Propofol vs Propofol-Ketamine ONSD Observational Study
ClinicalTrials.gov Studies
Summary
NIH registered an observational study (NCT07542015) comparing propofol-based anesthesia to propofol-ketamine anesthesia on optic nerve sheath diameter in patients undergoing elective endovascular treatment of unruptured intracranial aneurysms. The study aims to evaluate intraoperative hemodynamic parameters, cerebral oxygenation, and anesthetic requirements between the two techniques.
“ONSD, measured using ultrasonography, is a non-invasive surrogate marker of intracranial pressure.”
What changed
This is a clinical trial registration entry for an observational study comparing two anesthesia techniques. The study will measure optic nerve sheath diameter as a surrogate marker of intracranial pressure using ultrasonography, alongside hemodynamic parameters and cerebral oxygenation. No regulatory obligations are imposed; this is an informational record for healthcare providers and clinical investigators about an ongoing registered study.
Affected parties: Clinical investigators conducting anesthesia research in neurointerventional settings should note the study parameters and compare against their own protocols. The focus on ONSD as a non-invasive ICP monitoring tool may be relevant to institutions performing similar endovascular procedures.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Comparison of Propofol and Propofol-Ketamine Anesthesia on Optic Nerve Sheath Diameter in Endovascular Cerebral Aneurysm Procedures
Observational NCT07542015 Kind: OBSERVATIONAL Apr 21, 2026
Abstract
This study aimed to compare the effects of propofol-based anesthesia and propofol-ketamine anesthesia on optic nerve sheath diameter (ONSD) in patients undergoing elective endovascular treatment of unruptured intracranial aneurysms. ONSD, measured using ultrasonography, is a non-invasive surrogate marker of intracranial pressure. In addition, intraoperative hemodynamic parameters, cerebral oxygenation, and anesthetic requirements were evaluated to assess the safety and physiological impact of the two anesthesia techniques.
Conditions: Unruptured Intracranial Aneurysm, Cerebral Aneurysm Unruptured, Cerebral Aneurysms
Interventions: Propofol (Astra-Zeneca), Propofol and Ketamine Mixture (Ketofol)
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