Healthcare & Life Sciences

Multivalent Pneumococcal Conjugate Vaccine 21 Serotypes Sanofi

The USPTO issued Patent US12605435B2 to Sanofi Pasteur Inc. for a multivalent pneumococcal polysaccharide-protein conjugate composition covering 21 Streptococcus pneumoniae serotypes. The patent claims conjugates using tetanus toxoid and CRM197 carriers with application in prophylaxis against pneumococcal infection. The patent contains 15 claims and was granted on April 21, 2026.

Sublingual Semaglutide-BPC 157 Combination for Weight Loss

The USPTO granted patent US12605427B2 to Red Mountain Med Spa LLC on April 21, 2026, covering sublingual Semaglutide compositions combined with Body Protection Compound-157 (BPC-157) for weight loss applications. The invention comprises sublingual tablets providing approximately 500 mcg or 750 mcg of Semaglutide in combination with 300 mcg of gastric peptide, designed to mitigate gastrointestinal side effects associated with Semaglutide monotherapy. The patent is based on application number 18317232 filed on May 15, 2023, with 6 claims granted.

PHI Therapeutics Bacteriophage Eczema Patent Granted

The USPTO granted Patent US12605416B2 to PHI THERAPEUTICS, INC. on April 21, 2026, covering therapeutic compositions comprising bacteriophage and colloidal oatmeal for the treatment of skin diseases and conditions including eczema. The patent contains 17 claims classified under CPC A61K 35/76.

Inactivated SARS-CoV-2 Vaccine Patent Granted Colorado State

The USPTO granted Patent US12605442B2 on April 21, 2026 to Colorado State University Research Foundation. The patent covers methods for inactivating viral particles using UV light and riboflavin, including SARS-CoV-2 particles, and vaccine compositions comprising inactivated viral particles with adjuvants capable of promoting a Th1-type immune response. Inventors are Raymond P. Goodrich and Richard Bowen.

Phospholipid Compositions for Delivery of Therapeutic Compounds

The USPTO granted US Patent 12605411B2 to Aker BioMarine Human Ingredients AS on April 21, 2026. The patent covers phospholipid compositions designed to enhance bioavailability of bioactive compounds including ethyl esters, fish oil concentrates, cannabinoids, CoQ10, and curcumin. The patent contains 16 claims.

Plant TCM Composition for COVID-19 Treatment

The USPTO granted patent US12605420B2 to the National Research Institute of Chinese Medicine, Ministry of Health and Welfare, covering a traditional Chinese medicine composition for treating COVID-19 symptoms. The composition comprises ten herbal ingredients including Prepared Monkshood Daughter Root, Scutellaria Root, and Heartleaf Houttuynia Herb. The patent contains 8 claims and is classified under CPC A61K 36/714.

Audit and Feedback Study, 4 Nations, Primary Care

NIH ClinicalTrials.gov registered a multi-phase research study (NCT07542587) evaluating an optimized audit and feedback (AnF) strategy to improve primary healthcare provider clinical practice. The study will conduct a two-arm, multicentre RCT across Nepal, Mozambique, Tanzania, and China, focusing on hypertension and diabetes care quality.

SMART Trial Comparing Prescription and OTC Medications for Insomnia in Adults

The NIH has registered a new Phase 4 clinical trial (NCT07542756) comparing prescription insomnia medications (zolpidem, trazodone, doxepin) against over-the-counter alternatives (melatonin, diphenhydramine) in adults with insomnia disorder. The SMART Trial will assess relative effectiveness, safety, and durability across multiple dosage combinations and includes a placebo arm. Study interventions range from 3-100 mg across 11 treatment arms.

Propofol vs Propofol-Ketamine ONSD Observational Study

NIH registered an observational study (NCT07542015) comparing propofol-based anesthesia to propofol-ketamine anesthesia on optic nerve sheath diameter in patients undergoing elective endovascular treatment of unruptured intracranial aneurysms. The study aims to evaluate intraoperative hemodynamic parameters, cerebral oxygenation, and anesthetic requirements between the two techniques.

Observational Trial of Unapproved FDA Device NCT07543367

NIH registered a new observational clinical trial (NCT07543367) on ClinicalTrials.gov studying a medical device that is not approved or cleared by the U.S. FDA. The trial is categorized as observational and was posted on April 21, 2026. Clinical trial registrations on ClinicalTrials.gov are informational entries documenting investigator-initiated or sponsor-conducted research involving human subjects.

Phase 1 Study of HLX05-N vs ERBITUX in Metastatic Colorectal Cancer

NIH registered a Phase 1 multicentre, randomized, double-blind, parallel-controlled clinical trial (NCT07543471) comparing HLX05-N with US-sourced and EU-sourced ERBITUX in participants with metastatic colorectal cancer. Approximately 387 participants will be randomized in a 1:1:1 ratio and treated with study drug in combination with mFOLFOX6 chemotherapy. The study evaluates pharmacokinetic similarity, efficacy, safety, and immunogenicity across the three arms.

Lower Intersecting HIV-Related Stigmas to Facilitate Treatment as Prevention (LIFT), Kyrgyzstan

NIH registered ClinicalTrials.gov study NCT07541131, a randomized implementation study evaluating the LIFT multilevel intervention to reduce HIV transmission risk among people who inject drugs (PWID) in Kyrgyzstan. The study adapts and pilots peer-led group sessions focused on stigma reduction and HIV prevention efficacy, with participants randomized to intervention or control arms.

BPX-601 CAR T-Cell Phase 1 Study for Advanced Prostate Cancer

The National Institutes of Health has registered a Phase 1 clinical study (NCT07543055) evaluating BPX-601, an investigational CAR T-cell therapy manufactured from patients' own T-cells, in adults with advanced prostate cancer that has returned and is resistant to treatment. The study will assess side effects, optimal dosing, and preliminary efficacy of the therapy.

Miles for Mental Health Study, Group Exercise, Apr 21

The NIH ClinicalTrials.gov registry has posted a new clinical study, NCT07541443, titled 'Miles for Mental Health,' examining whether combining group cardiovascular exercise with group therapy improves mental health outcomes in adults with generalized anxiety disorder and depressive disorders. The study will use exercise as the sole intervention type, with an enrollment period beginning April 21, 2026. This is an informational registry entry and does not create any regulatory obligations.

Calm Health App Mindfulness Study for Adults With Chronic Kidney Disease

NIH ClinicalTrials.gov has registered NCT07541495, a study testing a digital mindfulness app called Calm Health among adults with chronic kidney disease. Participants will use the app for 6 weeks while wearing a wrist sensor that tracks sleep, physical activity, heart rate, and other health signals. The study will measure the app's acceptability and feasibility and whether it may improve stress, anxiety, and quality of life.

Medeliver Intracranial Drug Coated Balloon Catheter Clinical Trial for Symptomatic Intracranial Stenosis

Beijing Jiu Shi Shen Kang Medical Technology Co., Ltd. registered a clinical trial (NCT07542938) on ClinicalTrials.gov evaluating the Medeliver® Intracranial Drug-Coated Balloon Catheter for endovascular treatment of symptomatic intracranial atherosclerotic stenosis. The trial enrolls participants receiving either the Medeliver® drug-coated balloon or the Diveroad® intracranial balloon dilatation catheter as interventions.

Medical Instrument Patent, Acclarent, Inc., Apr 21

USPTO granted patent US12605216B2 to Acclarent, Inc. on April 21, 2026. The patent covers a medical instrument with a rotary end effector, position sensor, and electromagnetic interference (EMI) reduction design. The apparatus includes a body with a bore sized to receive a portion of a medical instrument having a rotary member, with the position sensor configured to offset interference generated by the rotating member. The patent contains 20 claims.

Brainlab SE Atlas Trajectory Planning Method

USPTO granted Patent US12605214B2 to Brainlab SE for a computer-implemented method of planning straight trajectories in medical images. The method divides an atlas into first and second areas during image registration, restricting transformation of the first area to maintain straight trajectory geometry while allowing unrestricted transformation of second areas. The patent contains 14 claims and covers CPC classifications in diagnostic imaging and medical image processing.

Siemens Healthineers AR Medical System, Apr 21

USPTO granted Patent US12605207B2 to Siemens Healthineers AG for an augmented reality medical system combining image acquisition devices, dual display units, and spatial tracking elements to generate planning-based AR visualizations during medical procedures. The patent, filed on July 15, 2021 under Application No. 17376310, contains 18 claims and covers CPC classifications related to computer-aided surgery and medical image processing.

Blue Belt Technologies Patent For Image Free Implant Revision Surgery

The USPTO has granted US Patent 12605215B2 to Blue Belt Technologies, Inc. for systems and methods of planning and performing image free implant revision surgery. The patent covers methods including collecting pre-defined parameters characterizing a target bone, generating a 3D model, collecting intraoperative surface points, and generating a reshaped 3D model. The patent contains 19 claims.

Siemens Healthineers GAN Generates Medical Robot Configurations

The USPTO granted patent US12605218B2 to Siemens Healthineers AG on April 21, 2026. The patent covers a generative adversarial network (GAN) or other generative modeling technique trained to translate performance, operation, safety, or task-specific specifications into configurations of robot modules forming a robotic system. A second machine-learning system converts the estimated configurations back to performance, enabling anatomy-based modeling relative to medical imaging.

MANAGE-HCM: Mavacamten Effectiveness in Obstructive Hypertrophic Cardiomyopathy, Japan

NIH ClinicalTrials.gov registered observational study NCT07541833 titled MANAGE-HCM on April 21, 2026. The study will assess real-world effectiveness and safety of mavacamten in adults diagnosed with symptomatic obstructive hypertrophic cardiomyopathy receiving cibenzoline in Japan. The study is categorized as observational with mavacamten as the sole intervention.

Mindfulness Training RCT for Hotel Staff

NIH's ClinicalTrials.gov has registered NCT07541027, a mixed-methods randomized controlled trial evaluating a 6-week mindfulness-based professional development program for 60 hotel staff at a hotel in Shatin, Hong Kong. The study will examine psychological well-being, work-related stress, and work performance outcomes using mixed-effects modeling, mediation analysis, and thematic analysis. Data collection includes both quantitative and qualitative measures of job-related outcomes and participant lived experiences.

Phase 3 Giredestrant Trial, ER+/HER2- Early Breast Cancer, Apr 21

The National Library of Medicine has registered a Phase 3 clinical trial (NCT07541079) evaluating the adherence, tolerability, and patient-reported outcomes of giredestrant in participants with ER+/HER2- early breast cancer who are intolerant to prior aromatase inhibitor therapy. The trial, designated novERA Breast Cancer, will enroll participants with Stage I-III disease across risk categories as adjuvant endocrine therapy.

Observational Study on Microplastic Exposure and Gastric Carcinogenesis Risk

NIH registered an observational clinical trial (NCT07542652) on ClinicalTrials.gov to investigate whether microplastic exposure levels correlate with increased risk of gastric mucosal carcinogenesis. The study will use structured questionnaires to assess external microplastic exposure and evaluate microplastics as an independent risk factor for gastric carcinoma and related precancerous lesions. No compliance obligations or deadlines are imposed.

Serratiopeptidase vs Standard Care After Mandibular Third Molar Surgery

A randomized controlled trial registered on ClinicalTrials.gov (NCT07543146) is examining whether serratiopeptidase, an enzyme with anti-inflammatory properties, reduces postoperative complications compared to standard postoperative care alone in patients undergoing surgical removal of mesioangular mandibular third molars.

Effects of Conditioning Activities in Female Athletes

NIH ClinicalTrials.gov registered a study (NCT07542119) investigating warm-up strategies and their effects on physical performance in female athletes. The study will enroll 18 female athletes practicing invasion sports and evaluate three warm-up conditions using tests of vertical jump performance and change-of-direction speed.

Hip and Ankle Mobility Rehabilitation for Soccer Players With Patellofemoral Pain

NIH registered a new randomized controlled trial (NCT07542236) evaluating whether a 6-week hip- and ankle-mobility-based rehabilitation program, performed 3 times per week in addition to regular soccer training, improves pain, knee-related function, neuromuscular coordination, and physical performance in male soccer players with patellofemoral pain. The study compares an intervention group receiving the mobility program against a control group continuing regular training alone. This is a study registration announcement with no direct compliance implications.

Cervical Lordosis Study Compares Standing Radiographs vs MRI

NIH registered Clinical Trial NCT07541586, a retrospective cross-sectional study comparing cervical lordosis measurements from standing lateral radiographs and supine magnetic resonance imaging (MRI) in individuals without structural cervical pathology. The study will also evaluate the independent contribution of T1 slope to cervical alignment and whether imaging modality significantly alters measured lordosis values. No interventions are involved; the study is purely observational.

AI Mindfulness for Emotional Distress Trial

NIH's ClinicalTrials.gov has registered NCT07542561, a randomized clinical trial evaluating whether an artificial intelligence-assisted internet-based mindfulness intervention (iMIED) can reduce anxiety and depressive symptoms in adults with subclinical emotional distress. Participants will be assigned to iMIED plus usual mental health resources or to usual resources alone, with follow-up assessments at 3, 6, 12, 18, and 24 months after the intervention. The trial uses a WeChat mini-program and AI support tool delivered over a 49-day period.

IBS Low-FODMAP Diet Mobile App Randomized Trial: AI-App vs Dietary Booklet

NIH ClinicalTrials.gov registers a randomized controlled trial (NCT07543354) evaluating an AI-assisted mobile application against a standard low-FODMAP diet (LFD) booklet for treating Irritable Bowel Syndrome (IBS). The three-phase study spans approximately 20 weeks and will track gastrointestinal symptoms, psychological traits, and quality of life outcomes across both intervention arms.

Boston Scientific Active Alignment System for Laser Intravascular Lithotripsy

USPTO issued Patent US12605205B2 to Boston Scientific Scimed, Inc. on April 21, 2026, covering a catheter system with an active alignment mechanism for optimizing optical coupling of a multiplexer in a laser-driven intravascular lithotripsy device. The patent includes 20 claims and names Christopher A. Cook, Gerald D. Bacher, and John F. Black as inventors.

AtriCure Ablation Device Patent US12605202B2

The USPTO granted patent US12605202B2 to AtriCure, Inc. on April 21, 2026, covering devices and accessories for percutaneous endoscopic access and ablation systems. The patent application was filed on July 16, 2024 under application number 18773970, with 9 claims granted. The technology relates to methods and devices for accessing and therapeutically treating tissue areas using minimally invasive or open surgical procedures.

Olympus Patent Grant US12605200B2, Electrosurgical Device

The USPTO granted Patent US12605200B2 to OLYMPUS WINTER & IBE GMBH for an electrosurgical handheld device with a funnel-shaped feedthrough design. The patent, classified under CPC A61B 18/149, claims 21 patent claims covering the device's handle, main body, and adapter components. The filing date was April 1, 2022, with application number 17711373.

Microwave Ablation Electrode with Cooling Structures

The USPTO granted patent US12605203B2 to Mianyang Lide Electronics Co., Ltd. for a microwave ablation electrode featuring dual cooling structures. The non-working end circulation cooling structure allows a refrigerant medium to reach and cool the non-working end and surrounding tissues, with provisions for return flow. The working end liquid injection structure allows refrigerant to reach the working end to cool it and surrounding tissues. The patent includes 6 claims and was filed on May 18, 2023.

Relievant Medsystems Patent Covers Vertebral Denervation Device

The USPTO granted Patent US12605199B2 to Relievant Medsystems, Inc. on April 21, 2026. The patent covers systems and methods for treating back pain associated with a vertebral body using an external energy source configured to deliver therapeutic energy that modulates nerves within or near the vertebral body. The patent includes 20 claims and CPC classifications spanning surgical devices (A61B 18/14), linear drive systems, and therapeutic energy delivery configurations.

Endovascular Implant Decision Support in Medical Imaging

The USPTO granted patent US12605206B2 to Siemens Healthineers AG covering a vascular implant decision support system using medical imaging. The system employs physics-based modeling of endovascular implants to simulate deployment in patient-specific vessel models, and uses machine-learned networks to select implants and predict deployment outcomes. The patent names Viorel Mihalef and Saikiran Rapaka as inventors and contains 19 claims across multiple CPC classifications.

Intuitive Surgical Electrosurgical Generator Control Patent Granted

The USPTO granted Patent US12605197B2 to Intuitive Surgical Operations, Inc. on April 21, 2026. The patent covers an electrosurgical system with RF power delivery between electrodes, measurement circuitry for current and voltage, and processing circuitry using a proportional-integral-derivative control loop. The 17 claims address dynamic control of RF power based on measured current, voltage, calculated power, and calculated impedance.

Arrhythmogenic Foci Locator Patent US12605201B2 Granted

The USPTO granted patent US12605201B2 to inventor Riccardo Cappato on April 21, 2026. The patent covers a locator assembly with electrodes for determining the location of arrhythmogenic foci in or near a heart by receiving electrical signals from cardiac tissue. The patent contains 20 claims and is classified under CPC categories A61B 18/1492, A61B 5/0004, and related cardiac mapping and monitoring classifications.

Heraeus Medical Bone Cement Mixing Device with Depressurization US12605196B2

The USPTO granted Patent US12605196B2 to Heraeus Medical GmbH on April 21, 2026, covering a method and device for mixing bone cement with depressurization. The invention uses a cartridge with a drive piston and a central piston permeable to gases and monomer liquid but impermeable to cement powder. The method expels residual gases through drive piston movement, displaces gases between powder particles with inflowing monomer liquid, and depressurizes the cartridge cavity by partially removing monomer liquid. The patent contains 14 claims directed to both the method and the device.

Hangzhou Broncus Medical US12605198B2 Multi-Path Perfusion Control Injection Pump Patent

USPTO granted patent US12605198B2 to Hangzhou Broncus Medical Co., Ltd. for a multi-path perfusion control method and apparatus for injection pump used in ablation procedures. The patent covers technology for real-time temperature-based control of perfusion channels during ablation tasks, with 7 claims allowed. The invention aims to reduce operation delay and errors caused by manual determination while improving timeliness, accuracy, and pertinence of liquid perfusion.

In situ Assembly of Prosthetic Pacing Valves

The USPTO granted Patent US12605553B1 to Smartvalves Ltd on April 21, 2026 for an electrical-component add-on used with prosthetic cardiac valves. The invention comprises a support structure configured to assume delivery and deployed configurations, shaped as a ring when deployed to receive the prosthetic valve's tubular frame. The add-on includes an antenna and electrodes supported by the support structure. The patent contains 24 claims and covers positioning at, above, or below the annulus of a native cardiac valve.

Clinical Impact of Crystalloid Solutions on Kidney Injury Biomarkers After Lumbar Fusion Surgery in Elderly Patients

NIH has registered a new clinical trial NCT07542353 comparing sodium acetate Ringer's solution versus sodium lactate Ringer's solution for effects on early postoperative renal function, kidney injury biomarkers, and acute kidney injury in elderly patients undergoing lumbar fusion surgery. The two-arm study will assign patients to receive either intervention and evaluate renal outcomes. Healthcare institutions performing spinal fusion surgery on elderly patients may wish to track trial outcomes as evidence on optimal intraoperative fluid selection continues to develop.

EDP-978 Phase 1 Study in Healthy Adults, Chronic Urticaria

A Phase 1 clinical trial for EDP-978, an oral drug candidate for Chronic Inducible Urticaria and Chronic Spontaneous Urticaria, has been registered on ClinicalTrials.gov. The randomized, double-blind, placebo-controlled study will assess safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple ascending doses in healthy adult subjects.

RAMP Mind-Body Telehealth Intervention for Rural Veterans Chronic Pain

The National Institutes of Health registered a new clinical trial (NCT07541599) for the RAMP mind-body program, a Whole Health telehealth intervention targeting rural Veterans with chronic pain. The program explores the connection between mind and body to provide pain management tools. The trial is categorized as an observational study using the RAMP Program intervention.

Palm Olein and Palm Kernel Oil Diet Effects on Gut Hormones and Appetite

NIH ClinicalTrials.gov registered this randomized crossover study (NCT07541300) comparing postprandial effects of palm olein and palm kernel oil diets against a PUFA-rich sunflower oil diet on gut hormones and appetite in healthy adults. Participants will attend three study visits two weeks apart, providing blood samples and completing appetite questionnaires over four-hour assessment periods.

Screen Time Before Sleep and Posture Disorders NCT07541963

NIH registered NCT07541963, an observational study examining whether pre-sleep screen exposure contributes to poor posture, musculoskeletal problems, and balance deficits. The study assesses forward head posture, rounded shoulders, and neuromuscular performance related to screen use before sleep.

55 Women, Czech Republic, 21-Day Spa Treatment for Infertility

NIH ClinicalTrials.gov registered a new prospective clinical study (NCT07542600) titled 'Effect of Comprehensive Spa Rehabilitation on Female Infertility: A Clinical Study in Adult Women (Infertility-Spa).' The study will evaluate the effects of a 21-day comprehensive spa treatment on hormonal profile in 55 women aged 20-40 diagnosed with infertility at a spa facility in Františkovy Lázně, Czech Republic. This is a procedural registration entry with no compliance obligations for external parties.

Ladera Suture-Mediated Large Bore Closure Pivotal Study

The NIH ClinicalTrials.gov registry has registered a new pivotal clinical study for the Ladera Suture-Mediated Large Bore Closure (LBC) System. The study aims to demonstrate the safety and efficacy of the investigational vascular closure device for achieving hemostasis of common femoral artery access sites in patients undergoing percutaneous interventional catheterization procedures using 10 to 24 French introducer sheaths.

VR Training vs Traditional Lectures for Geriatric Care

NIH registered clinical trial NCT07542834 comparing cinematic virtual reality (VR) training against traditional didactic lectures for medical student education in geriatric care. The study will assess whether immersive VR scenarios improve clinical skills and preparedness for residency compared to conventional teaching methods. Researchers will evaluate student performance on clinical skills assessments and explore experiences with the VR training tool.