Healthcare & Life Sciences

Patent Application for Free LIGHT Detection and Treatment

The USPTO has published a patent application (US20260085112A1) from Avalo Therapeutics, Inc. for methods of detecting and treating conditions associated with elevated free LIGHT using anti-LIGHT antibodies. The application covers methods for diagnosing conditions like acute lung injury, ARDS, and Crohn's Disease.

Patent Application for SLIT2 Related Compositions and Methods

The USPTO has published a new patent application (US20260085111A1) filed by EVEREST MEDICINES (SINGAPORE) PTE. LTD. The application relates to antibodies that bind to SLIT2 and related substitution mutants, including their manufacture and use.

Patent Application: Production Method for Product to Prevent Membrane Clogging

The USPTO has published a patent application from FUJIFILM Corporation detailing a production method for a product that aims to prevent membrane clogging during cell culture. The method involves specific mathematical expressions related to poloxamer concentration, product concentration, and hydrophobicity index to optimize the cell culture process.

Patent Application: Filtration Condition Evaluation and Cell Product Production

The USPTO has published a new patent application (US20260085109A1) from Asahi Kasei Life Science Corporation detailing a method for evaluating filtration conditions and producing cell products. The application was filed on November 14, 2023, and published with a projected application date of March 26, 2026.

Methods for Separating Chelator from Mixture Using Chromatography

The USPTO has published a new patent application, US20260085108A1, detailing methods for separating a chelator from a mixture using chromatography. This application, filed on September 8, 2023, by inventors Jason Huang and Qiang Li, describes techniques useful in adjusting the concentration of chelators in protein compositions.

Polyproline Nanocage Compound and Manufacturing Method

The USPTO has published a patent application for a polyproline nanocage compound and its manufacturing method. The application details a compound comprising two cyclic peptide scaffolds connected by molecules, with each scaffold containing polyproline helix rods and turn-angle molecules. This is a routine publication of a new patent application.

Stapled Peptide and Use Thereof Patent Application

The USPTO has published a patent application (US20260085094A1) for a stapled peptide and its use, filed by inventors Zhixiang PAN, Haiying HE, Zhigan JIANG, and Shuhui CHEN. The application details a series of stapled peptides, specifically relating to polypeptides with sequences shown in formulas (I-1)-(I-5) and (II-6), and their pharmaceutically acceptable salts.

Patent Application for AAV Capsid Variants and Uses

The USPTO has published a new patent application (US20260085095A1) detailing adeno-associated virus (AAV) capsid variants and their uses. The application was filed on June 1, 2023, and is scheduled for publication on March 26, 2026. This represents a new disclosure in the field of gene therapy vectors.

Stabilized trimeric class I fusion proteins patent application

The USPTO has published a patent application (US20260085096A1) for stabilized trimeric class I fusion proteins. The application details specific mutations in the HR2 domain to enhance protein stability. This is a routine publication of a new patent application.

Patent Application for Endoglin Antibodies Detecting Cancer Splice Variants

The USPTO has published a patent application (US20260086096A1) for endoglin antibodies designed to detect cancer splice variants. The application, filed by Nam Yong Lee, details methods and compositions for improved cancer diagnosis.

Metabolic Selection via Serine Biosynthesis Pathway Patent Application

The USPTO has published a new patent application, US20260085327A1, related to metabolic selection via the serine biosynthesis pathway. The application details an isolated mammalian cell with reduced expression of Phosphoserine Phosphatase (PSPH) and its use in recombinant protein production.

Karyocreate Patent Application US20260085330A1 Details CRISPR Technology

The USPTO has published patent application US20260085330A1 from Karyocreate detailing CRISPR technology for inducing aneuploidy. The application, filed on September 8, 2023, describes fusion proteins and guide RNAs that interfere with chromosome segregation.

Cell Culture Method Suppressing Foam Aggregates

The USPTO has published a new patent application (US20260085282A1) from FUJIFILM Corporation detailing a cell culture method. The method aims to suppress foam aggregate formation by adjusting poloxamer concentration or foam liquid viscosity during cell culture at high densities.

Method for preparing biologically active complexes using polypeptides and oleic acid

Method for preparing biologically active complexes using polypeptides and oleic acid

Patent Application for Chromatographic Fractionation Method

The USPTO has published a new patent application (US20260085089A1) detailing a method and apparatus for continuous gradient elution chromatographic fractionation. The application, filed on September 12, 2023, describes a process for separating products of interest from impurities using chromatography matrices and elution solutions.

Method for Reducing Host Cell Proteins in Affinity Chromatography

The USPTO has published a patent application from Genentech, Inc. detailing a method for purifying antibodies by reducing host cell proteins using a low conductivity aqueous solution in affinity chromatography. This application, filed on December 2, 2025, describes a specific purification technique for biopharmaceutical products.

Melanocortin Receptor Ligands Patent Application

The USPTO has published a new patent application (US20260085092A1) for compounds acting as ligands for melanocortin receptors. The application details specific compounds and their potential use in treating mammals, filed by inventors Zeng Xin Dong and Jacques-Pierre Moreau.

Patent Application: Peptide Binds Trop2 for Cancer Treatment

The USPTO has published a patent application (US20260085091A1) from Kyungpook National University Industry-Academic Cooperation Foundation for a peptide that selectively binds to Trop 2. The peptide is intended for targeted therapeutic agents and anticancer drugs for resistant cancers such as breast, pancreatic, and cholangiocarcinoma.

Ginkgo Bioworks Patent for Protein Production and Secretion Systems

The USPTO has published a new patent application (US20260085107A1) filed by Ginkgo Bioworks, Inc. The patent describes expression systems for enhanced production and secretion of proteins, including specific examples like bovine lactoferrin. This application is part of the ongoing patent process for novel biotechnological methods.

Chimeric Antigen Receptor System for Signalling

The USPTO has published a new patent application, US20260085106A1, detailing a chimeric antigen receptor (CAR) system. This system is designed to control signalling based on the presence or absence of a specific agent, potentially impacting the development of targeted therapies.

Heterodimeric Human IgG1 Polypeptides with Isoelectric Point Modifications

The USPTO has published a new patent application, US20260085132A1, titled 'Heterodimeric Human IgG1 Polypeptides with Isoelectric Point Modifications'. The application details methods for purifying desired heterodimer immunoglobulin variants from contaminating homodimer variants by modifying isoelectric points.

MAGEA4 Specific T Cell Receptors Patent Application

The USPTO has published a patent application (US20260085105A1) filed by Amgen Inc. for recombinant T-cell receptors designed to selectively recognize MAGE-A4-derived peptides. The application details screening for cross-reactivity and alloreactivity.

Patent Application for Detecting Immune Cells Using Fusion Proteins

The USPTO has published a new patent application (US20260085104A1) detailing fusion proteins for detecting and isolating immune cells. The application, filed by Patrick Schlegel, describes specific fusion proteins involving a dysfunctional purinergic P2X7 receptor epitope and an antibody Fc region.

Patent Application: Bispecific Antibodies and Uses Thereof

The USPTO has published a new patent application (US20260085131A1) for bispecific antibodies and their uses. The application, filed on August 20, 2025, describes antibodies that bind to two different antigens with varying affinities.

Base Editing of Plant Cell Organelle DNA

The USPTO has published a patent application (US20260085323A1) detailing a method for base editing plant cell organelle DNA. The application, filed by the Institute for Basic Science, describes a composition and method for editing adenine to guanine and cytosine to thymine in plant cell organelle DNA.

USPTO Patent Application for Fusion Polypeptides

The USPTO has published a new patent application (US20260085300A1) detailing systems and compositions for fusion polypeptides and their methods of use in regulating target genes. The application was filed on October 27, 2023, by inventors Thomas Blair Gainous, Xiao Yang, Giovanni Carosso, Lei S. Qi, and Daniel O. Hart, II.

Takeda's Monoclonal Antibody Inhibitor of Factor XIIa Patent Application

The USPTO has published a patent application from Takeda Pharmaceutical Company Limited for a monoclonal antibody inhibitor of Factor XIIa. The application, filed on August 12, 2025, describes methods for treating diseases associated with Factor XII, including hereditary angioedema and ocular diseases.

CD163 Binding Protein Patent Application

The USPTO has published a patent application (US20260085129A1) filed by ECO ANIMAL HEALTH LTD. on October 11, 2023. The application relates to an antibody that binds to porcine CD163, specifically its membrane-bound form.

Anti-CD157 Antibodies, Fragments, Compositions, and Methods

The USPTO has published a patent application (US20260085128A1) detailing anti-CD157 antibodies, antigen-binding fragments, compositions, and methods for their use. The application was filed on July 18, 2023, and describes potential diagnostic reagents and kits.

Bispecific Antibody Targets TIM-3 and CD39 for Cancer

The USPTO has published a patent application (US20260085127A1) for a bispecific antibody designed to target both TIM-3 and CD39 antigens. This antibody aims to enhance immune activity against cancer cells and is intended for cancer treatment.

Patent Application for Agonistic TNF Receptor Binding Agents

The USPTO has published a new patent application, US20260085126A1, for agonistic TNF receptor binding agents. The application, filed on August 27, 2025, by inventors including Ugur Sahin, details binding agents for TNF superfamily receptors and their potential medical uses.

Patent Application for Apelin Receptor Binding Polypeptides and Methods

The USPTO has published a new patent application (US20260085125A1) for apelin receptor binding polypeptides and methods of treatment. The application was filed on November 25, 2025, and details antibodies and polypeptides that specifically bind to the apelin receptor (APJ).

ANSM Recalls Omnipaque and Visipaque Lots Due to Particle Contamination

ANSM has issued a precautionary recall, in coordination with GE Healthcare SAS, for specific lots of Omnipaque 350 mg I/mL and Visipaque 320 mg I/mL injectable solutions (100 mL vials). The recall was initiated after particles were detected adherent to the internal wall of certain vials. If these particles detach and are not detected prior to injection, they may pose a patient safety risk. Healthcare establishments, pharmaceutical distribution channels, and professionals who received affected lots are being notified directly.

Resoundant Acoustic Transducer for MRI - Safety Action

The French National Agency for Medicines and Health Products Safety (ANSM) has registered a safety action concerning the Resoundant acoustic transducer for MRI, identified under number R2606244. Healthcare facilities and medical imaging centers using this device have been notified.

Product Recall: Klassiker Crutches and Rubber Tips

The ANSM has been informed of a product recall for Klassiker crutches and rubber tips, initiated by Ossenberg GmbH. This safety action, registered under number R2603198, affects pharmacies, community care facilities, large and medium-sized stores, and home healthcare providers. Affected users have been notified directly by the manufacturer.

ANSM Security Alert for Orbis Medication Prescription Aid Software

The ANSM has issued a security alert (R2608925) regarding the Orbis Medication prescription aid software (version 3.x) from DH Healthcare GMBH. Affected healthcare providers have been notified directly by the company.

ANSM Safety Alert: Atellica CH Urine Albumin Reagent

The French National Agency for Medicines and Health Products Safety (ANSM) has issued a safety alert regarding the Atellica CH Urine Albumin reagent from Siemens Healthcare Diagnostics Inc. The alert, registered under number R2602998, informs medical biology laboratories of a safety action implemented by the manufacturer.

Patent Application: Treating Blood Clots with Nerve Stimulation

The USPTO has published a patent application from ElectroCore, Inc. detailing systems and methods for treating blood clots using nerve stimulation, particularly for post-COVID conditions. The application describes transcutaneous electrical impulses to a vagus nerve branch to reduce antibodies associated with blood clotting.

NEC Corporation Patent for Information Processing Device

The USPTO has published a patent application from NEC Corporation for an information processing device. The device utilizes machine learning models to analyze human feature values and set types associated with these models, aiding in user decision-making.

Computer-assisted method for patient examination positioning information

The USPTO has published a new patent application (US20260088186A1) from Siemens Healthineers AG for a computer-assisted method to generate patient examination positioning information. The application details a system that uses image data and an evaluation model to create positioning data for examination protocols.

Patent Application for Blood Flow and Shear Stress Calculation

The USPTO has published a patent application (US20260088181A1) for a method to calculate blood flow and shear stress in aortas with bicuspid aortic valves. The application, filed by the University of Seoul Industry Cooperation Foundation, details a process using characteristic values of the valve to compute these metrics.

Prediction Device, Method, and Non-Transitory Computer-Readable Recording Medium

The USPTO has published a patent application (US20260088183A1) by NEC Corporation for a prediction device and method. The invention aims to support decision-making regarding a target person's health by analyzing health data distributions across different age groups.

Medical Application Live Chat and Voice Assistant Patent Filed

The USPTO has published a patent application (US20260088188A1) for a live chat and voice assistant platform designed for medical applications. The system aims to facilitate messaging between medical applications on doctor and patient devices.

USPTO Patent: Convert Chest Radiology Data to Numerical Vectors

The USPTO has published a patent application detailing a method and device for converting chest radiology data into numerical vectors using deep learning algorithms. This technology aims to analyze, predict, or diagnose diseases based on extracted anatomical and disease-related features from the data.

Lung function curve prediction method and apparatus

The USPTO has published a patent application detailing a method and apparatus for predicting lung function curves. The invention uses a Taylor series expansion to model the relationship between flow rates at different sampling points, enabling prediction of true lung function curve data from a finite set of points.

Bifunctional degraders with electrophilic PROTACs

The USPTO has published a patent application (US20260083722A1) detailing bifunctional degraders comprising electrophilic PROTACs that engage DCAF1. The application was filed on May 19, 2023, and published with a projected application date of March 26, 2026.

Patent application for Dichrostachys glomerata health and wellness benefits

Patent application for Dichrostachys glomerata health and wellness benefits

Patent Application for Reducing Food Intake Using Plants

The USPTO has published a new patent application (US20260083800A1) detailing methods and compositions using Dichrostachys glomerata or Cissus quadrangularis to reduce food intake or appetite in mammals. The application was filed on September 26, 2024, by inventors Shil Kothari and Julius Enyoug Oben.

Patent Application for Reducing Visceral Fat Using Plants

The USPTO has published a new patent application (US20260083801A1) detailing methods and compositions for reducing visceral fat in mammals using plants like Dichrostachys glomerata or Cissus quadrangularis. The application was filed on September 26, 2024, and is expected to be published on March 26, 2026.

Patent Application: Methods for Reducing Blood Lipids Using Plants and Spices

The USPTO has published a new patent application (US20260083802A1) detailing methods and compositions for reducing blood lipids using plants and spices, specifically Dichrostachys glomerata or Cissus quadrangularis. The application was filed on September 26, 2024.