Clinical & Radiographic Evaluation of CGF With Auto Transplanted Closed Apex Teeth
ClinicalTrials.gov Studies
Summary
NIH ClinicalTrials.gov has registered a clinical study (NCT07538921) evaluating Concentrated Growth Factors (CGF) in autotransplantation of closed apex teeth. The study will assess clinical outcomes including tooth stability, periodontal health, and radiographic bone healing over a defined follow-up period, with completion anticipated April 20, 2026. CGF, as an advanced generation of platelet concentrates, may enhance tissue regeneration and improve the success rate of transplanted teeth.
What changed
NIH ClinicalTrials.gov registered a new clinical study evaluating the effect of Concentrated Growth Factors (CGF) on outcomes of autotransplanted closed apex teeth. The study will involve treatment of patients requiring tooth autotransplantation using CGF at the recipient site, with clinical and radiographic follow-up assessments.
Affected parties include dental and oral surgery practitioners, clinical researchers in regenerative dentistry, and patients with missing teeth being considered for autotransplantation. The findings may inform future clinical practice regarding CGF use in tooth transplantation, though this study registration itself does not create compliance obligations.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Clinical & Radiographic Evaluation of Concentrated Growth Factors (CGF) With Auto Transplanted Closed Apex Teeth
N/A NCT07538921 Kind: NA Apr 20, 2026
Abstract
This study aims to clinically and radiographically evaluate the effect of Concentrated Growth Factors (CGF) on the outcomes of autotransplantation of closed apex teeth. Tooth autotransplantation is considered a viable treatment option for replacing missing teeth; however, its success may be influenced by factors such as periodontal healing and pulpal revascularization, especially in teeth with closed apices.
Concentrated Growth Factors (CGF), as an advanced generation of platelet concentrates, are rich in growth factors that may enhance tissue regeneration, promote healing, and improve the success rate of transplanted teeth.
In this study, patients requiring tooth autotransplantation will be treated using CGF at the recipient site. Clinical outcomes, including tooth stability, periodontal health, and presence of complications, will be assessed. Radiographic evaluation will be performed to monitor bone healing, root resorption, and periodontal ligament integrity over a defined follow-up period.
The findings of this study are expected to provide evidence regarding the potential benefits of CGF in improving the success and prognosis of autotransplanted closed apex teeth.
Conditions: Concentrated Growth Factor
Interventions: closed apex teeth auto transplantation
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