Bispecific Antibody Targets TIM-3 and CD39 for Cancer

The USPTO has published a patent application (US20260085127A1) for a bispecific antibody designed to target both TIM-3 and CD39 antigens. This antibody aims to enhance immune activity against cancer cells and is intended for cancer treatment.

Anti-CD157 Antibodies, Fragments, Compositions, and Methods

The USPTO has published a patent application (US20260085128A1) detailing anti-CD157 antibodies, antigen-binding fragments, compositions, and methods for their use. The application was filed on July 18, 2023, and describes potential diagnostic reagents and kits.

CD163 Binding Protein Patent Application

The USPTO has published a patent application (US20260085129A1) filed by ECO ANIMAL HEALTH LTD. on October 11, 2023. The application relates to an antibody that binds to porcine CD163, specifically its membrane-bound form.

Takeda's Monoclonal Antibody Inhibitor of Factor XIIa Patent Application

The USPTO has published a patent application from Takeda Pharmaceutical Company Limited for a monoclonal antibody inhibitor of Factor XIIa. The application, filed on August 12, 2025, describes methods for treating diseases associated with Factor XII, including hereditary angioedema and ocular diseases.

Patent Application: Bispecific Antibodies and Uses Thereof

The USPTO has published a new patent application (US20260085131A1) for bispecific antibodies and their uses. The application, filed on August 20, 2025, describes antibodies that bind to two different antigens with varying affinities.

Heterodimeric Human IgG1 Polypeptides with Isoelectric Point Modifications

The USPTO has published a new patent application, US20260085132A1, titled 'Heterodimeric Human IgG1 Polypeptides with Isoelectric Point Modifications'. The application details methods for purifying desired heterodimer immunoglobulin variants from contaminating homodimer variants by modifying isoelectric points.

Polyproline Nanocage Compound and Manufacturing Method

The USPTO has published a patent application for a polyproline nanocage compound and its manufacturing method. The application details a compound comprising two cyclic peptide scaffolds connected by molecules, with each scaffold containing polyproline helix rods and turn-angle molecules. This is a routine publication of a new patent application.

USPTO Patent Application for Fusion Polypeptides

The USPTO has published a new patent application (US20260085300A1) detailing systems and compositions for fusion polypeptides and their methods of use in regulating target genes. The application was filed on October 27, 2023, by inventors Thomas Blair Gainous, Xiao Yang, Giovanni Carosso, Lei S. Qi, and Daniel O. Hart, II.

Base Editing of Plant Cell Organelle DNA

The USPTO has published a patent application (US20260085323A1) detailing a method for base editing plant cell organelle DNA. The application, filed by the Institute for Basic Science, describes a composition and method for editing adenine to guanine and cytosine to thymine in plant cell organelle DNA.

Metabolic Selection via Serine Biosynthesis Pathway Patent Application

The USPTO has published a new patent application, US20260085327A1, related to metabolic selection via the serine biosynthesis pathway. The application details an isolated mammalian cell with reduced expression of Phosphoserine Phosphatase (PSPH) and its use in recombinant protein production.

Patent Application for Endoglin Antibodies Detecting Cancer Splice Variants

The USPTO has published a patent application (US20260086096A1) for endoglin antibodies designed to detect cancer splice variants. The application, filed by Nam Yong Lee, details methods and compositions for improved cancer diagnosis.

Karyocreate Patent Application US20260085330A1 Details CRISPR Technology

The USPTO has published patent application US20260085330A1 from Karyocreate detailing CRISPR technology for inducing aneuploidy. The application, filed on September 8, 2023, describes fusion proteins and guide RNAs that interfere with chromosome segregation.

Cell Culture Method Suppressing Foam Aggregates

The USPTO has published a new patent application (US20260085282A1) from FUJIFILM Corporation detailing a cell culture method. The method aims to suppress foam aggregate formation by adjusting poloxamer concentration or foam liquid viscosity during cell culture at high densities.

Missouri AG Orders 33 Unlicensed Dispensaries to Cease Sales

Missouri Attorney General Catherine Hanaway has issued cease and desist letters to 33 unlicensed dispensaries selling intoxicating cannabis products. The AG's office found these products contained dangerous contaminants and violated the Missouri Merchandising Practices Act.

Passmore v. State of Florida - Appeal Affirmed

The District Court of Appeal of Florida, First District, affirmed the lower court's decision in Passmore v. State of Florida. The appeal, docketed as 1D2025-0978, concerned a case originating from the Circuit Court for Leon County.

Bonner v. State of Florida - Criminal Appeal

The Florida District Court of Appeal, First District, affirmed the lower court's decision in Bonner v. State of Florida. The appeal, docketed as 1D2024-2502, was decided on March 26, 2026, with no known citations.

Gower v. State of Florida - Criminal Appeal

The District Court of Appeal of Florida affirmed the lower court's decision in the case of Gower v. State of Florida. The appeal, docketed as 1D2024-2434, was reviewed by Judges Winokur, M.K. Thomas, and Treadwell.

Maguire v. Florida - Appeal Affirmed

The District Court of Appeal of Florida affirmed the lower court's order in the case of Maguire v. State of Florida. The appeal, identified by docket number 4D2025-3828, concerned an order denying a rule 3.800 motion. The court's decision was issued on March 26, 2026.

Hall v. State of Florida - Criminal Appeal

The District Court of Appeal of Florida affirmed the lower court's decision in the case of Jerome Alexander Hall v. State of Florida. The court cited Awolowo v. State as precedent for its decision. The appeal was denied, and no further motions are pending.

Angelo Coicou v. State of Florida - Criminal Appeal

The District Court of Appeal of Florida affirmed the lower court's decision in the case of Angelo Coicou v. State of Florida. The appeal concerned an order denying a rule 3.850 motion. The court's disposition was 'Affirmed'.

Sippio v. Florida - Criminal Appeal

The District Court of Appeal of Florida affirmed the lower court's decision in the case of Demitrice Anton Sippio v. State of Florida. The appeal, docketed as 5D2024-2558, concerned a criminal matter. The court's disposition was an affirmation, meaning the lower court's ruling stands.

Nairn v. State of Florida - Affirmation of Ruling

The District Court of Appeal of Florida, First District, affirmed a ruling in the case of Nairn v. State of Florida. The court's decision, issued on March 26, 2026, upholds the lower court's judgment without modification. No further details on the specific nature of the affirmed ruling were provided.

Mario Williams v. State of Florida - Criminal Appeal

The Florida District Court of Appeal, Fourth District, affirmed the lower court's decision in the case of Mario Williams v. State of Florida. The appellate court issued its opinion on March 26, 2026, upholding the prior ruling without significant new commentary.

Lincoln v. State of Florida - Criminal Appeal

The Florida District Court of Appeal, First District, affirmed the lower court's decision in Lincoln v. State of Florida. The appeal, docketed as 1D2024-2545, concerned a criminal matter. The court's disposition indicates no further action or modification of the original ruling.

Jeffrey Rogers v. Randy M. Goldberg - Appeal Disposition

The District Court of Appeal of Florida, Fourth District, has affirmed the lower court's decision in the case of Jeffrey Rogers v. Randy M. Goldberg. The appeal, identified by docket number 4D2025-2674, resulted in the affirmation of the original disposition.

Robinson v. Florida - Appeal Disposition

The District Court of Appeal of Florida, Fifth District, affirmed the lower court's decision in the case of Michael Lawrence Robinson v. State of Florida. The appeal, docketed as 5D2024-1684, involved a criminal matter originating from Marion County. The court's disposition was 'Affirmed'.

Lawrie Anne Molle v. American Honda Motor Co Inc. - Affirmed Appeal

The District Court of Appeal of Florida, Fourth District, affirmed the lower court's decision in Lawrie Anne Molle v. American Honda Motor Co Inc. The case, identified by docket number 4D2024-3349, involved an appeal related to product liability claims against American Honda Motor Co., Inc. The court's disposition was to affirm the prior ruling.

Armstrong v. State of Florida - Affirmation of Lower Court Ruling

The District Court of Appeal of Florida affirmed the lower court's ruling in the case of Bursey Jerome Armstrong, Jr. v. State of Florida. The appeal, docketed as 5D2024-2660, resulted in the affirmation of the original disposition without further detail provided in this summary.

A.M. v. Josaphat - Appeal from Palm Beach County Affirmed

The Florida District Court of Appeal affirmed a lower court's decision in the case of A.M. v. Josaphat. The appeal originated from Palm Beach County, and the appellate court found no grounds to overturn the trial court's ruling. The case involves parties identified as 'the Father' and Ndapewa Josaphat.

David Orfinger v. Deer Run Property Owners Association, Inc. - Appeal Disposition

The District Court of Appeal of Florida, Fourth District, affirmed the lower court's decision in the case of David Orfinger v. Deer Run Property Owners Association, Inc. The appeal was filed under docket number 4D2025-0363. The court's disposition was issued on March 26, 2026.

Marc H. Gold v. Cambridge Diagnostic Products, Inc. - Appeal of Nonfinal Order

The District Court of Appeal of Florida affirmed a nonfinal order in the case of Marc H. Gold v. Cambridge Diagnostic Products, Inc., et al. The appeal concerned a shareholder dispute. The court's decision upholds the lower court's ruling without modification.

T.B. v. State of Florida - Appeal of Juvenile Case

The District Court of Appeal of Florida affirmed the lower court's decision in the case of T.B., a Child v. State of Florida. The appeal, docketed as 5D2025-1296, involved a juvenile case. The court issued its opinion on March 26, 2026.

Taylor v. State of Florida - Appeal Affirmance

The Florida District Court of Appeal, Fourth District, affirmed a lower court's ruling in the case of Kenneth A. Taylor v. State of Florida. The appeal concerned a criminal matter, and the court's disposition was to affirm the prior decision.

Majka v. Department of Children and Families - Affirmed

The District Court of Appeal of Florida, First District, affirmed a lower court's decision in Majka v. Department of Children and Families and Brandon Cullum. The per curiam ruling, issued on March 26, 2026, upholds the original disposition without significant elaboration.

FAA Acknowledgement Letter Withdrawn

The Federal Aviation Administration (FAA) has withdrawn an acknowledgement letter related to docket FAA-2026-3014-0003. The withdrawal was made at the request of the FAA, and no documents are available for viewing.

FAA Decision Document

The Federal Aviation Administration has posted a decision document related to Docket FAA-2024-0512. This document, titled 'Decision_FAA-2024-0512_Southern Flint', is available for download.

FAA Decision Document

The Federal Aviation Administration has posted a decision document related to REED BROS LLC. This document is part of an ongoing administrative process within the FAA.

FAA Acknowledgement Letter for Docket FAA-2025-2167

The Federal Aviation Administration (FAA) has issued an acknowledgement letter for Docket FAA-2025-2167, related to a submission from Amor Fati Industries Corp. This notice confirms receipt of the submission within the specified rulemaking process.

FAA Decision Document

The Federal Aviation Administration (FAA) has posted a decision document related to docket FAA-2020-0807. The document, titled 'Decision_FAA-2020-0807_FarmiTude In', is available for review and download.

Precision Drone Solutions Petition

The Federal Aviation Administration (FAA) has received a petition from Precision Drone Solutions. This filing initiates a public comment period for the petition, allowing interested parties to submit their views on the matter.

FAA Request for Information on Drones

The Federal Aviation Administration (FAA) has issued a Request for Information (RFI) regarding drone operations. This RFI seeks public input to inform future policy and regulatory development concerning the integration of drones into the national airspace.

FAA Request for Information on AI Ag Spray

The Federal Aviation Administration (FAA) has issued a Request for Information (RFI) regarding the use of Artificial Intelligence (AI) in agricultural spraying operations. This RFI seeks public input to help the FAA understand the potential impacts and regulatory considerations of AI-powered agricultural aircraft.

FAA Request for Information on Air Apply LLC

The Federal Aviation Administration (FAA) has issued a Request for Information (RFI) regarding the "Air Apply LLC" system, seeking public input on its potential impact and integration within the aviation sector. This RFI is part of an ongoing effort to gather data and perspectives on emerging technologies.

FAA Acknowledgement Letter for Meng Family Farms Document

The Federal Aviation Administration (FAA) has issued an acknowledgement letter regarding a document submitted by Meng Family Farms. This notice serves as confirmation of receipt for the submitted materials.

FAA Final Rule Updates Morristown, NJ Class D Airspace Coordinates

The FAA has issued a final rule updating the geographic coordinates for Class D airspace at Morristown Municipal Airport, NJ. The rule also replaces a reference to the "Airport/Facility Directory" with "Chart Supplement" in the airspace legal description. These changes do not alter the airspace boundaries or operating requirements.

FAA Decision on New Frontier Ag LLC Exemption

The Federal Aviation Administration has issued a decision regarding an exemption for New Frontier Ag LLC. The decision, identified by Docket No. FAA-2025-5381 and Exemption No. 25506, grants specific relief to the company.

FAA Acknowledgement Letter for Document FAA-2026-3318-0002

The Federal Aviation Administration (FAA) has issued an acknowledgement letter for document FAA-2026-3318-0002. This notice confirms receipt of a submission related to Daehler Aerial LLC.

FAA Closeout Letter for AAR Corp.

The Federal Aviation Administration (FAA) has issued a closeout letter for AAR Corp., referencing docket FAA-2024-2267. This notice serves as a formal closure of a specific matter concerning the company.

FAA Decision Document

The Federal Aviation Administration has posted a decision document related to Pratt and Whitney. This document is part of a larger regulatory process, with the posting date of March 26, 2026.

FAA Decision Document

The Federal Aviation Administration has posted a decision document related to aerial agriculture operations. This document, identified by docket number FAA-2026-2686, provides the agency's final determination on a matter concerning aerial application services.