Patent Application for Chromatographic Fractionation Method
Summary
The USPTO has published a new patent application (US20260085089A1) detailing a method and apparatus for continuous gradient elution chromatographic fractionation. The application, filed on September 12, 2023, describes a process for separating products of interest from impurities using chromatography matrices and elution solutions.
What changed
This document is a publication of a patent application filed with the USPTO, specifically application number US20260085089A1, titled "CONTINUOUS GRADIENT ELUTION CHROMATOGRAPHIC FRACTIONATION". The application describes a method and apparatus for separating a product of interest from impurities using a multi-step chromatographic process involving loading feed solutions onto a chromatography matrix, contacting it with an elution solution, and collecting specific elution fractions. The process can be repeated, potentially using the same or different chromatography matrices.
As this is a patent application, it does not impose direct regulatory obligations or compliance deadlines on entities. However, it represents new intellectual property in the field of chemical separation techniques. Companies involved in drug manufacturing, pharmaceutical development, or biotechnology may find the described methods relevant to their research and development or manufacturing processes. Monitoring patent filings is crucial for understanding technological advancements and potential future licensing or patent infringement considerations.
Archived snapshot
Mar 26, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
CONTINUOUS GRADIENT ELUTION CHROMATOGRAPHIC FRACTIONATION
Application US20260085089A1 Kind: A1 Mar 26, 2026
Inventors
Oliver BOSCHEINEN, Matthias GUNNE, Daniel SCHEPS, Jochen STRUBE, Steffen ZOBEL-ROOS
Abstract
The present invention relates to a method for separating a product of interest from impurities and an apparatus for performing the method. The method comprises the steps in the indicated order: (1) loading on a chromatography matrix a first volume of a feed solution comprising the product of interest and impurities; (2) contacting the chromatography matrix with an elution solution; (3) collecting a) optionally an elution fraction 1 (EF1) in a side fraction container (SFC), b) an elution fraction 2 (EF2) in a product container, and c) optionally an elution fraction 3 (EF3) in a SFC, wherein at least one of EF1 and EF3 is collected; (4) loading on a chromatography matrix EF1 and/or EF3 and a second volume of the feed solution simultaneously or subsequently. Steps (2) to (4) are repeated at least once, and the chromatography matrices of step (1) and (4) are the same or different.
CPC Classifications
C07K 1/22 B01D 15/166 B01D 15/1864 B01D 15/247 B01D 15/325 B01D 15/424
Filing Date
2023-09-12
Application No.
19111122
Named provisions
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