IJV Collapsibility and Perfusion Index as Predictors of Post-Spinal Hypotension in Cesarean Sections
Summary
NIH registered a prospective observational study (NCT07539896) evaluating whether preoperative internal jugular vein collapsibility index (IJV-CI) and baseline perfusion index (PI) can predict post-spinal hypotension in patients undergoing elective cesarean section under spinal anesthesia. The study will assess 40-70% incidence rates of post-spinal hypotension, which can compromise maternal hemodynamic stability and uteroplacental perfusion. No additional intervention beyond standard clinical practice will be applied.
What changed
NIH registered a new prospective observational clinical study on ClinicalTrials.gov. The study will evaluate whether preoperative internal jugular vein collapsibility index (IJV-CI), assessed by ultrasonography, and baseline perfusion index (PI), obtained via pulse oximetry, can predict post-spinal hypotension (PSH) in patients undergoing elective cesarean section under spinal anesthesia. PSH occurs in 40-70% of such cases.
For clinical research institutions and healthcare providers, this study represents an observational investigation into predictive biomarkers for anesthesia-related complications. Anesthesiology departments and obstetric care teams may wish to monitor findings from this single-center study as they could inform preoperative risk assessment protocols for cesarean deliveries.
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Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
The Role of Preoperative Internal Jugular Vein Collapsibility and Perfusion Index in Predicting Hypotension After Spinal Anesthesia in Elective Cesarean Sections: A Prospective Observational Study
Observational NCT07539896 Kind: OBSERVATIONAL Apr 20, 2026
Abstract
Spinal anesthesia is widely preferred for elective cesarean delivery due to its favorable safety profile and superior postoperative analgesia. However, post-spinal hypotension (PSH) remains a common complication, with reported incidence rates ranging from 40% to 70%, potentially compromising maternal hemodynamic stability and uteroplacental perfusion. Early identification of patients at high risk for PSH is therefore of critical clinical importance.
This prospective observational study aims to evaluate the predictive performance of preoperative internal jugular vein collapsibility index (IJV-CI), assessed by ultrasonography, and baseline perfusion index (PI), obtained via pulse oximetry, for the development of PSH in patients undergoing elective cesarean section under spinal anesthesia. While IJV-CI reflects intravascular volume status and preload, PI represents peripheral vascular tone; thus, their combined use may improve predictive accuracy.
Study Design This is a single-center, prospective observational study conducted in patients scheduled for elective cesarean delivery under spinal anesthesia. No additional intervention will be applied, and all anesthetic management will follow standard clinical practice.
Objectives
Primary Objective:
To assess the ability of preoperative IJV collapsibility index (IJV-CI) and baseline perfusion index (PI) to predict post-spinal hypotension.
Secondary Objectives:
To evaluate the relationship between IJV-CI and PI with:
Duratio...
Conditions: Postspinal Hypotension, Cesarean Birth
Interventions: Baseline PI will be recorded,IJV diameters will be measured via ultrasound
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