Compositions and Methods for Treatment of Liquid Cancers

The USPTO issued Patent US12594301B2 to Beam Therapeutics Inc. for genetically modified immune cells with enhanced anti-neoplasia activity and methods for treating liquid cancers. The patent, with 12 claims, covers compositions providing resistance to immune suppression and decreased graft-versus-host reaction risk. No compliance obligations or deadlines are associated with this patent grant.

Exosomes from stem cells for NASH treatment, patent granted

USPTO granted Patent US12594303B2 to BREXOGEN INC. on April 7, 2026. The patent covers pharmaceutical compositions comprising exosomes derived from induced pluripotent stem cell-derived mesenchymal stem cells for preventing or treating non-alcoholic steatohepatitis (NASH). The patent application was filed August 12, 2020, and contains 2 claims.

CMOS Potentiostat for ENFM Glucose Sensor

USPTO granted Patent US12594011B2 to the University of South Florida on April 7, 2026, covering a CMOS-based low-power potentiostat circuit integrated with an ENFM-based amperometric glucose sensor. The invention includes a working electrode with electrospun nanofibrous membrane, reference and counter electrodes, voltage control unit, and transimpedance amplifier for measuring current flow corresponding to blood glucose levels. The patent contains 20 claims.

Method and device for high field strength electrotransfection of microvesicles and cells

The USPTO granted Patent US12594556B2 to The Charles Stark Draper Laboratory, Inc. covering a method and device for high field strength electrotransfection of microvesicles and cells using microfluidic arrangements under elevated pressure. The patent contains 18 claims and lists four inventors: Jonathan R. Coppeta, Timothy J. Biliouris, Daniel F. King, and Vishal Tandon.

Simultaneous gene editing and haploid induction

USPTO granted patent US12593765B2 to Syngenta Crop Protection AG covering methods for simultaneous gene editing and haploid induction in crops. The patent describes using a transformed haploid inducing line as a parent in plant crosses, where gene editing machinery operates during embryonic development after one set of parental chromosomes is lost. Inventors are Qiudeng Que and Timothy Kelliher.

Compositions and methods for protecting against airborne pathogens and irritants

USPTO granted Patent US12594285B2 to Applied Biological Laboratories, Inc. covering antimicrobial compositions for protecting respiratory membranes against airborne pathogens including bacteria, fungi, and viruses. The patent contains 8 claims and relates to methods for preventing and treating respiratory infections through inhalation or ingestion of pathogens.

CBL inhibitors and compositions for expansion of immune cells

The USPTO granted Nurix Therapeutics Patent US12594263B2 covering CBL inhibitors and compositions for expanding immune cells to enhance cell-based immunotherapy efficacy. The patent includes 31 claims and lists inventors Jennifa Gosling, Arthur T. Sands, Sarah Anne Whelan, and Michael Lotze. This biotechnology patent covers methods and compositions related to CPC classifications in A61K (pharmaceutical preparations) and C12N (microorganisms/cells).

CRISPR Compositions and Methods for PCSK9 Gene Targeting

USPTO granted Scribe Therapeutics Patent US12594349B2 covering CRISPR-based gene repressor systems for targeting PCSK9. The patent includes 24 claims for fusion proteins comprising DNA binding domains and guide RNAs useful in repressing PCSK9 transcription. The patent lists 8 inventors including Jason Fernandes, Sean Higgins, and Sarah Denny.

Smartphone application with pop-open soundwave guide for diagnosing otitis media

The USPTO granted Patent US12594006B2 to Wavely Diagnostic Inc. for a smartphone application system designed to remotely detect otitis media (ear infections) in children for telemedicine use. The patent covers a pop-open soundwave guide that directs audio signals from a smartphone speaker to the eardrum and back to the microphone for analysis. The patent includes 5 claims and was filed on September 30, 2022.

Photoacoustic imaging spectral image processing apparatus and method

USPTO granted Patent US12593985B2 to Canon Kabushiki Kaisha for an image processing apparatus and method using photoacoustic imaging technology. The patent covers spectral image acquisition based on photoacoustic signals at multiple wavelengths, contrast agent detection, and display control for distinguishing contrast agent regions from other tissue. The patent has 31 claims and names five inventors.