USPTO Patent Application for Modulating SMN2 RNA and Protein

The USPTO has published a patent application (US20260085313A1) detailing compounds, methods, and pharmaceutical compositions for modulating SMN2 RNA and protein. This application, filed on May 2, 2025, aims to ameliorate symptoms of neurodegenerative disorders.

Composition for Regulating Interfering Ribonucleic Acid Production

The USPTO has published a new patent application (US20260085312A1) detailing compositions and methods for regulating interfering ribonucleic acid (miRNA) production. The application describes techniques to decrease the bioavailability of target biomolecules by degrading or inactivating their corresponding messenger RNA (mRNA).

Patent Application: Compositions and Methods for Reducing RNA Levels

The USPTO has published a new patent application (US20260085311A1) detailing compositions and methods for reducing RNA levels and treating diseases caused by toxic gain-of-function proteins. The application was filed on June 20, 2023.

Patent Application for Antisense Oligonucleotide Targeting TDP-43 mRNA

The USPTO has published a patent application (US20260085310A1) filed by NIPPON SHINYAKU CO., LTD. The application describes an antisense oligonucleotide targeting TDP-43 mRNA or pre-mRNA for potential therapeutic use. The filing date was May 26, 2023.

Patent Application for cDNA Synthesis and Transcriptome Profiling

The USPTO has published a patent application (US20260085309A1) for compositions and methods related to cDNA synthesis and transcriptome profiling. The application details optimized template switching oligonucleotides designed to improve reverse transcription specificity and prevent concatemer formation. This is a new patent application filing, not a final rule or guidance.

Graves County Water District Joint Motion to Continue Stay

The Kentucky Public Service Commission has received a joint motion from Graves County Water District and Milburn Water District to continue an existing stay of proceedings until June 30, 2027. This motion follows previous orders granting stays to allow for the development of a comprehensive water supply plan for Carlisle County.

PSC Investigates Water District Board Vacancy

The Kentucky Public Service Commission has opened an investigation into the North McLean County Water District's board of commissioners. The investigation will determine if a vacancy exists due to a commissioner allegedly failing to complete mandatory training within the required timeframe, as stipulated by state law.

Martin Gas Inc. GCR Rate Report Approval

The Kentucky Public Service Commission has approved Martin Gas Inc.'s proposed Gas Cost Recovery (GCR) rate report, effective April 1, 2026. The approved GCR rate is $6.5621 per Mcf, an increase of $0.1622 per Mcf from the previous rate. Martin Gas is also required to submit invoices and usage reports with future GCR filings.

Informal Conference on Gas Cost Recovery Rate Filing

The Kentucky Public Service Commission Staff has scheduled an informal conference to discuss issues related to the calculation methodology of the Gas Cost Recovery rate filing for Western Lewis-Rectorville Water and Gas District. The conference will address natural gas purchase and sale volumes and calculation methods.

Millennium Energy Gas Cost Recovery Rate Report Approval

The Kentucky Public Service Commission approved Millennium Energy's Gas Cost Recovery (GCR) rate report, setting a new GCR rate of $2.6431 per Mcf, effective April 1, 2026. This represents a decrease of $0.7842 per Mcf from the previous rate. Millennium is also required to submit invoices and usage reports with future GCR filings.