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EPO Patent: Therapeutic Cells Using Nucleic Acid Nanocarriers

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Published March 18th, 2026
Detected March 24th, 2026
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Summary

The European Patent Office has published patent application EP4711465A2 concerning compositions and methods for programming therapeutic cells using targeted nucleic acid nanocarriers. The patent, filed by Fred Hutchinson Cancer Center, describes a "hit and run" approach for transient expression leading to permanent therapeutic changes in modified cells.

What changed

This document is a publication of a European patent application (EP4711465A2) by Fred Hutchinson Cancer Center. It details "compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers," specifically focusing on a technique for transient nucleic acid expression to achieve permanent therapeutic changes in cells, referred to as "hit and run" effects. The patent application is classified under IPC C12N 15/62 and is designated for multiple European states.

As this is a patent publication, it does not impose direct compliance obligations on regulated entities. However, it represents a development in the field of cell therapy and gene editing technologies. Companies involved in biotechnology, pharmaceutical research, and cell therapy development should be aware of this patent's claims as it may impact future research, development, and commercialization strategies in this area. No specific compliance deadlines or actions are mandated by this publication.

Source document (simplified)

← EPO Patent Bulletin

COMPOSITIONS AND METHODS TO PROGRAM THERAPEUTIC CELLS USING TARGETED NUCLEIC ACID NANOCARRIERS

Publication EP4711465A2 Kind: A2 Mar 18, 2026

Applicants

Fred Hutchinson Cancer Center

Inventors

STEPHAN, Matthias, MOFFETT, Howell F.

Abstract

Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as "hit and run" effects.

IPC Classifications

C12N 15/62 20060101AFI20230309BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

View original document →

Named provisions

Compositions and Methods to Program Therapeutic Cells Using Targeted Nucleic Acid Nanocarriers

Source

Analysis generated by AI. Source diff and links are from the original.

Classification

Agency
EPO
Published
March 18th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
EP4711465A2

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing 3254.1 Biotechnology
Activity scope
Cell Therapy Gene Editing
Geographic scope
European Union EU

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Research & Development
Topics
Biotechnology Gene Therapy

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