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Compositions and Methods for Treatment of Liquid Cancers

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Published April 7th, 2026
Detected April 7th, 2026
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Summary

The USPTO issued Patent US12594301B2 to Beam Therapeutics Inc. for genetically modified immune cells with enhanced anti-neoplasia activity and methods for treating liquid cancers. The patent, with 12 claims, covers compositions providing resistance to immune suppression and decreased graft-versus-host reaction risk. No compliance obligations or deadlines are associated with this patent grant.

What changed

The USPTO granted Patent US12594301B2 to Beam Therapeutics Inc. covering compositions and methods for treating liquid cancers using genetically modified immune effector cells. The patent, application No. 17762690 filed September 25, 2020, includes 12 claims spanning multiple CPC classifications related to immune cell engineering (C12N 5/0636) and therapeutic proteins (C07K 14/705). The inventors include Jason Michael Gehrke, Aaron D. Edwards, Ryan Murray, and Waseem Qasim.

Patent holders should maintain documentation of this grant for IP portfolio management. No immediate compliance actions are required as this is an IP issuance rather than a regulatory obligation. Third parties should be aware that the patented technology is now exclusively available to Beam Therapeutics for the duration of the patent term.

Source document (simplified)

← USPTO Patent Grants

Compositions and methods for treatment of liquid cancers

Grant US12594301B2 Kind: B2 Apr 07, 2026

Assignee

Beam Therapeutics Inc.

Inventors

Jason Michael Gehrke, Aaron D. Edwards, Ryan Murray, Waseem Qasim

Abstract

As described below, the present invention features genetically modified immune cells having enhanced anti-neoplasia activity, resistance to immune suppression, and decreased risk of eliciting a graft versus host reaction, or a combination thereof. The present invention also features methods for producing and using these modified immune effector cells.

CPC Classifications

A61K 35/12 A61K 40/11 A61K 40/22 A61K 40/31 A61K 40/418 A61K 40/4224 A61K 2035/124 C12N 5/0636 C12N 2510/00 C07K 14/705

Filing Date

2020-09-25

Application No.

17762690

Claims

12

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Source

Analysis generated by AI. Source diff and links are from the original.

Classification

Agency
USPTO
Published
April 7th, 2026
Instrument
Notice
Legal weight
Binding
Stage
Final
Change scope
Minor
Document ID
US12594301B2

Who this affects

Applies to
Pharmaceutical companies
Industry sector
3254.1 Biotechnology
Activity scope
Patent Issuance
Geographic scope
United States US

Taxonomy

Primary area
Intellectual Property
Operational domain
Legal
Topics
Healthcare Pharmaceuticals

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