Anti-HER2 Antibodies and Methods of Use Thereof
Summary
The USPTO published patent application US20260109781A1 for anti-HER2 antibodies on April 23, 2026, filed October 8, 2025 under application number 19352786. The application covers antibodies binding to subdomain II and/or subdomain IV of human HER2, including bispecific formats using a common light chain, for treating cancer and brain metastasis. Inventors include Abira Bandyopadhyay, Allisa Jayne Clemens, Do Jin Kim, Michelle E. Pizzo, Lu Shan, Richard Théolis Jr., and Raymond Ka Hang Tong.
“In one aspect, antibodies that bind to subdomain II of human HER2 are provided.”
About this source
USPTO classification C07K covers peptides: short amino-acid chains that form the backbone of antibodies, hormones, vaccines, and increasingly a wider class of therapeutic modalities. Every newly published application in C07K lands in this feed, around 175 a month. Applications publish 18 months after filing, so this feed reveals what antibody engineering groups, vaccine developers, and plant biotech researchers were working on in the prior year and a half. Watch this if you compete in biologics, file freedom-to-operate analyses on antibody drug candidates, scout acquisition targets in vaccine platforms, or track protein-based agricultural biotech filings.
What changed
The USPTO published patent application US20260109781A1 covering anti-HER2 antibodies that bind to subdomain II and/or subdomain IV of human HER2 protein, including bispecific antibody formats using a common light chain polypeptide. The application also discloses methods of treating cancer and treating brain metastasis of cancer using these antibodies. The patent claims priority to application 19352786 and was published April 23, 2026.
Pharmaceutical and biotechnology companies developing HER2-targeted oncology therapies should monitor this application for potential freedom-to-operate considerations or licensing opportunities. The broad subdomain II/IV dual-targeting approach and common light chain format represent specific claim scope that may overlap with existing or planned bispecific antibody programs targeting HER2.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
ANTI-HER2 ANTIBODIES AND METHODS OF USE THEREOF
Application US20260109781A1 Kind: A1 Apr 23, 2026
Inventors
Abira BANDYOPADHYAY, Allisa Jayne CLEMENS, Do Jin KIM, Michelle E. PIZZO, Lu SHAN, Richard THÉOLIS, Jr., Raymond Ka Hang TONG
Abstract
In one aspect, antibodies that bind to subdomain II of human HER2 are provided. In another aspect, antibodies comprising a light chain polypeptide that pairs with both a heavy chain polypeptide for binding to subdomain II of human HER2 and a heavy chain polypeptide for binding to subdomain IV of human HER2 are provided. In a further aspect, antibodies that bind to both subdomain II and subdomain IV of human HER2 comprising a common light chain polypeptide are provided. Methods of treating a cancer or treating brain metastasis of a cancer using these antibodies are also provided.
CPC Classifications
C07K 16/32 A61K 35/00 A61K 45/06 A61K 2039/505 C07K 2317/31 C07K 2317/526 C07K 2317/565 C07K 2317/71 C07K 2317/72 C07K 2317/732 C07K 2317/92
Filing Date
2025-10-08
Application No.
19352786
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