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Transnasal Testosterone Gel for Hypogonadism in Males with Allergic Rhinitis

USPTO published patent application US20260108531A1 by inventor Natalia Tkachenko on April 23, 2026, covering methods of treating hypogonadism in males via intranasal testosterone bio-adhesive gel formulations. The application discloses 4.0% and 4.5% testosterone gel compositions that remain effective when allergic rhinitis occurs or when topical nasal vasoconstrictors or decongestants are used during treatment. Filing date was March 20, 2025; application number 19085870.

Routine Notice Intellectual Property
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Fused Amino Pyrimidine Compounds Treat Tinnitus, Hearing Loss, Meniere's

USPTO published Patent Application US20260108529A1 on April 23, 2026, filed by inventor Zhong Zhong on October 23, 2025 (Application No. 19366802), covering fused amino pyrimidine compounds for treating tinnitus, acute sensorineural hearing loss, age-related hearing loss, and Meniere's disease. The application discloses therapeutic compositions containing compounds according to Formula (I) or their pharmaceutically acceptable salts, classified under CPC codes A61K 31/5377, A61K 31/519, A61K 31/5517, A61K 45/06, and A61P 27/16.

Routine Notice Intellectual Property
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Compound A Methods for RAS Protein-Related Disease Treatment

USPTO published patent application US20260108528A1 on April 23, 2026, covering methods of treating RAS protein-related diseases using Compound A or a pharmaceutically acceptable salt thereof, including combination therapies with additional therapeutic agents. The application (No. 19363949) was filed October 21, 2025, naming nine inventors: Jingjing Jiang, Lingyan Jiang, Benjamin Maldonato, Mallika Singh, Sophia Sohoni, Zhengping Wang, Zhican Wang, Caroline E. Weller, and Muhammad Ali. CPC classifications include A61P 35/00 (antineoplastic) and various protein/antibody classifications, indicating cancer treatment applications.

Routine Notice Intellectual Property
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Methods for Treatment of Psoriatic Arthritis - Patent Application US20260108530A1

Three inventors — Pille Harrison, Luc Meuleners, and Chantal Thérèse Tasset — filed Application US20260108530A1 on 2025-05-13, published April 23, 2026, covering a compound according to Formula I, or a pharmaceutically acceptable salt, solvate, or salt of a solvate thereof, pharmaceutical compositions comprising the same, and methods of treatment using the same, for use in the treatment of psoriatic arthritis. The application is classified under CPC codes A61K 31/541 and A61P 19/02.

Routine Notice Intellectual Property
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Cannabis Nanoplatform Treats Menopause Symptoms, Published 23rd Apr

USPTO published patent application US20260108538A1 (filed October 21, 2024) for a cannabinoid-based nanoplatform composition targeting menopause symptoms. The composition combines phytocannabinoids (CBD, CBG, CBN) with isoflavones and polyphenols in a nanoplatform designed for enhanced bioavailability and controlled release. The disclosed kit includes oral capsules and intravaginal ovules formulated to address vasomotor symptoms, genitourinary syndrome of menopause, bone loss, mood disturbances, sleep disorders, and cardiovascular disease risks.

Routine Notice Intellectual Property
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Meibomian Gland Dysfunction Treatment Using Keratolytic Agents

USPTO inventors Yair Alster, Omer Rafaeli, Kirsten Angela Macfarlane, Cary Reich, Shimon Amselem, and Doron Friedman filed Application US20260108533A1 on August 29, 2025 (Application No. 19315391), published April 23, 2026. The application discloses topical compositions comprising keratolytic agents such as salicylic acid or selenium disulfide for treating meibomian gland dysfunction via administration to the eyelid margin. Pharmaceutical companies developing ophthalmic or dermatologic therapeutics should review the disclosed claims for freedom-to-operate implications and competitive landscape assessment.

Routine Notice Intellectual Property
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Astura Medical Auto-locking Expandable Corpectomy Column Patent Application

The USPTO has published patent application US20260108360A1 for an auto-locking expandable corpectomy column system, assigned to Astura Medical Inc. The application was filed on October 19, 2024, under application number 18920851, with inventors Ross Dusterhoft and Thomas Purcell. The system comprises a vertebral body replacement device featuring an auto-locking mechanism designed to simplify surgical use without requiring additional instrumentation.

Routine Notice Intellectual Property
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Custom Density 3D-Printed Spinal Implants

USPTO published patent application US20260108359A1 filed on October 24, 2025 (Application No. 19368950) for a spinal implant with custom density manufactured via 3D printing. The implant body defines a longitudinal axis with distal and proximal end portions, opposed side surfaces, and top and bottom surfaces configured to engage vertebral bodies with a surface roughness between 3-4 μm. A cavity extends through the top and bottom surfaces covering at least 25% of the surface area, with first orifices through the top surface and second orifices through the bottom surface connected by a plurality of channels. Four inventors are listed: Thomas Morrison, Richard W. Woods, Richard Pellegrino, and Michael Prosser. Medical device manufacturers developing 3D-printed spinal implants should review this intellectual property filing for potential freedom-to-operate implications or licensing considerations.

Routine Rule Intellectual Property
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Femoral Implant With Laterally Rotated Trochlea

USPTO published patent application US20260108357A1 for a femoral implant design featuring a laterally rotated trochlear groove positioned between medial and lateral compartments, with a central axis perpendicular to the posterior condylar axis. The application was filed on October 16, 2025 by inventor James P. Crutcher, JR. under application number 19359792, with CPC classification A61F 2/3859. Patent applications are published for public inspection and do not grant enforceable rights until formally examined and issued.

Routine Notice Intellectual Property
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Alcon Ocular Implant Delivery System with Dual-Curved-Cannula and Camera

Alcon Inc. filed patent application US20260108386A1 on September 5, 2025, covering ocular implants, delivery systems, and methods of deploying an ocular implant. The published application describes implants comprising supporting frames and spines, with a distal supporting frame configured as an open trough, tool engagement ears curled inward, and a delivery system including a cannula with proximal and distal curved bends in opposite directions, plus a coupled camera. Application No. 19320393 was published April 23, 2026.

Routine Notice Intellectual Property
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Hip Joint Prosthetic Device for Osteoarthritis, Peter Forsell Inventor

USPTO published patent application US20260108356A1 for a hip joint prosthetic device designed to treat hip joint osteoarthritis in human patients. The application, filed December 19, 2024 by inventor Peter Forsell, discloses an artificial caput femur surface adapted to contact the acetabulum surface and a fixating member stabilized by cortical bone of the collum femur. Medical device manufacturers and orthopedic companies should monitor this application for potential competitive implications in the hip replacement market.

Routine Notice Intellectual Property
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Prosthetic Attachment System Vacuum Mechanical Suspension Patent Application

USPTO published patent application US20260108369A1 (application no. 19363285, filed 2025-10-20) for a prosthetic attachment system combining vacuum suspension and mechanical suspension. The system includes an attachment pin extending from a prosthetic liner, a connector assembly securing to a prosthetic socket, and a lanyard assembly with an external securing system. CPC classifications include A61F 2/7812 (prosthetic socket vacuum or weight-bearing chamber), A61F 2/60, A61F 2/80, and A61F 2002/7875. Five inventors are listed: Hafsteinn JONASSON, Sigurdur HANNESSON, Oskar Thor LARUSSON, Margret Sol RAGNARSDOTTIR, and Halldor ALBERTSSON.

Routine Notice Intellectual Property
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Bunion Screw System with Offset Channel

USPTO published patent application US20260108358A1 on April 23, 2026, covering a bunion repair system with a primary bunion screw having a cannulated interior, threaded exterior, and offset channel, plus a secondary support sized for placement within the channel. Inventors: Ryan Niver, Natan Pheil, and Samuel Nader. Filing date: October 18, 2024. Application number: 18919702. CPC classifications: A61F 2/4225, A61B 17/8635, A61B 17/864, A61B 17/8886.

Routine Rule Intellectual Property
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Interbody Device for Minimally Invasive Lumbar Fusion

USPTO published patent application US20260108362A1 titled 'Interbody Device, System, and Method, for Minimally Invasive Kambin Lumbar Lateral Interbody Fusion' on April 23, 2026. The application, filed October 6, 2025 under Application No. 19350506, covers an interbody device with a radiopaque outer body and an insertion portion whose width increases from a first end to a second end, configured for entry into a disc space during spinal fusion surgery. Inventors Anand Agarwal, Niraj Vasavada, and Darshak Shah are named on the application.

Routine Notice Intellectual Property
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Expandable Vertebral Implant for Spinal Procedures

Two inventors, Colm McLaughlin and James Himmelberger, filed patent application 19424613 on December 18, 2025, for an expandable vertebral implant for spinal procedures. The application was published by the USPTO on April 23, 2026, disclosing a prosthetic implant with first and second members configured to coaxially interdigitate and move along a longitudinal axis.

Routine Notice Intellectual Property
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Duchenne Muscular Dystrophy Treatment, University of Pennsylvania

The USPTO published patent application US20260109998A1 by The Trustees of the University of Pennsylvania, covering triple-splice mutants of dystrophin or utrophin, viral vectors encoding them, and compositions for treating Duchenne Muscular Dystrophy in human patients. Inventor Hansell Stedman filed the application on September 15, 2025, with CPC classifications C12N 15/86 and C07K 14/4708 indicating biotech/pharmaceutical subject matter. The application is published under Application No. 19328483.

Routine Notice Intellectual Property
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BDNF Gene Therapy Targets Obesity, Metabolic Disorders

The USPTO has published patent application US20260109997A1 for BDNF expression constructs and vectors intended to treat metabolic disorders including obesity. The application, filed on October 11, 2023 by five named inventors including Alexandria Forbes and Matthew During, claims the disclosed gene therapy is more effective than existing BDNF-based gene therapy constructs for metabolic indications.

Routine Notice Intellectual Property
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Juno Therapeutics Patents BCMA-Specific CARs for Immunotherapy

Juno Therapeutics, Inc. has published a patent application (US20260109774A1) for chimeric antigen receptors (CARs) specific to B-cell maturation antigen (BCMA) and encoding polynucleotides, published April 23, 2026. The application covers anti-BCMA antibodies, antigen-binding fragments, and genetically engineered cells expressing the CARs for use in adoptive cell therapy. The invention includes human antibodies that compete for BCMA binding with reference antibodies and is directed toward immunotherapy applications including potential cancer treatments.

Routine Notice Intellectual Property
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Phage-Derived Particles Deliver DNA Into C. Acnes, Eligo Bioscience

USPTO published patent application US20260109991A1 by Eligo Bioscience on April 23, 2026, covering phage-derived particles for delivering DNA payloads into Cutibacterium acnes bacteria. The application, filed October 24, 2025, discloses engineered vectors with C. acnes phage packaging signals and genes of interest, along with producer cells, phage-derived particles, and methods for transducing C. acnes with transgenes. Inventors include Aymeric LEVEAU, Ines CANADAS BLASCO, Aurelie MATHIEU, and Antoine DECRULLE.

Routine Notice Intellectual Property
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TNAP Marker Isolates Adult Multipotential Cells, Mesoblast

Mesoblast, Inc. has filed USPTO patent application US20260109783A1 (Application No. 19080304), published April 23, 2026, covering the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and isolating adult multipotential cells. The application names Stan Gronthos, Andrew Christopher William Zannettino, and Paul John Simmons as inventors and discloses cell populations enriched by the disclosed methods along with therapeutic uses of these cells. The filing date was March 14, 2025.

Routine Notice Intellectual Property
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CRISPR-Cas Type I-F3 Transposon Systems for DNA Integration Patent Application

USPTO published patent application US20260110001A1 disclosing recombinant Type I-F3 transposon-associated CRISPR-Cas systems and methods for DNA integration. The application, filed June 7, 2023 by inventors Rodolphe Barrangou and Avery Roberts under application number 18872321, covers CRISPR-Cas nucleic acid constructs combined with Tn7-like transposon systems. This publication makes the invention publicly available for examination and potential licensing or competing development.

Routine Notice Intellectual Property
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University of California Files Tumor-Neoantigen Antibody Patents for Cancer

The Regents of the University of California filed patent application US20260109786A1 on April 23, 2026, covering chemically controlled monoclonal antibodies reactive with tumor-specific neoantigens and neoantigen-binding fragments. The application also discloses related nucleic acids, expression cassettes, and expression vectors encoding the antibodies. Inventors include Charles S. CRAIK, Kevan M. SHOKAT, Ziyang ZHANG, and Peter J. ROHWEDER. The antibodies and fragments are disclosed as useful for cancer diagnosis and treatment.

Routine Notice Intellectual Property
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Merck Stable PD-1 Antibody Formulations 5-250 mg/mL Pembrolizumab Cancer Treatment

Merck Sharp & Dohme LLC filed USPTO Application US20260109768A1 on April 23, 2026, covering stable formulations of anti-PD-1 antibodies (5-250 mg/mL concentration range) with buffer, stabilizer, surfactant, and antioxidant excipients, specifically identifying pembrolizumab as the target antibody. The application names William P. Forrest Jr., Chakravarthy Nachu Narasimhan, and Yogita Krishnamachari as inventors and claims methods for treating various cancers via intravenous or subcutaneous administration. Patent prosecution will determine scope and grant likelihood.

Routine Rule Intellectual Property
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MESOTHELIN-TARGETED CD40 AGONISTIC MULTISPECIFIC ANTIBODY CONSTRUCTS FOR SOLID TUMORS

Amgen Inc. filed patent application US20260109776A1 covering human agonistic CD40 multispecific antibody constructs engineered to target the CD40 pathway on tumor-associated APCs for the treatment of solid tumors without systemic CD40 activation. The application was published on April 23, 2026 with filing date December 16, 2025 and application number 19421479, naming six inventors including Xin Yu, Jackson Egen, Fernando Garces, Shunsuke Takenaka, AeRyon Kim, and Deepali Sawant. CPC classifications span C07K 16 antibody constructs and A61P 35/04 for antineoplastic agents.

Routine Rule Intellectual Property
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Anti-PiLRA Antibodies, Uses Thereof, and Related Methods and Reagents

Denali Therapeutics Inc. filed patent application 18714069 on December 16, 2022, published as US20260109763A1 on April 23, 2026, covering anti-PILRA antibodies with selectivity profiles allowing comparable binding to cynomolgus and human PILRA proteins while exhibiting much weaker binding to human PILRB protein. The antibodies bind both PILRA G78 and R78 variants and may be used in animal studies without surrogate molecules and for treating subjects with either PILRA variant. This is a standard USPTO patent application publication and does not create compliance obligations.

Routine Notice Intellectual Property
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Monovalent CD47 Binding Proteins - Caedo Oncology, Apr 23, 2026

Caedo Oncology AS has published patent application US20260109764A1 for monovalent CD47 binding proteins and antibodies for therapeutic use. The application, filed October 9, 2023, claims binding proteins with one antigen binding domain targeting specific amino acid residues (Q19, N45, T120, R121, E122, G123) within CD47 as defined by SEQ ID NO:19. The inventors are Kjetil Hestdal, Rolf Dagfinn Pettersen, Nina Richartz, Sittana Matar, and Seham Skah. This publication makes the application available for public inspection and potential prior art challenges.

Routine Notice Intellectual Property
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Formulations With Reduced Degradation of Polysorbate, Genentech

USPTO published patent application US20260108611A1 assigned to Genentech, Inc. on April 23, 2026, with a filing date of December 18, 2025. The application covers aqueous pharmaceutical formulations comprising a polypeptide, polysorbate, and cyclodextrin designed to reduce polysorbate degradation and decrease visible and sub-visible particle formation. Inventors are Brian ConnOLLY, Lydia Hamburg, and Emily Holz.

Routine Rule Intellectual Property
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Selective Targeting of Host CD70+ Alloreactive Cells to Prolong Allogeneic CAR T Cell Persistence

Allogene Therapeutics, Inc. filed USPTO Patent Application US20260109771A1, published April 23, 2026, covering CD70-binding proteins, engineered immune cells (CAR-T cells), and methods for treating cancer including solid tumors and hematologic tumors. The application also claims engineered cells expressing both a CD70 CAR and a second CAR targeting a cancer-characteristic molecule, with optional reduction of TRAC, CD52, or CD70 expression. The filing date was December 15, 2025.

Routine Rule Pharmaceuticals
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Chugai Seiyaku Bispecific Antibody Substitutes Coagulation Factor VIII

Chugai Seiyaku Kabushiki Kaisha filed patent application US20260109782A1 for bispecific antibodies that specifically bind to both Factor IX/Factor IXa and Factor X, functionally substituting for blood coagulation Factor VIIIa. The disclosed antibody A44/B26 reduced coagulation time by 50 seconds or more compared to untreated controls. The inventors further developed commonly shared light-chain antibodies using the L chain from antibody A44, demonstrating that A44L can serve as shared L chains for multispecific antibody constructs with appropriate CDR shuffling.

Routine Notice Intellectual Property
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Harpoon Therapeutics Trispecific Protein BCMA Patent Application

Harpoon Therapeutics, Inc. filed patent application US20260109773A1 covering B cell maturation agent (BCMA) targeting trispecific proteins. The disclosed proteins comprise a CD3 binding domain, a half-life extension domain, and a BCMA binding domain, along with pharmaceutical compositions, nucleic acids, and methods of use for treating diseases and disorders. Application No. 19249844 was filed June 25, 2025, with inventors Holger Wesche, Bryan D. Lemon, and Richard J. Austin listed.

Routine Notice Intellectual Property
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Anti-HER2 Antibodies and Methods of Use Thereof

The USPTO published patent application US20260109781A1 for anti-HER2 antibodies on April 23, 2026, filed October 8, 2025 under application number 19352786. The application covers antibodies binding to subdomain II and/or subdomain IV of human HER2, including bispecific formats using a common light chain, for treating cancer and brain metastasis. Inventors include Abira Bandyopadhyay, Allisa Jayne Clemens, Do Jin Kim, Michelle E. Pizzo, Lu Shan, Richard Théolis Jr., and Raymond Ka Hang Tong.

Routine Rule Intellectual Property
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Anti-IL6 Receptor Antibody Treats Rheumatoid Arthritis

USPTO published patent application US20260108601A1 on April 23, 2026, filed September 22, 2025, covering methods of treating rheumatoid arthritis using an anti-IL6 receptor antibody in subjects with specific serum biomarker concentrations. The application names Anita Boyapati, Jérôme Msihid, and Moshe E. Zilberstein as inventors. Pharmaceutical and biotechnology companies developing IL-6 targeted therapies for autoimmune conditions may wish to monitor this application's prosecution for potential freedom-to-operate considerations.

Routine Notice Intellectual Property
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University of Chicago Bacteriophage Patent for Bacterial Infections

The University of Chicago has received a published patent application (US20260108570A1) for bacteriophage compositions and methods targeting Enterobacteriaceae infections, including Klebsiella. The application, filed August 1, 2023, covers isolated bacteriophage sequences with at least 99% identity to SEQ ID NO:1-74, along with associated devices, kits, and treatment methods. Inventors include Mark MIMEE and Ella ROTMAN.

Routine Notice Intellectual Property
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Mycobacteriophage Compositions and Related Methods, Oregon State University

USPTO published patent application US20260108571A1 for Oregon State University on April 23, 2026, covering isolated bacteriophages with lytic activity against mycobacterial species, including the specific phage Pill582 and variants thereof. The application (filed 2025-10-20, Application No. 19363116) discloses phage cocktails, pharmaceutical compositions, and methods for treating mycobacterial infections and associated disease conditions.

Routine Notice Intellectual Property
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Probiotic Preparation Containing Akkermansia Muciniphila Akk11 Strain for Alleviating Hypertension

USPTO published patent application US20260108565A1 on April 23, 2026, covering a probiotic preparation combining Akkermansia muciniphila Akk11 strain with Lactobacillus rhamnosus LRa05 strain for alleviating hypertension. The application, originally filed July 9, 2024 under application number 18879015, names Shuguang Fang, Yao Dong, Yunjiao Zhao, Zhonghui Gai, and Jianguo Zhu as inventors. The CPC classifications include A61K 35/741, A61P 9/12, and A61K 2035/115, indicating pharmaceutical preparations containing probiotics and anti-hypertensive agents.

Routine Notice Intellectual Property
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Engineered Immune Effector Cell with CD16 Protein for Shear Resistance

USPTO published patent application US20260108605A1, filed September 27, 2023, covering a genetically modified immune effector cell expressing a recombinant human CD16 protein engineered with amino acid additions, deletions, and replacements that confer enhanced shear resistance. The application names five inventors: Fuwei JIANG, Tingting LIU, Yifang WANG, Cuiqing YANG, and Zhuoxiao CAO. CPC classifications span immunology (A61K 38/1774, A61K 39/39558), oncology (A61P 35/00), and protein engineering (C07K 14/7051, C07K 16/2803).

Routine Rule Intellectual Property
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Anti-Cancer Therapy Methods Using Autophagy Induction via DBI Inhibition

USPTO published patent application US20260108602A1 covering methods and systems for improving anti-cancer therapies through autophagy induction via inhibition of extracellular diazepam binding inhibitor (DBI). Inventors include Mark de Boer, Guido Kroemer, Léa Montegut, Isabelle Martins, Hui Pan, Hui Chen, and Sijing Li, with application number 19361314 filed October 17, 2025. The application claims therapeutic compositions, methods, and regimens for cancer treatment, including chemo- and immunotherapies.

Routine Notice Intellectual Property
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US20260108572A1 - Alzheimer's Dementia Suppressant Using Sesamum Indicum Extract

USPTO published patent application US20260108572A1, filed September 1, 2023 and made publicly available on April 23, 2026, disclosing an Alzheimer-type dementia suppressant composition and method of manufacture using an aboveground part of Sesamum indicum (sesame plant) or an extract thereof as the active ingredient. The application names Sakamoto Yakusouen, LLC as assignee and Johji YAMAHARA as inventor. CPC classifications include A61K 36/185, A61K 31/7048, A61P 25/28, and related formulation codes A61K 2236/17, A61K 2236/333, A61K 2236/51, and A61K 2236/53. The application does not yet represent an issued patent and carries no compliance obligation.

Routine Notice Intellectual Property
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Methods of Treating Fibromyalgia With Psilocybin Compositions - Tryp Therapeutics

Tryp Therapeutics Inc. filed patent application US20260108545A1 with the USPTO on September 11, 2023 (application no. 19110772), published April 23, 2026. The application covers methods for treating fibromyalgia using psychedelics such as psilocybin or metabolites thereof, optionally combined with psychotherapy, with patient outcomes assessed through observer-rated and subject-reported measures as well as biological and clinical indicators. The inventors are James GILLIGAN and Peter GUZZO. Pharmaceutical and biotech companies pursuing psychedelic-based therapeutic research should monitor this filing as it may affect competitive patent positioning in fibromyalgia treatment.

Routine Notice Intellectual Property
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FGF21 GLP1 Double Gene-Modified Mesenchymal Stem Cell Patent Application for Metabolic Disease Treatment

The USPTO published patent application US20260108558A1, filed August 21, 2025, covering a modified mesenchymal stem cell engineered to co-express FGF21 and GLP-1 proteins, intended for treating metabolic diseases. The application names inventors Haifeng DUAN, Binghua XUE, Jing XIE, and Zhenli ZHANG, and specifies CPC classifications including A61K 35/28, A61P 3/10, C07K 14/50, C07K 14/605, and various C12N cellular-therapy classifications. Publication of this application creates prior art that may affect freedom-to-operate analyses for parties developing related cellular-therapy approaches for metabolic disease.

Routine Notice Intellectual Property
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EGFR Inhibitors for Treatment-Resistant Non-Small Cell Lung Cancer

USPTO has published patent application US20260108524A1 for methods of treating treatment-resistant non-small cell lung cancer using EGFR inhibitors. The application, filed October 16, 2023, names David A. Nathanson, Jonathan Tsang, and Timothy F. Cloughesy as inventors. CPC classifications include A61K 31/519, A61K 31/517, and A61P 35/00. This publication represents new intellectual property activity in the targeted oncology space.

Routine Notice Intellectual Property
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Bifidobacterium Longum Subsp. Infantis BI03 Strain for Alleviating Parkinson's Disease

The USPTO has published application US20260108568A1 for a Bifidobacterium longum subsp. infantis BI03 strain (CGMCC No. 24473, deposited March 7, 2022) for alleviating Parkinson's disease. The application claims the strain can alleviate Parkinson's-related dyskinesia and corticosterone elevation, weaken associated neuroinflammation, promote glutathione, and reduce brain oxidative stress damage. Inventors include Shuguang FANG, Yao DONG, Yixuan FAN, Zhonghui GAI, and Jianguo ZHU; the application was filed May 27, 2024.

Routine Notice Pharmaceuticals
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Bispecific CARs Targeting CD20 BCMA, AbelZeta, Autoimmune, Cancer

AbelZeta Inc. filed US Patent Application US20260108557A1 for a bispecific chimeric antigen receptor (CAR) targeting both CD20 and BCMA antigens simultaneously. The CAR construct comprises an scFv targeting CD20 and an scFv targeting BCMA, a hinge region, a transmembrane domain, a co-stimulatory region, and a cytoplasmic signaling domain. The application was filed on October 13, 2025, and published on April 23, 2026, with claims directed to methods of treating autoimmune disorders and cancer using the disclosed CAR.

Routine Rule Intellectual Property
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Longitudinal Study of Debt Advice, £1,767,867

The Money and Pensions Service has modified contract C0668 for the Longitudinal Study of Debt Advice, increasing the total contract value from £1,250,000 to £1,767,867. The study, awarded to IFF Research Ltd in April 2024, runs for 64 months and is conducted in Bedfordshire and Hertfordshire (UKH2). The research uses a randomised encouragement design across four waves to measure the causal impact of debt advice on financial wellbeing outcomes over short, medium, and long terms.

Routine Notice Government Contracting
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Bristol City Council £6M Cashless Parking Market Engagement Notice

Bristol City Council has issued a preliminary market engagement notice for cashless telephone parking services covering the City of Bristol, with an estimated contract value of £6,000,000 including VAT over a five-year term (December 2026 to November 2031) extendable to ten years. The council is hosting a virtual supplier information event on 11 May 2026 from 1:30–2:30pm via MS Teams to brief prospective bidders on requirements and procurement approach ahead of formal ITT publication estimated for 18 May 2026. Interested contractors must register by emailing penny.sharp@bristol.gov.uk.

Routine Notice Government Contracting
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Repair, Maintenance and Servicing of Laundry Equipment, £90k, 7th May

The Ministry of Defence has published a below-threshold open competition tender for the repair, maintenance and servicing of laundry equipment over a three-year period from 14 May 2026 to 31 March 2029. The estimated contract value is £75,000 excluding VAT (£90,000 including VAT). Tender submissions are due by 7 May 2026 at 10:00am via the electronic submission address at contracts.mod.uk, with the Most Advantageous Tender evaluation criteria applying to contract award.

Routine Notice Government Contracting
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Hackney Parent Carer Forum Hosting Contract, £47,897, Deadline 20 May 2026

The London Borough of Hackney has published a tender notice seeking a provider to host a Parent Carer Forum for Special Educational Needs and Disability (SEND) services. The contract is valued at £47,897 including VAT, running from 1 August 2026 to 31 July 2027 with an optional 12-month extension. The procurement is open to SMEs and VCSEs, with quality weighted at 80% and price at 20% of the award criteria. Tenders must be submitted electronically by 20 May 2026 at 12:00pm.

Routine Notice Government Contracting
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Thanet District Council Backup Solution Platform Procurement

Thanet District Council has published a tender notice for a replacement backup solution platform covering all council data held on premises and in its Google environment. The estimated contract value is £288,000 including VAT, with a five-year term from July 2026 to July 2031. Suppliers must submit completed tender documents via the Kent Business Portal by 12:00pm on 18 May 2026, with clarifications due by 7 May 2026. Evaluation will be weighted 60% on quality and 40% on price.

Routine Notice Government Contracting
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Halton Place Care at the Chemist £39k Pharmacy Contract Award

NHS Cheshire and Merseyside Integrated Care Board awarded a £39,000 contract via Direct Award A to selected Halton pharmacies for the Care at the Chemist (CATC) minor ailment service. The one-year contract commenced 1 April 2026 and expires 31 March 2027. The contract was awarded under the Provider Selection Regime (PSR) confirming that Public Contracts Regulations 2015 do not apply to this procurement.

Routine Notice Government Contracting
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Birmingham City Council Awards £180k Pest Control Contract to JMS BFD Limited

Birmingham City Council has awarded a £180,000 contract for pest control products and application equipment to JMS BFD Limited (trading as Copley Pest Solutions Ltd). The three-year contract runs from 11 May 2026 to 10 May 2029. The procurement was conducted as a below-threshold open competition exercise under the Procurement Act 2023.

Routine Notice Government Contracting

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10 sources

Sweden

10 sources

UAE

8 sources

Malta

8 sources

China

8 sources

Colombia

8 sources

Austria

7 sources

Luxembourg

7 sources

Türkiye

7 sources

Belgium

7 sources

Chile

7 sources

Nigeria

6 sources

UK

6 sources

Ghana

6 sources

Sri Lanka

6 sources

Greece

6 sources

Taiwan

6 sources

Egypt

5 sources

Romania

5 sources

Hungary

5 sources

Cyprus

5 sources

Czechia

4 sources

Estonia

4 sources

Thailand

4 sources

Mauritius

4 sources

Kenya

4 sources

Argentina

4 sources

Philippines

3 sources

Pakistan

3 sources

Nepal

3 sources

Israel

3 sources

Bulgaria

3 sources

Malaysia

3 sources

Saudi Arabia

3 sources

Croatia

3 sources

Mexico

3 sources

Russian Federation

3 sources

Kyrgyzstan

2 sources

Iceland

2 sources

Albania

2 sources

Indonesia

2 sources

Portugal

2 sources

Guernsey

2 sources

Tanzania

2 sources

Cayman Islands

2 sources

Barbados

2 sources

Botswana

2 sources

Honduras

2 sources

Panama

2 sources

Ecuador

2 sources

Kazakhstan

2 sources

Gibraltar

2 sources

Jordan

2 sources

Slovenia

2 sources

Uzbekistan

2 sources

El Salvador

2 sources

Costa Rica

2 sources

Slovakia

2 sources

Vietnam

2 sources

Moldova

1 sources

Lebanon

1 sources

Turks and Caicos Islands

1 sources

Venezuela

1 sources

Tunisia

1 sources

Armenia

1 sources

Tonga

1 sources

Namibia

1 sources

Oman

1 sources

Montenegro

1 sources

Rwanda

1 sources

Bermuda

1 sources

Zambia

1 sources

Zimbabwe

1 sources

Latvia

1 sources

Bosnia and Herzegovina

1 sources

Bhutan

1 sources

Peru

1 sources

Malawi

1 sources

Myanmar

1 sources

Fiji

1 sources

Uganda

1 sources

Vanuatu

1 sources

Ethiopia

1 sources

Serbia

1 sources

Bangladesh

1 sources

Iraq

1 sources

XX

1 sources

Liechtenstein

1 sources

Samoa

1 sources

Ukraine

1 sources

Azerbaijan

1 sources

Anguilla

1 sources

Virgin Islands, British

1 sources

Bahamas

1 sources

Morocco

1 sources

Isle of Man

1 sources

Saint Kitts and Nevis

1 sources

Maldives

1 sources

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