Fear of Cancer Recurrence, Tailored Support for Survivors
A clinical trial registration has been published on ClinicalTrials.gov for study NCT07542821. The study aims to develop and evaluate tailored support interventions for cancer survivors experiencing fear of recurrence, covering breast, head and neck, colorectal, and prostate cancer. Participants will be stratified by concern level and randomized to receive either psychological cognitive training (ConquerFear) or individualized exercise and nutrition guidance.
CTZ Paste for Emergency Dental Treatment in Public Health Settings: A Randomized Trial
The NIH has registered a randomized, pragmatic, controlled, non-inferiority clinical trial (NCT07542639) evaluating the clinical and radiographic non-inferiority of CTZ paste compared to conventional pulpectomy with zinc oxide-eugenol (ZOE) in primary molars with pulp necrosis. The single-center trial will follow participants at 3, 6, and 12 months, measuring pain resolution and absence of clinical signs of infection as primary outcomes.
Phase 3 Nerandomilast Trial for Fibrosing ILD Progression
NIH registered Phase 3 clinical trial NCT07540988 (FIBRONEER-ACT) to evaluate nerandomilast tablets versus placebo in adults with non-IPF fibrosing interstitial lung disease at risk for progressive pulmonary fibrosis. The randomized, double-blind study has an estimated duration of approximately 2 years and 4 months. Primary efficacy endpoints include forced vital capacity (FVC) and diffusing capacity (DLCO), with high-resolution CT imaging for disease monitoring.
Group Digital Gaming Study for Dementia
The NIH registered a new clinical trial (NCT07541144) titled 'Group Digital Gaming: Experiences of Older Adults Living With Dementia in an Activity for Cognitive Impairment.' The study uses a pretest/posttest mixed-methods design to examine the effects of a group digital gaming intervention on cognitive function, mood, and behaviors in individuals with early to moderate dementia, employing Obie Technology.
DI-SOUND Study: Digital Heart Sound Classification in Pediatric Patients
NIH registered an observational clinical trial (NCT07542509) titled 'DI-SOUND Study' to develop a digital classifier using commercially available digital stethoscopes to categorize pediatric heart sounds as physiological or pathological. The proof-of-concept study aims to address limitations in current neonatal screening for congenital cardiovascular diseases, including sensitivity failures and false positives. The trial is registered as observational with no prospective assignment.
tPBM 10Hz vs 40Hz for Somatic Symptoms in Treatment-Resistant Depression
The NIH National Library of Medicine has registered a new clinical trial (NCT07543328) evaluating transcranial photobiomodulation (tPBM) at 10Hz versus 40Hz frequencies in patients with treatment-resistant depression. The study will assess differential efficacy across depressive symptoms and the somatic symptom-dominant subtype, while collecting paired-pulse neurophysiological parameters including SICI, ICF, and LICI to explore cortical excitability mechanisms.
Conscious Sedation vs General Anesthesia in PFA for Paroxysmal A-Fib
A clinical trial comparing conscious sedation and general anesthesia in patients undergoing pulsed-field ablation for paroxysmal atrial fibrillation has been registered on ClinicalTrials.gov. The randomized controlled study will assign participants at a 1:1 ratio and monitor for composite safety endpoints including persistent hypotension or hypoxemia exceeding 60 seconds intraoperatively. Follow-up assessments are scheduled at 12-24 hours, 30 days, and 90 days post-procedure.
SPSIPB vs ESPB Block for Breast Surgery Pain
NIH registered ClinicalTrials.gov Study NCT07541040, a prospective randomized assessor-blinded trial comparing serratus posterior superior intercostal plane block (SPSIPB) and erector spinae plane block (ESPB) for postoperative analgesia in unilateral breast surgery. 54 patients will be randomized to receive either intervention before general anesthesia. Primary outcome is postoperative pain scores within 24 hours; secondary outcome is opioid consumption.
KQB368 Phase 1 Study for Advanced Solid Cancers
A Phase 1 clinical trial (NCT07542704) evaluating KQB368 as an oral monotherapy for adults with advanced solid malignancies including colorectal, non-small cell lung, and uterine cancers. The study will assess safe dosing, tumor response, and pharmacokinetics in 21-day cycles. The trial is registered on ClinicalTrials.gov with no new regulatory requirements imposed.
Sitagliptin in Recurrent/Progressive Grade 4 Glioma, Phase 1
NIH has registered a Phase 1 clinical trial (NCT07541781) evaluating sitagliptin in combination with bevacizumab for the treatment of recurrent or progressive grade 4 malignant glioma. The trial is enrolling adult patients with glioblastoma or recurrent glioma and is expected to run through April 2026. The study aims to assess efficacy and determine the maximum appropriate dose of sitagliptin when combined with standard-of-care bevacizumab.
Method and Apparatus for Continuous Vitals Monitoring - US12605078B2
USPTO granted Patent US12605078B2 to Rythmos LLC for a health monitoring device using fiber Bragg grating (FBG) sensors to detect physiological attributes. The device places FBG sensors in contact with skin near arteries or veins to measure refractive index changes and estimates physiological attributes based on strain-induced Bragg wavelength shifts. The patent contains 20 claims.
Impedance Cardiography Device Patent, Tallinn University, Apr 21
The USPTO granted patent US12605084B2 to Tallinn University of Technology on April 21, 2026, covering an impedance cardiography device. The device includes an impedance measuring unit, differentiator, comparator, microcontroller with analog-to-digital converter, and two peak voltage detection units with different polarities. The patent contains 8 claims and was filed on March 27, 2023 under Application No. 18190622.
US12605079B2 Physiological Parameter Measurement System, Sonion Nederland
The USPTO granted Patent US12605079B2 to Sonion Nederland B.V. for a system and method measuring physiological parameters of blood-perfused tissue using dual radiation sensors—one sensor measures blood volume via radiation absorption, while the second measures blood flow speed via Doppler shift—with a controller determining the physiological parameter from both data streams. The patent contains 13 claims and covers CPC classifications in the A61B medical diagnosis category.
Physiological Sensor Delivery Device - US12605075B2
USPTO granted patent US12605075B2 to ACIST Medical Systems, Inc. on April 21, 2026, covering an intravascular sensor delivery device and method for measuring physiological parameters such as blood pressure within vascular structures. The device is sized to pass over guidewires for use in coronary and peripheral arteries and can measure pressure gradients across stenotic lesions or heart valves. The patent contains 19 claims with a filing date of April 19, 2021.
Adaptive Pulse Wave Analysis for Blood Pressure Monitoring
The USPTO granted Patent US12605080B2 to Senbiosys on April 21, 2026. The patent covers an adaptive signal processing technique for pulse wave analysis that improves blood pressure estimation by transforming the pulsatility signal to define fiducial points more precisely. The patent application (No. 17455540) was filed on November 18, 2021, and contains 15 claims.
MRI and Focused Ultrasound Thermal Ablation System
USPTO granted patent US12605071B2 to Shanghai Shende Green Medical Era Healthcare Technology Co., Ltd. for a compatible system enabling synchronized operation of magnetic resonance imaging and focused ultrasound thermal ablation. The system includes a signal collector and control circuit that detects MRI radio frequency signals, records trigger times, and controls focused ultrasound heating duration. The patent contains 8 claims.
Photoplethysmogram System Patent, Multiple Light Sources
The USPTO granted Patent US12605077B2 to PranaQ Pte. Ltd. for a photoplethysmogram (PPG) system using multiple light sources of different frequencies (red, infrared, green). The system includes a PPG sensor that detects light after passage through a subject's skin and a processor that estimates physiological parameters including blood oxygen saturation, respiratory effort, pulse rate, and pulse rate variability. The patent contains 12 claims and covers dynamic signal processing methods including calibration using a green light source and imputation of inconsistent PPG signals.
Photoacoustic and Ultrasonic Imaging Device, OPTICHO INC
USPTO issued Patent No. US12605072B2 to OPTICHO INC., LTD. for a photoacoustic and ultrasonic imaging device that combines laser light and ultrasonic wave technologies for tissue imaging. The patent covers an imaging probe with a laser emitter and ultrasonic transducer, and an operation unit for image formation from photoacoustic and ultrasonic signals. 19 claims were granted.
Multiple Antihypertensives Increase Post-Induction Hypotension Risk in Cardiac Surgery
NIH has registered observational study NCT07541222 investigating whether preoperative use of multiple antihypertensive drug classes increases post-induction hypotension burden in cardiac surgery patients. Researchers will observe whether combinations of ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers correlate with higher incidence and severity of blood pressure drops and increased vasoactive support needs between anesthesia induction and surgical incision.
JADE101 IgA Nephropathy Phase 2 Study
NIH registered a Phase 2 clinical trial (NCT07541287) for JADE101 in participants with immunoglobulin A (IgA) nephropathy on ClinicalTrials.gov. The open-label study will evaluate the safety and efficacy of JADE101 as an investigational treatment for this kidney condition.
Rezdiffra Pregnancy and Lactation Registry, NCT07541469
The NIH has registered an observational study (NCT07541469) on ClinicalTrials.gov titled 'Rezdiffra Pregnancy and Lactation Registry'. The study evaluates pregnancy and clinical outcomes in women with MASH (Metabolic Dysfunction-Associated Steatohepatitis) and their infants after exposure to Rezdiffra at any time during pregnancy and/or lactation. The study is sponsored by a pharmaceutical firm and is listed as observational, generating no new compliance obligations for affected parties.
MBSR Training Reduces Fear, Improves Bonding, Breastfeeding
NIH's ClinicalTrials.gov published a randomized controlled study (NCT07540923) evaluating Mindfulness-Based Stress Reduction (MBSR) training for adolescent pregnant women and their partners. The study will assess the intervention's effects on fear of childbirth, maternal and paternal bonding, and breastfeeding success compared to routine care controls.
NYCBS Cancer Biorepository Collects Patient Samples
New York Cancer and Blood Specialists (NYCBS) registered an observational biorepository study on ClinicalTrials.gov under NCT07543159. The study collects and stores biological samples and clinical data from cancer patients, high-risk populations, and survivors to support translational cancer research. Samples will be used to understand cancer progression and develop new therapies.
Balance & Respiratory Muscle Strength in Healthy Adults
The NIH registered a new observational study (NCT07541950) examining the acute effects of balance exercises on balance performance in healthy individuals aged 18-25. The single-blind pre-test/post-test study will assess participants using the Single Leg Stance Test before and after an 8-10 minute balance exercise program including single-leg stance, eyes-closed balance, and unstable surface training.
International Federated Wearable Motor Monitoring in Young Children With Spinal Muscular Atrophy: Active-NBS Study
NIH registered NCT07543003, an international observational study evaluating wearable-derived remote motor monitoring in young children with spinal muscular atrophy (SMA). The study will recruit up to 60 SMA patients and 30 healthy controls over a maximum of 30 months using the Syde and MAIJU wearable devices worn at home, without additional hospital visits. The federated data model enables collaborative sites across the UK and internationally to collect harmonised motor development data.
BECOME-D Intervention Pilot for Dementia, NCDs, Mental Health
NIH ClinicalTrials.gov has registered a new pilot study (NCT07543341) evaluating the BECOME-D behavioral intervention adapted for individuals with dementia or mild cognitive impairment and their caregivers. The study targets co-occurring noncommunicable diseases (diabetes, hypertension) and common mental disorders (depression, anxiety) using community health worker-delivered skills-based training adapted to cognitive capacities. This is a research study registration with no compliance obligations for external parties.
Phase 3 DEXmedetomidine vs Midazolam for Delirium in Critically Ill Children
NIH has registered a Phase 3 clinical trial (NCT07542990) evaluating dexmedetomidine as first-line sedation in critically ill children requiring mechanical ventilation for more than 12 hours. The trial will compare dexmedetomidine against midazolam, measuring whether it reduces the proportion of children experiencing at least one delirium episode during their ICU stay. Participants are randomized to receive sedation per study protocol.
System health light service app
USPTO granted patent US12605069B2 to Drägerwerk AG & Co. KGaA for a system that transmits health status codes from a first device lacking an alphanumeric display to a second device used by a service technician. The system uses lights and/or sounds from the first device to encode health status information. The second device decodes the series of blinks or sounds to determine the transmitted health status code and may provide repair information or communicate with a remote computer for decoding assistance. The patent contains 19 claims and was filed on June 8, 2023.
Washington University Cardiac Ablation Patent Granted
The USPTO granted US Patent 12605070B2 to Washington University covering a method for selecting ablation targets for non-invasive cardiac arrhythmia treatment using segmented mapping models. The patent names Clifford Robinson, Phillip Cuculich, and Geoffrey Hugo as inventors and contains 13 claims with filing date May 31, 2022.
OPTOMED PLC Ophthalmic Apparatus Alignment Method
USPTO granted Patent US12605068B2 to OPTOMED PLC for an ophthalmic apparatus with an alignment arrangement that outputs converging alignment light rays forming a predetermined reflection pattern on a target plane. The apparatus includes a communication interface that outputs reflection pattern information from the posterior surface of the eye's crystalline lens to guide or control user positioning by finding the working distance where the predetermined pattern shape appears on the posterior surface.
US12605064B2 Refractive Pattern Patent Granted
The USPTO granted US Patent 12605064B2 to Shenzhen Thondar Technology Co., Ltd. covering a method and device for generating refractive patterns using fundus imaging of the human eye. The patent includes claims for capturing fundus images, calculating image resolutions, confirming target resolutions, generating a refractive matrix, and producing a refractive pattern. The patent names Ningli Wang, Xuechuan Dong, Yequan Huang, Yan Cui, and Jingyun Guo as inventors.
Olympus Winter & Ibe Patent for Albarran and Pull Wire Carrier
The USPTO granted patent US12605052B2 to Olympus Winter & Ibe GmbH for an Albarran and pull wire carrier assembly used in endoscopic instruments. The invention includes a pull wire carrier with a through-bore for a tubular shaft and a receptacle for a releasable cover element, with pull wires fixable between the carrier and cover. The patent contains 12 claims.
Verily Health Inc. Patent US12605063B2 — Visual Acuity Measurement in VR Headset
The USPTO granted Patent US12605063B2 to Verily Health Inc. on April 21, 2026. The patent covers a dual-display virtual reality headset with dichroic filter optics configured for automated visual acuity testing, using a smaller secondary display synchronized with pixel-control circuitry to present test patterns. The application was filed March 30, 2023, with 20 claims allowed.
Automatic Pupil Detection Method System Google
The USPTO granted patent US12605065B2 to Google LLC for a method and system of detecting pupillary positions on a subject's head. The system uses a camera and light source positioned in front of the subject to capture image data, detect the subject's face, identify up to two eyes, detect the reflection of the light source on each eye, and estimate pupillary position based on the light source reflection. The patent also covers determination of interpupillary distance, left pupil distance, and right pupil distance from the estimated pupillary positions. The patent was filed on July 27, 2020, and contains 19 claims.
Optical element movement mechanism for multi-modality ophthalmic imaging systems
USPTO granted US Patent 12605067B2 to Optos plc for an optical element movement mechanism in multi-modality ophthalmic imaging systems. The mechanism rotates optical elements to alternate between imaging modes by moving elements into and out of optical paths. The patent contains 14 claims.
Neuroptics Inc. Anisocoria Monitoring Patent US12605066B2 Granted April 21 2026
The USPTO granted patent US12605066B2 to Neuroptics, Inc. on April 21, 2026, covering methods, systems, and devices for monitoring anisocoria and asymmetry of pupillary reaction to stimulus. The patent discloses synchronized recording and display of bilateral pupil response images in response to the same stimulus. The patent contains 3 claims and spans multiple CPC classifications including A61B 3/112, A61B 3/14, and related medical device and healthcare informatics categories.
Intuitive Surgical Patent: Axial Support Device
USPTO has granted U.S. Patent No. US12605053B2 to Intuitive Surgical Operations, Inc. for flexible elongate devices with axial support structures. The patent covers articulable body portions with transverse support segments and tubular struts for use in surgical applications. The patent contains 23 claims and was filed on June 5, 2024.