Genetically modified Bacillus subtilis strain for D-psicose 3-epimerase production

USPTO granted patent US12595473B2 to ROQUETTE FRERES for a genetically modified Bacillus subtilis strain transformed with an optimized vector for producing D-psicose 3-epimerase. The patent covers the bacterial strain, vectors, and methods of using the strain for enzyme production. The grant date is April 7, 2026, with 4 claims.

Mannanase variants and polynucleotides encoding same

USPTO granted patent US12595472B2 to BASF SE for mannanase enzyme variants at least 75% identical to SEQ ID NO: 2 or 3, including encoding polynucleotides, expression constructs, and host cells. The patent, filed February 12, 2021, contains 14 claims and is classified under CPC C12N 9/2488.

GEVO patents NKR variants for isobutanol production

GEVO patents NKR variants for isobutanol production

OrthoPediatrics Osteotomy Device Patent Granted

USPTO granted patent US12594100B2 to OrthoPediatrics Corp. covering osteotomy devices and methods including bone plates, bridging devices, and spreading mechanisms with 18 claims. The patent relates to surgical tools for performing osteotomies with scissors-type spreading mechanisms and ergonomic designs.

Universal broach system for humeral implants - Patent Grant

The USPTO granted Patent US12594083B2 to Zimmer, Inc. for a universal broach system designed for preparing bone to receive humeral prosthesis anchors. The patent covers a distal broach component with radially extending cutting spokes and a proximal broach component with spacer spokes in an interval pattern. The 12-claim patent was filed on October 9, 2023.

Gender-specific mesh implant with barrier for inguinal hernia repair

USPTO granted Patent US12594153B2 to Hexagon Health, Inc. on April 7, 2026. The patent covers a gender-specific implantable mesh for inguinal hernia repair featuring an anti-adhesive barrier configured to prevent direct contact with the spermatic cord and genital nerve, and a keyhole designed to accommodate these structures without constriction. The invention includes 22 claims covering the mesh structure and its oblique positioning relative to centerlines.

Aqueous humor drainage device with adjustable tube diameter for glaucoma

USPTO granted Patent US12594186B2 to The Catholic University of Korea Industry-Academic Cooperation Foundation for an aqueous humor drainage device with adjustable tube diameter for glaucoma treatment. The device comprises an annular outer tube and inner tube made of biodegradable material with a shrinkage hole, designed to be inserted into the eyeball to drain aqueous humor externally. The patent contains 13 claims and was filed on June 28, 2021.

Implant stability sensor system and method

USPTO granted patent US12594029B2 to OrthoIQ, LLC for an implant stability sensor system designed to detect motion between an implant and bone. The patent covers a system with bone locator means, implant attachment means with detection capabilities, and data analysis means. The patent includes 20 claims and was assigned CPC classifications related to medical implants and sensor technologies.

PayPal blockchain transaction validation and storage patent

The USPTO granted Patent US12597026B2 to PayPal, Inc. on April 7, 2026. The patent covers a system and method for validating and storing blockchain transaction data using challenge-response authentication and cryptographic hash verification across linked data blocks. The patent, filed as Application No. 18596060 with 20 claims, was granted nearly two years after its March 2024 filing date.

Customized retail environments using weight sensors

USPTO granted Amazon Technologies, Inc. Patent US12597006B1 for systems using weight sensors in retail environments to identify items priced per unit weight. The patent covers dual-weight sensor configurations in inventory locations and shopping carts/stations, enabling automated item identification through weight comparisons. The patent names inventors Jonathan E. Cohn, Ejaz Ahmed, and Gregory Hager.