributors face 2 to 10 years' imprisonment and 2 to 5 strokes of the cane.

NCT07539597: CHW-Led Hypertension Study N=15, Single-Arm, Quasi-Experimental

NIH registered a new single-center, single-arm quasi-experimental feasibility study (NCT07539597) on ClinicalTrials.gov. The study will enroll 15 emergency department patients with asymptomatic hypertension and assess a community health worker (CHW)-led intervention addressing social determinants of health. Participants will complete SDOH surveys in REDCap with CHW-facilitated referrals to community organizations. Medical record review via EPIC and Healthix will evaluate healthcare utilization one year before and after the index ED visit.

Observational ICU Diaphragm Physiotherapy Trial NCT07538102

The NIH registered an observational clinical trial (NCT07538102) on April 20, 2026, evaluating whether respiratory physiotherapy protects diaphragm muscle structure in patients receiving mechanical ventilation in the ICU. The study compares standard ICU physiotherapy against neuromuscular electrical stimulation (NMES) as interventions, using ultrasonography to measure changes in diaphragm thickness. No compliance obligations are created by this trial registration.

Peritoneal Dialysis Specialized LLM for PD Management

NIH registered a randomized controlled trial (NCT07539428) on ClinicalTrials.gov evaluating large language model-assisted workflows against physician-only decision-making for peritoneal dialysis management. The study uses clinical vignettes to assess quality differences and identify potential risks such as generating erroneous or harmful suggestions. Conditions include Peritoneal Dialysis and Large Language Models; interventions include a PD-specialized LLM and generalized LLM tools.

DCB vs DES Intervention Clinical Trial for Multivessel Coronary Artery Disease

NIH ClinicalTrials.gov registered a new prospective, multicenter, randomized clinical trial (NCT07539324) comparing drug-coated balloon-based percutaneous coronary intervention (DCB-based PCI) against drug-eluting stent-based PCI in patients with multivessel coronary artery disease. The trial will evaluate lesions measuring 2.25 mm to 4.0 mm in diameter using GENOSS DCB and second/third-generation drug-eluting stents.

Loss Aversion Messaging Effect on Exercise Adherence in Older Adults - NCT07540052

The NIH has registered a new clinical trial (NCT07540052) evaluating whether loss aversion messaging can improve exercise adherence in older adults with mobility disability. The 4-month study will enroll participants in a daily at-home strength training program and compare loss aversion messaging against standard adherence reminders. The trial will measure anticipated regret and exercise frequency as primary outcomes.

Phase 2 CAR-T Combined With ASCT for High-risk Relapsed/Refractory Large B-cell Lymphoma

The NIH has registered a Phase 2 clinical study (NCT07538635) evaluating axicabtagene ciloleucel combined with autologous stem cell transplantation (ASCT) in patients with relapsed/refractory large B-cell lymphoma (LBCL) who have high-risk factors. The trial is prospective, single-arm, single-center, and open-label. Axicabtagene ciloleucel is the sole intervention. ClinicalTrials.gov registrations are informational public listings and do not constitute regulatory approvals or enforceable obligations.

Observational Darolutamide ADT Study for Non-metastatic Prostate Cancer, China

NIH registered an observational study (NCT07538843) on ClinicalTrials.gov evaluating darolutamide combined with androgen deprivation therapy (ADT) in Chinese men with non-metastatic castration-resistant prostate cancer (nmCRPC) whose disease progressed following prior bicalutamide plus ADT treatment. The single-arm study aims to observe treatment efficacy and safety in approximately 75 participants over 36 months using standard-of-care darolutamide.

Phase 2 Peiyuan Guben Tongluo Ointment for Elderly Sarcopenia NCT07538674

The NIH ClinicalTrials.gov registry has published a Phase 2 clinical trial (NCT07538674) evaluating Peiyuan Guben Tongluo Ointment (Ejiao concentrated formula) for treatment of sarcopenia in elderly patients. The randomized, parallel-group study enrolls elderly sarcopenia patients and measures DXA-measured limb muscle mass increase from baseline after 12 weeks of treatment. The trial uses an agarose concentrating group as parallel control and includes exercise and nutritional intervention as co-interventions.

Phase 2 Dalpiciclib Radiotherapy Breast Cancer Brain Metastases

NIH registered Phase 2 clinical trial NCT07539753 evaluating brain radiotherapy combined with dalpiciclib and endocrine therapy in 46 HR-positive/HER2-negative advanced breast cancer patients with brain metastases. The prospective open-label study will assess safety and efficacy per RECIST v1.1, with clinic visits every 3 months until disease progression or withdrawal.

GLP-1 Compounding Rules, Board Membership, Renewal Info

The Wisconsin Pharmacy Examining Board newsletter advises pharmacies dispensing compounded GLP-1 medications (such as semaglutide or tirzepatide) to ensure compliance with Wis. Admin. Code ch. Phar 15 requirements, including facility, process, documentation, and verification standards. The newsletter references FDA guidance warning that compounders may not produce drugs essentially copies of FDA-approved drugs unless documented shortages apply. The newsletter also announces the upcoming license renewal period opening April 12, 2026 and closing May 31, 2026, and notes that 2025 WI Act 167 will add two pharmacy technician seats to the Board.

Medicare Preventive Services Codes Coverage Information

CMS Medicare Learning Network published MLN006559, an informational product providing codes and coverage information for Medicare preventive services. The publication includes links to related resources covering advance care planning, diabetes self-management training, Medicare Diabetes Prevention Program, Part D vaccines, wellness visits, and screening examinations.

Governor and LDH Secretary Urge Emotional Support After Shreveport Shooting

The Louisiana Department of Health and Governor Jeff Landry issued a public health notice encouraging residents to utilize the Louisiana 988 crisis hotline for free, confidential emotional support following a shooting in Shreveport. The notice provides information about available mental health resources including crisis support teams and behavioral health services. No compliance obligations or regulatory requirements are created.

Pain Neuroscience Education Versus Kinesio Tape for Carpal Tunnel Syndrome

NIH ClinicalTrials.gov registered NCT07539480, a randomized controlled trial comparing Pain Neuroscience Education (PNE) versus Kinesio Tape for functional outcomes in patients with carpal tunnel syndrome. The study targets 160 participants with mild-to-moderate CTS, with an estimated completion date of April 20, 2026. This is an informational clinical trial registration with no compliance obligations.

The Effect of Coffee Consumption on Balance, University Students

NIH registered an observational study (NCT07540559) investigating the effects of daily coffee consumption on balance performance in healthy university students. Participants will be categorized by habitual caffeine intake and assessed using standardized clinical balance tests. The study focuses on whether caffeine influences neuromuscular control, reaction time, and postural stability.

ANS02 Phase 1 Study for EGFR Mutation-Positive NSCLC

NIH registered a first-in-human Phase 1 clinical trial (NCT07538804) evaluating ANS02 monotherapy in patients with EGFR mutation-positive advanced non-small cell lung cancer (NSCLC). The multi-center, open-label study will assess safety, tolerability, preliminary efficacy, pharmacokinetics, and anti-tumor activity. This registration documents the trial on ClinicalTrials.gov, supporting transparency requirements for federally funded clinical research.

Chlorhexidine vs Morus Nigra Mouthwash Periodontal Trial

NIH ClinicalTrials.gov has registered study NCT07540624, a randomized controlled trial evaluating the comparative efficacy of chlorhexidine gluconate (0.12%) and Morus nigra (blackberry, 5%) mouthwashes as adjuncts to non-surgical periodontal treatment. The study will enroll patients with periodontitis across three arms: scaling and root planing (SRP) alone, SRP plus chlorhexidine, and SRP plus Morus nigra mouthwash. Investigators will assess clinical periodontal parameters, gingival crevicular fluid inflammatory markers (TNF-a, IL-1b, IL-10), and subgingival plaque microbiological profiles at baseline, 1 month, and 3 months.

Intestinal Ultrasound Predicts Crohn's Disease Relapse in Deep Remission

NIH registered a multicenter prospective observational study evaluating transabdominal intestinal ultrasound as a non-invasive predictor of Crohn's disease relapse. The 18-month study will follow CD patients in deep remission, comparing color Doppler ultrasound parameters between relapse and non-relapse groups using stratified analysis by Montreal classification to establish a predictive model.

Randomized Controlled Study on Mandala Coloring for Quality of Life in Epilepsy

NIH registered a randomized controlled trial (NCT07540013) to assess mandala painting's effect on quality of life in epilepsy patients. The single-blind study at Gümüşhane State Hospital Neurology Polyclinic will enroll adult patients with generalized epilepsy, randomly assigning them to control or experimental groups via full simple randomization. The experimental group will receive mandala painting materials and instructions to complete one mandala at home three times weekly over twenty-four sessions, with data collected using the QOLIE-31 quality-of-life scale.

The REACH-OUT Trial - Blood Pressure Optimization for Women

NIH registered a new clinical trial (NCT07540143) titled the REACH-OUT Trial on ClinicalTrials.gov. The trial will test a technology-enabled strategy to optimize blood pressure among reproductive-aged women with hypertension receiving care at Federally Qualified Health Centers. The study will evaluate health literacy-informed education materials, BP monitors, portal tools, MeDS assessment, and patient navigator support.

Roy Model Medication Training Heart Failure Trial

NIH registered clinical trial NCT07538596 on ClinicalTrials.gov evaluating an Ignite-Based Medication Management Training program for heart failure patients. The trial will enroll participants with heart failure with reduced ejection fraction (HFrEF), randomizing them to receive structured medication training via WhatsApp or standard discharge education. Participants will be followed for 12 weeks with questionnaires at baseline, 4 weeks, and 12 weeks to assess medication adherence and symptom management outcomes.

Motivational Interviewing Prevents Early Childhood Caries, 228 Mother-Infant Pairs, Malaysia

NIH ClinicalTrials.gov registered a two-arm parallel cluster-randomized controlled trial (NCT07538219) in Malaysia comparing Motivational Interviewing-based Anticipatory Guidance versus conventional Ministry of Health Anticipatory Guidance for preventing early childhood caries. The study will recruit 228 mother-infant pairs from MOH Maternal and Child Health Clinics in Setiu and Hulu Terengganu, with data collection at infant ages 6, 9, and 12 months.

Fuchs Dystrophy Descemet Polishing Clinical Trial NCT07539012

The NIH ClinicalTrials.gov registry has posted a new clinical trial (NCT07539012) titled 'Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy.' The study will evaluate whether polishing the Descemet membrane prior to cultured endothelial cell injection improves guttae removal and cell adhesion in Fuchs dystrophy patients. Corneal endothelial keratoplasty is currently the reference treatment, but graft shortages have driven interest in cell-based therapies.

Comparison of 7-Day vs 1-Day Packaging for SQ-LNS in Ethiopia

NIH ClinicalTrials.gov registered a mixed-methods field study (NCT07540793) comparing 7-day (7dp) vs 1-day (1dp) packaging of Small Quantity Lipid-based Nutrient Supplements (SQ-LNS) for children 6-24 months in North Shoa Zone, Amhara Region, Ethiopia. The study, conducted by Edesia Nutrition in partnership with Nutriset Développement, will evaluate acceptability and adherence to the new packaging design. The new 140g 7dp packet reduces cost by over 15% through 40% less packaging and 20% improved transportation efficiency.

Randomized Trial of Tranexamic Acid and Sucralfate for Gastrointestinal Tumor Bleeding

NIH registered Clinical Trial NCT07540026, a randomized controlled trial evaluating endoscopic application of tranexamic acid and sucralfate powders for hemostasis in gastrointestinal tumor bleeding. The study will recruit 60 patients at National Cheng Kung University Hospital in Taiwan, comparing active treatment (3g sucralfate powder and 1.5g tranexamic acid powder) against standard treatment. The trial is listed as ongoing with an estimated completion date of April 20, 2026.

Factors Affecting Immediate Anterior Implants: Retrospective Clinical Study

The NIH ClinicalTrials.gov registry has posted a retrospective cohort study (NCT07539168) evaluating clinical, surgical, and prosthetic factors associated with outcomes of immediate implant placement in the anterior maxilla. The observational study aims to identify predictors of implant survival and complications within 12 months of placement, and will assess peri-implant marginal bone loss, prosthetic complications, and esthetic outcomes using the pink esthetic score.

Biomarker Panel Forecasts Chronic GVHD After Allo-HSCT

NIH registered a single-center observational clinical study (NCT07539220) investigating a biomarker panel for forecasting chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The discovery cohort enrolled 1000 consecutive patients retrospectively from January 2021 to June 2023, while a validation cohort of 500 recipients was enrolled from June 2023 to June 2024. Heparinized blood samples were collected at day +90 post-HSCT and analyzed using multiplex mass spectrometry with pooled plasma to compare proteomic profiles between patients with and without cGVHD.

Telerehabilitation in Patients With Bronchiectasis

The NIH registered a new randomized controlled trial (NCT07539571) on ClinicalTrials.gov evaluating home-based telerehabilitation for patients with bronchiectasis. The single-center trial will be conducted at Virgen del Rocío University Hospital in Spain, randomizing participants to usual care or a 12-week supervised telerehabilitation program three times per week. Outcome measures include the 6-minute walk test, quality-of-life questionnaires, pulmonary function tests, and inflammatory biomarkers.