Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation
ClinicalTrials.gov Studies
Summary
NIH registered clinical trial NCT07535892, a single-site pilot randomized controlled trial using a 2×2×2 factorial design to evaluate a multi-component behavioral intervention for weight loss maintenance following discontinuation of GLP-1 and anti-obesity medications. The trial will enroll participants randomized to a standardized 10-week foundational weight loss maintenance program combined with candidate support components including medically tailored meals, YMCA membership, and a structured mind-based program, with six-month follow-up.
What changed
NIH registered a new clinical trial (NCT07535892) on ClinicalTrials.gov, a single-site pilot randomized factorial trial evaluating a multi-component behavioral intervention for weight loss maintenance after GLP-1 and anti-obesity medication discontinuation. The trial employs a 2×2×2 factorial design combining a 10-week foundational weight loss maintenance program with support components (medically tailored meals, YMCA membership, SKY meditation program), with six-month participant follow-up. Conditions studied include weight loss, GLP-1 use, weight loss maintenance, and obesity/overweight.
Healthcare providers prescribing GLP-1 and anti-obesity medications should be aware of this trial as findings may inform future clinical guidance on weight loss maintenance strategies post-medication discontinuation. The trial targets adult patients eligible for participation, with outcomes including feasibility, acceptability, participant perceptions, and preliminary effects of the behavioral intervention components.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation
N/A NCT07535892 Kind: NA Apr 17, 2026
Abstract
This study is a single-site, pilot randomized factorial trial designed to evaluate the feasibility, acceptability, participant perceptions and preliminary effects of a multi-component behavioral intervention to support weight loss maintenance following discontinuation of GLP-1 and other anti-obesity medications. The intervention includes a standardized 10-week foundational weight loss maintenance program combined with candidate support components, including medically tailored meals, YMCA membership, and a structured mind-based program. Participants will be randomized using a 2 × 2 × 2 factorial design and followed for six months. Findings from this pilot study will inform optimization of a scalable intervention for future clinical trials.
Conditions: Weight Loss, GLP - 1, Weight Loss Maintenance, Obesity & Overweight
Interventions: Weight Loss Maintenance Program (Foundational), Mom's Meals, YMCA Membership, SKY Meditation Program
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