ClinicalTrials.gov Studies

BOUGIE CAP Cohort Study, Esophageal Strictures

The NIH ClinicalTrials.gov registry has posted an observational cohort study (NCT07534800) evaluating the BougieCap™ device (Ovesco Endoscopy AG) for treating benign and short esophageal strictures. The study aims to assess the device's performance and short-term effectiveness on dysphagia. This is an informational registration entry for an ongoing clinical study.

Phase 4 Trial Comparing Symptom-Based vs. Full-Course Antibiotic Stop Rules in Children

NIH has registered a Phase 4 clinical trial (NCT07532941) at the Royal Children's Hospital evaluating whether oral antibiotics can be safely stopped when symptoms resolve in children who have completed IV antibiotic courses for cellulitis, UTI, LRTI, and lymphadenitis. The two-arm study compares symptom-triggered antibiotic cessation against traditional full-course completion. Participants complete daily symptom trackers with telehealth follow-up at symptom resolution, plus surveys at days 14, 28, and 180. The trial seeks to determine if abbreviated oral antibiotic courses are non-inferior to completing prescribed durations.

Piloting a Generative Artificial Intelligence Chatbot in a Mobile Weight Loss Program

NIH has registered a new clinical trial (NCT07534254) evaluating the feasibility of integrating a generative AI chatbot into a 12-week smartphone-based behavioral weight loss program for young adults. The study will compare standard program delivery (1-2 brief daily messages) against the same program enhanced with an AI chatbot offering additional behavior change support. Participants will be assessed on program feasibility, acceptability, engagement, and weight change outcomes.

Trial Comparing Ultrasound-guided vs Arthroscopic Guided PRF Injection for TMJ Disc Displacement

NIH registered a clinical trial (NCT07535073) comparing ultrasound-guided versus arthroscopic guided platelet rich fibrin injection for temporomandibular joint disc displacement. The trial will evaluate pain reduction, improvement of mandibular function, and patient-reported outcomes. No regulatory obligations or compliance requirements are created by this study registration.

Guselkumab High-Dose vs Standard-Dose Study in Chinese Moderate-to-Severe Plaque Psoriasis

NIH registered a clinical trial (NCT07532486) on ClinicalTrials.gov evaluating the efficacy, safety, tolerability, and drug survival of guselkumab at high-dose and extended-interval regimens versus standard-dose in Chinese participants with moderate-to-severe plaque psoriasis. The interventional study compares two guselkumab dosing approaches. This is an administrative registration entry with no regulatory compliance obligations.

IPEX Observational Study on Pancreatic Exocrine Insufficiency in IPMN Patients

NIH registered the IPEX study (NCT07535125), a multicenter prospective observational cohort study evaluating pancreatic exocrine insufficiency (PEI) prevalence in patients with intraductal papillary mucinous neoplasms (IPMN) under surveillance. The study will assess whether PEI correlates with morphologic disease progression and whether it can serve as a functional marker complementary to imaging criteria in IPMN surveillance.

Congenital Ptosis Surgery Visual Function and Psychological Conditions Prospective Cohort Study

NIH ClinicalTrials.gov registered NCT07534436, an observational prospective cohort study evaluating 6-month outcomes of Levator Resection combined with Fascial Sheath Suspension surgery in patients with congenital ptosis. The study will assess improvements in best-corrected visual acuity, stereopsis, and patient-reported quality of life through standardized ophthalmological examinations at baseline and 1, 3, and 6 months post-operation. Enrollment includes patients already scheduled for this combined surgical procedure as part of their regular medical care.

ML/AI Model Predicts Head and Neck Cancerous Lesion Risk

NIH registered ClinicalTrials.gov study NCT07532538, an observational multi-center trial to develop and validate a deep learning/AI-based clinical prediction model for head and neck cancerous lesion risk. The study targets hypopharyngeal cancer, laryngeal cancer, and general head and neck cancer. The trial is registered as an observational study without stated enrollment or completion dates.

Preoperative Topical Lidocaine Versus Intravenous Fentanyl for Intubation Stress Reduction

NIH registered clinical trial NCT07533643 comparing preoperative topical lidocaine versus intravenous fentanyl for reducing stress response during endotracheal intubation under general anesthesia. The trial will evaluate hemodynamics after intubation using combined topical airway anesthesia (nebulized, mouth rinsing and gargling) against low-dose IV fentanyl. No compliance obligations are created by this trial registration.

Observational Trial of Deep Learning Model for Head and Neck Cancer Prognosis

NIH registered NCT07532928, an observational study developing a dynamic deep learning model using multimodal patient data to assess prognostic risk and recommend individualized adjuvant treatment for locally advanced head and neck squamous cell carcinoma. The model aims to assist clinicians in precision therapy decisions. The study is observational with an estimated enrollment of 500 participants, registered April 16, 2026.

Tpex Subsets in Negative Tumor Draining Lymph Nodes for Predicting Efficacy of PD-1 Inhibitors in Esophageal Squamous Cell Carcinoma

NIH registered an observational study (NCT07533357) examining Tpex subsets in negative tumor draining lymph nodes as predictors of PD-1 inhibitor efficacy in advanced or recurrent esophageal squamous cell carcinoma. The study aims to determine whether high proportions of precursor exhausted T cells correlate with longer overall survival and whether Tpex has better predictive efficacy for treatment response than PD-L1 CPS.

ACOD1 Gene Expression as Sepsis Mortality Predictor

NIH has registered a new observational clinical study (NCT07533994) on ClinicalTrials.gov evaluating ACOD1 gene expression in peripheral blood mononuclear cells as a prognostic biomarker for predicting sepsis mortality. The single-center study will enroll septic ICU patients and correlate ACOD1 expression with clinical severity scores and in-hospital mortality outcomes.

Structured Yoga Program Improves Balance in Children with Down Syndrome: Clinical Trial NCT07534085

NIH's ClinicalTrials.gov registry has posted a new study (NCT07534085) evaluating a 12-week adaptive yoga program on balance and functional performance in 15 children aged 7-12 with Down syndrome. The single-arm intervention includes yoga exercises, breathing techniques, and relaxation practices, with balance assessed using sensor-based digital systems. The study's primary completion date is April 16, 2026.

Metabolic Disorders Accelerate cACLD Progression in 4,307 Adults

ClinicalTrials.gov registered NIH observational cohort study NCT07534046 investigating how metabolic disorders (obesity, diabetes, high cholesterol) influence progression of compensated advanced chronic liver disease (cACLD) in approximately 4,307 adults. The multicenter study across six centers in China will follow participants every 3-6 months for up to 5 years collecting clinical assessments, MRI elastography imaging, metabolic indicators, and biological samples. No experimental treatments are administered; participants receive standard care.

VR Upper Limb Rehabilitation for Chronic Stroke Randomized Trial

NIH/NLM registered a randomized controlled trial (NCT07534124) evaluating non-immersive virtual reality rehabilitation (MindMotion GO) versus conventional occupational therapy for upper limb motor function in chronic stroke patients. The 8-week study with 3-month follow-up will assess motor function, daily living performance, quality of life, and neuroplastic changes via EEG. Enrollment and results will be posted to ClinicalTrials.gov.

NCT07533409 - Tactile and Pain Sensory Thresholds and Hand Grip Strength in Children

NIH registered an observational clinical trial (NCT07533409) on ClinicalTrials.gov comparing fingertip tactile sensation, hand and finger grip strength, and hand pain thresholds in children diagnosed with specific learning disorder with impairment in written expression versus healthy controls. The study is classified as observational with treatment outcome interventions.

Influence of Clear Aligner Marginal Termination Design on Subgingival Periodontal Microbiota: Split-Mouth Study

NIH registered a clinical trial (NCT07533058) examining whether supragingival versus juxtagingival clear aligner edge designs affect subgingival periodontal microbiota in orthodontic patients. The split-mouth study will compare aligner edge designs covering 2mm of gum tissue versus those following the gumline exactly over 8 weeks of wear. The trial will enroll participants undergoing finishing phase orthodontic treatment to assess disease-associated bacteria levels.

Post-Transplant Dental Cleaning to Prevent Chronic Graft-Versus-Host Disease

NIH's ClinicalTrials.gov registered a new clinical trial (NCT07535008) evaluating whether post-transplant dental cleaning can prevent chronic graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic cell transplant. The trial will study dental cleaning and dental plaque sampling as interventions against chronic and acute GVHD in patients with hematopoietic and lymphatic system neoplasms.

Impella 5.5 Echocardiographic Study on Heart Failure

The NIH has registered a prospective observational clinical study (NCT07534462) on ClinicalTrials.gov evaluating the effects of the Impella 5.5 mechanical circulatory support device on biventricular function in adult patients with end-stage heart failure. The study will assess echocardiographic parameters including left and right ventricular global longitudinal strain and myocardial work at baseline, immediately after device initiation, and during 7-14 day follow-up. This observational study involves collection of echocardiographic imaging and clinical data from patients requiring temporary mechanical circulatory support.

Randomized Controlled Trial of Dry Needling for Provoked Vestibulodynia

NIH registered a multicenter randomized controlled trial (NCT07534345) on ClinicalTrials.gov evaluating dry needling efficacy for provoked vestibulodynia (PVD), a chronic vulvar pain condition affecting up to 16% of women. The study will randomize 300 women to receive either real or sham dry needling over 8 weekly sessions, with outcomes assessed at baseline, post-treatment, and 6-month follow-up.

Testing Conversational Agents as a Digital Companion for Autistic Adults

NIH has registered a new clinical trial (NCT07533331) testing an AI-powered digital companion app using conversational-relational agents to provide self-directed goal coaching for autistic young adults ages 18-35. The single-arm study will evaluate whether the technology platform improves mental health, social connection, and life outcomes over a 6-month intervention period. The estimated primary completion date is April 16, 2026.

Real World MAIA UK Outcomes - Observational Myeloma Trial, DRd Therapy

The NIH registered observational study NCT07532473 on ClinicalTrials.gov to assess real-world use and clinical outcomes of triplet therapy daratumumab, lenalidomide, and dexamethasone (DRd) in transplant-ineligible patients with untreated myeloma in the United Kingdom. The observational study will describe treatment patterns and associated clinical outcomes outside of clinical trial settings.

VAP-Measured Lipid Subfractions and In-Stent Restenosis After PCI (NCT07533656)

NIH registered multicenter observational study NCT07533656 investigating association between VAP-measured lipid/lipoprotein subfractions and coronary in-stent restenosis after PCI. Includes retrospective cross-sectional component (patients with prior PCI undergoing repeat angiography) and prospective follow-up component (patients undergoing index PCI). No additional blood draws required; serum samples from routine clinical collection used for VAP testing. Target enrollment: 140 participants. Conditions: In-Stent Restenosis, Coronary Artery Disease. No intervention.

Sacral Fracture Fixation Trial Compares Open, Minimally Invasive Surgical Approaches

NIH's ClinicalTrials.gov has registered observational study NCT07534579 comparing open versus minimally invasive lumbopelvic fixation for unstable sacral fractures in adults. The retrospective study will review medical records and imaging of patients treated between January 2016 and December 2024 to evaluate physical function using the Majeed Pelvic Score, bone healing, surgical complications including wound infections and hardware failures, and clinical nerve function recovery.

Phase 1 Solid Tumor Trial of BMS-986504 Plus Standard-of-Care Therapy

NIH's ClinicalTrials.gov registered a Phase 1 clinical trial (NCT07532902) evaluating BMS-986504 in combination with standard-of-care anticancer therapies for patients with metastatic/advanced unresectable MTAP-deleted solid tumor cancers. The study will enroll participants with diffuse pleural mesothelioma, gastroesophageal carcinoma, and urothelial carcinoma. This is a routine clinical trial registration providing public access to study design and eligibility criteria.

Nurses' Knowledge of Initiating Mechanical Ventilation in ICUs (NCT07534202)

NIH ClinicalTrials.gov registered an observational study (NCT07534202) assessing intensive care unit nurses' knowledge regarding initiation of mechanical ventilation and associated nursing procedures in hospitals in southern Iraq. The study is categorized as observational with no interventional component.

Skin Acceptability Test for GINPI in Female Volunteers

NIH ClinicalTrials.gov registered Study NCT07533461, a Phase 4 clinical trial evaluating skin acceptability of the cosmetic product GINPI in healthy female adult volunteers under gynecological control. The study assesses organoleptic characteristics, subjective efficacy, and monitors for unexpected adverse events over a twice-daily application regimen for 54 participants.

BREATHE III Brazilian Registry of Heart Failure

NIH registered BREATHE III, a prospective multicenter observational registry on ClinicalTrials.gov studying acute heart failure patients in Brazil. The 12-month follow-up study will assess patient characteristics, treatment patterns, guideline-directed medical therapy adherence, time to treatment optimization, and clinical outcomes including barriers to implementation and regional variations in care.

Berry Mango Leaves Extract for Acute Rhinosinusitis Phase I Trial, 10 Subjects

ClinicalTrials.gov registered a Phase I controlled clinical trial (NCT07534280) studying the safety and efficacy of Berry leaves and Mango leaves herbal tea mixture for management of acute rhinosinusitis in adults. Ten subjects aged 18-70 will be enrolled from Minia University ENT outpatient clinic and followed for one month with telephone assessments at Days 0, 3, 7, 10, and 28.

Functional Outcomes and Control Using Synchron BCI - Australia (FOCUS-AUS)

NIH has registered a clinical trial on ClinicalTrials.gov for Synchron's brain-computer interface (BCI) device, known as the Stentrode. The FOCUS-AUS study will evaluate functional outcomes in patients with motor neuron disease and paralysis at Australian trial sites. The study has an anticipated completion date of April 16, 2026.

Radiographic Head and Neck Positional Changes in Response to Low-Powered Prismatic Lenses

NIH's ClinicalTrials.gov has registered a new observational study (NCT07532642) investigating short-term modifications in head and neck positioning through use of low-powered prismatic lenses in patients with Postural Deficiency Syndrome. The matched-pair study will evaluate patients using low-dose biplanar radiography before treatment and 15 minutes after lens application.

Phase 1 KSD-101 Trial for EBV-Associated Hematological Malignancies

NIH ClinicalTrials.gov registered a Phase 1 study (NCT07532746) evaluating KSD-101 for relapsed or refractory EBV-associated hematological malignancies. The single-arm trial will assess safety, tolerability, preliminary efficacy, immune response, and quality of life in participants treated with KSD-101.

Comparing Medial and Lateral Dissection Approaches to the Recurrent Laryngeal Nerve During a Thyroidectomy

NIH registered a new interventional clinical trial (NCT07532889) comparing medial versus lateral dissection approaches to the recurrent laryngeal nerve during thyroidectomy. The randomized study will evaluate length of hospital stay, surgical adverse events, and post-operative vocal cord function. Participants scheduled for thyroidectomy will be enrolled after informed consent.

Multicentre Retrospective Cohort Study of Palliative Care Pathways in Patients Who Died From Sarcoma

NIH ClinicalTrials.gov registered multicentre retrospective observational study NCT07532668 examining palliative care pathways in adult patients who died from sarcoma. The study aims to describe how sarcoma patients who died were followed by palliative care teams. No regulatory obligations or compliance requirements are imposed by this study registration.

MINIMALLY INVASIVE SURGERY FOR GRADE III HEMORRHOIDS - Observational Study NCT07534761

NIH ClinicalTrials.gov registered a new observational study (NCT07534761) evaluating minimally invasive surgery (MIS) for Grade III hemorrhoids using a closed excisional hemorrhoidectomy technique. The IDEAL Phase 2a study aims to assess reproducibility and technical feasibility of MIS in anal surgery with approximately 50 participants.

Short Fiber vs Injectable Resin Composite in Class I Restorations

NIH ClinicalTrials.gov registered a Phase 4 clinical trial (NCT07535086) comparing short fiber reinforced flowable bulk fill resin composite to conventional injectable flowable resin composite for restoring Class I carious molar cavities. The trial will evaluate clinical performance of these dental restoration materials. Estimated study completion date is April 16, 2026.

JZP3507 (ONC206) Phase 2 Trial for Recurrent Grade 2 or 3 Meningioma

NIH registered a Phase 2 clinical trial (NCT07533942) evaluating JZP3507 (ONC206) in patients with recurrent Grade 2 or 3 meningioma who have failed prior therapy. The single-arm study will administer oral JZP3507 and evaluate antitumor activity and safety. The trial is listed on ClinicalTrials.gov with an anticipated start date of April 16, 2026.

Gas6 and Soluble MerTK Periodontal Biomarkers Study

NIH registered an observational clinical study (NCT07535177) investigating Gas6 and soluble MerTK biomarker levels in gingival crevicular fluid and serum samples across three groups: 30 patients with stage III grade B periodontitis, 30 with gingivitis, and 30 periodontally healthy individuals. The study will measure clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, and plaque index. Biomarker levels will be determined using enzyme-linked immunosorbent assay with non-parametric statistical analysis.

Potassium Channel Study in Chronic Cocaine Users

NIH registered a clinical trial (NCT07532460) on ClinicalTrials.gov investigating the role of potassium channels in working memory impairments among chronic cocaine users. The study will test 4-aminopyridine (4-AP) versus placebo as an intervention for cognitive impairments associated with cocaine use disorder. The trial is registered with an estimated start date of April 16, 2026.

AI Thai Food App and CGM Monitoring Pilot Study for Type 2 Diabetes

NIH's ClinicalTrials.gov has registered NCT07533604, an 8-week randomized controlled pilot study evaluating an AI-powered Thai food analysis application (SnapD) combined with continuous glucose monitoring (CGM) for glycemic control in 45 patients with Type 2 Diabetes and overweight/obesity. The study has three arms: SnapD alone, SnapD with CGM, or standard diabetes self-management education. Participants will be monitored over 8 weeks with HbA1c as the primary endpoint.

Phase 2 Clinical Trial Evaluating HSK55718 for Postoperative Pain in Abdominal Surgery

NIH registered a Phase 2 clinical trial (NCT07533786) evaluating the efficacy and safety of investigational drug HSK55718 for postoperative pain treatment. The multi-center, randomized, double-blind, placebo/active-controlled study plans to enroll 200 subjects undergoing abdominal surgery under general anesthesia, comparing three dose levels of HSK55718 against morphine and placebo.

Ga-68 PSMA PET/CT vs mpMRI in Cognitive Prostate Biopsy (NCT07533344)

The NIH ClinicalTrials.gov registry has registered observational study NCT07533344, an NCI-affiliated trial conducted by Stanford University comparing Ga-68 PSMA PET/CT imaging with multiparametric MRI (mpMRI) in cognitive prostate biopsy for prostate cancer diagnosis. The single-arm study will enroll approximately 100 participants and is estimated to begin enrollment on April 16, 2026.

MPXV Viral Clearance, Transmission Dynamics, and Vaccine Effectiveness Study in Guinea

NIH's ClinicalTrials.gov registered an observational study (NCT07534267) in Guinea, West Africa examining Monkeypox virus (MPXV) elimination kinetics from infected individuals, transmission dynamics between cases and contacts, and effectiveness of the MVA-BN vaccine against MPXV infection and Mpox disease. The study has three components: MOVIE-West Africa, TRACE-West Africa, and VE-West Africa.

Hungarian ICU Transfusion Practices Survey

NIH ClinicalTrials.gov registered observational study NCT07532772, a Hungarian nationwide survey assessing transfusion practices in intensive care units. The study will evaluate how physiological parameters recommended as transfusion triggers are used in daily clinical practice across Hungarian hospitals. No regulatory obligations or compliance requirements are imposed by this registration.

Leaf Expander vs Hyrax for Molar Distalization

NIH ClinicalTrials.gov registered a randomized controlled trial comparing skeletally anchored modified Leaf Expander versus conventional Hyrax Expander for maxillary molar distalization in 30 patients aged 15-18 years. The three-year study will evaluate skeletal, dental, and arch dimensional changes using lateral cephalometric radiographs and digital dental models.

Fecal Microbiome Signature of Multi-Strain Probiotics Supplementation in Pediatric IBD

The NIH has registered a clinical trial (NCT07533890) to study fecal microbiome and metabolic profiles in children and adolescents with inflammatory bowel disease upon multi-strain probiotic supplementation. The study will enroll participants and begin interventions on April 16, 2026.