Simultaneous gene editing and haploid induction

ChangeBridge: Patent Grants - Biotech (C12N)

Published April 7th, 2026

Detected April 7th, 2026

Summary

USPTO granted patent US12593765B2 to Syngenta Crop Protection AG covering methods for simultaneous gene editing and haploid induction in crops. The patent describes using a transformed haploid inducing line as a parent in plant crosses, where gene editing machinery operates during embryonic development after one set of parental chromosomes is lost. Inventors are Qiudeng Que and Timothy Kelliher.

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What changed

USPTO granted patent US12593765B2 to Syngenta Crop Protection AG covering methods for simultaneous gene editing and haploid induction in crops. The patent describes using a transformed haploid inducing line as a parent in plant crosses, where gene editing machinery is delivered during pollination and operates during embryonic development after one set of parental chromosomes is lost, producing at least one haploid progeny with edited genes. The patent contains 10 claims under CPC classification C12N 15/82.

Patent holders should review the claims to understand the scope of protection and ensure their own gene editing and haploid induction technologies do not infringe. This grant confirms intellectual property rights in the agricultural biotechnology space; no compliance deadlines or regulatory obligations are imposed.

Source document (simplified)

← USPTO Patent Grants

Simultaneous gene editing and haploid induction

Grant US12593765B2 Kind: B2 Apr 07, 2026

Assignee

SYNGENTA CROP PROTECTION AG

Inventors

Qiudeng Que, Timothy Kelliher

Abstract

The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it encodes cellular machinery capable of editing genes. The transformed haploid inducing line is used as a parent in a cross between two plants. During pollination, the parental gametes fuse to form an embryo; and the gene editing machinery is also delivered to the embryo at this time. During embryonic development, one set of parental chromosomes are lost, and the gene editing machinery operates on the remaining set of chromosomes. Thus, at least one haploid progeny with edited genes is produced from the cross.