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Effect of Acoustic Conditions on 6-Minute Walk Test Performance and Recovery

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Summary

NIH ClinicalTrials.gov registered an observational study (NCT07540455) examining the acute effects of three auditory conditions—metronome, binaural beats, and silent control—on 6-Minute Walk Test performance, post-exercise recovery physiology, and perceived exertion in healthy young adults aged 18-35. The randomized cross-over study will expose all participants to all three conditions on separate days to assess how rhythmic auditory stimuli and cortical neural entrainment affect walking efficiency and recovery.

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What changed

NIH ClinicalTrials.gov recorded a new observational study (NCT07540455) titled 'The Effect of Different Acoustic Conditions on 6-Minute Walk Test Performance and Recovery.' The study employs a randomized cross-over design to compare three auditory conditions—metronome rhythmic stimulation, binaural beats at theta frequency, and silent control—across three separate testing sessions. Participants are healthy young adults aged 18-35 with no cardiovascular, pulmonary, neurological, or musculoskeletal conditions.

This study registration is informational and does not create compliance obligations for regulated entities. Compliance readers monitoring clinical research activities may note the study's focus on auditory-motor coupling mechanisms and parasympathetic recovery, which could inform future research on acoustic stimulation applications in rehabilitation or fitness contexts.

Archived snapshot

Apr 21, 2026

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The Effect of Different Acoustic Conditions on 6-Minute Walk Test Performance and Recovery

Observational NCT07540455 Kind: OBSERVATIONAL Apr 20, 2026

Abstract

Study Design: Randomized Cross-Over Study

Objective:

This study aims to compare the acute effects of three different auditory conditions (metronome, binaural beats, and silent control) on 6-Minute Walk Test (6MWT) performance, post-exercise recovery physiology, and perceived exertion in healthy young adults.

Background:

Auditory-motor coupling mechanisms suggest that rhythmic auditory stimuli can lower the excitation threshold of motor neurons, thereby enhancing walking efficiency. Rhythmic stimuli such as metronomes are known to improve walking speed and coordination. Binaural beats are an auditory stimulus type generated by presenting two tones of slightly different frequencies to each ear, triggering cortical neural entrainment. It has been reported that listening to binaural beats at theta frequency following exercise increases parasympathetic activation and accelerates recovery. This study aims to examine these two auditory stimuli in comparison with a control condition in healthy young adults.

Participants:

Healthy young adults aged 18-35 who can walk independently and have no cardiovascular, pulmonary, neurological, or musculoskeletal conditions. Minimum sample size will be calculated using G*Power following a pilot study, with a 20% dropout margin added.

Randomization:

All participants will be exposed to all three conditions on separate days. The order of application will be determined by computer-based simple randomization (randomizer.org). Six possible s...

Conditions: Recovery, Fatigue Recovery, Healhty

Interventions: Metronome, Bineural Beats, Control

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Last updated

Classification

Agency
NIH
Published
April 20th, 2026
Instrument
Notice
Branch
Executive
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
NCT07540455

Who this affects

Applies to
Clinical investigators Healthcare providers
Industry sector
5417 Scientific Research
Activity scope
Clinical trial registration Walking test research Acoustic stimulation study
Threshold
Healthy young adults aged 18-35 who can walk independently and have no cardiovascular, pulmonary, neurological, or musculoskeletal conditions
Geographic scope
United States US

Taxonomy

Primary area
Healthcare
Operational domain
Clinical Operations
Topics
Public Health Pharmaceuticals

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