Metabolic Selection via Serine Biosynthesis Pathway Patent Application
Summary
The USPTO has published a new patent application, US20260085327A1, related to metabolic selection via the serine biosynthesis pathway. The application details an isolated mammalian cell with reduced expression of Phosphoserine Phosphatase (PSPH) and its use in recombinant protein production.
What changed
This document is a published patent application from the USPTO concerning a novel method for metabolic selection using the serine biosynthesis pathway. The application, titled 'Metabolic Selection via the Serine Biosynthesis Pathway,' describes an isolated mammalian cell engineered to have reduced or eliminated expression of Phosphoserine Phosphatase (PSPH). It also outlines methods for preparing these cells and utilizing them for the production of recombinant proteins.
As this is a patent application, it does not impose direct regulatory obligations on companies. However, it signifies potential future intellectual property developments in biotechnology and pharmaceutical manufacturing. Companies involved in recombinant protein production or cell-based therapies should be aware of this filing as it may impact future research, development, and commercialization strategies in this area.
Archived snapshot
Mar 26, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
METABOLIC SELECTION VIA THE SERINE BIOSYNTHESIS PATHWAY
Application US20260085327A1 Kind: A1 Mar 26, 2026
Inventors
Mary Otto, James Ravellette, David Razafsky, Jason A. Gustin, Trissa Borgschulte
Abstract
The present disclosure provides an isolated mammalian cell comprising a reduced or eliminated expression of Phosphoserine Phosphatase (PSPH). Further provided are methods for preparing such cells and methods for using such cells for the production of recombinant proteins.
CPC Classifications
C12N 15/85 C07K 16/00 C12N 5/0682 C12N 9/226 C12N 9/93 C12N 15/111 C07K 2317/31 C12N 2310/20 C12N 2510/00 C12Y 301/03003 C12Y 603/01002 C12Y 603/05004
Filing Date
2023-09-29
Application No.
19112686
Named provisions
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