Expandable fusion device with integrated deployable retention spikes

The USPTO granted Globus Medical, Inc. Patent US12589009B2 for an expandable spinal fusion device featuring integrated deployable retention spikes designed to resist expulsion when implanted in the intervertebral disc space. The patent covers the device's actuator assembly and sidecar assembly with pivotable upper and lower spikes. Three inventors are credited: Catherine Krawiec, Damien Kahmer, and George Yacoub.

Dynamic implant fixation plate

USPTO granted patent US12589008B2 to NANOHIVE MEDICAL LLC for a dynamic implant fixation plate designed to reduce stress shielding and permit enhanced loading of implant sites. The patent covers the plate mechanism and compatible implant configuration allowing multi-plane fixation with relative motion capability. The grant includes 18 claims with 8 listed inventors.

Intradiscal fixation systems

USPTO granted Globus Medical, Inc. Patent No. US12589007B2 for intradiscal fixation systems used in spinal disc repair. The patent covers expandable implants and flexible anchors with shape-memory materials, with 9 claims. Inventors include Myles Sullivan, Carly Taubenkraut, and Mark Weiman.

Adjustable Interbody Spinal Cage Patent Grant

The USPTO granted Patent US12589005B2 on March 31, 2026 to inventors Nazmi Peyman, Edmond Zahedi, and Steven Fiore for an adjustable interbody spinal cage. The device features telescoping tubes with actuators and retention members that can be operated non-invasively after implantation. The patent includes 5 claims covering the flexible shell, variable-length rods, and adjustment mechanisms.

Expandable vertebral implant and method

USPTO granted patent US12589006B2 to SeaSpine Orthopedics Corporation on March 31, 2026, covering an expandable vertebral implant system with multi-core architecture, gear-driven expansion, and polyaxial endplate configurations for spinal fusion procedures. The patent includes 42 claims and names Michael Roscoe Harper, Samuel Hunter Hatcher, and Adam James Lipson as inventors.

Bone Fusion Method and System for Sternal Closure

The USPTO granted Patent US12588999B2 to THORAGENIX INNOVATIONS, INC. covering systems and methods for fusing bone sections using sternal wires and harvested cancellous bone tissue to create a sternal construct acting as a bone gasket for improved healing.

4C Medical Prosthetic Heart Valve

The USPTO granted patent US12588998B1 to 4C Medical Technologies, Inc. for a collapsible and expandable prosthetic heart valve implant designed for implantation in a heart chamber. The patent includes 126 claims and was filed on April 23, 2025 under Application No. 19187060. Inventors are Saravana B. Kumar, Steven D. Kruse, and Jason S. Diedering.

Patient-Specific Total Disc Replacement Spinal Implant Patent

USPTO granted Patent US12589004B2 to Nexus TDR, Inc. for a patient-specific total disc replacement spinal implant system. The patent covers methods for tailoring spinal implants to individual patient needs by pre-operative evaluation and modifying implant flexure features. Assignee: Nexus TDR, Inc.; Inventors: David T. Hawkes, Peter Halverson.

Spinal Interbody Spacer Patent Grant - Astura Medical

The USPTO granted Patent US12589003B2 to Astura Medical Inc. for a spinal interbody spacer featuring an asymmetrical open end, asymmetrical screw fixation plate, and locking mechanism. The patent covers 14 claims and names inventors Ross Dusterhoft and Thomas Purcell. The patent expires June 29, 2043 based on the filing date of June 29, 2023.

Systems and methods for preparing a meniscal tissue for implant

The USPTO granted patent US12589002B2 to Arthrex, Inc. on March 31, 2026. The patent covers systems and methods for preparing meniscal tissue for implant, including meniscal allografts with bone blocks and techniques for shaping them using clamp and jig arrangements. Shane Noble is listed as lead inventor alongside four co-inventors, with 14 claims total.

Substituted Entecavir Monophosphate Alaninamide Phenolic Esters for Hepatitis B

The USPTO granted Patent No. US12590097B2 to Beijing Junke Huayuan Med Tech Co., Ltd. on March 31, 2026, covering entecavir monophosphate alaninamide phenolic ester derivatives for hepatitis B treatment. The patent grants exclusive rights to the pharmaceutical compound for resisting hepatitis B virus. This is a routine patent grant notification.

Spiroindoline pyrrolopyrrole triones NRF2-β-TrCP inhibitors for fatty liver treatment

USPTO granted Patent US12590100B2 to researchers from Universidad Autonoma de Madrid and CSIC for spiroindoline pyrrolopyrrole trione compounds that inhibit the NRF2-β-TrCP interaction for treating fatty liver disease. The patent covers 3 claims and relates to therapeutic applications for chronic inflammation and oxidative stress-related liver conditions.

Inhibitors of histone deacetylase useful for the treatment or prevention of HIV infection

USPTO granted Patent US12590099B2 to Merck Sharp & Dohme LLC covering HDAC (histone deacetylase) inhibitors useful for treating or preventing HIV infection. The patent protects compounds of Formula I, pharmaceutical compositions thereof, and methods of treatment. Four claims were granted. The patent application was filed on November 4, 2019.

Pyrimido pyrimidinone compound and pharmaceutical composition comprising the same

The USPTO granted Patent US12590098B2 to Axceso Biopharma Co., Ltd. on March 31, 2026, covering a pyrimido pyrimidinone compound that inhibits PD-L1 expression for cancer treatment. The patent includes 9 claims and names 8 inventors including Young Jun Park and Sung Jun Park.

Imidazo[2,1-f][1,2,4]triazin-4-amine as TLR8 agonists for cancer treatment

USPTO granted Patent US12590096B2 to BeOne Medicines GmbH for an imidazo[2,1-f][1,2,4]triazin-4-amine derivative as a TLR8 agonist for treating cancers. The patent contains 18 claims and was filed on July 31, 2020 (Application No. 17632027). The compound is classified under 12 CPC codes spanning antineoplastic, antiviral, and anti-inflammatory applications.

Crystalline Forms of Orally Available Selective KIT and PDGFR Kinase Inhibitor

USPTO granted patent US12590095B2 to Sandoz AG on March 31, 2026, covering crystalline forms of avapritinib, a KIT and PDGFR kinase inhibitor. The patent (CPC C07D 487/04) protects polymorphs and hydrates of the compound for treating gastrointestinal stromal tumors (GIST) and advanced systemic mastocytosis (AdvSM). Inventors include Verena Adamer, Andrea Thaler, and Erwin Schreiner.

Compounds for the treatment of neurodegenerative and metabolic disorders

USPTO granted Patent US12590094B2 to University of Florida Research Foundation for heterocyclic compounds targeting neurodegenerative diseases linked to protein misfolding, including Alzheimer's, Parkinson's, ALS, and prion diseases, as well as metabolic disorders. The patent covers 8 lead compound series demonstrating NAD-restoring properties and therapeutic efficacy in cellular and animal models.

Indolo[2′,3′:3,4]pyrido[2,1-b]quinazoline compound and use thereof

USPTO granted patent US12590093B2 to the Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, covering an indolo[2′,3′:3,4]pyrido[2,1-b]quinazoline compound for treating cardiovascular and cerebrovascular diseases. The patent lists 13 inventors and contains 4 claims, with applications including increasing expression of AMPK, ABCA1, and SR-BI, and inhibiting NLRP3, IL-1β, NF-κB, and MAPKs.

Antiviral agents and uses thereof

The USPTO granted Patent US12590092B2 to Griffith University for antiviral compounds of Formula (I) and pharmaceutical compositions for treating viral infections. The patent, with 21 allowed claims, names Mark Von Itzstein, Ibrahim El-Deeb, Patrice Guillon, and Larissa Heilig as inventors. Filing date was January 28, 2022.

Bristol-Myers Squibb pyrrolo TLR9 inhibitors for fibrosis, 31st Mar

Bristol-Myers Squibb pyrrolo TLR9 inhibitors for fibrosis, 31st Mar

Marker Localization Patent Granted to Cianna Medical

USPTO granted Patent US12588829B2 to Cianna Medical, Inc. for apparatus, systems, and methods used to localize markers or tissue structures within a patient's body, such as for breast lesion localization. The patent (18 claims) covers implantable markers and electromagnetic signal probes for detecting and removing tissue specimens including lesions.

Methods and Systems for Diagnosing and Treating Fibromyalgia

The USPTO granted Patent US12588828B2 to inventor Robert S. Katz, covering methods and systems for diagnosing and treating fibromyalgia using pressure measurements from saline injection into muscle locations. The patent protects a device comprising a needle, saline-filled syringe, connecting tube, and pressure sensor. The patent contains 12 claims.

Atlasense Biomed remote physiological monitor patent granted

USPTO granted patent US12588822B2 to Atlasense Biomed Ltd. for a remote physiological monitor system featuring wireless sensors, fall detection algorithms, and alert capabilities. The patent includes 32 claims covering a micromonitor with non-optical pulse wave or ECG sensors and condition monitoring/prediction functionality. Filed August 2, 2021 as Application No. 17392128.

Body temperature estimation, single sensor, Korea Electronics Technology Institute

Body temperature estimation, single sensor, Korea Electronics Technology Institute

Determining different sleep stages in a wearable medical device patient

USPTO granted patent US12588827B2 to ZOLL Medical Corporation for a patient monitoring device that uses ECG and motion sensors to determine sleep stages and adjust cardiac arrhythmia detection parameters accordingly. The device differentiates between immobilized and non-immobilized sleep states to optimize monitoring modes. The patent covers 16 claims filed under Application No. 17907650.

Photoplethysmogram Sensor Arrangement Patent

The USPTO granted Patent US12588826B2 to Polar Electro Oy for a photoplethysmogram sensor arrangement. The invention features a light emitter and photo detector in a diagonal orientation with an opaque mask covering part of the detector. The patent contains 12 claims and covers medical sensing technology used in heart rate monitoring devices.

Cardiac pulse wave retrieval from an electrical signal

USPTO granted Patent US12588824B2 to Onera Technologies B.V. for a method and system of determining cardiac pulse wave signals by processing ECG and electrical signals. The patent includes 20 claims and names inventors Jantina Catharina de Vries and Hartmut Schneider.

Machine Learning Blood Pressure Monitoring Using Digital Twin Technology

The USPTO granted Twin Health, Inc. Patent US12588823B2 for a machine learning-based blood pressure monitoring system using digital twin technology. The platform generates short-term and long-term blood pressure predictions based on patient-reported nutrition data, sensor readings, and lab test results. The system updates a digital twin of the patient's metabolic profile to enable continuous health monitoring. The patent includes 17 claims and was applied for on April 28, 2021.

Foghorn Therapeutics Patent for Heterocyclic Compounds Treating BAF Disorders

The USPTO granted patent US12590079B2 to Foghorn Therapeutics Inc. on March 31, 2026, covering heterocyclic compounds useful for treating BAF complex-related disorders. The patent names inventors Sabine K. Ruppel, Zhaoxia Yang, and Jason T. Lowe, with claims encompassing 20 compound variations classified under CPC codes C07D 401/14, C07D 471/04, C07D 471/10, and C07D 487/04.

Fused imidazole derivatives as GLP-1 receptor agonists for diabetes treatment

USPTO granted Patent US12590081B2 to Jiangsu Hengrui Pharmaceuticals Co., Ltd. for fused imidazole derivatives as GLP-1 receptor agonists for diabetes treatment. The patent covers 21 claims for compounds, preparation methods, and pharmaceutical compositions containing the derivatives.

Heterocyclic compound for organic electroluminescent elements

USPTO granted Patent US12590076B2 to Idemitsu Kosan Co., Ltd. for a heterocyclic compound represented by formula (1) used in organic electroluminescent elements. The patent, filed on May 10, 2019 (Application No. 17053630), contains 26 claims and covers compounds classified under CPC codes including C07D 307/91 and H01L 51/0052.

Implant delivery device

USPTO granted patent US12588988B2 to 4C Medical Technologies, Inc. covering an implant delivery device with a constrained/relaxed configuration system. The patent includes a strut with hub-captured end, swivel body, pusher catheter, gauge handle with force measurement, and bushing for guided implant delivery. This represents routine issuance of intellectual property rights for medical device technology.

Guernsey ETA requirement for non-visa nationals

The States of Guernsey Committee for Home Affairs has introduced an Electronic Travel Authorisation (ETA) requirement for non-visa nationals travelling to the Bailiwick of Guernsey from outside the Common Travel Area. The ETA application process opens 9th April 2026, with the requirement taking effect 23rd April 2026. The ETA costs £16 (increasing to £20) and is valid for two years or until passport expiry, permitting multiple journeys of up to six months each.

Housing Site Availability Framework

The Committee for Housing, States of Guernsey, has published the Housing Site Availability Framework in partnership with the Guernsey Building Trades Employers Association (GBTEA). The Framework consolidates information on housing sites across Guernsey into a single document, drawing on data from the planning process and other public sources. The resource will be updated at least twice annually.

Storm Goretti Damages Alderney Breakwater, Fishermen Access Restricted

The States of Guernsey's Committee for the Environment & Infrastructure announced plans to install a new barrier at Alderney breakwater following damage from Storm Goretti. The barrier will restrict pedestrian access to damaged sections while restoring fishermen's access to the slipway for landing catch. Large holes on the lower walkway require repair as weather permits.

Alaska Beak Deformity Observations, comments due June 1

Alaska Beak Deformity Observations, comments due June 1

ITAR Information Collection Extension for Request to Change End-User, End-Use and/or Destination of Defense Articles

The Department of State's Directorate of Defense Trade Controls (DDTC) is requesting public comments on an extension of an approved information collection (OMB Control No. 1405-0173) for Form DS-6004. The form is used to request approval for changes to end-user, end-use, and/or destination of defense articles under the International Traffic in Arms Regulations (ITAR). Comments are due April 30, 2026. Approximately 1,695 respondents are affected with a total estimated burden of 2,234 hours.

Day of Service Application Instructions Revision Comment Request

AmeriCorps (CNCS) published a 30-day notice requesting public comment on revisions to Day of Service Application Instructions for MLK and 9/11 grant competitions. Key changes include raising the Single Audit threshold from $750,000 to $1,000,000, updating the equipment definition to $10,000 or more per unit (from $5,000), and increasing the de minimis rate to 15% of modified total direct costs (from 10%). Comments are due April 30, 2026.

Woodsy Owl Symbol Commercial Use Licensing Information Collection Renewal

The USDA Forest Service published a notice seeking public comments on the renewal of an approved information collection for commercial licensing of the Woodsy Owl symbol (OMB No. 0596-0164). The collection solicits information from businesses and nonprofits seeking to use the Woodsy Owl mascot and conservation slogans ('Give a Hoot, Don't Pollute' and 'Lend a Hand, Care for the Land') on merchandise and in media. Comments are due June 1, 2026.

2026 Tariff-Rate Quota Limits for US-Australia Free Trade Agreement

The Office of the United States Trade Representative published a notice establishing tariff-rate quota quantitative limits for originating goods of Australia under the US-Australia Free Trade Agreement for calendar year 2026. The notice sets specific metric ton and liter quantities for beef (71,695 MT), dairy products, and horticultural goods entered under various HTSUS subheadings 9822.04.05 through 9822.04.35.

Shoreline Management Plan Update - Housatonic River Pumped Storage Project

FERC issued a notice that FirstLight CT Housatonic LLC filed a Shoreline Management Plan Update for the Housatonic River Pumped Storage Project (P-2576-215) in Connecticut. The update expands land designations to include non-shoreline lands within the project boundary, modifies allowable use restrictions, streamlines authorization requirements, and revises the permit application fee structure. FERC is inviting comments, motions to intervene, and protests by April 27, 2026.

Fuel Sector Regulation Transfer to URCO

The Cayman Islands Cabinet has approved drafting instructions to consolidate fuel-sector licensing and regulation under the Utility Regulation and Competition Office (URCO), transferring licensing authority from the Department of Commerce and Investment. This structural reform addresses fragmented oversight across over 400 regulated sites and establishes a unified, sustainable regulatory framework with clear enforcement authority.

Caymanians in Careers campaign launches, highlights tourism sector

The Ministry of Caymanian Employment and Immigration (MCEI) launched the 'Caymanians in Careers' campaign on March 30, 2026, to showcase Caymanian professionals across various industries and highlight career pathways available in the Cayman Islands. The initial phase focuses on the tourism sector, featuring Caymanian workers and their career journeys to inspire other Caymanians and inform students and job seekers about industry opportunities.

CBC Visa Regulation Amendments for Border Security

The Cayman Islands Cabinet approved amendments to the Customs and Border Control (Visas, Entry and Landing) Regulations, effective April 2, 2026. The changes introduce new visa requirements for nationals of Peru and Venezuela (for entry and transit) and in-transit visa requirements for Haiti and Dominican Republic. New exemptions were added for cruise ship passengers and operational crew members.

Investor Alert: Relationship Scams and Impersonation Fraud

The SEC's Office of Investor Education and Assistance issued an Investor Bulletin on March 31, 2026 warning investors about relationship investment scams (long cons using friendship or romance to lure victims into fake investments) and impersonation schemes (fraudsters posing as legitimate investment professionals or registered firms). The bulletin, issued during Financial Literacy Month, directs investors to existing resources on Investor.gov covering asset allocation, diversification, tax-advantaged accounts, and fee disclosures. The bulletin explicitly states it represents staff views and is not an SEC rule, regulation, or statement.

ERISA Fiduciary Duties and Alternative Assets Investment Rule

The Department of Labor's EBSA published a proposed rule (RIN 1210-AC38) clarifying fiduciary duty of prudence under ERISA for selecting designated investment alternatives in participant-directed individual account plans, including asset allocation funds with alternative assets. The proposal provides a safe harbor to alleviate regulatory burdens and litigation risk, implementing Executive Order 14330. Public comments are due June 1, 2026.

E-Rate Program Debarment Notice - Simon Goldbrener

The FCC issued a Notice of Debarment (DA 26-266) against Simon Goldbrener from the Federal E-Rate program for a period of three years. The debarment commences on March 31, 2026 or upon Goldbrener's receipt of the debarment letter, whichever occurs first. This enforcement action bars Goldbrener from participating in E-Rate program activities and affects schools, libraries, and service providers involved with E-Rate funding.

Review of the Commission's Rules Governing the 896-901/935-940 MHz Band

The FCC published a final rule (91 FR 15889) reviewing and amending its rules governing the 896-901/935-940 MHz spectrum band, which is allocated for narrowband and broadband public safety and commercial communications. The rule takes effect April 30, 2026. Affected parties include licensed spectrum users in this frequency range under FCC Part 2, Part 27, and Part 90 rules.

Sunshine Act Meeting Item Deletion

The Federal Communications Commission published a notice on March 31, 2026 announcing the deletion of an item from its March 26, 2026 open meeting under the Sunshine Act. The notice provides no details about the nature of the deleted item. This is a routine administrative procedural notice with no new requirements or obligations for regulated entities.

Energy Conservation Standards for Fluorescent Lamp Ballasts

The Department of Energy (DOE) proposes new energy conservation standards for fluorescent lamp ballasts under the Energy Conservation Program. The proposed rule establishes minimum energy efficiency requirements for these products and opens a 62-day public comment period. Manufacturers and importers of fluorescent lamp ballasts should review the proposed standards and submit comments by June 1, 2026.