Bi-specific Peptides for Cancer Treatment Granted Patent

The USPTO has granted a patent (US12583888B2) to the University of Tartu for bi-specific peptides designed to target cancer cells and the extracellular matrix. These peptides bind to fibronectin extra domain B (FN-EDB) and/or tenascin-C C domain (TNC-C). The patent was granted on March 24, 2026.

USPTO Patent Grant for Peptides Treating Type 1 Diabetes

The USPTO has granted patent US12583891B2 to PHOENIX ALPHA for peptides and methods used in the treatment of type 1 diabetes. The patent covers specific peptide sequences and their application in generating cytolytic CD4+ T cells.

USPTO Patent Grant US12583892B2: Conus Peptides for Neurodegenerative Conditions

The USPTO has granted patent US12583892B2 to Technion Research and Development Foundation Limited for modified Conantokin peptides and their use in treating neurodegenerative conditions. The patent covers specific peptide forms, nucleic acids encoding them, and compositions for modulating NMDA receptors.

DC DISB Receives CSBS Mortgage Accreditation

The DC Department of Insurance, Securities and Banking (DISB) has achieved accreditation status for mortgage supervision from the Conference of State Bank Supervisors (CSBS). This accreditation signifies that the Department meets national standards for state supervision of mortgage lenders, promoting consumer protection and a sound financial regulatory system.

EPA Approves SWCAA Delegation for Incineration Unit Pollutants

The EPA is approving the delegation of authority to the Southwest Clean Air Agency (SWCAA) for implementing and enforcing Federal plan requirements for several categories of incineration units in Washington State. This action amends regulatory text in accordance with the Clean Air Act.

PHMSA Announces $98 Million for Pipeline Infrastructure Modernization

The Pipeline and Hazardous Materials Safety Administration (PHMSA) announced an investment of nearly $100 million through its Natural Gas Distribution Infrastructure Safety and Modernization grant program. This funding aims to repair, replace, or modernize aging and leak-prone natural gas distribution pipeline systems across the United States.

FCC Information Collection Review

The Federal Communications Commission (FCC) has published a notice regarding an information collection that is currently under review. This notice indicates that the comment period for this review will close on May 26, 2026.

FCC Proposes Rule Reforms for Network Modernization

The Federal Communications Commission (FCC) has proposed new rule reforms aimed at accelerating network modernization and transitioning to an all-IP future. This initiative seeks to update legacy regulations to better suit modern telecommunications infrastructure.

FCC Information Collection Review

The Federal Communications Commission (FCC) has published a notice regarding an information collection that is currently under review. The notice indicates that the public comment period for this review will close on May 26, 2026.

FCC Open Commission Meeting on Offshore Call Centers

The Federal Communications Commission (FCC) announced an open commission meeting scheduled for March 26, 2026. The meeting agenda includes discussions on offshore call centers. This notice serves as an announcement of the meeting details.

Energy Department Privacy Act System of Records Notice DOE-21

The Department of Energy is reestablishing a Privacy Act System of Records notice (SORN) for the Asset Readiness Management System (ARMS), designated DOE-21. This system is used by the Office of Nuclear Incident Response to track personnel and equipment for federal responses to nuclear or radiological emergencies.

Energy Department Privacy Act System of Records Notice Modification

The Department of Energy (DOE) is modifying its Privacy Act System of Records Notices (SORNs) by adding routine uses that permit disclosure of records to the Department of the Treasury. These disclosures are for identifying, preventing, or recouping fraud and improper payments, in accordance with Executive Order 14249.

Energy Department Renews Environmental Management Advisory Board

The Department of Energy has published a notice regarding the renewal of the Environmental Management Site-Specific Advisory Board. The projected renewal date for the board is April 7, 2026. This notice serves to inform the public about the continuation of this advisory body.

NIST Cybersecurity Framework 2.0 Informative References Quick-Start Guide

NIST has released an initial public draft of the SP 1347, 'NIST Cybersecurity Framework 2.0: Informative References Quick-Start Guide.' This document explains informative references and their role in achieving CSF 2.0 outcomes, introducing NIST tools for managing them and exploring AI's support for reference data.

PRA Fines Bank of London £2m for Integrity Failures

The Prudential Regulation Authority (PRA) has fined The Bank of London Group Limited and its parent company Oplyse Holdings Limited £2 million for misleading the PRA about their capital positions and failing to act with integrity. This is the PRA's first finding against a firm for acting without integrity and its first enforcement action against a parent financial holding company.

William Jimenez Appeal - Ammunition Possession Sentence

The Second Circuit Court of Appeals affirmed the District Court's judgment against William Jimenez, who pleaded guilty to possessing ammunition after a felony conviction. The court upheld the special conditions of supervised release, including electronic device searches and mental health counseling, and found that an appeal waiver barred challenges to his 105-month sentence.

Safdieh v. Commissioner - Tax Court Appeal on Penalty Assessment

The Second Circuit Court of Appeals reversed a Tax Court decision, holding that the Commissioner of Internal Revenue may assess penalties under I.R.C. § 6038(b) through administrative assessment rather than requiring a federal district court judgment. This decision impacts how the IRS collects penalties for failure to report control of foreign businesses.

United States v. Aryeetey - Firearm Possession Appeal

The Second Circuit Court of Appeals affirmed the conviction and sentence of Ivanjoel Aryeetey for being a felon in possession of a firearm. The court found no abuse of discretion in admitting DNA evidence and deemed the sentence substantively reasonable.

Kellogg v. Nichols - Judicial Immunity and Firearms Licensing

The Second Circuit Court of Appeals amended its opinion in Kellogg v. Nichols, affirming the dismissal of claims against a New York state court judge regarding firearms license applications. The court reaffirmed that judicial officers have absolute immunity for decisions made in their judicial capacity and that Article III's case-or-controversy requirement bars official-capacity claims against them for injunctive and declaratory relief.

Peña Garcia v. Department of Labor - Permanent Disability Claim Review

The Second Circuit Court of Appeals denied a petition for review concerning the reimbursement of medical cannabis edibles for a permanently disabled worker under the Longshore and Harbor Workers' Compensation Act. The court affirmed the Department of Labor's decision that marijuana's federal Schedule I classification prevents its accepted medical use, thus precluding coverage.

Miller v. Lamanna - Court Opinion on Equal Protection Claim

The Second Circuit Court of Appeals vacated a district court's dismissal of a former corrections officer's race discrimination and retaliation claims. The appellate court found the district court erred by converting a summary judgment motion into a Rule 12(b)(6) dismissal motion, considering only the complaint's allegations.

Bugliotti v. Republic of Argentina - Sovereign Bond Dispute

The Second Circuit Court of Appeals partially affirmed and partially vacated a district court's dismissal of a lawsuit by bondholders against the Republic of Argentina. The court found that some of the bondholders' claims for defaulted sovereign bond payments are timely under New York law, and that they now have the authority under Argentine law to sue.

GEICO v. Mayzenberg - Insurance No-Fault Benefits

The Second Circuit Court of Appeals vacated a district court judgment in favor of GEICO in GEICO v. Mayzenberg. The court ruled that GEICO could not deny no-fault insurance benefits based on alleged patient referral kickbacks, citing a clarification from the New York Court of Appeals regarding the Eligibility Regulation.

Sacaza v. City of New York - Qualified Immunity Ruling

The Second Circuit Court of Appeals reversed a lower court's decision, ruling that a New York City detective is entitled to qualified immunity in a false arrest and malicious prosecution case. The court found that arguable probable cause existed for the arrest and charges against Dennis Sacaza, despite conflicting video evidence.

Jin v. City of New York - Qualified Immunity Appeal

The Second Circuit Court of Appeals reversed a district court's denial of qualified immunity to NYPD officers in a false arrest claim brought by Guo Hua Jin. The appellate court found that arguable probable cause existed for Jin's arrest, overturning the lower court's decision and dismissing the claim against the officers.

Asylum, Withholding, CAT Case 22-6392 Decided

The Second Circuit Court of Appeals granted in part a petition for review in a case involving asylum and withholding of removal. The court remanded the case to the Board of Immigration Appeals (BIA) to determine if the petitioner would be eligible for asylum or withholding of removal but for the material support bar. The petition for review of the denial of relief under the Convention Against Torture was denied.

Suarez v. Sullivan - Eighth Amendment Conditions of Confinement and Medical Needs

The Second Circuit Court of Appeals vacated a district court's grant of summary judgment in a case brought by Elvin Suarez against New York State correctional and mental health officials. The court found genuine disputes of material fact regarding alleged Eighth Amendment violations related to conditions of confinement and medical needs.

2nd Circuit Court of Appeals - Denial of Rehearing En Banc

The Second Circuit Court of Appeals denied a petition for rehearing en banc in cases 23-258 and 23-354. While the majority denied the petition, several judges filed opinions concurring in or dissenting from the denial, indicating ongoing judicial debate on the underlying issues.

Russell v. Scott - Sexual Abuse Allegations by Pretrial Detainee

The Second Circuit Court of Appeals affirmed the denial of qualified immunity to a corrections officer accused of sexually abusing a pretrial detainee. The court clarified the distinct constitutional standards for pretrial detainees under the Fourteenth Amendment compared to convicted prisoners under the Eighth Amendment.

Leadenhall Capital Partners LLP v. Advantage Capital Holdings - Preliminary Injunction Appeal

The Second Circuit Court of Appeals vacated a district court's preliminary injunction freezing guarantor assets in Leadenhall Capital Partners LLP v. Advantage Capital Holdings. The court found that the plaintiffs failed to demonstrate a lien or equitable interest in the guarantors' assets, as required by Supreme Court precedent.

Parker v. Alexander - New York Law Preemption Case

The Second Circuit Court of Appeals has certified a question of New York law to the New York Court of Appeals regarding the preemption of the New York City Victims of Gender-Motivated Violence Protection Law by state laws. This case concerns whether the city's revival window for civil claims is superseded by the earlier revival periods established by the state's Child Victims Act and Adult Survivors Act.

CDC Milestone Tracker App User Surveys Notice

The Centers for Disease Control and Prevention (CDC) has posted a notice regarding user surveys for the CDC Milestone Tracker App. This notice provides information about the app and its associated surveys.

FDA Orange Book Excerpt Publication

The Food and Drug Administration (FDA) has posted an excerpt of the Orange Book on March 24, 2026. This publication provides information related to approved drug products and their patent and exclusivity status.

FDA Suitability Petition from Lachman Consulting Services

The Food and Drug Administration (FDA) has received a suitability petition from Lachman Consulting Services, Inc. The petition concerns a specific aspect of regulatory compliance for drug manufacturers. No documents are currently available for viewing or download.

PREMARIN Package Insert Revision

The U.S. Food and Drug Administration (FDA) has issued a final notice regarding a revision to the PREMARIN package insert. This update pertains to FDA New Drug Application (NDA) #004782. The notice is part of the agency's ongoing regulatory oversight of pharmaceutical product information.

FDA Acknowledgement Letter to Lachman Consulting Services, Inc.

The Food and Drug Administration (FDA) has issued an acknowledgement letter to Lachman Consulting Services, Inc. The document indicates that the FDA has received correspondence from the company. No further details or specific regulatory actions are outlined in the provided information.

FDA Proposes Draft Package Insert for Conjugated Estrogen Tablets

The U.S. Food and Drug Administration (FDA) has issued a draft package insert for Conjugated Estrogen Tablets. This proposal aims to update and standardize the labeling information provided to healthcare professionals and patients regarding the use, risks, and benefits of this medication.

CDC DELTA Cooperative Agreement Evaluation Notice

The Centers for Disease Control and Prevention (CDC) has issued a final notice regarding the evaluation of DELTA Cooperative Agreements. This notice was published on Regulations.gov and had a comment closing date.

EPA Visits Geocycle, Holcim Facilities for Scrap Tires

The Environmental Protection Agency (EPA) conducted visits to Geocycle and Holcim facilities to observe their processes for managing scrap tires. These visits are part of the EPA's ongoing efforts to gather information on tire management practices across the industry.

USMTA Reports Tire Recycling Progress

The General Services Administration (GSA) has published a notice regarding tire recycling progress as reported by the US Materials Management Association (USMTA). The notice highlights advancements and calls for continued collaboration among stakeholders to further recycling efforts.

EPA Document on CM Shredders Scrap Tire Business

The Environmental Protection Agency (EPA) has published a document concerning CM Shredders' scrap tire business. The document is available on Regulations.gov but is restricted due to copyright.

CDC Fact Sheet on Eastern Equine Encephalitis Virus

The Centers for Disease Control and Prevention (CDC) has issued a fact sheet providing information on Eastern Equine Encephalitis Virus (EEE). This fact sheet aims to educate the public and healthcare professionals about the virus, its transmission, symptoms, and prevention methods.

EPA Document Restricted Due to Copyright

The Environmental Protection Agency (EPA) has published a notice regarding a document that is restricted due to copyright. The content of the document is not available for public viewing on Regulations.gov.

EPA Carcinogen Risk Assessment Guidelines

The Environmental Protection Agency (EPA) has posted its guidelines for carcinogen risk assessment. These guidelines provide a framework for evaluating the potential cancer risks associated with various substances and exposures.

EPA - Microbial Risks in Groundwater Outbreaks

The Environmental Protection Agency (EPA) has published a document concerning microbial risks in groundwater outbreaks. This notice provides information and guidance related to public health and water quality.

EPA Comment from Sonny Pierce

The Environmental Protection Agency (EPA) has posted a public comment submitted by Sonny Pierce regarding a rulemaking. The comment is part of the public record for EPA-HQ-OW-2002-0026. This notice serves to make the comment publicly accessible.

Colorado Bill Restricts Child Abuse Record Access

Colorado Bill HB26-1234 proposes changes to access records of child abuse or neglect. The bill restricts the release of identifying data and information to authorized persons, with specific provisions for attorneys, designees, and individuals named in the record. It also requires county departments to establish processes for clients to access their case records.

Colorado Resolution on Ute Water Rights Obligations

The Colorado Legislature has introduced a resolution calling on the federal government to fulfill its obligations to the Southern Ute Indian Tribe and the Ute Mountain Ute Tribe regarding water rights. The resolution is currently under consideration.

Colorado Bill Increases Petroleum Storage Tank Fund Liability and Allows ASTM Standard Exceptions

Colorado SB26-122 proposes to increase the maximum liability of the petroleum storage tank fund for individual incidents from $2,000,000 to $2,500,000. The bill also allows the director of the division of oil and public safety to grant exceptions to ASTM International standards for petroleum products through rulemaking or policy guidance.

Barber & Cosmetologist Act Continuation

The Colorado Legislature is considering HB26-1181 to continue the "Barber and Cosmetologist Act" until 2037. The bill implements recommendations from a 2025 sunset review, including updating definitions, exempting certain services, and replacing gendered language.