Bi-specific Peptides for Cancer Treatment Granted Patent
Summary
The USPTO has granted a patent (US12583888B2) to the University of Tartu for bi-specific peptides designed to target cancer cells and the extracellular matrix. These peptides bind to fibronectin extra domain B (FN-EDB) and/or tenascin-C C domain (TNC-C). The patent was granted on March 24, 2026.
What changed
The United States Patent and Trademark Office (USPTO) has issued patent US12583888B2 to the University of Tartu for novel bi-specific peptides. These peptides are engineered to specifically bind to cancer cells and the extracellular matrix, particularly targeting fibronectin extra domain B (FN-EDB) and tenascin-C C domain (TNC-C). This patent grant signifies the recognition of novel therapeutic compositions and methods for cancer treatment.
While this is a patent grant and not a regulatory rule, companies involved in peptide-based cancer therapeutics, particularly those utilizing fibronectin or tenascin-C binding mechanisms, should be aware of this intellectual property. The patent may impact research and development efforts, licensing opportunities, and potential market exclusivity for similar technologies. No immediate compliance actions are required for regulated entities, but awareness of this granted patent is advisable for strategic planning.
Source document (simplified)
Bi-specific extracellular matrix binding peptides and methods of use thereof
Grant US12583888B2 Kind: B2 Mar 24, 2026
Assignee
University of Tartu
Inventors
Tambet Teesalu, Prakash Lingasamy
Abstract
Disclosed are compositions, compounds, and methods relating to peptides that can target and home to cancer, tumors, and extracellular matrix. This is based on the discovery of peptides that can specifically bind to fibronectin extra domain B (FN-EDB), tenascin-C C domain (TNC-C), or both.
CPC Classifications
C07K 7/08 C07K 7/06 C07K 14/00 A61K 38/00 A61P 35/00
Filing Date
2020-02-03
Application No.
17428484
Claims
24
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