Novel CXC receptor ligands from GCP2

USPTO published patent application US20260092091A1 for novel polypeptide ligands of CXCR1 and/or CXCR2 derived from GCP2. The application (No. 19120219) was filed October 11, 2023, by inventors Kouvatsos, Day, Dell'Accio, and Caxaria. The invention covers polynucleotides encoding the ligands, compositions, and uses thereof.

NGF Mutein Production Process Patent Application

Chiesi Farmaceutici SpA filed USPTO patent application US20260092090A1 on April 2, 2026, for a process producing nerve growth factor (NGF) and muteins at high purity from recombinant sources. The muteins may exhibit improved detectability and reduced nociceptive activity compared to wildtype human NGF. Application No. 19265384 was filed July 10, 2025.

Recombinant Vaccine Against Helminths in Pichia pastoris

USPTO published patent application US20260092089A1 by Fundação Oswaldo Cruz disclosing recombinant production of Sm14 Schistosoma mansoni vaccine antigen using genetically engineered Pichia pastoris strains with methanol-inducible (AOX1) and constitutive (GAP) promoters. The application covers synthetic gene construction, fermentation processes, and protein purification methods scalable for industrial vaccine manufacturing.

Variant Anti-Viral Polypeptides

The USPTO published patent application US20260092088A1 for variant lectin anti-viral polypeptides filed by inventors Cristina BONGIORNI, Mai DU, David A. ESTELL, Keith FROGUE, Amy Deming LIU, and Darshana KADEKAR. The application covers engineered anti-viral lectin compositions for treating and preventing viral diseases in animals, with a filing date of September 19, 2023.

Method of Making a Pharmaceutical Composition Comprising a p80 Protein

USPTO published patent application US20260092087A1 by Prime Bio, Inc. covering a method for producing recombinant p80 polypeptide using E. coli culture with L-Arabinose induction. The p80 protein functions as a tight junction modulator to enhance intestinal permeability for therapeutic agents. The application (No. 19352451) was filed October 7, 2025.

Princeton University patent for cloacaenodin, antimicrobial lasso peptide

Princeton University patent for cloacaenodin, antimicrobial lasso peptide

Near-zero labor force growth affects breakeven employment, GDP

Federal Reserve economists Seth Murray and Ivan Vidangos published a FEDS Notes analysis on April 2, 2026, examining how projected near-zero labor force growth in the United States will affect breakeven employment levels and potential GDP growth. The paper highlights that the labor force is expected to grow at near-zero rates starting in 2026, driven by weak population growth from low net immigration and declining labor force participation due to population aging. The research notes that this would represent an unprecedented shift in U.S. labor market dynamics.

FIAU Enforcement Process and Settlement Provisions Training

The FIAU Malta announced two legal notices (LN 82 and LN 83 of 2026) amending the PMLFTR and CBAR Regulations, introducing settlement agreement powers for administrative penalties and transitional provisions for out-of-court settlements in pending appeals. The FIAU is hosting training sessions on April 2, 2026, to explain the forthcoming Enforcement Guide and new settlement framework.

DOCSIS Profile Optimization for Cable Networking

USPTO published patent application US20260095343A1 for DOCSIS profile optimization in cable networking systems. The application, filed December 8, 2025, discloses methods for managing and optimizing profiles assigned to user devices over network communication channels using memorization matrices. Inventors are Karthik Sundaresan, Gregory C. White, and Jingjie Zhu.

Federated Fraud Detection with Homomorphic Encryption

The USPTO published Patent Application US20260094206A1 for an apparatus and method enabling federated fraud detection across multiple entities using privacy-preserving techniques including homomorphic encryption and federated learning. The system ingests signals from financial, transactional, or compliance data exchanges, normalizes and enriches the data, and computes risk scores using statistical or neural network models to generate alerts and route operations. Inventors are Sebastian Pascal and Marie France Pascal.