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Predictors of Clinical Response After Interlaminar Cervical Epidural Steroid Injection for Cervical Radiculopathy

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Summary

NIH registered a new observational retrospective cohort study (NCT07535476) on ClinicalTrials.gov to evaluate predictors of clinical response after interlaminar cervical epidural steroid injection in patients with cervical radiculopathy. The study will analyze demographic, clinical, and procedure-related variables including pain scores before and after the procedure. Enrollment is anticipated to begin April 17, 2026.

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What changed

NIH registered a new observational retrospective cohort study on ClinicalTrials.gov titled 'Predictors of Clinical Response After Interlaminar Cervical Epidural Steroid Injection for Cervical Radiculopathy' (NCT07535476). The study will examine demographic, clinical, and procedure-related variables that may predict treatment response following interlaminar cervical epidural steroid injection in patients with cervical radiculopathy. Pain scores will be analyzed before and after the procedure to identify predictors of clinical outcome.

For compliance officers, this represents a clinical trial registration for a retrospective observational study on pain management procedures. Clinical investigators conducting research on spinal injection outcomes should note the study's focus on patient selection criteria and predictor identification for this commonly used treatment option for cervical radicular pain.

Archived snapshot

Apr 18, 2026

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Predictors of Clinical Response After Interlaminar Cervical Epidural Steroid Injection for Cervical Radiculopathy

Observational NCT07535476 Kind: OBSERVATIONAL Apr 17, 2026

Abstract

Cervical epidural steroid injection is a commonly used treatment option for patients with cervical radicular pain who do not improve adequately with conservative treatment. Cervical radicular pain typically radiates from the neck to the shoulder, arm, or hand and may be accompanied by numbness, weakness or changes in reflexes. The most common causes are cervical disc herniation and cervical spondylosis. By reducing inflammation around the affected nerve root, epidural steroid injection may help relieve pain and improve function. Among available techniques, the interlaminar approach is frequently preferred in the cervical region because of its technical feasibility and safety profile.

Although interlaminar cervical epidural steroid injection is widely used, treatment response varies among patients, and not all individuals experience the same degree of benefit. Identifying the factors associated with better or poorer clinical response may help improve patient selection and reduce unnecessary procedures.

This retrospective cohort study aims to evaluate clinical outcomes after interlaminar cervical epidural steroid injection in patients with cervical radiculopathy and to investigate demographic, clinical, and procedure-related variables which may predict treatment response. By analyzing pain scores before and after the procedure, this study seeks to better define the predictors of clinical outcome following this intervention.

Conditions: Radiculopathy, Cervical Region, Neck Pain, Disc Disease, Radicular Pain

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Last updated

Classification

Agency
NIH
Published
April 17th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
NCT07535476
Docket
NCT07535476

Who this affects

Applies to
Clinical investigators Healthcare providers
Industry sector
6211 Healthcare Providers
Activity scope
Clinical trial registration Pain management research
Geographic scope
United States US

Taxonomy

Primary area
Healthcare
Operational domain
Clinical Operations
Compliance frameworks
GxP
Topics
Medical Devices Pharmaceuticals

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