Crystalline Benzamide Salt Forms for T-Type Calcium Channel Diseases

USPTO published patent application US20260092037A1 disclosing crystalline salt forms of N-((1-(2-(tert-butylamino)-2-oxoethyl)piperidin-4-yl)methyl)-3-chloro-5-fluorobenzamide useful for treating T-type calcium channel diseases including epilepsy, essential tremor, and major depressive disorder. The application (No. 19311876) was filed August 27, 2025, naming inventors David T. Jonaitis and Lisa McCracken.

Cannabinoid receptor 1 antagonists/inverse agonists and uses thereof

The USPTO published patent application US20260092038A1 disclosing novel cannabinoid receptor 1 (CB1) antagonists/inverse agonists for treating metabolic disorders including diabetes, dyslipidemia, cardiovascular disorders, obesity, and cancer. Invented by Marshall Morningstar, the application covers compound compositions and therapeutic uses. Filing date was September 26, 2025.

Epicardial Device and Methods for Right Heart Support During LVAD

The USPTO published patent application US20260090887A1 for an epicardial implant system designed to prevent right heart failure following left ventricular assist device (LVAD) implantation. Inventor John M. MacMahon's device provides dual-mechanism support through separate adjustable elements for ventricular wall constraint and tricuspid valve annular geometry optimization. Preclinical validation demonstrated six-minute implantation with independent component efficacy.

Passive Alignment of Commissures in Prosthetic Heart Valve Implantation

St. Jude Medical, Cardiology Division, Inc. published a patent application for a delivery device enabling passive alignment of commissures during prosthetic heart valve implantation. The device features an inner shaft, outer shaft, distal sheath, and a biasing spine that directs bending in a pre-determined direction to facilitate proper valve positioning. The application (US20260090886A1) was published April 2, 2026, with a filing date of December 9, 2025.

Heart valve prosthesis with leaflet clipping mechanism

The USPTO published patent application US20260090885A1 for a heart valve prosthesis featuring a leaflet clipping mechanism. Inventors Ji Zhang, Brandon G. Walsh, Cheng Yong Yang, Jinhua Zhu, and Dennis McMahon disclosed a device combining a valve anchor with U-shaped members, an expandable valve frame, and a link mechanism that collectively engage prosthetic or native valve leaflets. The application claims priority to filing date December 1, 2025.

Mechanical Guides for Controlling Leaflet Folding Behavior During Crimping

The USPTO published patent application US20260090884A1 for mechanical guides controlling leaflet folding behavior during crimping of transcatheter valve prostheses. The invention by inventors Grant Menon, Yogesh Darekar, and George Hallak includes a leaflet folding accessory with guide fingers configured to hold leaflets in predetermined configurations during compression. The technology applies to transcatheter aortic and other heart valve replacements.

Sinus-Engaging Valve Fixation Member

Medtronic Ventor Technologies Ltd. filed USPTO patent application US20260090883A1 for a sinus-engaging valve fixation member used in prosthetic valve delivery systems. The application, published April 2, 2026, describes methods for delivering and deploying valve prostheses using engagement arms that flare outwardly during deployment. The invention relates to A61F classifications covering cardiac and vascular prosthetics.

Prosthetic Valve for Native Atrioventricular Valve Implantation

The USPTO published patent application US20260090882A1 for an implantable prosthetic heart valve designed for native atrioventricular valve replacement. The application, filed by 8 inventors, describes a radially collapsible and expandable valve with serpentine arm anchors. This publication represents a published patent application; no regulatory compliance obligations are created.

Prosthetic Frame Covers Patent Application

The USPTO published patent application US20260090881A1 for prosthetic frame covers for valvular prosthetics. The application, filed by 6 inventors including Radhika Vaid and Jessica Louise Blair, describes systems and methods for synthesizing covers via depositing, submersion, and/or printing techniques. The covers can be applied directly onto valvular frames or transferred from temporary substrates.

Prosthetic Heart Valve with Paravalvular Leak Mitigation Features

USPTO published patent application US20260090880A1 by St. Jude Medical for a prosthetic heart valve with paravalvular leak mitigation features. The application claims novel cuff configurations and finger elements positioned radially outward from stent cells, along with tapered struts for improved fatigue resistance. The filing date is December 8, 2025.