Patent Application for cDNA Synthesis and Transcriptome Profiling

ChangeBridge: Patent Apps - Biotech (C12N)

Published September 14th, 2023

Detected March 27th, 2026

Summary

The USPTO has published a patent application (US20260085309A1) for compositions and methods related to cDNA synthesis and transcriptome profiling. The application details optimized template switching oligonucleotides designed to improve reverse transcription specificity and prevent concatemer formation. This is a new patent application filing, not a final rule or guidance.

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What changed

The United States Patent and Trademark Office (USPTO) has published a new patent application, US20260085309A1, filed on September 14, 2023. The application, titled 'Compositions for cDNA Synthesis and Transcriptome Profiling and Methods of Use Thereof,' describes optimized template switching oligonucleotides with modifications to enhance the specificity of reverse transcription and prevent concatemer formation. The inventors listed are Anna Marie Pyle and Li-Tao Guo.

This publication represents a new patent application filing and does not impose any immediate regulatory obligations or compliance deadlines on regulated entities. Companies involved in biotechnology, pharmaceutical research, or molecular diagnostics may find the disclosed technology relevant to their research and development efforts. Compliance officers should note this as a potential future intellectual property development in the biotech sector.

Source document (simplified)

← USPTO Patent Applications

Compositions for cDNA Synthesis and Transcriptome Profiling and Methods of Use Thereof

Application US20260085309A1 Kind: A1 Mar 26, 2026

Inventors

Anna Marie Pyle, Li-Tao Guo

Abstract

The present invention provides optimized template switching oligonucleotides, methods, and kits for performing reverse transcription. The optimized template switching oligonucleotides include modifications of 5′ and 3′ ends to prevent the formation of concatemers and to enhance the specificity of reverse transcription.