TNAP Marker Isolates Adult Multipotential Cells, Mesoblast
Summary
Mesoblast, Inc. has filed USPTO patent application US20260109783A1 (Application No. 19080304), published April 23, 2026, covering the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and isolating adult multipotential cells. The application names Stan Gronthos, Andrew Christopher William Zannettino, and Paul John Simmons as inventors and discloses cell populations enriched by the disclosed methods along with therapeutic uses of these cells. The filing date was March 14, 2025.
“ISOLATION OF ADULT MULTIPOTENTIAL CELLS BY TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE”
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GovPing monitors USPTO Patent Applications - Biotech (C12N) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 258 changes logged to date.
What changed
The USPTO published patent application US20260109783A1, assigned to Mesoblast, Inc., covering the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and isolating adult multipotential cells. The application also discloses cell populations enriched by TNAP-based isolation methods and therapeutic uses thereof. The patent is in the early application stage and has not yet been granted.
Parties in the cell therapy, regenerative medicine, and biotechnology sectors should monitor the prosecution of this application, particularly if their own cell isolation or biomarker-based cell selection technologies may overlap with the claimed subject matter. Competitors developing similar stem cell or progenitor cell isolation methods using alkaline phosphatase markers may need to evaluate potential freedom-to-operate considerations once the application advances toward grant.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
ISOLATION OF ADULT MULTIPOTENTIAL CELLS BY TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE
Application US20260109783A1 Kind: A1 Apr 23, 2026
Assignee
Mesoblast, Inc.
Inventors
Stan Gronthos, Andrew Christopher William Zannettino, Paul John Simmons
Abstract
The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also relates to cell populations enriched by methods of the present invention and therapeutic uses of these cells.
CPC Classifications
C07K 16/40 C12N 5/0081 C12N 5/0663 C12N 5/163 C12Q 1/42 G01N 33/577 G01N 33/68 A61K 2035/124 C07K 2317/76 C12N 2533/56 G01N 2333/916
Filing Date
2025-03-14
Application No.
19080304
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