Gas6 and Soluble MerTK Periodontal Biomarkers Study
Summary
NIH registered an observational clinical study (NCT07535177) investigating Gas6 and soluble MerTK biomarker levels in gingival crevicular fluid and serum samples across three groups: 30 patients with stage III grade B periodontitis, 30 with gingivitis, and 30 periodontally healthy individuals. The study will measure clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, and plaque index. Biomarker levels will be determined using enzyme-linked immunosorbent assay with non-parametric statistical analysis.
What changed
This document registers a new observational clinical study on ClinicalTrials.gov investigating biomarker levels (Gas6 and soluble MerTK) in gingival crevicular fluid and serum of patients with and without periodontal disease. The study includes 90 participants divided equally into three groups based on periodontal health status. Biomarkers will be measured using enzyme-linked immunosorbent assay.
For clinical researchers and healthcare providers, this study represents an emerging area of periodontal disease research that may identify diagnostic biomarkers for gum disease progression. No immediate compliance obligations are created by this registry listing. Researchers conducting similar biomarker studies should be aware of this concurrent investigation to avoid duplication and consider how findings may inform future clinical practice guidelines.
What to do next
- Monitor for study results upon completion
Archived snapshot
Apr 16, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Gas6 and Soluble MerTK in Periodontal Diseases
Observational NCT07535177 Kind: OBSERVATIONAL Apr 16, 2026
Abstract
This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease. A total of 90 individuals, 30 patients with stage III grade B periodontitis, 30 with gingivitis and 30 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index were recorded. GCF and serum sMerTK and Gas6 levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.
Conditions: Periodontitis
Interventions: gingival crevicular fluid collection
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