Observational ICU Diaphragm Physiotherapy Trial NCT07538102
Summary
The NIH registered an observational clinical trial (NCT07538102) on April 20, 2026, evaluating whether respiratory physiotherapy protects diaphragm muscle structure in patients receiving mechanical ventilation in the ICU. The study compares standard ICU physiotherapy against neuromuscular electrical stimulation (NMES) as interventions, using ultrasonography to measure changes in diaphragm thickness. No compliance obligations are created by this trial registration.
What changed
This document registers a new observational clinical trial on ClinicalTrials.gov and does not constitute a regulatory change or impose compliance obligations. The trial will study whether respiratory physiotherapy and neuromuscular electrical stimulation affect diaphragm thickness in ICU patients on mechanical ventilation.
Affected parties — ICU clinicians, respiratory therapists, and clinical researchers — may wish to note this trial's registration as a signal of ongoing research interest in diaphragm-protective ventilation strategies, but no immediate action is required.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Respiratory Physiotherapy and Diaphragm Thickness in Ventilated ICU Patients
Observational NCT07538102 Kind: OBSERVATIONAL Apr 20, 2026
Abstract
This study aims to evaluate the effect of respiratory physiotherapy on diaphragm thickness in patients receiving mechanical ventilation support in the intensive care unit. Thinning and dysfunction of the diaphragm muscle observed during mechanical ventilation complicate the extubation process and increase the risk of respiratory failure in patients. Diaphragm dysfunction prolongs ventilator use and increases ICU mortality. The main objective of this research is to determine whether respiratory physiotherapy has protective or ameliorative effects on diaphragm muscle structure and function, to optimize the ventilator weaning process, and to provide scientific contributions to the field of respiratory rehabilitation. Changes in diaphragm thickness will be objectively evaluated using ultrasonography, and the aim is to obtain evidence-based data on the effectiveness of respiratory physiotherapy.
Conditions: Diaphragm Dysfunction
Interventions: Standard ICU Physiotherapy, Neuromuscular Electrical Stimulation (NMES)
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