Hip-allograft In Proximal Humerus Fractures Versus Plate Implantation Alone: a Randomized Controlled Trial
Summary
This registry entry documents NIH ClinicalTrials.gov study NCT07538700, a randomized controlled trial evaluating the effectiveness of mushroom-shaped femoral allograft augmentation combined with locking compression plate fixation versus locking compression plate fixation alone for displaced 3- and 4-part proximal humerus fractures in adults and the elderly. The study will assess clinical and functional outcomes at 24 months post-operatively. No regulatory obligations or compliance actions are imposed by this registration document.
What changed
This ClinicalTrials.gov registry entry records a newly registered randomized controlled trial, NCT07538700, examining whether adding a mushroom-shaped femoral allograft to locking plate fixation improves outcomes over locking plate fixation alone for displaced proximal humerus fractures. The trial targets adult and elderly patients with 3- or 4-part fractures and will follow participants for 24 months post-operatively. Healthcare providers, orthopedic surgeons, and clinical trial sponsors involved in fracture management research should note this study as a contributing evidence source for future treatment guideline development, though this registry entry itself imposes no compliance obligations.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Hip-allograft In Proximal Humerus Fractures Versus Plate Implantation Alone: a Randomized Controlled Trial
N/A NCT07538700 Kind: NA Apr 20, 2026
Abstract
Proximal humerus fractures (PHFs) are common osteoporotic fractures in adults and the elderly, leading to significant disability and reduced quality of life. Current treatment options for displaced PHFs include locking plate fixation (LCP) and various augmentation techniques, but there is no consensus on the optimal treatment. Although, femoral allografts have shown promising results, there is a need for more definitive evidence regarding the utilization of femoral graft augmentation in addition to locking plate fixation in 3- and 4-part PHFs. This study aims to evaluate the effectiveness of using a mushroom-shaped femoral allograft combined with LCP fixation compared to LCP fixation alone. We hypothesize that femoral allograft augmentation with LCP fixation will result in better clinical and functional outcomes than LCP fixation alone at 24 months post-operative
Conditions: Proximal Humeral Fractures
Interventions: Locking plate fixation with femoral allograft augmentation
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