Fuchs Dystrophy Descemet Polishing Clinical Trial NCT07539012
The NIH ClinicalTrials.gov registry has posted a new clinical trial (NCT07539012) titled 'Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy.' The study will evaluate whether polishing the Descemet membrane prior to cultured endothelial cell injection improves guttae removal and cell adhesion in Fuchs dystrophy patients. Corneal endothelial keratoplasty is currently the reference treatment, but graft shortages have driven interest in cell-based therapies.
Comparison of 7-Day vs 1-Day Packaging for SQ-LNS in Ethiopia
NIH ClinicalTrials.gov registered a mixed-methods field study (NCT07540793) comparing 7-day (7dp) vs 1-day (1dp) packaging of Small Quantity Lipid-based Nutrient Supplements (SQ-LNS) for children 6-24 months in North Shoa Zone, Amhara Region, Ethiopia. The study, conducted by Edesia Nutrition in partnership with Nutriset Développement, will evaluate acceptability and adherence to the new packaging design. The new 140g 7dp packet reduces cost by over 15% through 40% less packaging and 20% improved transportation efficiency.
Randomized Trial of Tranexamic Acid and Sucralfate for Gastrointestinal Tumor Bleeding
NIH registered Clinical Trial NCT07540026, a randomized controlled trial evaluating endoscopic application of tranexamic acid and sucralfate powders for hemostasis in gastrointestinal tumor bleeding. The study will recruit 60 patients at National Cheng Kung University Hospital in Taiwan, comparing active treatment (3g sucralfate powder and 1.5g tranexamic acid powder) against standard treatment. The trial is listed as ongoing with an estimated completion date of April 20, 2026.
Factors Affecting Immediate Anterior Implants: Retrospective Clinical Study
The NIH ClinicalTrials.gov registry has posted a retrospective cohort study (NCT07539168) evaluating clinical, surgical, and prosthetic factors associated with outcomes of immediate implant placement in the anterior maxilla. The observational study aims to identify predictors of implant survival and complications within 12 months of placement, and will assess peri-implant marginal bone loss, prosthetic complications, and esthetic outcomes using the pink esthetic score.
Biomarker Panel Forecasts Chronic GVHD After Allo-HSCT
NIH registered a single-center observational clinical study (NCT07539220) investigating a biomarker panel for forecasting chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The discovery cohort enrolled 1000 consecutive patients retrospectively from January 2021 to June 2023, while a validation cohort of 500 recipients was enrolled from June 2023 to June 2024. Heparinized blood samples were collected at day +90 post-HSCT and analyzed using multiplex mass spectrometry with pooled plasma to compare proteomic profiles between patients with and without cGVHD.
Telerehabilitation in Patients With Bronchiectasis
The NIH registered a new randomized controlled trial (NCT07539571) on ClinicalTrials.gov evaluating home-based telerehabilitation for patients with bronchiectasis. The single-center trial will be conducted at Virgen del Rocío University Hospital in Spain, randomizing participants to usual care or a 12-week supervised telerehabilitation program three times per week. Outcome measures include the 6-minute walk test, quality-of-life questionnaires, pulmonary function tests, and inflammatory biomarkers.
HBVCare Mobile App Chronic Hepatitis B Treatment Adherence Randomized Controlled Trial
NIH registered clinical trial NCT07540637, a multicenter randomized controlled trial evaluating the HBVCare mobile application for improving treatment adherence in chronic Hepatitis B patients at Hoang Long Clinic and Hanoi Medical University Hospital in Vietnam. Patients are randomized to standard care or HBVCare app intervention, with adherence outcomes assessed at three months.
Celsio Cryocatheter Disposable System Bronchoscopy Study
NIH registered a new clinical trial on ClinicalTrials.gov evaluating the Celsio Disposable Cryocatheter System for diagnostic and interventional bronchoscopy in patients with lung cancer and interstitial lung disease. The study aims to generate real-world evidence on device performance and identify best practices without interfering with standard clinical care.
Functionally Optimized CD33 CAR-T for AML, Phase 1 Trial NCT07538713
NIH registers Phase 1 trial NCT07538713 evaluating functionally optimized CD33 CAR-T (FO33 CAR-T) cell therapy in patients with recurrent/refractory acute myeloid leukemia (AML). The single-arm study will assess safety, tolerability, and preliminary efficacy of the CD33-targeted therapy. CD33 is expressed in leukemia cells from over 80% of AML patients and was selected as the target antigen due to higher expression levels across AML subtypes compared to alternative targets such as CLL-1 and CD123.
Investigation of Patients Presenting With Acute Functional Neurological Symptoms
NIH ClinicalTrials.gov registered NCT07538414, a retrospective single-center observational study analyzing patients presenting with acute functional neurological symptoms. The study aims to characterize the frequency, clinical features, diagnostic pathways, and healthcare utilization of patients with functional neurological disorder. Data collection is limited to retrospective patient data review; no prospective interventions are involved.
Technical Review Panel Public Meeting Notice
Indiana Department of Health has posted a public meeting notice for the Technical Review Panel. The meeting is scheduled for Friday, March 27, 2026, at 10 a.m. EST in the Robert O. Yoho Board Room at 2 N. Meridian St., Indianapolis, IN 46204. Virtual attendance options via Microsoft Teams and telephone are available.
Hospital Violence Intervention Program (HVIP+) Community Model, Central Arkansas
The National Institutes of Health has registered a new clinical trial (NCT07539142) testing the preliminary efficacy of a Hospital-based Violence Intervention Program (HVIP) in Central Arkansas. The optimization randomized control trial will evaluate interventions including Brief Bedside, Peer Support, Case Management with Voucher, and SELF Group Therapy Sessions for hospital-based violence intervention, community firearm violence, and firearm behaviors.
Observational Safety Trial of CT0494BCP in Advanced Gastric/Esophagogastric Junction Adenocarcinoma
A new observational safety trial (NCT07538856) evaluating CT0494BCP cell therapy in participants with advanced gastric/esophagogastric junction adenocarcinoma has been registered on ClinicalTrials.gov. The study uses Bayesian optimal interval (BOIN) design for dose escalation across six dose groups. CT0494 cells are assigned to three escalating doses (3.0×10⁸, 4.5×10⁸, 6.0×10⁸), and CT7095 cells to two escalating doses (1.5×10⁸, 3.0×10⁸). The trial will assess safety, tolerability, preliminary efficacy, and cellular metabolism kinetics.
Effectiveness of Ambulatory Transcutaneous Tibial Nerve Stimulation for Overactive Bladder
NIH has registered a randomized clinical trial (NCT07540273) comparing ambulatory versus clinic-based transcutaneous tibial nerve stimulation for treating overactive bladder in adults aged 18-65. The two-arm study will enroll participants receiving identical electrical stimulation parameters (20 Hz, 200 µs) delivered either at home via portable device or in-clinic twice weekly over 2 weeks. The trial will assess urgency episode frequency, bladder symptoms, and quality of life outcomes.
WECARE Study, Chinese American Dementia Caregivers
NIH has registered a new clinical trial, NCT07539350, titled 'WECARE Study,' testing a seven-week multimedia wellness intervention for Chinese American family caregivers of persons with Alzheimer's disease and related dementias. The trial aims to determine whether the WECARE program improves caregiver well-being and reduces stress related to caregiving for persons with caregiver burden. The study does not create compliance obligations for regulated entities.
Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow
The National Institutes of Health registered a prospective observational clinical study (NCT07540481) evaluating the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general anesthesia. The study will assess ONSD changes at two time points and secondary Doppler parameters. No compliance obligations or deadlines are imposed by this registration.
Pilot RCT Tests ACT for Perinatal Loss Mental Health
NIH registered a pilot randomized controlled trial (NCT07538011) evaluating an Acceptance and Commitment Therapy-based psychosocial intervention for women who have experienced perinatal loss. The 4-week mixed-format program includes four in-person sessions and two videoconferencing sessions, with a 30-minute booster one month post-completion. The study will assess feasibility, acceptability, and preliminary effects on perinatal grief, PTSD, depression, anxiety, psychological flexibility, and social support.
Controlled Cold Exposure Combined With PD-1/PD-L1 Immunotherapy in Solid Tumors (NIVALIS)
NIH ClinicalTrials.gov has registered a single-arm, open-label Phase I exploratory study (NCT07538479) evaluating controlled cold exposure combined with standard PD-1/PD-L1 inhibitor-based therapy in 24 participants with solid malignancies. The primary objectives are to evaluate safety, tolerability, and feasibility of the cold exposure intervention. Secondary objectives include exploring preliminary antitumor activity and effects on brown adipose tissue activation, peripheral immune profiling, circulating cytokines, metabolomics, gut microbiota, and tumor biomarkers.
HDM2024 Phase 1 Trial, Advanced Solid Tumors
NIH registered a Phase 1 clinical trial (NCT07539285) for HDM2024, an investigational drug, in participants with advanced solid tumors. The trial will evaluate drug safety, tolerability, and antitumor activity. Participants receive the study drug once every three weeks, with imaging-based efficacy assessments every six weeks.
Bambini Kids Robot-Assisted Gait Training Safety and Effectiveness Trial in Children With Cerebral Palsy
NIH has registered a clinical trial evaluating the safety and effectiveness of the Bambini Kids pediatric robotic exoskeleton in children with cerebral palsy (CP). The single-arm study will assess robot-assisted gait training (RAGT) as an intervention for gait impairment and motor performance limitations in the pediatric CP population. The trial is registered as NCT07539389 with an estimated completion date of April 20, 2026.
Ultrasound-Guided Percutaneous Needle Tenotomy vs Percutaneous Ultrasonic Needle Tenotomy for Gluteal Tendinosis
NIH ClinicalTrials.gov registered a new clinical study (NCT07540806) comparing two tenotomy techniques for gluteal tendinosis: standard percutaneous needle tenotomy (PNT) versus percutaneous ultrasonic tenotomy (PUT) using the Tenex device. The study's primary endpoints are pain improvement and functional outcomes. This is an informational database entry; no regulatory obligations or compliance requirements are created.
Youth Cannabis Use Continued to Decline in 2025
The Minnesota Department of Health released findings from the 2025 Minnesota Student Survey showing 96% of students reported not using cannabis in the last month, and a 57.7% decrease in past 12-month use among eighth, ninth, and 11th graders since 2013. The survey, conducted between January and June 2025, is Minnesota's first since adult cannabis use was legalized in 2023.