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Bi-specific Peptides for Cancer Treatment Granted Patent

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Published March 24th, 2026
Detected March 24th, 2026
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Summary

The USPTO has granted a patent (US12583888B2) to the University of Tartu for bi-specific peptides designed to target cancer cells and the extracellular matrix. These peptides bind to fibronectin extra domain B (FN-EDB) and/or tenascin-C C domain (TNC-C). The patent was granted on March 24, 2026.

What changed

The United States Patent and Trademark Office (USPTO) has issued patent US12583888B2 to the University of Tartu for novel bi-specific peptides. These peptides are engineered to specifically bind to cancer cells and the extracellular matrix, particularly targeting fibronectin extra domain B (FN-EDB) and tenascin-C C domain (TNC-C). This patent grant signifies the recognition of novel therapeutic compositions and methods for cancer treatment.

While this is a patent grant and not a regulatory rule, companies involved in peptide-based cancer therapeutics, particularly those utilizing fibronectin or tenascin-C binding mechanisms, should be aware of this intellectual property. The patent may impact research and development efforts, licensing opportunities, and potential market exclusivity for similar technologies. No immediate compliance actions are required for regulated entities, but awareness of this granted patent is advisable for strategic planning.

Source document (simplified)

← USPTO Patent Grants

Bi-specific extracellular matrix binding peptides and methods of use thereof

Grant US12583888B2 Kind: B2 Mar 24, 2026

Assignee

University of Tartu

Inventors

Tambet Teesalu, Prakash Lingasamy

Abstract

Disclosed are compositions, compounds, and methods relating to peptides that can target and home to cancer, tumors, and extracellular matrix. This is based on the discovery of peptides that can specifically bind to fibronectin extra domain B (FN-EDB), tenascin-C C domain (TNC-C), or both.

CPC Classifications

C07K 7/08 C07K 7/06 C07K 14/00 A61K 38/00 A61P 35/00

Filing Date

2020-02-03

Application No.

17428484

Claims

24

View original document →

Source

Analysis generated by AI. Source diff and links are from the original.

Classification

Agency
USPTO
Published
March 24th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12583888B2

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing 3254.1 Biotechnology
Activity scope
Drug Discovery Therapeutic Development
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Research & Development
Topics
Cancer Research Biotechnology

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