Healthcare & Life Sciences

Observational Study of Oral Microbiota in Children With Autism

The NIH ClinicalTrials.gov registry posted an observational study (NCT07538232) investigating oral microbiota distribution and salivary IgA levels in children with autism. The non-interventional study will collect dental plaque and saliva samples for analysis without experimental intervention. The study focuses on three conditions: Autism, Caries, and Dental health.

LLM Integration Tests Nursing Student Research Competency

NIH registered a mixed-method interventional study (NCT07540078) on ClinicalTrials.gov examining whether integrating ChatGPT into undergraduate nursing research courses improves research competency and attitudes among third-year students. Researchers will compare assessment grades and measure outcomes using the Research Competence Scale and Revised Attitudes Towards Research scale. The study focuses on an LLM-Integration intervention for education purposes.

Observational Study on Dual-Task Effects on Gait in Parkinson's Disease

The National Institutes of Health has registered an observational study (NCT07540325) evaluating gait in individuals with Parkinson's Disease under cognitive dual-task conditions, comparing results with age and sex-matched healthy controls. The study will assess which cognitive function has the greatest impact on gait in Parkinson's Disease patients.

Active Breaks and Executive Function in Scholars

NIH ClinicalTrials.gov registered NCT07538453, a randomized controlled study examining whether 10-minute exercise breaks performed during the school day improve thinking skills, creativity, and emotional wellbeing in primary school children. Children aged 11-12 years will be assigned to an aerobic exercise break, a strength-based exercise break, or a seated control activity, with outcomes measured across attention, working memory, creativity, and emotional wellbeing.

Effect of Intraoperative Live Video Viewing on Kinesiophobia After ACL Reconstruction

NIH has registered clinical trial NCT07540715, a randomized controlled trial investigating whether intraoperative live arthroscopic video viewing improves postoperative psychological and functional outcomes in patients undergoing primary ACL reconstruction under spinal anesthesia. Participants are randomly assigned to either a video-viewing group or a control group receiving standard care without visual feedback. The primary objective is to determine whether this patient-specific visual biofeedback reduces postoperative kinesiophobia at 24 weeks.

Six-Week Accentuated Eccentric Training for Young Football Players

NIH registered a new clinical trial (NCT07538557) on ClinicalTrials.gov investigating the effects of a six-week accentuated eccentric load training program on balance, strength, sprint, change of direction, and jump performance in young football players. Participants will undergo baseline assessments followed by supervised training and post-intervention testing using validated measurement tools in a controlled environment. The study aims to generate evidence for evidence-based athletic training strategies.

AI-Based Multimodal Model for Predicting Post-GI Surgery Cardiovascular Events vs Traditional Risk Scores

NIH registered an observational study (NCT07539532) at Bach Mai Hospital comparing an AI-based multimodal model against traditional cardiac risk scores (RCRI, ACS NSQIP MICA, and ACS NSQIP SRC) for predicting major cardiovascular events within 30 days after gastrointestinal surgery in adults. The study will use retrospective 2025 medical records and prospective 2026 data collection. No changes to routine clinical care are involved.

Benmelstobart Plus Anlotinib, Chemotherapy and Thoracic Radiation for Limited-Stage Small Cell Lung Cancer

Phase 2 clinical trial NCT07538258 registered at Shanghai Pulmonary Hospital, Tongji University, evaluating benmelstobart (immunotherapy) plus anlotinib (anti-angiogenic) combined with platinum-etoposide chemotherapy and concurrent thoracic radiotherapy as first-line treatment for previously untreated, unresectable limited-stage small cell lung cancer. The single-arm, single-center exploratory study enrolling 18-75 year old participants with measurable disease will assess objective response rate as primary endpoint, with secondary endpoints including progression-free survival, overall survival, and safety. Study completion is targeted for April 20, 2026.

Center for Scientific Review; Notice of Closed Meeting

The National Institutes of Health (NIH) has published a notice of a closed virtual meeting of the Center for Scientific Review Special Emphasis Panel on April 28, 2026, from 9:00 a.m. to 6:00 p.m. The meeting is closed to the public pursuant to sections 552b(c)(4) and 552b(c)(6) of Title 5 U.S.C. to protect confidential trade secrets, commercial property, and personal privacy information associated with grant applications under review. The panel will review and evaluate grant applications related to Heart, Lung, Blood, and Sleep (HLBS) diseases and disorders.

Continuous Care Model, Psychological Distress, Postmenopausal Women, Urinary Incontinence

NIH ClinicalTrials.gov registered a new study (NCT07538752) evaluating the effect of a continuous care model on psychological distress and quality of life among postmenopausal women with urinary incontinence. The study has conditions including Psychological Distress, Quality of Life, and Menopause. No compliance obligations or deadlines are established by this registration.

ORI Monitoring in Low and Normal Flow Anesthesia Applications

NIH registered an observational clinical study (NCT07538817) on ClinicalTrials.gov investigating Oxygen Reserve Index (ORI) monitoring during laparoscopic nephrectomy. The study compares low and normal fresh gas flow anesthesia approaches to determine optimal oxygenation levels, aiming to prevent both hypoxemia and hyperoxemia in surgical patients.

Nursing Students Compare 360-Degree Video and Slideshow for MS Education

The National Institutes of Health registered NCT07538063, a comparative educational study evaluating immersive 360-degree video versus slideshow presentations for teaching nursing students about Multiple Sclerosis. Participants were assigned to either the 360-degree video experience or a PowerPoint slideshow with equivalent content, with knowledge outcomes measured using the MSMRIKQ and MSKQ instruments. This study is registered with no stated compliance obligations or regulatory implications.

Music Therapy Trial, Rural Arizona, 6 Weeks

NIH ClinicalTrials.gov registered a new clinical trial (NCT07538427) evaluating whether a 6-week music-based intervention reduces stress, anxiety, depression, and chronic pain among adults in residential care settings in northern Arizona. Participants attend weekly one-hour music classes involving active music activities such as drumming and rhythm exercises, completing pre- and post-intervention surveys. Researchers will compare responses to determine whether the intervention improves health and coping outcomes. The trial also includes optional participant interviews.

Laser Acupuncture for Fatigue in Hemodialysis Patients

NIH ClinicalTrials.gov registered a new clinical trial (NCT07538310) evaluating low-level laser acupuncture as a treatment for fatigue in adults with end-stage renal disease undergoing hemodialysis. The randomized controlled study will compare active laser acupuncture to sham treatment over 4 weeks, assessing fatigue severity, quality of life, microcirculation, and autonomic nervous system markers. Participants will be evaluated at baseline, 4 weeks, and 8 weeks.

Observational Study Validates AI-Based G-FAST Score for Stroke Screening

NIH registered observational study NCT07538492 evaluating an artificial intelligence system that automatically calculates the G-FAST score for stroke screening. The study compares AI-generated G-FAST results against standardized manual assessments performed by trained professionals to determine consistency and accuracy. No compliance obligations, deadlines, or penalties are established by this registration.

Laughter Yoga Reduces Nursing Student Stress in Randomized Controlled Trial

NIH's ClinicalTrials.gov registered a randomized controlled trial (NCT07540039) evaluating laughter yoga as a non-invasive intervention to reduce perceived stress and improve self-efficacy among first-year nursing students. The study uses pre-test, post-test, and follow-up measures across experimental and control groups. The trial registration identifies laughter yoga as a complementary medicine practice combining unconditional laughter with breathing techniques.

Comparison of 3D Printed Metal Fixed Retainer Versus Conventional Fixed Bonded Retainer

NIH ClinicalTrials.gov registered a new randomized controlled trial (NCT07538869) comparing 3D-printed metal fixed retainers against conventional fixed bonded retainers in dental/orthodontic patients. The study will evaluate bond failure outcomes at immediate and 12-month timepoints, addressing a gap in long-term clinical evidence for titanium and 3D-printed retainer materials. Conditions under study are bond and pair; the trial is registered with an anticipated update date of April 20, 2026.

LiveWell mBC Pilot RCT, 48 Women, Metastatic Breast Cancer

This pilot randomized controlled trial (NCT07539649) will enroll 48 women with metastatic breast cancer experiencing at least mild distress. Participants will be randomized to receive LiveWell mBC, a group-based adapted Dialectical Behavioral Therapy Skills Training protocol, or Usual Care. Investigators will evaluate feasibility, acceptability, and preliminary efficacy of the intervention for reducing distress as the primary outcome and improving psychological well-being, symptom burden, and quality of life as secondary outcomes.

Dipotassium Oxalate for Postoperative Sensitivity in NCCLs (NCT07540299)

The National Institutes of Health has registered a randomized controlled trial (NCT07540299) on ClinicalTrials.gov evaluating dipotassium oxalate gel as a pre-treatment agent for reducing postoperative sensitivity in non-carious cervical lesion (NCCL) Class V composite restorations. The study will enroll 64 participants randomly assigned to intervention (dipotassium oxalate + adhesive) or control (standard adhesive protocol) groups, with sensitivity assessed via Visual Analog Scale at baseline, 24 hours, 7 days, and 30 days.

CDC Proposes Data Collection Under Paperwork Reduction Act; Comments Due June 22, 2026

The CDC has published a notice in the Federal Register (91 FR 21292) announcing a proposed data collection under the Paperwork Reduction Act. The agency is soliciting public comments on the proposed collection of information. The comment period closes on June 22, 2026, providing 62 days for public input. This is a standard administrative notice related to the agency's information collection activities.

Proposed Data Collection Submitted for Public Comment and Recommendations

The CDC has published a notice in the Federal Register (91 FR 21295) announcing a proposed data collection under docket CDC-2026-0628. The notice opens a 62-day public comment period, which closes on June 22, 2026. Interested parties may submit comments via Regulations.gov or directly through the Health and Human Services Department submission portal.

Proposed Data Collection Under Paperwork Reduction Act

The CDC published a Federal Register notice announcing a proposed data collection under the Paperwork Reduction Act and requesting public comment. The notice solicits recommendations on the proposed collection. The comment period runs for 62 days, closing on June 22, 2026. The notice applies to all parties subject to CDC information collection requests under the Paperwork Reduction Act.

CDC Proposes Data Collection for Public Comment

The CDC has published a notice proposing a new data collection under OMB Control No. 60Day-26-0314, seeking public comment for 60 days through June 22, 2026. The notice is a standard Paperwork Reduction Act 60-day pre-submission notice typical of federal data collection activities.

FY2026 Drug Precaution Revisions for Biologics

PMDA published FY2026 precaution revisions for 6 drugs/biologics on April 21, 2026. Revised products include infliximab and etanercept (both with biosimilars), calcium chloride hydrate (injection), calcium gluconate hydrate, avelumab, and regorafenib hydrate. Each revision includes a PRECAUTIONS document and Summary of Investigation.

PRISMES: Precarity Impact on Mental Health of Health Students (NCT07539207)

The NIH ClinicalTrials.gov registry has posted a new observational study, NCT07539207 (PRISMES), examining the relationship between financial precarity and mental health among health profession students in France. The study, led by Institut national de la santé et de la recherche médicale U1073 under supervision of the Conférence Nationale des Doyens de Médecine, enrolled over 12,000 participants in a 2024 national survey finding that 12% experienced severe financial insecurity and 20% moderate insecurity, strongly associated with anxiety, depression, and emotional exhaustion. This registry entry documents the study's parameters and is for informational purposes only — no compliance obligations are created.

Stress Ball Effects on Nausea, Anxiety, and Fatigue in Stomach Cancer Patients Undergoing Chemotherapy

The National Institutes of Health registered a new clinical trial on ClinicalTrials.gov (NCT07540169) studying the effect of stress ball intervention on chemotherapy-induced nausea, anxiety, and fatigue in patients with stomach cancer. The trial will observe patients receiving the stress ball as a non-pharmacological supportive care tool during cancer treatment.

Hip-allograft In Proximal Humerus Fractures Versus Plate Implantation Alone: a Randomized Controlled Trial

This registry entry documents NIH ClinicalTrials.gov study NCT07538700, a randomized controlled trial evaluating the effectiveness of mushroom-shaped femoral allograft augmentation combined with locking compression plate fixation versus locking compression plate fixation alone for displaced 3- and 4-part proximal humerus fractures in adults and the elderly. The study will assess clinical and functional outcomes at 24 months post-operatively. No regulatory obligations or compliance actions are imposed by this registration document.

Phase 4 Community Health Worker Respiratory Health Intervention Trial in Nepal

NIH has registered a Phase 4 clinical trial (NCT07540000) on ClinicalTrials.gov testing whether a community health volunteer-delivered multi-component program can improve lung health for people at risk of chronic respiratory diseases in Bhaktapur, Nepal. The 40-month study will enroll index participants and household members, with 11 research visits including spirometry, exhaled carbon monoxide measurements, blood pressure checks, and accelerometer monitoring. The intervention focuses on reducing tobacco smoke and air pollution exposure, preventing respiratory infections through vaccination and mask use, and encouraging safe physical activity.

SPIRIT Study FVIII Tolerance Hemophilia A Children

The NIH has registered the SPIRIT observational cohort study (NCT07539402) investigating immunological tolerance mechanisms to clotting factor VIII (FVIII) in children under 18 years with congenital hemophilia A who are using Non-Factor Therapy prophylaxis. The study seeks to understand how robust FVIII tolerance is in patients with infrequent FVIII exposure enabled by NFT. Findings may inform clinical understanding of inhibitor development risk but do not alter current treatment standards or create compliance obligations.

VIRal Pulmonary Infections in Older AGE

The National Institutes of Health registered an observational study (NCT07539103) examining viral respiratory infections in hospitalized older adults aged 60 and older. The study aims to determine the proportion of severe acute respiratory infections attributable to specific PCR-confirmed viral pathogens including influenza, RSV, hMPV, PIV, adenoviruses, rhinoviruses, and SARS-CoV-2. Research sites will enroll subjects prospectively to characterize the burden and prevalence of different viral etiologies.

Anecatibin Fumarate PK and Safety Trial

NIH registered Phase 1 trial NCT07538973 evaluating the pharmacokinetics and safety of Anecatibin Fumarate Capsules in subjects with impaired liver function versus subjects with normal liver function. The trial is conducted in subjects with lung cancer as the condition. The intervention under study is Anecatibin Fumarate Capsules.

Early Partial Weight-bearing After Pelvic Fixation Surgeries, NCT07538726

NIH registered a randomized clinical trial (NCT07538726) comparing immediate partial weight-bearing versus delayed weight-bearing in individuals who underwent pelvic fixation surgeries. The study will evaluate functional recovery, pain, gait, reduction quality, muscle strength, and quality of life outcomes. The trial is registered as an observational study entry with no compliance obligations.

Biomechanical Muscle Properties and Balance in Children With Spastic Hemiplegia

The National Institutes of Health has registered a new observational clinical trial, NCT07538297, titled 'Biomechanical Muscle Properties and Balance in Children With Spastic Hemiplegia.' The study will investigate the relationship between muscle tone, dynamic stiffness, balance control, and postural stability in children diagnosed with spastic hemiplegia compared to a typically developing control group. This is a registration entry for an observational study; no regulatory compliance obligations are created.

Prophylactic Radiotherapy to Prevent Bone Complications in Metastatic Solid Cancers NCT07540650

NIH registered a new prospective, randomized, single-center Phase 2 clinical trial (NCT07540650) to evaluate whether early prophylactic radiotherapy to high-risk asymptomatic or minimally symptomatic bone metastases reduces the 1-year rate of skeletal-related events in patients with metastatic solid cancers. Patients will be randomized 1:1 to receive either standard of care systemic therapy or observation, or prophylactic radiotherapy plus standard of care. The primary endpoint is the 1-year rate of skeletal-related events; secondary endpoints include adverse events, quality of life, economic burden, pain-free survival, and overall survival.

Montana Celebrates National Home Visiting Week, April 20-24, 2026

The Montana Department of Public Health and Human Services (DPHHS) announces the Second Annual National Home Visiting Week (April 20-24, 2026), celebrating home visiting professionals who support expectant parents and families of young children through evidence-based coaching programs. Healthy Montana Families served 948 families in 2025 through 18 programs across 16 counties. Governor Greg Gianforte issued a state proclamation designating this period as Home Visiting Week in Montana.

Champions for Montana's Children and Families Recognized at Annual Awards Ceremony

DPHHS and Montana Children's Trust Fund hosted their annual Prevent Child Abuse and Neglect Conference awards ceremony on April 16, 2026, in Missoula. Foster parents, child protection workers, youth, and nonprofit organizations from across Montana were honored for their service to children and families. Recipients include six recipients of the Jana Elliott Memorial Resource Parent of the Year award, youth achievement honorees, and recognition for multiple child welfare professionals and organizations.

George Bertalan, M.D. - Administrative Hearing April 27, 2026

The Ohio Medical Board has scheduled an administrative hearing for Dr. George Bertalan on Monday, April 27, 2026, starting at 10:00 AM. The hearing will be held in person at Rhodes State Office Tower, with a virtual viewing option available via Microsoft Teams registration. The Medical Board's Hearing Examiners conduct administrative hearings for applicants and licensees who request a hearing based on a citation issued by the Medical Board.

Mohammad Ahmad MD Administrative Hearing

The Ohio Medical Board has scheduled an administrative hearing for Mohammad Ahmad MD on April 29, 2026 at 9:30 AM. The hearing will be held in person at Rhodes State Office Tower. Virtual participation via Microsoft Teams is also available for those who register in advance. The board's Hearing Examiners conduct administrative hearings for licensees and applicants who request a hearing based on citations issued by the Medical Board.

Dietary Guidelines Group Intervention for Obesity Trial

NIH registered clinical trial NCT07538362 on ClinicalTrials.gov evaluating group-based food and nutrition education interventions grounded in Brazilian Dietary Guidelines for treatment of overweight and obesity. The randomized study will compare outcomes of collective education sessions with individual nutritional counseling in outpatient participants over four monthly sessions, measuring dietary quality, clinical parameters, and anthropometric measures.

IJV Collapsibility and Perfusion Index as Predictors of Post-Spinal Hypotension in Cesarean Sections

NIH registered a prospective observational study (NCT07539896) evaluating whether preoperative internal jugular vein collapsibility index (IJV-CI) and baseline perfusion index (PI) can predict post-spinal hypotension in patients undergoing elective cesarean section under spinal anesthesia. The study will assess 40-70% incidence rates of post-spinal hypotension, which can compromise maternal hemodynamic stability and uteroplacental perfusion. No additional intervention beyond standard clinical practice will be applied.

PCSK9 Inhibitors vs Statin for Large-Artery Atherosclerotic Ischemic Stroke

The NIH has registered a prospective multicenter observational cohort study (NCT07540741) evaluating PCSK9 inhibitor therapy in patients with large-artery atherosclerotic acute ischemic stroke. The study will compare evolocumab plus statin against statin alone, assessing early neurological improvement, lipid-lowering effect, 90-day functional outcome, recurrent cardio-cerebrovascular events, and safety outcomes. Enrollment and operational details are determined by the sponsoring institution.

Real-World Immunotherapy Study for Pan-Cancer Lymph Node Metastases, 5000+ Patients

NIH registered a new observational study (NCT07540377) on ClinicalTrials.gov evaluating immunotherapy efficacy for pan-cancer lymph node metastases. The single-center, retrospective study at Sun Yat-sen Memorial Hospital plans to enroll at least 5000 patients treated with immune checkpoint inhibitors. Researchers will assess objective response rates at both primary tumor and metastatic lymph node levels, and explore whether beta-blocker use during immunotherapy affects treatment outcomes.

Effect of Discharge Education on Recovery Quality and Self-Efficacy After Hysterectomy

A randomized controlled trial registered on ClinicalTrials.gov investigated whether enhanced discharge education based on Orem's Self-Care Theory improves postoperative recovery quality and self-efficacy in women undergoing hysterectomy, compared to standard discharge education. The study enrolled 64 women (n=32 per group) at a training and research hospital in Çorum, Türkiye, with data collection from December 2024 through May 2025 and a 4-week postoperative telephone follow-up.

MCE Molecular Imaging for ICI Myocarditis Phase 1 Trial

NIH registered a Phase 1 clinical trial (NCT07538544) evaluating whether myocardial contrast echocardiography using Sonazoid, an inflammation-targeted contrast agent, can diagnose immune checkpoint inhibitor (ICI) myocarditis. The single-arm study will assess this diagnostic approach in patients receiving ICI cancer therapy who develop suspected myocarditis. This study addresses a critical diagnostic gap, as rapid identification of ICI myocarditis is essential for reversing this potentially fatal adverse event.

Prediction of Rectus Femoris Graft Size in ACL Reconstruction

This is a clinical trial registry entry for observational study NCT07538245, registered with the NIH. The study aims to develop and validate a predictive model for estimating the diameter of a quadrupled rectus femoris tendon graft used in anterior cruciate ligament reconstruction. Researchers will analyze patient anthropometric characteristics and intraoperative tendon measurements to identify reliable predictors of graft size.

Observational Survival Analysis, Epithelial Ovarian Carcinoma Patients

The National Institutes of Health registered an observational survival analysis study (NCT07540403) evaluating outcomes in epithelial ovarian carcinoma patients with unfavorable prognosis. The study aims to improve patient categorization and management by analyzing survival in recurrent disease patients. Conditions studied include ovarian cancer.

Single Visit Clinical Validation of ScreenFire HPV Test, El Salvador, 1,000 Women

NIH ClinicalTrials.gov registered a cross-sectional study (NCT07538050) to validate ScreenFire, a low-cost HPV test, in El Salvador. The study will enroll 1,000 women in remote areas over 10-15 weeks to assess a same-day screen-and-treat approach versus the standard two-visit regime. The hypothesis targets at least 10% fewer women lost to follow-up at six months compared to the historical >20% loss under the two-visit method.

Effects of Clinical Pilates on Pain and Quality of Life in Women With Dyspareunia

A clinical study on dyspareunia has been registered on ClinicalTrials.gov under identifier NCT07540195. The study will investigate the effects of clinical Pilates exercises on pain, self-esteem, body image, depression, and quality of life in women with dyspareunia. The research evaluates pelvic floor-focused clinical Pilates interventions as an approach to treatment.

Evuzamitide PET-CT Imaging for Detection of Cardiac Amyloidosis in Patients With Inconclusive Nuclear Scans

NIH has posted an observational clinical trial (NCT07538518) evaluating whether PET-CT imaging using evuzamitide can detect transthyretin cardiac amyloidosis in patients whose standard nuclear imaging results are inconclusive but who have elevated TAD1 blood levels. Eligible participants will receive a single PET-CT scan with evuzamitide and will be monitored for approximately 28 days for safety and clinical data collection. The trial is registered on ClinicalTrials.gov as an informational study record with no direct compliance obligations for external parties.

CAIX PET/CT Guided Radiation Therapy for Recurrent Clear Cell Renal Cell Carcinoma

This is a prospective, single-arm clinical trial (NCT07540260) investigating CAIX-targeted PET/CT imaging combined with stereotactic ablative radiotherapy (SABR) for adults with recurrent or metastatic clear cell renal cell carcinoma (ccRCC). Participants will receive standard systemic therapy (targeted therapy plus anti-PD-1 immunotherapy) and undergo dual PET/CT imaging (FDG and CAIX-targeted) to map disease sites, with PET/CT-visible lesions treated when feasible. The study plans to enroll approximately 70 participants and will evaluate progression-free survival, local control of treated lesions, and treatment-related adverse events.