CMOS Potentiostat for ENFM Glucose Sensor

ChangeBridge: Patent Grants - Biotech (C12N)

Published April 7th, 2026

Detected April 7th, 2026

Summary

USPTO granted Patent US12594011B2 to the University of South Florida on April 7, 2026, covering a CMOS-based low-power potentiostat circuit integrated with an ENFM-based amperometric glucose sensor. The invention includes a working electrode with electrospun nanofibrous membrane, reference and counter electrodes, voltage control unit, and transimpedance amplifier for measuring current flow corresponding to blood glucose levels. The patent contains 20 claims.

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What changed

The USPTO issued Patent US12594011B2 to inventors Kavyashree Puttananjegowda, Sylvia Thomas, and Arash Takshi (assignee: University of South Florida) for a glucose sensing system combining CMOS potentiostat technology with ENFM-based electrodes on a silicon chip. The system measures current flow between working and counter electrodes, where current strength corresponds to glucose concentration in a blood sample. The patent was filed as Application No. 18164525 on February 3, 2023, and includes CPC classifications related to electrochemical sensors (G01N 27/3271) and enzymes (C12N 9/0006).\n\nThis is a routine patent grant announcement with no compliance obligations. Entities interested in glucose sensor technology or CMOS-based potentiostat circuits may review the patent claims for freedom-to-operate considerations or licensing opportunities. No action is required from regulated entities, and there are no penalties or enforcement implications associated with this issuance.

Source document (simplified)

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CMOS-based low-power, low-noise potentiostat circuit and its integration with an ENFM-based glucose sensor

Grant US12594011B2 Kind: B2 Apr 07, 2026

Assignee

UNIVERSITY OF SOUTH FLORIDA

Inventors

Kavyashree Puttananjegowda, Sylvia Thomas, Arash Takshi

Abstract

The present disclosure presents glucose sensing methods and systems. One such system comprises an electrospun-nanofibrous-membrane (ENFM)-based amperometric glucose sensor integrated on a silicon chip, in which the glucose sensor has a working electrode, a reference electrode, and a counter electrode, wherein the working electrode comprises an ENFM-based sensing electrode. The system further comprises a potentiostat circuit integrated on the silicon chip such that the potentiostat circuit comprises a voltage control unit to control a voltage difference between the working electrode and the reference electrode and a transimpedance amplifier to measure a current flow between the working electrode and the counter electrode, in which a strength of the current flow corresponds to an amount of glucose present in a sample of blood on the glucose sensor.