Indiana Amends Pipeline Safety Regulations 170 IAC 5-3

The Indiana Utility Regulatory Commission (IURC) is amending pipeline safety regulations under 170 IAC 5-3. This rulemaking affects definitions, calibration of instruments, pre-tested pipe, farm taps, construction packets, establishment of MAOP on distribution systems, acquisition of pipe or components, and waivers of compliance. Informal comments are due by April 6, 2026.

Gooding v. Nevro Corporation et al - Product Liability

A new product liability case, Gooding v. Nevro Corporation et al, was filed in the U.S. District Court for the Northern District of California. The complaint alleges personal injury and product liability claims against the defendants. The filing includes a request for injunction against the US government/official or APA vacatur.

California AG Sues Trump Administration Over Oil Pipeline Order

California Attorney General Rob Bonta has filed a lawsuit against the Trump Administration challenging the Department of Energy's order that purports to authorize the restart of two onshore oil pipelines. The lawsuit argues the order unlawfully supersedes state law and court orders, infringing on California's sovereign power.

AG Bonta Sues Trump Administration Over Discriminatory USDA Grant Conditions

California Attorney General Rob Bonta, leading a coalition of 21 attorneys general, filed a lawsuit challenging the Trump Administration's attempt to impose discriminatory conditions on USDA grants. The lawsuit argues that these new conditions, related to immigration, gender ideology, transgender athletes, and DEI, exceed USDA's statutory authority and violate the U.S. Constitution and APA.

EPO Patent: Therapeutic Cells Using Nucleic Acid Nanocarriers

The European Patent Office has published patent application EP4711465A2 concerning compositions and methods for programming therapeutic cells using targeted nucleic acid nanocarriers. The patent, filed by Fred Hutchinson Cancer Center, describes a "hit and run" approach for transient expression leading to permanent therapeutic changes in modified cells.

Klotho mRNA Patent EP4711452A2 Published

The European Patent Office published patent application EP4711452A2 on March 18, 2026, related to Klotho messenger-RNA (mRNA) technology. The patent application was filed by ADvantage Therapeutics, Inc. and details specific compositions and sequences for Klotho polypeptides.

Ionis Pharmaceuticals - Conjugated Antisense Compounds Patent

The European Patent Office has published patent application EP4711459A2 for Ionis Pharmaceuticals, detailing conjugated antisense compounds, specifically those conjugated to N-Acetylgalactosamine. This publication relates to advancements in oligonucleotide therapeutics and their potential applications.

EPO Publishes Patent Application for Porous Hydrogel Scaffolds

The European Patent Office (EPO) has published a patent application (EP2026030014A1) for porous hydrogel scaffolds created by cryogelation. The publication date is March 18, 2026, and it details potential applications in biotechnology and medical fields. The designation of inventors has not yet been filed.

EPO Patent Application EP2026030013A1: Clearing Senescent Cells

The European Patent Office has published patent application EP2026030013A1 concerning a method for clearing senescent cells using natural antibodies. The application was published on March 18, 2026, and lists designated states across Europe.

TAQ DNA POLYMERASE MUTANT Patent Publication

The European Patent Office has published patent application EP2026030656A1 concerning a TAQ DNA POLYMERASE MUTANT. The publication date is March 18, 2026. The inventors have not yet filed their designation.