Healthcare & Life Sciences

NCT07539597: CHW-Led Hypertension Study N=15, Single-Arm, Quasi-Experimental

NIH registered a new single-center, single-arm quasi-experimental feasibility study (NCT07539597) on ClinicalTrials.gov. The study will enroll 15 emergency department patients with asymptomatic hypertension and assess a community health worker (CHW)-led intervention addressing social determinants of health. Participants will complete SDOH surveys in REDCap with CHW-facilitated referrals to community organizations. Medical record review via EPIC and Healthix will evaluate healthcare utilization one year before and after the index ED visit.

Observational ICU Diaphragm Physiotherapy Trial NCT07538102

The NIH registered an observational clinical trial (NCT07538102) on April 20, 2026, evaluating whether respiratory physiotherapy protects diaphragm muscle structure in patients receiving mechanical ventilation in the ICU. The study compares standard ICU physiotherapy against neuromuscular electrical stimulation (NMES) as interventions, using ultrasonography to measure changes in diaphragm thickness. No compliance obligations are created by this trial registration.

Peritoneal Dialysis Specialized LLM for PD Management

NIH registered a randomized controlled trial (NCT07539428) on ClinicalTrials.gov evaluating large language model-assisted workflows against physician-only decision-making for peritoneal dialysis management. The study uses clinical vignettes to assess quality differences and identify potential risks such as generating erroneous or harmful suggestions. Conditions include Peritoneal Dialysis and Large Language Models; interventions include a PD-specialized LLM and generalized LLM tools.

DCB vs DES Intervention Clinical Trial for Multivessel Coronary Artery Disease

NIH ClinicalTrials.gov registered a new prospective, multicenter, randomized clinical trial (NCT07539324) comparing drug-coated balloon-based percutaneous coronary intervention (DCB-based PCI) against drug-eluting stent-based PCI in patients with multivessel coronary artery disease. The trial will evaluate lesions measuring 2.25 mm to 4.0 mm in diameter using GENOSS DCB and second/third-generation drug-eluting stents.

Loss Aversion Messaging Effect on Exercise Adherence in Older Adults - NCT07540052

The NIH has registered a new clinical trial (NCT07540052) evaluating whether loss aversion messaging can improve exercise adherence in older adults with mobility disability. The 4-month study will enroll participants in a daily at-home strength training program and compare loss aversion messaging against standard adherence reminders. The trial will measure anticipated regret and exercise frequency as primary outcomes.

Phase 2 CAR-T Combined With ASCT for High-risk Relapsed/Refractory Large B-cell Lymphoma

The NIH has registered a Phase 2 clinical study (NCT07538635) evaluating axicabtagene ciloleucel combined with autologous stem cell transplantation (ASCT) in patients with relapsed/refractory large B-cell lymphoma (LBCL) who have high-risk factors. The trial is prospective, single-arm, single-center, and open-label. Axicabtagene ciloleucel is the sole intervention. ClinicalTrials.gov registrations are informational public listings and do not constitute regulatory approvals or enforceable obligations.

Observational Darolutamide ADT Study for Non-metastatic Prostate Cancer, China

NIH registered an observational study (NCT07538843) on ClinicalTrials.gov evaluating darolutamide combined with androgen deprivation therapy (ADT) in Chinese men with non-metastatic castration-resistant prostate cancer (nmCRPC) whose disease progressed following prior bicalutamide plus ADT treatment. The single-arm study aims to observe treatment efficacy and safety in approximately 75 participants over 36 months using standard-of-care darolutamide.

Phase 2 Peiyuan Guben Tongluo Ointment for Elderly Sarcopenia NCT07538674

The NIH ClinicalTrials.gov registry has published a Phase 2 clinical trial (NCT07538674) evaluating Peiyuan Guben Tongluo Ointment (Ejiao concentrated formula) for treatment of sarcopenia in elderly patients. The randomized, parallel-group study enrolls elderly sarcopenia patients and measures DXA-measured limb muscle mass increase from baseline after 12 weeks of treatment. The trial uses an agarose concentrating group as parallel control and includes exercise and nutritional intervention as co-interventions.

Phase 2 Dalpiciclib Radiotherapy Breast Cancer Brain Metastases

NIH registered Phase 2 clinical trial NCT07539753 evaluating brain radiotherapy combined with dalpiciclib and endocrine therapy in 46 HR-positive/HER2-negative advanced breast cancer patients with brain metastases. The prospective open-label study will assess safety and efficacy per RECIST v1.1, with clinic visits every 3 months until disease progression or withdrawal.

GLP-1 Compounding Rules, Board Membership, Renewal Info

The Wisconsin Pharmacy Examining Board newsletter advises pharmacies dispensing compounded GLP-1 medications (such as semaglutide or tirzepatide) to ensure compliance with Wis. Admin. Code ch. Phar 15 requirements, including facility, process, documentation, and verification standards. The newsletter references FDA guidance warning that compounders may not produce drugs essentially copies of FDA-approved drugs unless documented shortages apply. The newsletter also announces the upcoming license renewal period opening April 12, 2026 and closing May 31, 2026, and notes that 2025 WI Act 167 will add two pharmacy technician seats to the Board.

Medicare Preventive Services Codes Coverage Information

CMS Medicare Learning Network published MLN006559, an informational product providing codes and coverage information for Medicare preventive services. The publication includes links to related resources covering advance care planning, diabetes self-management training, Medicare Diabetes Prevention Program, Part D vaccines, wellness visits, and screening examinations.

Governor and LDH Secretary Urge Emotional Support After Shreveport Shooting

The Louisiana Department of Health and Governor Jeff Landry issued a public health notice encouraging residents to utilize the Louisiana 988 crisis hotline for free, confidential emotional support following a shooting in Shreveport. The notice provides information about available mental health resources including crisis support teams and behavioral health services. No compliance obligations or regulatory requirements are created.

Pain Neuroscience Education Versus Kinesio Tape for Carpal Tunnel Syndrome

NIH ClinicalTrials.gov registered NCT07539480, a randomized controlled trial comparing Pain Neuroscience Education (PNE) versus Kinesio Tape for functional outcomes in patients with carpal tunnel syndrome. The study targets 160 participants with mild-to-moderate CTS, with an estimated completion date of April 20, 2026. This is an informational clinical trial registration with no compliance obligations.

The Effect of Coffee Consumption on Balance, University Students

NIH registered an observational study (NCT07540559) investigating the effects of daily coffee consumption on balance performance in healthy university students. Participants will be categorized by habitual caffeine intake and assessed using standardized clinical balance tests. The study focuses on whether caffeine influences neuromuscular control, reaction time, and postural stability.

ANS02 Phase 1 Study for EGFR Mutation-Positive NSCLC

NIH registered a first-in-human Phase 1 clinical trial (NCT07538804) evaluating ANS02 monotherapy in patients with EGFR mutation-positive advanced non-small cell lung cancer (NSCLC). The multi-center, open-label study will assess safety, tolerability, preliminary efficacy, pharmacokinetics, and anti-tumor activity. This registration documents the trial on ClinicalTrials.gov, supporting transparency requirements for federally funded clinical research.

Chlorhexidine vs Morus Nigra Mouthwash Periodontal Trial

NIH ClinicalTrials.gov has registered study NCT07540624, a randomized controlled trial evaluating the comparative efficacy of chlorhexidine gluconate (0.12%) and Morus nigra (blackberry, 5%) mouthwashes as adjuncts to non-surgical periodontal treatment. The study will enroll patients with periodontitis across three arms: scaling and root planing (SRP) alone, SRP plus chlorhexidine, and SRP plus Morus nigra mouthwash. Investigators will assess clinical periodontal parameters, gingival crevicular fluid inflammatory markers (TNF-a, IL-1b, IL-10), and subgingival plaque microbiological profiles at baseline, 1 month, and 3 months.

Intestinal Ultrasound Predicts Crohn's Disease Relapse in Deep Remission

NIH registered a multicenter prospective observational study evaluating transabdominal intestinal ultrasound as a non-invasive predictor of Crohn's disease relapse. The 18-month study will follow CD patients in deep remission, comparing color Doppler ultrasound parameters between relapse and non-relapse groups using stratified analysis by Montreal classification to establish a predictive model.

Randomized Controlled Study on Mandala Coloring for Quality of Life in Epilepsy

NIH registered a randomized controlled trial (NCT07540013) to assess mandala painting's effect on quality of life in epilepsy patients. The single-blind study at Gümüşhane State Hospital Neurology Polyclinic will enroll adult patients with generalized epilepsy, randomly assigning them to control or experimental groups via full simple randomization. The experimental group will receive mandala painting materials and instructions to complete one mandala at home three times weekly over twenty-four sessions, with data collected using the QOLIE-31 quality-of-life scale.

The REACH-OUT Trial - Blood Pressure Optimization for Women

NIH registered a new clinical trial (NCT07540143) titled the REACH-OUT Trial on ClinicalTrials.gov. The trial will test a technology-enabled strategy to optimize blood pressure among reproductive-aged women with hypertension receiving care at Federally Qualified Health Centers. The study will evaluate health literacy-informed education materials, BP monitors, portal tools, MeDS assessment, and patient navigator support.

Roy Model Medication Training Heart Failure Trial

NIH registered clinical trial NCT07538596 on ClinicalTrials.gov evaluating an Ignite-Based Medication Management Training program for heart failure patients. The trial will enroll participants with heart failure with reduced ejection fraction (HFrEF), randomizing them to receive structured medication training via WhatsApp or standard discharge education. Participants will be followed for 12 weeks with questionnaires at baseline, 4 weeks, and 12 weeks to assess medication adherence and symptom management outcomes.

Motivational Interviewing Prevents Early Childhood Caries, 228 Mother-Infant Pairs, Malaysia

NIH ClinicalTrials.gov registered a two-arm parallel cluster-randomized controlled trial (NCT07538219) in Malaysia comparing Motivational Interviewing-based Anticipatory Guidance versus conventional Ministry of Health Anticipatory Guidance for preventing early childhood caries. The study will recruit 228 mother-infant pairs from MOH Maternal and Child Health Clinics in Setiu and Hulu Terengganu, with data collection at infant ages 6, 9, and 12 months.

Fuchs Dystrophy Descemet Polishing Clinical Trial NCT07539012

The NIH ClinicalTrials.gov registry has posted a new clinical trial (NCT07539012) titled 'Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy.' The study will evaluate whether polishing the Descemet membrane prior to cultured endothelial cell injection improves guttae removal and cell adhesion in Fuchs dystrophy patients. Corneal endothelial keratoplasty is currently the reference treatment, but graft shortages have driven interest in cell-based therapies.

Comparison of 7-Day vs 1-Day Packaging for SQ-LNS in Ethiopia

NIH ClinicalTrials.gov registered a mixed-methods field study (NCT07540793) comparing 7-day (7dp) vs 1-day (1dp) packaging of Small Quantity Lipid-based Nutrient Supplements (SQ-LNS) for children 6-24 months in North Shoa Zone, Amhara Region, Ethiopia. The study, conducted by Edesia Nutrition in partnership with Nutriset Développement, will evaluate acceptability and adherence to the new packaging design. The new 140g 7dp packet reduces cost by over 15% through 40% less packaging and 20% improved transportation efficiency.

Randomized Trial of Tranexamic Acid and Sucralfate for Gastrointestinal Tumor Bleeding

NIH registered Clinical Trial NCT07540026, a randomized controlled trial evaluating endoscopic application of tranexamic acid and sucralfate powders for hemostasis in gastrointestinal tumor bleeding. The study will recruit 60 patients at National Cheng Kung University Hospital in Taiwan, comparing active treatment (3g sucralfate powder and 1.5g tranexamic acid powder) against standard treatment. The trial is listed as ongoing with an estimated completion date of April 20, 2026.

Factors Affecting Immediate Anterior Implants: Retrospective Clinical Study

The NIH ClinicalTrials.gov registry has posted a retrospective cohort study (NCT07539168) evaluating clinical, surgical, and prosthetic factors associated with outcomes of immediate implant placement in the anterior maxilla. The observational study aims to identify predictors of implant survival and complications within 12 months of placement, and will assess peri-implant marginal bone loss, prosthetic complications, and esthetic outcomes using the pink esthetic score.

Biomarker Panel Forecasts Chronic GVHD After Allo-HSCT

NIH registered a single-center observational clinical study (NCT07539220) investigating a biomarker panel for forecasting chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The discovery cohort enrolled 1000 consecutive patients retrospectively from January 2021 to June 2023, while a validation cohort of 500 recipients was enrolled from June 2023 to June 2024. Heparinized blood samples were collected at day +90 post-HSCT and analyzed using multiplex mass spectrometry with pooled plasma to compare proteomic profiles between patients with and without cGVHD.

Telerehabilitation in Patients With Bronchiectasis

The NIH registered a new randomized controlled trial (NCT07539571) on ClinicalTrials.gov evaluating home-based telerehabilitation for patients with bronchiectasis. The single-center trial will be conducted at Virgen del Rocío University Hospital in Spain, randomizing participants to usual care or a 12-week supervised telerehabilitation program three times per week. Outcome measures include the 6-minute walk test, quality-of-life questionnaires, pulmonary function tests, and inflammatory biomarkers.

HBVCare Mobile App Chronic Hepatitis B Treatment Adherence Randomized Controlled Trial

NIH registered clinical trial NCT07540637, a multicenter randomized controlled trial evaluating the HBVCare mobile application for improving treatment adherence in chronic Hepatitis B patients at Hoang Long Clinic and Hanoi Medical University Hospital in Vietnam. Patients are randomized to standard care or HBVCare app intervention, with adherence outcomes assessed at three months.

Celsio Cryocatheter Disposable System Bronchoscopy Study

NIH registered a new clinical trial on ClinicalTrials.gov evaluating the Celsio Disposable Cryocatheter System for diagnostic and interventional bronchoscopy in patients with lung cancer and interstitial lung disease. The study aims to generate real-world evidence on device performance and identify best practices without interfering with standard clinical care.

Functionally Optimized CD33 CAR-T for AML, Phase 1 Trial NCT07538713

NIH registers Phase 1 trial NCT07538713 evaluating functionally optimized CD33 CAR-T (FO33 CAR-T) cell therapy in patients with recurrent/refractory acute myeloid leukemia (AML). The single-arm study will assess safety, tolerability, and preliminary efficacy of the CD33-targeted therapy. CD33 is expressed in leukemia cells from over 80% of AML patients and was selected as the target antigen due to higher expression levels across AML subtypes compared to alternative targets such as CLL-1 and CD123.

Investigation of Patients Presenting With Acute Functional Neurological Symptoms

NIH ClinicalTrials.gov registered NCT07538414, a retrospective single-center observational study analyzing patients presenting with acute functional neurological symptoms. The study aims to characterize the frequency, clinical features, diagnostic pathways, and healthcare utilization of patients with functional neurological disorder. Data collection is limited to retrospective patient data review; no prospective interventions are involved.

Technical Review Panel Public Meeting Notice

Indiana Department of Health has posted a public meeting notice for the Technical Review Panel. The meeting is scheduled for Friday, March 27, 2026, at 10 a.m. EST in the Robert O. Yoho Board Room at 2 N. Meridian St., Indianapolis, IN 46204. Virtual attendance options via Microsoft Teams and telephone are available.

Hospital Violence Intervention Program (HVIP+) Community Model, Central Arkansas

The National Institutes of Health has registered a new clinical trial (NCT07539142) testing the preliminary efficacy of a Hospital-based Violence Intervention Program (HVIP) in Central Arkansas. The optimization randomized control trial will evaluate interventions including Brief Bedside, Peer Support, Case Management with Voucher, and SELF Group Therapy Sessions for hospital-based violence intervention, community firearm violence, and firearm behaviors.

Observational Safety Trial of CT0494BCP in Advanced Gastric/Esophagogastric Junction Adenocarcinoma

A new observational safety trial (NCT07538856) evaluating CT0494BCP cell therapy in participants with advanced gastric/esophagogastric junction adenocarcinoma has been registered on ClinicalTrials.gov. The study uses Bayesian optimal interval (BOIN) design for dose escalation across six dose groups. CT0494 cells are assigned to three escalating doses (3.0×10⁸, 4.5×10⁸, 6.0×10⁸), and CT7095 cells to two escalating doses (1.5×10⁸, 3.0×10⁸). The trial will assess safety, tolerability, preliminary efficacy, and cellular metabolism kinetics.

Effectiveness of Ambulatory Transcutaneous Tibial Nerve Stimulation for Overactive Bladder

NIH has registered a randomized clinical trial (NCT07540273) comparing ambulatory versus clinic-based transcutaneous tibial nerve stimulation for treating overactive bladder in adults aged 18-65. The two-arm study will enroll participants receiving identical electrical stimulation parameters (20 Hz, 200 µs) delivered either at home via portable device or in-clinic twice weekly over 2 weeks. The trial will assess urgency episode frequency, bladder symptoms, and quality of life outcomes.

WECARE Study, Chinese American Dementia Caregivers

NIH has registered a new clinical trial, NCT07539350, titled 'WECARE Study,' testing a seven-week multimedia wellness intervention for Chinese American family caregivers of persons with Alzheimer's disease and related dementias. The trial aims to determine whether the WECARE program improves caregiver well-being and reduces stress related to caregiving for persons with caregiver burden. The study does not create compliance obligations for regulated entities.

Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow

The National Institutes of Health registered a prospective observational clinical study (NCT07540481) evaluating the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general anesthesia. The study will assess ONSD changes at two time points and secondary Doppler parameters. No compliance obligations or deadlines are imposed by this registration.

Pilot RCT Tests ACT for Perinatal Loss Mental Health

NIH registered a pilot randomized controlled trial (NCT07538011) evaluating an Acceptance and Commitment Therapy-based psychosocial intervention for women who have experienced perinatal loss. The 4-week mixed-format program includes four in-person sessions and two videoconferencing sessions, with a 30-minute booster one month post-completion. The study will assess feasibility, acceptability, and preliminary effects on perinatal grief, PTSD, depression, anxiety, psychological flexibility, and social support.

Controlled Cold Exposure Combined With PD-1/PD-L1 Immunotherapy in Solid Tumors (NIVALIS)

NIH ClinicalTrials.gov has registered a single-arm, open-label Phase I exploratory study (NCT07538479) evaluating controlled cold exposure combined with standard PD-1/PD-L1 inhibitor-based therapy in 24 participants with solid malignancies. The primary objectives are to evaluate safety, tolerability, and feasibility of the cold exposure intervention. Secondary objectives include exploring preliminary antitumor activity and effects on brown adipose tissue activation, peripheral immune profiling, circulating cytokines, metabolomics, gut microbiota, and tumor biomarkers.

HDM2024 Phase 1 Trial, Advanced Solid Tumors

NIH registered a Phase 1 clinical trial (NCT07539285) for HDM2024, an investigational drug, in participants with advanced solid tumors. The trial will evaluate drug safety, tolerability, and antitumor activity. Participants receive the study drug once every three weeks, with imaging-based efficacy assessments every six weeks.

Bambini Kids Robot-Assisted Gait Training Safety and Effectiveness Trial in Children With Cerebral Palsy

NIH has registered a clinical trial evaluating the safety and effectiveness of the Bambini Kids pediatric robotic exoskeleton in children with cerebral palsy (CP). The single-arm study will assess robot-assisted gait training (RAGT) as an intervention for gait impairment and motor performance limitations in the pediatric CP population. The trial is registered as NCT07539389 with an estimated completion date of April 20, 2026.

Ultrasound-Guided Percutaneous Needle Tenotomy vs Percutaneous Ultrasonic Needle Tenotomy for Gluteal Tendinosis

NIH ClinicalTrials.gov registered a new clinical study (NCT07540806) comparing two tenotomy techniques for gluteal tendinosis: standard percutaneous needle tenotomy (PNT) versus percutaneous ultrasonic tenotomy (PUT) using the Tenex device. The study's primary endpoints are pain improvement and functional outcomes. This is an informational database entry; no regulatory obligations or compliance requirements are created.

Youth Cannabis Use Continued to Decline in 2025

The Minnesota Department of Health released findings from the 2025 Minnesota Student Survey showing 96% of students reported not using cannabis in the last month, and a 57.7% decrease in past 12-month use among eighth, ninth, and 11th graders since 2013. The survey, conducted between January and June 2025, is Minnesota's first since adult cannabis use was legalized in 2023.

AI-Guided Atrial Fibrillation Detection After Ischemic Stroke: Prospective Randomized Trial

NIH registered a prospective randomized trial (NCT07540065) comparing AI-guided atrial fibrillation risk stratification plus intensified rhythm monitoring (wearable devices, extended ECG patches) against standard care in post-ischemic stroke patients. The trial enrolls an Active Follow-up Group and a Standard Follow-up Group, with conditions including Atrial Fibrillation, Stroke, and Artificial Intelligence. The primary hypothesis is that AI-assisted ECG analysis will significantly increase AF detection rates and enable earlier anticoagulation decisions while reducing unnecessary bleeding risk exposure.

VALsartan on atRIAl Mitral Regurgitation Pilot Randomized Controlled Trial Phase 2

NIH ClinicalTrials.gov registered a Phase 2 pilot randomized controlled trial (NCT07539298) evaluating valsartan versus placebo for treatment of atrial functional mitral regurgitation in adults with preserved left ventricular ejection fraction. The 12-month study will assess progression reduction, mitral valve leaflet remodeling, and safety/tolerability. Participants will undergo 3D echocardiography, 6-minute walk tests, and Kansas City Cardiomyopathy Questionnaire assessments.

BPS-Tech Pilot Trial for Eighth Graders

NIH has registered a pilot clinical trial (NCT07540819) testing a single-session writing exercise called Best Possible Self-Tech (BPS-Tech) with eighth graders. The study aims to assess feasibility and acceptability of classroom delivery, and to examine associations between textual features and positive affect outcomes.

Observational TFESI Efficacy in Lumbar Radicular Pain

NIH registered an observational study (NCT07538765) evaluating the effectiveness of transforaminal epidural steroid injections (TFESI) in patients aged 18 to 90 with radicular low back pain caused by lumbar disc herniation who did not improve with conservative treatment. The three-month study tracks pain reduction using the Visual Analog Scale and functional improvement using the Oswestry Disability Index. No compliance obligations or deadlines are created by this registry entry.

Virtual Intervention for Behavioral Health in Emerging Adults; VIBE in the Parks

NIH ClinicalTrials.gov has registered a randomized clinical trial (NCT07539636) evaluating a digital behavioral health intervention, 'VIBE in the Parks', for adolescents and young adults experiencing anxiety and depression. The study will be conducted at four Chicago Park District sites, comparing the digital treatment to a control condition using a digital workbook.

QI-019B Phase 1 Trial for Relapsed/Refractory Multiple Myeloma

NIH registered Phase 1 trial NCT07539233 evaluating QI-019B Injection in patients with relapsed/refractory multiple myeloma. The single-arm, open-label, single-center study will assess safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics of the investigational drug.

Optimizing Early Nutrition Management of Extremely and/or Very Preterm Infants

NIH ClinicalTrials.gov has registered a clinical quality improvement study (NCT07538999) evaluating an early nutrition management bundle for extremely and/or very preterm infants. The bundle combines three interventions: individualized human milk feeding, early enteral zinc supplementation, and routine parenteral carnitine supplementation. The study will assess clinical outcomes including growth, organ function, and neurodevelopment compared to routine nutritional strategies.