Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow
Summary
The National Institutes of Health registered a prospective observational clinical study (NCT07540481) evaluating the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general anesthesia. The study will assess ONSD changes at two time points and secondary Doppler parameters. No compliance obligations or deadlines are imposed by this registration.
What changed
This document registers a new prospective observational clinical trial on ClinicalTrials.gov. The study examines short-term changes in optic nerve sheath diameter following internal jugular vein catheterization and associations with carotid Doppler measurements and physiological parameters.
Healthcare institutions and clinical investigators conducting similar catheterization research may reference this registry entry when designing comparable studies. This is a notification of research activity with no compliance implications for regulated entities.
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Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow
Observational NCT07540481 Kind: OBSERVATIONAL Apr 20, 2026
Abstract
This prospective observational study aims to evaluate the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter (ONSD) measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general anesthesia.
ONSD will be measured noninvasively using transorbital ultrasonography, and carotid Doppler parameters will be assessed at two time points: after endotracheal intubation and approximately 5 minutes after catheterization. The primary objective is to assess short-term changes in ONSD following catheterization.
Secondary objectives include evaluating changes in carotid Doppler measurements and their relationship with ONSD, as well as associations with physiological parameters such as blood pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide.
Conditions: Intracranial Pressure, Ultrasonography
Interventions: Internal Jugular Vein Catheterization
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