Clinical Impact of Crystalloid Solutions on Kidney Injury Biomarkers After Lumbar Fusion Surgery in Elderly Patients
Summary
NIH has registered a new clinical trial NCT07542353 comparing sodium acetate Ringer's solution versus sodium lactate Ringer's solution for effects on early postoperative renal function, kidney injury biomarkers, and acute kidney injury in elderly patients undergoing lumbar fusion surgery. The two-arm study will assign patients to receive either intervention and evaluate renal outcomes. Healthcare institutions performing spinal fusion surgery on elderly patients may wish to track trial outcomes as evidence on optimal intraoperative fluid selection continues to develop.
What changed
This document registers a new clinical trial on ClinicalTrials.gov. The study will enroll elderly patients undergoing lumbar fusion surgery and compare two crystalloid solutions for their effects on renal function and acute kidney injury incidence. No compliance obligations or regulatory deadlines are created by this registration.
Healthcare providers and researchers focused on perioperative care and nephroprotection in geriatric surgical populations may benefit from monitoring this trial. The comparison between acetate-based and lactate-based Ringer's solutions addresses a specific clinical question about optimal intraoperative fluid choice for renal protection in elderly spine surgery patients.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Clinical Impact of Different Crystalloid Solution on Early Biomarkers of Kidney Injury After Lumbar Fusion Surgery in Elderly Patients
N/A NCT07542353 Kind: NA Apr 21, 2026
Abstract
This study aims to compare the effects of sodium acetate Ringer's solution versus sodium lactate Ringer's solution on early postoperative renal function indicators, renal injury biomarkers, and acute kidney injury (AKI) in elderly patients undergoing lumbar fusion surgery.
Conditions: Lumbar Fusion Surgery, Elderly Patients, Sodium Acetate Ringer's Solution, Sodium Lactate Ringer's Solution, Acute Kidney Injury, Biomarkers
Interventions: Sodium Acetate Ringer's Solution (Group A), Sodium Lactate Ringer's Solution (Group B)
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