Preoperative Topical Lidocaine Versus Intravenous Fentanyl for Intubation Stress Reduction

NIH registered clinical trial NCT07533643 titled 'Preoperative Topical Lidocaine Versus Intravenous Fentanyl to Obtund the Stress of Intubation Under Anesthesia.' The trial compares two interventions—topical lidocaine (nebulized, mouth rinsing, gargling) and low-dose intravenous fentanyl—to prevent hemodynamic stress from endotracheal intubation by direct laryngoscopy.

For healthcare providers and clinical investigators, this trial registration represents informational research activity rather than a compliance obligation. Sponsors and researchers conducting this trial must ensure compliance with FDA regulations for clinical investigations, including appropriate IRB approval and informed consent procedures.