Ind AS Implementation Clarifications, Insurance Sector

The Insurance Regulatory and Development Authority of India has issued clarifications on the implementation of Indian Accounting Standards (Ind AS) applicable to insurance companies operating in India. The circular provides guidance on specific accounting treatments and transition requirements. Insurers should review the clarifications to ensure compliance with Ind AS requirements in their financial reporting.

IRDAI Circular Clarifies Surveyors and Loss Assessors Annual Fee Payment

IRDAI India published a circular providing clarification on the payment of annual fees by surveyors and loss assessors operating in the insurance sector. The circular (document ID 9196320) is available as a downloadable PDF (607 KB) on the IRDAI document portal. The document appears to address compliance requirements for insurance surveyors and loss assessors regarding their annual fee obligations to the regulator.

IRDAI Policyholder Servicing Special Measures FY 2025-26

IRDAI has issued special measures for policyholder servicing applicable for the current Financial Year 2025-26. The circular titled 'Servicing to the Policyholders – Special Measure for the Current Financial Year 2025-26' outlines requirements that insurers must follow when providing services to policyholders. The document is available for download from the IRDAI official portal with a file size of 182 KB.

Data Protection Basics AI Guide Available in French Only

The CNPD Luxembourg published a Data Protection Basics guide focused on AI on May 5, 2026. The English-language version of this page confirms the guide is currently only available in French. The full substantive content of the AI guide is accessible via the linked French-language page on the CNPD website.

DAAZ Workshop Feedback and Graduation Ceremony, Luxembourg, 29th April

The Luxembourg National Data Protection Commission (CNPD) announces a DAAZ feedback workshop and graduation ceremony on 29 April 2026 from 5:30 p.m. to 7 p.m. at the House of Entrepreneurship, 14 rue Erasme, L-1468 Luxembourg. The event targets business leaders, young female entrepreneurs, and DAAZ tool 'Finishers', and will be held in French. Registration is open via the House of Entrepreneurship website.

MFDS Shares Zero Foodborne Illness Expertise with APEC 2026 Shenzhen Delegation

A delegation from China's Shenzhen Market Supervision and Administration Bureau (SAMR Shenzhen) visited Korea from April 13 to 15. The visit was arranged to benchmark Korea's food safety management system and policy models ahead of the APEC 2026 Leaders' Meeting, which Shenzhen will host. MFDS shared its zero foodborne illness expertise as part of the international knowledge-sharing engagement. The press release contains no compliance obligations, penalties, or new regulatory requirements for any parties.

MFDS Builds K-Brand Trust in Latin America Through Food Safety Cooperation Program

The Ministry of Food and Drug Safety (MFDS) and the Korea Agency of HACCP Accreditation and Services (KAHAS) announced the 'Strengthening the Capacity for Safety Management of Food Imports and Exports in Latin America and the Caribbean (2023–2027)' program. The initiative aims to build trust for Korean 'K-Brand' products in Latin American markets through enhanced food safety cooperation between Korea and the Latin America and Caribbean region. The program, registered on April 21, 2026, is managed by the Division of Import Inspection Management (수입검사관리과) under the Food Safety Minister OH Yu-kyoung.

WHO Gives Korea Perfect Score, World-Class Food Safety

The Republic of Korea received the highest possible score of 5 in the "Food Safety" area of the Joint External Evaluation (JEE) conducted by the World Health Organization (WHO), recognising Korea's food safety management system as world-class. The evaluation, conducted by WHO, awarded Korea a perfect score of 5 in food safety capacity. The announcement was made by MFDS Minister Oh Yu-Kyoung on 21 April 2026.

Minerva Catalog Searches California State Archive Collections

Minerva is an online catalog operated by the California State Archives, a division of the Office of the Secretary of State, providing summary descriptions of over 300 million items in its collections. Holdings include documents from the state's 1849 constitutional convention, Spanish and Mexican-era land grant records, campaign contribution statements, State Supreme Court and Courts of Appeal case files, legislative committee files, original laws, papers of elected officials, and photographic, cartographic, and audio/visual materials. The catalog is searchable by keyword and advanced search, and records may be requested by contacting the Archives Reference Desk at (916) 653-2246 or Reference@sos.ca.gov.

California State Archives Digital Exhibits and Collections

The California Secretary of State Archives provides public access to digitized historical collections and exhibits through its online portal. The page organizes materials into categories including online collections (photographs, trademarks, Japanese American incarceration records) and thematic exhibits covering African American history, women's suffrage, voting rights, LGBTQ history, and California's Constitution. These digital resources are intended to preserve and share California's historical records with the public.

Overseas-Registered Products Available for Cyclophosphamide and Ifosfamide Injection Shortages

Baxter Healthcare has notified TGA Australia that global supply constraints due to manufacturing issues are affecting Endoxan (cyclophosphamide) 2g and Holoxan (ifosfamide) 2g powder for injection vials. These medicines are used to treat various types of cancer, diseases of the immune system, and to prevent rejection of organ transplants. The shortages are expected to continue until the end of June 2026. TGA has approved the supply of multiple overseas-registered cyclophosphamide and ifosfamide injection products under section 19A of the Therapeutic Goods Act 1989 to reduce the impact of these shortages.

Türk Nippon Sigorta A.Ş. Veri İhlali Bildirimi – 193 Kişi Etkilendi

KVKK published Türk Nippon Sigorta A.Ş.'s data breach notification revealing that insufficient object-level authorization controls and query parameter manipulation on the company's claims inquiry screen allowed unauthorized access to third-party claims file contents. The breach began on April 6, 2026 and was discovered on April 9, 2026, affecting 193 individuals' personal data comprising names and vehicle license plates. KVKK's Personal Data Protection Board decided on April 22, 2026 to publish the notification on its website, with investigations continuing.

KVKK Publishes Data Breach Notice for English Time Eğitim Kurumları AŞ

KVKK published a public data breach notice regarding English Time Eğitim Kurumları AŞ following Board Decision No. 2026/798 dated April 15, 2026. The breach began April 4, 2026 and was discovered April 12, 2026, after attackers gained unauthorized access to the company's CRM panel and used automated tools to extract data in bulk. Approximately 300,000 individuals were affected, including students (whose identity, contact, location, and transaction data were exposed) and other personnel (whose identity, contact, location, and employment records were compromised).

Collection Device with Valve for Liquid Specimen Patent Granted

The USPTO granted Patent US12605149B2 to Zhongshan Ophthalmic Center of Sun Yat-Sen University on April 21, 2026, covering a collection device with a valve for liquid specimens. The device comprises a reservoir with a sealed cavity under negative pressure, a delivery tube with a valve between inlet and outlet, and a piercing component for tissue access. The patent contains 19 claims and was filed on May 30, 2018 under Application No. 16980417.

US12605518B2 Gas Passage for PAP Device with Noise Reduction

USPTO granted Patent US12605518B2 to WALLENBERG UNION LLC on April 21, 2026, covering a gas passage for use in a PAP (positive airway pressure) device with integrated noise reduction components. The patent claims 25 items and was filed on July 19, 2024, under Application No. 18778376. The invention includes a passage casing with air intake and outlet, a chamber for gas flow and accumulation, a blower, and noise reduction elements including a ventilation component, intake pipe, and flexible component.

Positive Pressure Breathing Device Patent Granted April 21 2026

USPTO granted Patent US12605521B2 to inventor Hsin-Yung Lin on April 21, 2026 for a breathing equipment device that provides positive pressure gas. The device combines a hydrogen generating device (using water electrolysis), a pressurizing device, a mixing device, an atomizing device, and an output device, all coupled to a gas channel. The patent contains 18 claims and covers methods for generating and delivering hydrogen gas mixed with positive pressure gas for therapeutic applications.

CPAP Humidifying Tank Patent, Murata Manufacturing, Granted

USPTO granted patent US12605522B2 to Murata Manufacturing Co., Ltd. on April 21, 2026, covering a CPAP apparatus humidifying tank design with improved flow-dividing and shielding sections. The patent application (18302850) was filed April 19, 2023, and contains 8 claims under CPC classifications A61M 16/00 through A61M 2205/123.

Boston Scientific Scimed Treatment Agent Delivery System Patent Granted

USPTO granted Patent US12605151B2 to Boston Scientific Scimed, Inc. on April 21, 2026, covering a treatment agent delivery system with 20 claims. The patent protects a medical device including a handle with an actuator, a shaft, an actuation member, a cartridge containing a treatment agent, and a plunger, where movement of the actuator controls delivery of the treatment agent from the cartridge. Inventors are Paul Smith, Travis Henchie, and Peter L. Dayton. The patent application was filed on April 12, 2023, under Application No. 18299161.

Becton Dickinson IV Catheter with Side Port for Blood Draw

The USPTO granted Patent US12605096B2 to Becton, Dickinson and Company on April 21, 2026, covering an integrated intravenous catheter device with a side port enabling simultaneous blood draw and fluid injection. The patent (application 17143979, filed January 7, 2021) contains 17 claims and CPC classifications spanning A61B 5/15, A61M 20/39, and A61M 25/00. Named inventor is Jithendra Kumar Sathyanarayana Naidu. The invention facilitates blood sample collection at the time of catheter insertion by providing separate fluid pathways for drawing blood and injecting fluids via an extension set.

Microneedle Electrical Interface Patent Granted to Biolinq

The USPTO granted Patent US12605100B2 to Biolinq Incorporated on April 21, 2026, covering methods for achieving an isolated electrical interface between an anterior surface of a microneedle structure and a posterior surface of a support structure. The patent describes a microneedle-based electrochemical biosensor structure comprising a substrate, microneedle biosensor, primary and secondary electrically conductive elements, and an electrically insulative annular barrier. The patent application (No. 19258472) was filed July 2, 2025, and contains 26 claims.

Belhaven BioPharma Intranasal Epinephrine Delivery Device Patent

Belhaven BioPharma Inc. received US Patent 12605517B1 on April 21, 2026, titled 'Compositions, devices, and methods for intranasal delivery of dry powder epinephrine.' The patent contains 15 claims and names Scott Lyman and Brian Taubenheim as inventors. The patented compositions include epinephrine with a stabilizing agent (citric acid or salt) and carrier for intranasal dry powder delivery. The patent is assigned under CPC classifications A61M 15/08, A61M 11/003, A61K 9/0043, and A61K 31/137. Belhaven BioPharma now holds enforceable intellectual property rights to this intranasal epinephrine formulation in the United States. Competitors developing similar intranasal epinephrine delivery systems for anaphylaxis or respiratory conditions should conduct Freedom to Operate analyses to assess potential infringement exposure.

NeuroLight Neuroenhancement Patent US12605104B2, Granted Apr 21

The USPTO granted Patent US12605104B2 to NeuroLight, Inc. on April 21, 2026, covering a method of facilitating skill learning or improving task performance through brainwave pattern analysis and targeted stimulation. The patent includes 23 claims under CPC classification A61M 21/00 and names Alexander I. Poltorak as the sole inventor. The application was filed on August 14, 2023, under application number 18233835.

Drägerwerk Patent for Breathing Activity Determination Granted

The USPTO granted US Patent 12605519B2 to Drägerwerk AG & Co. KGaA on April 21, 2026, covering a process and signal processing unit for determining pneumatic indicators for a patient's breathing activity. The patent, with 19 claims, describes technology that generates respiratory signals from measured values and determines two pneumatic indicators describing the activity of different regions of the respiratory system.

Visual Pressure Regulating Catheter Patent - Qingdao Biotech Medical

USPTO granted Patent US12605161B2 to QINGDAO BIOTECH MEDICAL CO., LTD on April 21, 2026, covering a visual pressure regulating catheter with integrated hydraulic dilation balloon, pressure regulating handle, endoscope pressure regulating cavity, and dilation liquid perfusion cavity. The invention enables direct endoscopic observation through the catheter into the dilation balloon. The patent contains 13 claims and lists CPC classifications spanning A61B, A61M, and related medical device categories.

US12605094B2 - Closed Arterial Blood Collection Apparatus

USPTO granted Patent US12605094B2 to MUNE CO., LTD. on April 21, 2026 for a closed type arterial blood collection apparatus comprising a saline bag with first and second ports, an A line, first and second three-way valves, a blood collection unit, and a fluid conveying means. The patent application was filed December 28, 2022 under application number 18270088, with 5 claims and multiple CPC classifications including A61M 5/44 and A61B 5/15.

Martti Randveer Confirmed Deputy Governor of Eesti Pank

The Eesti Pank Supervisory Board confirmed Martti Randveer, currently head of the Economics and Research Department, as Deputy Governor for a five-year term. Martti Randveer will take up the post on 7 June 2026. This appointment completes the new Executive Board composition alongside incoming Governor Ülo Kaasik and remaining Deputy Governor Andrus Alber.

Estonia Energy Prices Lower, Inflation Forecast 3.8% Peak

Eesti Pank economist Sulev Pert reports that Estonia was the only euro area country where energy prices fell in March 2026 (down 1.4%), while euro area energy prices rose 6.8% on average. Electricity exchange prices dropped 40% in March following high winter prices in the Baltic states. Motor fuels surged due to Middle East conflict tensions, with diesel up 27% and petrol up 14% month-over-month. The forecast projects consumer prices will rise 3.8% for 2026, with inflation peaking at year-end.

Estonia Attends IMF and World Bank Spring Meetings

Governor of Eesti Pank Madis Müller, Advisor on External Relations at the Ministry of Finance Märten Ross, and Deputy Director General of the Estonian Tax and Customs Board Janek Rozov attended the spring meetings of the IMF and World Bank on 15–18 April in Washington. Discussions focused on economic policy coordination amid uncertainty from the Middle East conflict, trade tensions, and tightening financing conditions, with the IMF recommending fiscal policy support monetary policy goals and the World Bank prioritizing job creation in developing countries. Estonia also held bilateral meetings with IMF and World Bank management, US Treasury staff, and presented its digital and AI solutions for tax and customs revenue collection.

FNE Pide TDLC Elimine Cobro Injustificado de Tarifa de Seguridad Aplicado a Importadores y Exportadores por Terminales Portuarios

La Fiscalía Nacional Económica (FNE) de Chile presentó argumentos ante el Tribunal de Defensa de la Libre Competencia (TDLC) en representación de importadores y exportadores afectados, solicitando el cese del cobro de una tarifa básica de seguridad impuesta por tres terminales portuarias en Valparaíso y San Antonio. Los terminales demandados —Terminal Pacífico Sur Valparaíso (TPS), San Antonio Terminal Internacional (STI) y DP World San Antonio (DPW)— comenzaron a cobrar esta tarifa entre septiembre de 2019 y febrero de 2021, pese a que las actividades de seguridad ya estaban remuneradas en las tarifas básicas de transferencia pagadas por las empresas navieras y sin que existieran inversiones extraordinarias que justificaran el cobro adicional. La FNE pidió al TDLC que imponga multas por un total de 26.897 Unidades Tributarias Anuales (UTA), equivalentes a aproximadamente US$ 25,1 millones.

FNE Realiza Visita Protocolar a Subsecretaría de Telecomunicaciones

El Fiscal Nacional Económico, Jorge Grunberg, realizó una visita protocolar a la Subsecretaria de Telecomunicaciones, Romina Garrido. En el encuentro las autoridades abordaron temas de interés común relacionados con la industria de las telecomunicaciones y conversaron sobre espacios de colaboración entre la FNE y la Subtel.

Chile FNE Co-Leads ICN Merger Working Group, 2026-2029

The Fiscalía Nacional Económica (FNE) of Chile has been selected to co-lead the International Competition Network's Merger Working Group (MWG) for the period 2026–2029, alongside France's Autorité de la Concurrence and Spain's Comisión Nacional de los Mercados y la Competencia. The MWG promotes best practices in merger review regimes, facilitates procedural and substantive convergence, and aims to reduce the time and cost of multi-jurisdictional reviews. The first working meeting is scheduled for May 6–8 in Manila, Philippines, during ICN's 25th Annual Conference.

EPPO Warns of Scam Messages Misusing Logo and Contact Details

EPPO has issued a public scam alert on 22 April 2026 warning citizens about fraudulent messages impersonating EPPO staff that misuse the office's logo and contact details. The alert clarifies that EPPO does not initiate contact with citizens via email, letter, or phone, and will never request personal data or payments. Citizens are advised to verify communications, avoid sharing sensitive information, and report suspicious activity to EPPO or police authorities.

Latvia Court Confiscates €230k, Luxury Car and Real Estate in EPPO Procurement Fraud Case

Riga City Court ordered the confiscation of a luxury vehicle, real estate in central Riga, and €230,000 in bank accounts under a non-conviction-based procedure, as part of an EPPO investigation into suspected procurement fraud at Daugavpils University involving European Social Fund financing. The fraud involved rigging of public procurement specifications and inflating costs, causing €306,957.24 in damage to the EU budget and €54,168.92 to the Latvian state budget. The pre-trial investigation remains ongoing and all persons concerned are presumed innocent until proven guilty.

COSALFA 52 Meets in Guyana, Advancing Foot-and-Mouth Disease Eradication

The 52nd Ordinary Meeting of COSALFA opened in Georgetown, Guyana on April 22, 2026, convening delegates from member countries, international organizations, and private sector representatives to advance the Region's progress toward eradicating foot-and-mouth disease. PAHO Director Dr. Jarbas Barbosa stated via video that the Americas is entering the final stage of eradication, with the inclusion of Venezuela on the WOAH-recognized list as a key remaining objective. Key agenda items included the new 2026-2030 Action Plan of PHEFA, Caribbean emergency preparedness, and the first year of operation of the Regional Antigen Bank (BANVACO).

Bahamas WHO-Certified for Eliminating Mother-to-Child HIV Transmission

The World Health Organization and Pan American Health Organization certified The Bahamas on April 22, 2026 as having eliminated mother-to-child transmission of HIV, making it the latest Caribbean nation to achieve this milestone. The Bahamas joins 12 countries and territories in the Region of the Americas certified for EMTCT, having met WHO's thresholds of less than 2% mother-to-child transmission rate, fewer than 5 new pediatric HIV infections per 1,000 live births, and 95% or higher coverage for antenatal care, HIV testing, and treatment. The achievement reflects sustained political commitment, universal antenatal care regardless of nationality or legal status, integrated laboratory networks, and multi-month dispensing of antiretroviral medicines.

PROTECT Project Advances Early Warning Systems Along South American Bioceanic Corridors

PAHO reported on April 22, 2026 that six South American countries — Argentina, Bolivia, Brazil, Chile, Paraguay, and Peru — reviewed progress on coordinated early warning systems for public health threats along biooceanic corridors. The work, under the PROTECT project (Pandemic Response Optimization Through Engaged Communities and Territories), builds on foundations laid in October 2025 in Asunción, Paraguay, and targets governance, systems interoperability, epidemiological surveillance, laboratory capacities, and workforce development through the end of 2026. The initiative is funded by the Pandemic Fund and implemented jointly by PAHO, the World Bank, and PANAFTOSA/SPV.

Governor Kevin Greenidge Speech, Central Bank Barbados

Governor Kevin Greenidge of the Central Bank of Barbados delivered a keynote speech at an administrative professionals conference themed 'Elevating Excellence in a Changing World' on April 22, 2026. The speech acknowledged the role of administrative staff in building BiMPay, Barbados's national mobile payment infrastructure, and addressed how professionals can adapt to technological change, including artificial intelligence. The Governor emphasised that while AI can handle routine tasks, human judgment, relationships, and discretion remain essential to organisational excellence.

Hochul Announces Westchester Crossing Groundbreaking in Port Chester

Governor Kathy Hochul announced the groundbreaking of Westchester Crossing in Port Chester on April 22, 2026, a major redevelopment of the former United Hospital site. The approximately $65 million project will receive up to $10 million from the Mid-Hudson Momentum Fund and is expected to deliver 957 new housing units, including 105 affordable homes. Infrastructure improvements include new water, sewer, and stormwater systems, internal roadways and walkways, a High Street bypass, and widening of the I-287 Exit 11 off-ramp and Boston Post Road.

Governor Hochul Expands Volunteer Firefighter Training Stipend to Five New Courses

New York State is expanding its Volunteer Firefighter Training Stipend program to cover five additional training courses for volunteer firefighters, with stipend amounts ranging from $250 to $500 per course. The new eligible courses include Firefighter Survival ($250), Firefighter Assist and Search Team/Rapid Intervention Crew ($350), and three advanced leadership programs ($500 each). Since 2023, over 4,000 volunteer firefighters have completed training through the program, and participation in existing courses has grown by up to 35 percent.

Governor Hochul Signs Executive Order Banning NY State Employees From Insider Trading on Prediction Markets

New York Governor Kathy Hochul signed Executive Order No. 60 on April 22, 2026, prohibiting covered state officers and employees from using confidential information acquired in the course of their official duties to further personal financial interests through prediction markets. The order also bars assisting others in profiting on confidential information through these markets. The order takes effect immediately and builds on New York State's Code of Ethics to create what the Governor's office claims are the strongest protections against insider trading on prediction markets in the nation. The order references $1 billion in 'perfectly-timed' bets surrounding the war in Iran, including location and timing of military strikes, as context for the action.

Hochul Expands NY Volunteer Firefighter Training Stipend with 5 New Courses

Governor Kathy Hochul announced the expansion of New York's Volunteer Firefighter Training Stipend program to cover five additional training courses. The new eligible courses include Firefighter Survival: Self-Rescue ($250), FAST and RIC teams ($350), and Fire and Emergency Services Instructor 1, Fire Officer II, and Firefighter 2 ($500). Since 2023, over 4,000 volunteer firefighters have completed training through this program, with course completion rates increasing 20 percent for exterior firefighting operations and 35 percent for Fire Officer I. Applications are submitted through the state Office of Fire Prevention and Control.

Pendragon Theatre Grand Opening in Saranac Lake

Governor Kathy Hochul announced the official opening of Pendragon Theatre's new downtown facility in Saranac Lake on April 22, 2026. The $11 million project was supported by more than $5.5 million in state investment, including a $2.5 million Downtown Revitalization Initiative grant, a $2 million Empire State Development Restore NY grant, a $500,000 ESD Market NY grant, $400,000 in Smart Growth grants, and a $145,000 NYSCA grant. The theatre will host an open house on April 25 and its first full performance, Noises Off, on June 24, 2026.

Abbott Celebrates First TEFA Funding Round, 42,000 Texas Families

Governor Greg Abbott celebrated the first funding round of the Texas Education Freedom Accounts (TEFA) program, with over 42,000 Texas families receiving awards. Administered by the Texas Comptroller of Public Accounts under Acting Comptroller Kelly Hancock, the TEFA program prioritizes students with disabilities and those from low-income households at or below 500 percent of the federal poverty level. Families can use allotted funds for school enrollment, instructional materials, educational therapies, and other educational expenses.

$25M Grant Funding for Rural Hospitals, Deadline May 28

Governor Greg Abbott and the Texas Health and Human Services Commission announced $25 million in grant funding available to eligible rural hospitals, with a maximum award of $5 million per hospital distributed over three years. The application deadline is May 28, 2026. Priority populations include pregnant women, children, older adults, and uninsured individuals.

Abbott Meets SBA Administrator Kelly Loeffler, Texas Business Partnership

Governor Greg Abbott met with SBA Administrator Kelly Loeffler on April 22, 2026, in Austin, Texas, to discuss Texas' partnership with the SBA supporting small businesses and entrepreneurs. The Governor highlighted Texas being named the Best State for Business for 21 consecutive years, the national leader in job creation, and its business-friendly climate with constitutional amendments banning taxes on income, capital gains, securities transactions, and inheritance. No new regulatory obligations, policy changes, or funding commitments were announced.

Digital Lifestyle Intervention for Migrants: RCT in Sweden

A randomized controlled trial (NCT07545239) will evaluate the feasibility, acceptability, and efficacy of a culturally and linguistically adapted 8-week digital lifestyle intervention targeting migrants with moderate psychological distress in Sweden. Participants (N=240) will be randomized to the digital intervention or a wait-list control receiving a general lifestyle module. Assessments will occur at baseline, post-treatment (8 weeks), 2-month follow-up, and 6-month follow-up.

Tiaozhong-Yiqi Decoction RCT for Substance Withdrawal, 80 Patients

A randomized controlled clinical trial registered on ClinicalTrials.gov (NCT07543809) is evaluating Tiaozhong-Yiqi Decoction (TZYD) for treating substance withdrawal syndrome in 80 patients. The intervention group (n=40) receives 200mL TZYD twice daily for 3 months plus routine care; the control group (n=40) receives routine care only. Primary outcome measures withdrawal syndrome symptom improvement via standardized clinical scale; secondary outcomes include serum neurotransmitter levels (dopamine, norepinephrine, 5-hydroxytryptamine), inflammatory factors (IL-6, IL-1β, TNF-α), BDNF, and quality of life scores (QOL-DA V2.0). The study combines network pharmacology analysis with clinical validation to explore TZYD's potential regulatory mechanism on neuroendocrine and immune systems.

ADHELASKIN for Systemic Sclerosis Skin Assessment (NCT07543679)

A clinical trial (NCT07543679) evaluating ADHELASKIN technology by Tactinnov and École Centrale de Lyon for objective assessment of skin damage in patients with systemic sclerosis has been registered on ClinicalTrials.gov. The trial addresses limitations of the modified Rodnan skin score (mRSS), including inter- and intra-observer variability and limited sensitivity to subtle changes. ADHELASKIN uses an indentation method with ruby-based measurement to quantify rigidity, firmness, and elasticity of skin with improved accuracy. The study will classify patients as diffuse cutaneous or limited cutaneous SSc based on skin fibrosis extent.

Teen Vulnerability to Irritability: Brain and Estrogen Changes (NCT07544966)

NIH registered a Phase 4 clinical trial (NCT07544966) titled "Teen Vulnerability to Irritability: Brain and Estrogen Changes," enrolling 50 female adolescents ages 12-16 at risk of suicide. The randomized, placebo-controlled, cross-over study will test the impact of estradiol (E2) and progesterone (P4) stabilization via continuous combined oral contraceptive (Kurvelo) versus placebo on brain networks associated with irritability over two 8-week treatment arms. Each participant undergoes daily hormone sampling, daily symptom ratings, and neuroimaging sessions across conditions.

MBP vs No MBP in Laparoscopic Right Hemicolectomy

A randomized controlled trial (NCT07546565) registered at University Medical Center Ho Chi Minh City will compare mechanical bowel preparation (MBP) versus no MBP in patients undergoing laparoscopic right hemicolectomy with intracorporeal anastomosis for colon cancer. The trial will enroll eligible patients randomly assigned to either group and measure surgical site infection rates within 30 days as the primary outcome, alongside secondary outcomes including anastomotic leakage, postoperative ileus, operative time, and length of hospital stay. Findings aim to clarify whether MBP reduces postoperative infections in this specific surgical context.