Observational TFESI Efficacy in Lumbar Radicular Pain
Summary
NIH registered an observational study (NCT07538765) evaluating the effectiveness of transforaminal epidural steroid injections (TFESI) in patients aged 18 to 90 with radicular low back pain caused by lumbar disc herniation who did not improve with conservative treatment. The three-month study tracks pain reduction using the Visual Analog Scale and functional improvement using the Oswestry Disability Index. No compliance obligations or deadlines are created by this registry entry.
What changed
NIH registered a retrospective observational study on ClinicalTrials.gov examining whether transforaminal epidural steroid injections (TFESI) can effectively reduce pain and improve physical function in patients with radicular low back pain caused by lumbar disc herniation. Participants aged 18 to 90 will be monitored for three months with pain and disability metrics. This is a registry entry reflecting an active research program; it creates no compliance obligations or deadlines.
Healthcare providers and clinical investigators may monitor this study for emerging evidence on TFESI efficacy relative to surgery, but no regulatory action is required based on this document alone. The study does not impose any obligations on manufacturers, providers, or patients.
Archived snapshot
Apr 20, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Efficacy of TFESI in Lumbar Radicular Pain
Observational NCT07538765 Kind: OBSERVATIONAL Apr 20, 2026
Abstract
The goal of this retrospective study is to evaluate the effectiveness of transforaminal epidural steroid injections (TFESI) in patients with radicular low back pain caused by lumbar disc herniation who did not improve with conservative treatment.
The main questions it aims to answer are:
How effective is TFESI in reducing pain and improving physical function over a three-month period?
Can this procedure serve as a viable alternative to surgery for patients with persistent radiculopathy?
Participants aged 18 to 90 underwent image-guided injections and were monitored for three months. Researchers tracked changes in their pain levels (using the Visual Analog Scale) and their ability to perform daily activities (using the Oswestry Disability Index) to determine the treatment's success.
Conditions: Transforaminal Epidural Steroid Injection, Radicular Low Back Pain
Interventions: transforaminal epidural steroid injections (TFESI)
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