Engineered Immune Effector Cell with CD16 Protein for Shear Resistance

USPTO published patent application US20260108605A1, filed September 27, 2023, covering a genetically modified immune effector cell expressing a recombinant human CD16 protein engineered with amino acid additions, deletions, and replacements that confer enhanced shear resistance. The application names five inventors: Fuwei JIANG, Tingting LIU, Yifang WANG, Cuiqing YANG, and Zhuoxiao CAO. CPC classifications span immunology (A61K 38/1774, A61K 39/39558), oncology (A61P 35/00), and protein engineering (C07K 14/7051, C07K 16/2803).

Anti-Cancer Therapy Methods Using Autophagy Induction via DBI Inhibition

USPTO published patent application US20260108602A1 covering methods and systems for improving anti-cancer therapies through autophagy induction via inhibition of extracellular diazepam binding inhibitor (DBI). Inventors include Mark de Boer, Guido Kroemer, Léa Montegut, Isabelle Martins, Hui Pan, Hui Chen, and Sijing Li, with application number 19361314 filed October 17, 2025. The application claims therapeutic compositions, methods, and regimens for cancer treatment, including chemo- and immunotherapies.

US20260108572A1 - Alzheimer's Dementia Suppressant Using Sesamum Indicum Extract

USPTO published patent application US20260108572A1, filed September 1, 2023 and made publicly available on April 23, 2026, disclosing an Alzheimer-type dementia suppressant composition and method of manufacture using an aboveground part of Sesamum indicum (sesame plant) or an extract thereof as the active ingredient. The application names Sakamoto Yakusouen, LLC as assignee and Johji YAMAHARA as inventor. CPC classifications include A61K 36/185, A61K 31/7048, A61P 25/28, and related formulation codes A61K 2236/17, A61K 2236/333, A61K 2236/51, and A61K 2236/53. The application does not yet represent an issued patent and carries no compliance obligation.

Methods of Treating Fibromyalgia With Psilocybin Compositions - Tryp Therapeutics

Tryp Therapeutics Inc. filed patent application US20260108545A1 with the USPTO on September 11, 2023 (application no. 19110772), published April 23, 2026. The application covers methods for treating fibromyalgia using psychedelics such as psilocybin or metabolites thereof, optionally combined with psychotherapy, with patient outcomes assessed through observer-rated and subject-reported measures as well as biological and clinical indicators. The inventors are James GILLIGAN and Peter GUZZO. Pharmaceutical and biotech companies pursuing psychedelic-based therapeutic research should monitor this filing as it may affect competitive patent positioning in fibromyalgia treatment.

FGF21 GLP1 Double Gene-Modified Mesenchymal Stem Cell Patent Application for Metabolic Disease Treatment

The USPTO published patent application US20260108558A1, filed August 21, 2025, covering a modified mesenchymal stem cell engineered to co-express FGF21 and GLP-1 proteins, intended for treating metabolic diseases. The application names inventors Haifeng DUAN, Binghua XUE, Jing XIE, and Zhenli ZHANG, and specifies CPC classifications including A61K 35/28, A61P 3/10, C07K 14/50, C07K 14/605, and various C12N cellular-therapy classifications. Publication of this application creates prior art that may affect freedom-to-operate analyses for parties developing related cellular-therapy approaches for metabolic disease.

EGFR Inhibitors for Treatment-Resistant Non-Small Cell Lung Cancer

USPTO has published patent application US20260108524A1 for methods of treating treatment-resistant non-small cell lung cancer using EGFR inhibitors. The application, filed October 16, 2023, names David A. Nathanson, Jonathan Tsang, and Timothy F. Cloughesy as inventors. CPC classifications include A61K 31/519, A61K 31/517, and A61P 35/00. This publication represents new intellectual property activity in the targeted oncology space.

Bifidobacterium Longum Subsp. Infantis BI03 Strain for Alleviating Parkinson's Disease

The USPTO has published application US20260108568A1 for a Bifidobacterium longum subsp. infantis BI03 strain (CGMCC No. 24473, deposited March 7, 2022) for alleviating Parkinson's disease. The application claims the strain can alleviate Parkinson's-related dyskinesia and corticosterone elevation, weaken associated neuroinflammation, promote glutathione, and reduce brain oxidative stress damage. Inventors include Shuguang FANG, Yao DONG, Yixuan FAN, Zhonghui GAI, and Jianguo ZHU; the application was filed May 27, 2024.

Bispecific CARs Targeting CD20 BCMA, AbelZeta, Autoimmune, Cancer

AbelZeta Inc. filed US Patent Application US20260108557A1 for a bispecific chimeric antigen receptor (CAR) targeting both CD20 and BCMA antigens simultaneously. The CAR construct comprises an scFv targeting CD20 and an scFv targeting BCMA, a hinge region, a transmembrane domain, a co-stimulatory region, and a cytoplasmic signaling domain. The application was filed on October 13, 2025, and published on April 23, 2026, with claims directed to methods of treating autoimmune disorders and cancer using the disclosed CAR.

Longitudinal Study of Debt Advice, £1,767,867

The Money and Pensions Service has modified contract C0668 for the Longitudinal Study of Debt Advice, increasing the total contract value from £1,250,000 to £1,767,867. The study, awarded to IFF Research Ltd in April 2024, runs for 64 months and is conducted in Bedfordshire and Hertfordshire (UKH2). The research uses a randomised encouragement design across four waves to measure the causal impact of debt advice on financial wellbeing outcomes over short, medium, and long terms.

Bristol City Council £6M Cashless Parking Market Engagement Notice

Bristol City Council has issued a preliminary market engagement notice for cashless telephone parking services covering the City of Bristol, with an estimated contract value of £6,000,000 including VAT over a five-year term (December 2026 to November 2031) extendable to ten years. The council is hosting a virtual supplier information event on 11 May 2026 from 1:30–2:30pm via MS Teams to brief prospective bidders on requirements and procurement approach ahead of formal ITT publication estimated for 18 May 2026. Interested contractors must register by emailing penny.sharp@bristol.gov.uk.

Repair, Maintenance and Servicing of Laundry Equipment, £90k, 7th May

The Ministry of Defence has published a below-threshold open competition tender for the repair, maintenance and servicing of laundry equipment over a three-year period from 14 May 2026 to 31 March 2029. The estimated contract value is £75,000 excluding VAT (£90,000 including VAT). Tender submissions are due by 7 May 2026 at 10:00am via the electronic submission address at contracts.mod.uk, with the Most Advantageous Tender evaluation criteria applying to contract award.

Hackney Parent Carer Forum Hosting Contract, £47,897, Deadline 20 May 2026

The London Borough of Hackney has published a tender notice seeking a provider to host a Parent Carer Forum for Special Educational Needs and Disability (SEND) services. The contract is valued at £47,897 including VAT, running from 1 August 2026 to 31 July 2027 with an optional 12-month extension. The procurement is open to SMEs and VCSEs, with quality weighted at 80% and price at 20% of the award criteria. Tenders must be submitted electronically by 20 May 2026 at 12:00pm.

Thanet District Council Backup Solution Platform Procurement

Thanet District Council has published a tender notice for a replacement backup solution platform covering all council data held on premises and in its Google environment. The estimated contract value is £288,000 including VAT, with a five-year term from July 2026 to July 2031. Suppliers must submit completed tender documents via the Kent Business Portal by 12:00pm on 18 May 2026, with clarifications due by 7 May 2026. Evaluation will be weighted 60% on quality and 40% on price.

Halton Place Care at the Chemist £39k Pharmacy Contract Award

NHS Cheshire and Merseyside Integrated Care Board awarded a £39,000 contract via Direct Award A to selected Halton pharmacies for the Care at the Chemist (CATC) minor ailment service. The one-year contract commenced 1 April 2026 and expires 31 March 2027. The contract was awarded under the Provider Selection Regime (PSR) confirming that Public Contracts Regulations 2015 do not apply to this procurement.

Birmingham City Council Awards £180k Pest Control Contract to JMS BFD Limited

Birmingham City Council has awarded a £180,000 contract for pest control products and application equipment to JMS BFD Limited (trading as Copley Pest Solutions Ltd). The three-year contract runs from 11 May 2026 to 10 May 2029. The procurement was conducted as a below-threshold open competition exercise under the Procurement Act 2023.

University of Chester Seeks Fire Safety Maintenance Services, Deadline April 30

The University of Chester has published a preliminary market engagement notice under the Procurement Act 2023 for forthcoming fire safety equipment maintenance services. The university plans to tender via open procedure for statutory compliance and planned preventative maintenance on fire safety equipment, with an estimated contract period from August 1, 2026 to July 31, 2029, potentially extendable to July 31, 2031. Engagement deadline is April 30, 2026, and the tender notice is estimated to publish on the same date. The opportunity is open to SMEs and VCSE organisations.

Derbyshire Police High Risk Offender PRS Accommodation Sourcing Trial

The Police and Crime Commissioner for Derbyshire has issued a Preliminary Market Engagement (PME) notice under the Procurement Act 2023 to gather market information from providers capable of sourcing private rented sector tenancies for high-risk offenders. The proposed pilot (reference DP1085-01) would run from 1 June 2026 to 31 May 2027 and targets SMEs and voluntary, community and social enterprises. Providers must respond via the UK e-Procurement Portal by 8 May 2026, with the formal tender notice estimated for publication on 22 May 2026. The engagement covers accommodation services classified under social work services with accommodation and related property management CPV codes.

Forestry England Security Services, £504k, deadline 15th May

Forestry England, operating under the Forestry Commission, has published a preliminary market engagement notice under the Procurement Act 2023 seeking expressions of interest for a Security Service contract across multiple sites in England. The contract is structured into four geographical lots (East, West, South, Central) spanning all of England, with an estimated total value of £504,000 including VAT over a five-year term from 1 September 2026 to 31 August 2031. The engagement deadline is 15 May 2026; however, the notice explicitly states it does not commit Forestry England to any future procurement.

British Embassy Baghdad Internet Contract £311k to Supercell

The Foreign, Commonwealth and Development Office (FCDO) has awarded a contract for internet infrastructure and associated services at the British Embassy in Baghdad to Supercell Network for Internet Services Ltd. The contract has an initial one-year value of £143,264, with options to extend for up to two additional years bringing the total potential value to £311,336 excluding VAT. Hardware costs are capped at £50,000 and the contract covers high-availability internet connectivity, hardware supply, configuration, testing, deployment, and ongoing support.

13 Pounder Design Organisation, £3M, deadline 29th May

Defence Equipment and Support (DE&S) has published a tender notice for a Design Organisation (DO) to provide through-life design authority, engineering assurance, configuration management, and technical documentation support for the Ordnance Quick Fire 13-Pounder ceremonial guns operated by The King's Troop Royal Horse Artillery. The estimated contract value is £2,500,000 excluding VAT (£3,000,000 including VAT), with an initial performance period from 13 October 2026 to 15 October 2029, extendable to 8 October 2030. Bids must be submitted electronically via the MOD contracts portal by 29 May 2026 at 11:59pm.

Xie v. United States Department of State et al

Zefan Xie filed a civil complaint in the Northern District of California on April 23, 2026, naming as defendants the United States Department of State, Secretary of State Marco Rubio, the U.S. Consulate General in Guangzhou, China, and Pauline Kao. The case is classified under 'Other Immigration Actions' nature of suit. The complaint seeks judicial review of consular or departmental actions affecting the plaintiff's immigration status or benefits.

WH Smith H1 Revenue Up 5% to £748m

WH Smith PLC released H1 FY2026 interim results for the period ended 28 February 2026, reporting total Group revenue of £748m, a 5% increase year-over-year (2025: £716m). The Board has suspended the dividend to reduce debt and strengthen the Group's financial position, with FY26 headline profit before tax expected in the range of £90m-£105m. By division, UK revenue was £392m (+2%), North America £204m (+5% or +10% constant currency), and Rest of World £152m (+10% or +8% constant currency).

RWS Holdings H1 Trading Statement, £360m Revenue

RWS Holdings plc, a global AI solutions company listed on AIM (RWS.L), reports first half revenue of approximately £360m for the six months ended 31 March 2026, representing approximately 5% growth on the prior year. Organic constant currency revenue grew by approximately 7%, with the Generate segment delivering strong double-digit growth driven by the TrainAI business unit, while the Transform segment declined as the company pivots to technology-first solutions. Adjusted profit before tax is expected to be approximately £24m, up from £18m in H1 FY25, with net debt of approximately £33m as of 31 March 2026. The company confirms full-year performance is expected to be in line with market guidance.

RELX AGM Trading Update, Strong Growth Outlook

RELX PLC has issued its AGM trading update for April 2026, reporting strong underlying revenue and profit growth across all four business areas (Risk, Scientific Technical & Medical, Legal, and Exhibitions) in the first quarter. The company reaffirms its full-year outlook, expecting strong underlying growth in revenue and adjusted operating profit, as well as strong growth in adjusted earnings per share on a constant currency basis. The update highlights continued shift in business mix toward higher-growth AI-enabled analytics and decision tools driving the improving long-term growth trajectory.

SEGRO Q1 2026 Trading Update: £23M New Rent, £73M Development Pipeline, £106M Disposals

SEGRO plc reports £23 million of new headline rent contracted in Q1 2026 (January–March), comprising £11 million from the existing portfolio and £12 million of development lettings. Customer retention stood at 83 percent and occupancy at 94.8 percent, with development completions of 40,000 sq m generating £4 million of headline rent. Development projects under construction or in advanced negotiations represent £73 million of potential rent at a 7.6 percent development yield. The group completed £106 million of disposals above book value with a further £138 million exchanged and due to complete later in 2026.

AJ Bell Q2 Update: Record 723k Customers, £2.7bn Net Inflows

AJ Bell plc, one of the UK's largest investment platforms, reports Q2 performance for the three months ended 31 March 2026. Customer numbers grew by a record 50,000 in the quarter to reach 723,000 (up 22% year-on-year), with total advised customers at 189,000 and D2C customers at 534,000. Assets under administration (AUA) stood at £108.7 billion, up 20% year-on-year, while record gross inflows of £5.6 billion and net inflows of £2.7 billion were achieved (up 40% and 42% respectively versus the prior year). The investment business reported AUM of £9.8 billion with net inflows of £0.3 billion.

Foxtons Q1 2026 Trading Update

Foxtons Group plc (LSE: FOXT) released its Q1 2026 trading update for the three months ended 31 March 2026, reporting total group revenue of £39.6m, down 10% year-on-year. Lettings revenue grew 5% to £26.4m driven by organic growth and two acquisitions completed in Milton Keynes and Birmingham, while Sales revenue fell 35% to £10.7m due to market headwinds and a strong prior-year comparator. The Group announced a proactive cost-reduction programme targeting at least £3m of annualised savings and confirmed full-year guidance remains unchanged.

ASOS H1 FY26: 51% AEBITDA Growth, FY26 Guidance Confirmed

ASOS Plc released H1 FY26 interim results for the 26 weeks to 1 March 2026, reporting a 51% year-over-year increase in adjusted EBITDA to £64.0m from £42.5m. Gross merchandise value declined 9% YoY to £1,170.1m and adjusted group revenue fell 14% to £1,113.5m, while adjusted gross margin improved 330 basis points to 48.5%. The company confirmed full-year FY26 guidance including adjusted EBITDA of £150m-£180m and gross margin improvement of at least 100bps.

LSEG Q1 2026 Record Revenue, +9.8%, Upper Half Guidance

London Stock Exchange Group plc reported record Q1 2026 total income excluding recoveries of +9.8% on an organic constant currency basis, with all four divisions accelerating over Q4 2025. Data & Analytics grew +5.1%, FTSE Russell +8.8%, Risk Intelligence +10.5%, and Markets +15.5%, driven by strong trading volumes across multiple asset classes. The company completed £1.1 billion of share buybacks in Q1 and confirmed full-year revenue growth is expected to be in the upper half of the 6.5-7.5% guidance range.

FINTRAC Publishes Extortion Money Laundering Indicators for South Asian Diaspora

FINTRAC published a new Special Bulletin on money laundering associated with extortion directed at Canada's South Asian diaspora to assist reporting businesses in detecting and reporting suspicious transactions. Since the beginning of 2026, FINTRAC has generated more than 100 financial intelligence disclosures related to extortion for law enforcement agencies, identifying over 300 subjects and including more than 63,000 financial transactions. The bulletin is part of the Government of Canada's broader Countering Extortion Partnership strategy.

Chinese National Arrested at JFK for Photographing Nebraska Military Base

Tianrui Liang, 21, a Chinese national, was arrested at John F. Kennedy International Airport on federal charges for allegedly illegally photographing Air Force aircraft at Offutt Air Force Base in Bellevue, Nebraska. Liang entered the United States on a valid B1/B2 visa via Vancouver, Canada, on March 28, 2026, and drove to New York after being confronted by the FBI in Nebraska. A federal magistrate initially released Liang on April 7, but federal prosecutors successfully appealed, and Liang was returned to federal custody on April 10, 2026, by order of the Chief District Court Judge for the District of Nebraska.

Strike Force Charges Two Chinese Nationals, Restrains $700M Crypto

The Scam Center Strike Force, led by U.S. Attorney Jeanine Ferris Pirro and Assistant Attorney General A. Tysen Duva, announced criminal charges against two Chinese nationals for managing a cryptocurrency investment fraud compound in Burma and attempting to establish another in Cambodia, seizure of a Telegram channel used to recruit human trafficking victims for law enforcement impersonation scams, and seizure of 503 fake investment websites. The DOJ has restrained more than $700 million in cryptocurrency allegedly tied to money laundering from cryptocurrency scams, with coordinated actions including Treasury sanctions against Cambodian scam center operators and State Department rewards for information on the Tai Chang scam center in Burma. Reported losses from these pig butchering scams rose from $3.96 billion in 2023 to over $7.2 billion in 2025.

Fergeson Vulnerable Adult Neglect Conviction Appeal Affirmed

The Virginia Supreme Court affirmed Jason Joseph Fergeson's misdemeanor conviction for abuse or neglect of a vulnerable adult under Code § 18.2-369, rejecting his argument that his girlfriend Lindsey Thompson was not a 'vulnerable adult' because her incapacitation from a drug overdose was temporary rather than chronic. The court held that Fergeson became a 'responsible person' under the statute when he assumed control of the scene and prevented bystanders from rendering aid to Thompson, who had overdosed on ten times the therapeutic dose of fentanyl. The conviction for attempted interference with a 9-1-1 call was also upheld.

Commonwealth v. Richerson, DUI Conviction Reinstated

The Virginia Supreme Court reversed the Court of Appeals and reinstated Lonnie Lewis Richerson's conviction for driving under the influence, third offense within ten years. The Court held that sufficient circumstantial evidence supported the conviction, including the odor of alcohol from the vehicle and Richerson's person, his glassy eyes, slurred speech, sweating, and avoiding eye contact with officers. The Court rejected the Court of Appeals' conclusion that the evidence created only a suspicion or probability of guilt rather than proof beyond a reasonable doubt.

Butcher v. General R.V. Center - Attorney Fees After Settlement

The Supreme Court of Virginia affirmed the Court of Appeals' judgment in Record No. 250213, upholding a trial court's award of attorney fees to William and Traci Butcher for their pre-settlement litigation against General R.V. Center and Keystone R.V. Company over a defective recreational vehicle. The court found the trial court acted within its discretion in awarding fees for work on the underlying claims under the Magnuson-Moss Warranty Act and Virginia Consumer Protection Act, but properly denied fees for time spent litigating the post-settlement fee motion itself. The Butchers had purchased the RV for approximately $80,000 and received a $106,500 settlement; their counsel sought $40,810 in fees plus costs.

Virginia Supreme Court Reverses Miranda Ruling, Fayne

The Virginia Supreme Court reversed the Court of Appeals' judgment in Fayne v. Commonwealth, reinstating the circuit court's denial of Fayne's motion to suppress. The Court held that despite officers continuing to question Fayne after he unequivocally invoked his right to counsel in violation of Edwards v. Arizona, Fayne subsequently reinitiated contact by opening the interrogation room door and requesting Detective Smith. The Court further held that Fayne knowingly and intelligently waived his right to counsel before making additional statements. On December 18, 2020, police detained Fayne following a shooting that resulted in the death of a pregnant woman; after invoking his right to counsel and officers continuing questioning for approximately one hour and fifteen minutes in violation of Edwards, Fayne reopened the door himself and asked to speak with Detective Smith.

Nasdaq Q1 2026 Revenue $1.4B, Up 14%

Nasdaq, Inc. reported first quarter 2026 financial results for the period ended March 31, 2026, demonstrating double-digit net revenue growth across all divisions. Net revenue was $1.4 billion, representing 14% growth over Q1 2025 on a reported basis and 13% organic growth. GAAP diluted earnings per share was $0.91, up 33% year-over-year. Annualized Recurring Revenue reached $3.2 billion, growing 13% year-over-year.

Senate Debates: Syria Sanctions Relief, Health Disinformation, Cancer Awareness

On April 22, 2026, the Senate of Canada published its daily Hansard transcript recording proceedings in the 1st Session of the 45th Parliament. Senator Mohammad Al Zaibak discussed Canada's February 18 amendments to the Special Economic Measures (Syria) Regulations, which lifted restrictions on trade and financial activity with Syria, enabling Syrian Canadians to send remittances and allowing Canadian companies to participate in Syria's reconstruction estimated at over $500 billion. Senator Stan Kutcher addressed health disinformation, calling for collaborative action by national medical and health organizations. Senator Andrew Cardozo marked Cancer Awareness Day in the Senate, noting that over 40% of Canadians will be diagnosed with cancer in their lifetimes.

Temporary Exemptions From Driver Regulations

The Minister of Infrastructure issued an announcement (Obwieszczenie) on April 22, 2026, regarding temporary exemptions from provisions concerning driving time, breaks, and rest periods for drivers. The document was published in Monitor Polski, the Polish official gazette, at position 410 on April 23, 2026. This announcement concerns transport companies and drivers operating under Polish and EU driver hour regulations.

Minister of Energy Sets Maximum Liquid Fuel Prices at Gas Stations

The Minister of Energy issued an official announcement (Obwieszczenie) setting maximum prices for liquid fuels at gas stations, published on 23 April 2026 in Monitor Polski under position 409. The document is accessible via an attached PDF file (M2026000040901.pdf). This price-setting instrument applies to all liquid fuel retail operators in Poland.

Jason Amerine Successfully Completes Probation, Order Terminated

The Supreme Court of Missouri has terminated the probation of Jason C. Amerine (Missouri Bar No. 50857) following his successful completion of the probationary period imposed by the Court's order dated May 23, 2023. The Court found that Amerine satisfied all conditions of probation and accordingly ordered the probation terminated as successful. Costs of the proceeding were taxed to Amerine.

NH AG Updates on Ashland Officer-Involved Shooting Autopsy Findings

The New Hampshire Attorney General's Office released autopsy findings for Demitri Zimmer, age 24 of Laconia, NH, who died from multiple gunshot wounds during an officer-involved shooting on April 20, 2026 on Main Street in Ashland. The Office of the Chief Medical Examiner determined the manner of death was homicide, defined as the killing of one person by another. The Ashland Police Department officer who was struck by one of Mr. Zimmer's gunshots was released from the hospital on April 21. The investigation into the officer-involved use of deadly force remains ongoing, with officer identities to be disclosed once formal interviews are completed.

Peter Mancini Arrested for Unemployment Fraud

Peter Mancini, age 47, was arrested on April 22, 2026, in connection with alleged unemployment compensation fraud committed from October 2025 to February 2026. The charges allege that Mancini falsely represented that an offer of employment was rescinded, and that between January and February 2026 he and another individual acted in concert to represent he performed work searches and was available to work, while omitting that he was incarcerated. Mancini allegedly received more than $11,000 in unemployment compensation, including over $2,000 after his incarceration began on January 6, 2026. He is charged with class A felony offenses, each punishable by 7½ to 15 years in state prison.

Joint Advisory Covers Volt Typhoon, Flax Typhoon Threat Actors Using Covert Networks of Compromised Devices

A joint advisory from CISA, FBI, NSA, NCSC-UK, and eleven other international cyber agencies describes a major shift in China-nexus threat actor TTPs toward using large-scale covert networks of compromised SOHO routers, IoT devices, and smart devices instead of individually procured infrastructure. The advisory names Volt Typhoon (using the KV Botnet, mainly vulnerable Cisco and NetGear routers) and Flax Typhoon (using the Raptor Train botnet, which infected over 200,000 devices worldwide in 2024 and was controlled by Integrity Technology Group). Network defenders are advised that traditional IP blocklists are less effective against dynamic botnets with hundreds of thousands of endpoints, and that compensating controls must be applied to end-of-life devices no longer receiving security patches.

US Federal Register Vol. 91 No. 78 April 23 2026

The Office of the Federal Register published the daily Table of Contents for Vol. 91, No. 78, covering pages 21713-21936. The compilation includes entries from agencies including the Environmental Protection Agency, Agriculture Department, Commerce Department, Education Department, and Bureau of the Fiscal Service, with notices and proposed rules listed across multiple topic areas including air quality, hazardous waste, and defense production. No specific regulatory actions or compliance obligations are detailed in this index page itself.

Federal Register Vol. 91, No.78, April 23, 2026

GPO published Federal Register Volume 91, Number 78 on April 23, 2026. This entry is a volume/issue index page with no substantive document content. The Federal Register is the official daily publication for federal rules, proposed rules, and notices from U.S. government agencies. No specific rules, enforcement actions, or regulatory content are detailed in this publication index.

Federal Register Table of Contents - April 23, 2026

This is the table of contents for Federal Register Volume 91 Number 78, published on April 23, 2026. The Federal Register is the official daily publication for federal regulations, proposed rules, and notices issued by U.S. government agencies. This document serves as an index listing the contents of that day's Federal Register but does not contain the full text of any specific regulatory action.

SBA Offers Low Interest Disaster Loans to Oklahoma Drought-Affected Small Businesses

The U.S. Small Business Administration has announced that Economic Injury Disaster Loans (EIDL) of up to $2 million are now available to small businesses and private nonprofit organizations in Oklahoma, as well as parts of Arkansas, Kansas, Missouri, and Texas, following a drought declaration by the U.S. Secretary of Agriculture effective November 15, 2025. Interest rates are set at 4% for small businesses and 3.625% for private nonprofits, with terms up to 30 years; no interest accrues and no payments are due until 12 months after the first loan disbursement. The filing deadline for completed loan applications is December 10, 2026, and SBA cannot provide loans to agricultural producers, farmers, or ranchers except for small aquaculture enterprises.

Missouri Drought Relief Loans, Deadline Dec. 10

The U.S. Small Business Administration announced Economic Injury Disaster Loans (EIDLs) for small businesses and private nonprofit organizations in Missouri, Arkansas, and Illinois counties affected by drought beginning November 1, 2025. Loans of up to $2 million are available at interest rates as low as 4% for small businesses and 3.625% for nonprofits, with repayment terms up to 30 years and no interest accrual until 12 months after first disbursement. Completed applications must be submitted to SBA by December 10.

SBA Offers Up to $2M Drought Disaster Loans at 4% Interest to NM Small Businesses

The SBA announced availability of low-interest Economic Injury Disaster Loans (EIDLs) to small businesses and private nonprofit organizations in New Mexico and parts of Arizona, Colorado, Texas, and Utah affected by drought beginning November 1, 2025. Loans up to $2 million are available at 4% interest for small businesses and 3.625% for nonprofits, with terms up to 30 years and no payments due until 12 months after first disbursement. Applications must be submitted by December 10.