USPTO Patent Application: Antibody Conjugates with Bis-MSPT Linker

The USPTO has published a new patent application (US20260083854A1) detailing antibody conjugates that utilize a bis-MSPT linker. The application, filed by inventors Riazul Alam, Guillermo S. Cortez, and Yan Wang, describes pharmaceutical compositions and methods related to these conjugates.

USPTO Patent Application: CD70 Antibody Drug Conjugates

The USPTO has published a new patent application (US20260083853A1) detailing CD70 antibody drug conjugates for treating cancer and autoimmune diseases. The application was filed on October 25, 2023, by inventors Xiao Shang and others.

USPTO Patent Application for Peptoid Nucleic Acid Delivery

The USPTO has published a patent application (US20260083769A1) detailing novel hydroxyalkyl-capped cationic peptoids for nucleic acid delivery. The application, filed by inventors from various institutions, describes compositions and methods for delivering polyanionic compounds to cells and eliciting immune responses.

Emergency Sirens Test Scheduled for April 7

The Delaware Division of Public Health announced a scheduled test of emergency sirens for Tuesday, April 7, 2026, at 7:20 PM. This test is part of the state's emergency preparedness measures, particularly concerning the Salem/Hope Creek Nuclear Generating Station.

MDE Approves Air Permit for Frederick Data Center

The Maryland Department of the Environment (MDE) has approved an air quality permit for Amazon Data Services, Inc. for emergency backup generators at a new data center campus in Frederick. The permit ensures generators will only be used during emergencies and includes continuous oversight under the Clean Air Act.

ICO fines TMAC Ltd £100,000 for PECR breaches

The UK's Information Commissioner's Office (ICO) has fined TMAC Ltd £100,000 for breaches of the Privacy and Electronic Communications Regulations (PECR). The company made over 260,000 unsolicited marketing calls to individuals registered on the Telephone Preference Service and failed to provide required caller information.

EPA Proposes Hazardous Waste Delisting for WRB Refining

The Environmental Protection Agency (EPA) has proposed to delist hazardous waste generated by WRB Refining from the hazardous waste regulations under the Resource Conservation and Recovery Act (RCRA). This proposed rule is open for public comment.

EPA Approves Iowa Air Quality Regulations Revisions

The Environmental Protection Agency (EPA) has published a proposed rule to approve revisions to Iowa's air quality regulations. This action is part of the EPA's review process for state implementation plans under the Clean Air Act. The public has a comment period to provide input on the proposed approval.

EPA TSCA Confidential Business Information Renewal for OMB Review

The Environmental Protection Agency (EPA) has submitted a renewal request for its collection of TSCA Confidential Business Information (CBI) to the Office of Management and Budget (OMB) for review and approval. This notice provides an opportunity for public comment on the information collection activities.

EPA Modifies Privacy Act System of Records

The EPA is proposing to modify a Privacy Act system of records to add a new routine use as required by Executive Order 14249 and OMB Memorandum M-25-32. The agency is also updating contact information for the Agency Privacy Officer. The comment period for this notice closes on April 27, 2026.