Post-Transplant Dental Cleaning to Prevent Chronic Graft-Versus-Host Disease
Summary
NIH's ClinicalTrials.gov registered a new clinical trial (NCT07535008) evaluating whether post-transplant dental cleaning can prevent chronic graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic cell transplant. The trial will study dental cleaning and dental plaque sampling as interventions against chronic and acute GVHD in patients with hematopoietic and lymphatic system neoplasms.
What changed
NIH registered a new clinical trial NCT07535008 titled 'Dental Cleaning to Prevent Chronic Graft-Versus-Host Disease.' The trial will evaluate the feasibility and effectiveness of post-transplant dental cleaning for preventing chronic GVHD in allogeneic hematopoietic cell transplant recipients.
Healthcare providers and clinical investigators involved in transplant care should note this trial's focus on the relationship between oral bacteria in dental plaque and chronic GVHD development. The trial involves dental cleaning and dental plaque sampling interventions and will enroll patients with hematopoietic and lymphatic system neoplasms.
Archived snapshot
Apr 16, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Dental Cleaning to Prevent Chronic Graft-Versus-Host Disease
N/A NCT07535008 Kind: NA Apr 16, 2026
Abstract
This clinical trial evaluates the feasibility and effectiveness of a post-transplant dental cleaning for the prevention of chronic graft versus host disease (GVHD) in patients undergoing an allogeneic hematopoietic cell transplant (HCT). HCT is the only curative treatment for some types of blood cancer. Unfortunately, this approach can lead to the development of GVHD, which is a disease caused when cells from a donated stem cell graft attack the normal tissue of the transplant patient. Some research has shown that the bacteria that is present in the dental plaque soon after transplant may affect the development of chronic GVHD. Dental cleanings prior to transplant are part of the normal standard of care for patients undergoing HCT. Adding an additional cleaning shortly after HCT may be effective for preventing the development of chronic GVHD.
Conditions: Chronic Graft Versus Host Disease, Acute Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm
Interventions: Dental Cleaning, Dental Plaque sampling
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