VIRal Pulmonary Infections in Older AGE
Summary
The National Institutes of Health registered an observational study (NCT07539103) examining viral respiratory infections in hospitalized older adults aged 60 and older. The study aims to determine the proportion of severe acute respiratory infections attributable to specific PCR-confirmed viral pathogens including influenza, RSV, hMPV, PIV, adenoviruses, rhinoviruses, and SARS-CoV-2. Research sites will enroll subjects prospectively to characterize the burden and prevalence of different viral etiologies.
What changed
NIH registered a new observational clinical study on ClinicalTrials.gov. The study will enroll hospitalized older subjects aged 60 years and older to determine the proportion of severe acute respiratory infections attributable to specific viral pathogens confirmed by polymerase chain reaction testing.
Affected parties include clinical investigators, hospital research staff, and public health researchers studying viral respiratory disease burden in older populations. Healthcare providers and research institutions conducting respiratory infection surveillance may find the study findings relevant to clinical practice and outbreak preparedness. The study has no compliance implications for regulated entities.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
VIRal Pulmonary Infections in Older AGE
Observational NCT07539103 Kind: OBSERVATIONAL Apr 20, 2026
Abstract
Severe acute respiratory infections (SARIs) represent one of the leading causes of hospitalization and mortality worldwide. These infections are associated with substantial in-hospital mortality and often constitute a turning point in the medium-term prognosis of older patients and those with comorbid conditions.
SARIs are most frequently of viral origin, involving well-known pathogens such as Orthomyxoviridae (influenza A and B viruses), Pneumoviridae [(respiratory syncytial virus (RSV), human metapneumovirus (hMPV)], Paramyxoviridae [parainfluenza viruses (PIV)], adenoviruses, or rhinoviruses, as well as emerging viruses such as pandemic influenza strains and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic.
Age-related immune decline (immunosenescence) increases the risk of severe forms and related respiratory or cardiovascular complications. However, the prevalence and burden of the different viral etiologies of Severe acute respiratory infections (SARIs) in older adults remain limited and insufficiently characterized.
The primary objective is to determine the proportion of viral respiratory infections attributable to polymerase chain reaction (PCR)-confirmed pathogen agents among hospitalized older subjects (≥60 years old).
Conditions: Viral Pulmonary Infections
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