ClinicalTrials.gov Studies

Ego-Tucking: Exploring Psychological Mechanisms of Fo-xi Phenomenon Among University Students

The NIH registered observational study NCT07536711 on ClinicalTrials.gov examining psychological mechanisms, stress, and mental fatigue among university students. The cross-sectional study uses a structured questionnaire to explore individual experiences, family dynamics, and macro-social environments contributing to behavioral changes in academic and professional competition contexts.

PD-1 Plus Lenvatinib vs Regorafenib for Unresectable Hepatocellular Carcinoma

NIH ClinicalTrials.gov registered a new Phase 2/3 clinical trial (NCT07537985) comparing the efficacy and safety of PD-1 inhibitor combined with Lenvatinib versus PD-1 inhibitor combined with Regorafenib for unresectable hepatocellular carcinoma (UHCC) after failure of first-line treatment with bevacizumab plus sintilimab. The study aims to provide evidence-based guidance for selecting optimal second-line treatment regimens. Estimated enrollment and completion date are listed in the registry.

High-flow Nasal Cannula Versus Conventional Oxygen Therapy in High-altitude Pulmonary Edema

NIH has registered Clinical Trial NCT07536477, a randomized controlled study evaluating High-flow Nasal Cannula Oxygen Therapy (HFNC) versus Conventional Oxygen Therapy (COT) in patients with High-Altitude Pulmonary Edema (HAPE). The single-center trial plans to enroll 168 participants, with an estimated completion date of April 17, 2026. HFNC is the sole intervention under investigation.

SBRT Followed by PD-1 Inhibitor, Bevacizumab and TAS-102 as Third-Line Therapy for Recurrent/Metastatic Colorectal Cancer

NIH's ClinicalTrials.gov has registered a new Phase 2 clinical trial (NCT07535632) at Zhongshan Hospital, Fudan University in China. The trial will study stereotactic body radiotherapy (SBRT) combined with sintilimab, bevacizumab, and TAS-102 as third-line therapy for 58 patients with recurrent or metastatic colorectal cancer. The 24-month study has a primary endpoint of progression-free survival.

Risk Factors and Prediction Model for Liver-Related Outcomes in Elderly Patients With Steatotic Liver Disease

NIH registered a retrospective cohort study (NCT07537829) on steatotic liver disease in elderly patients. The single-center observational study will analyze approximately 10,000 participants aged 60 and older from the Nanjing Elderly Steatotic Liver Disease Cohort to investigate liver-related and extrahepatic adverse outcomes. Risk prediction models will be developed using machine learning algorithms; no intervention is involved.

Serum GFAP, NfL, VEGF and Clinical Progression in Progressive MS

NIH registered an observational clinical trial (NCT07535242) investigating whether serum biomarkers GFAP, NfL, and VEGF serve as indicators of clinical progression in progressive multiple sclerosis. The study aims to better understand MS pathophysiology through biomarker analysis. This registry entry provides transparency on ongoing research but imposes no regulatory obligations on affected parties.

ESP Block Trial for Postoperative Spinal Pain Relief

NIH registered clinical trial NCT07537647, titled 'The Effect of Bilateral Erector Spina Plane Block on Postoperative Pain in Spinal Surgery.' The trial studies whether ultrasound-guided ESP block with bupivacaine reduces postoperative pain in patients undergoing lumbar spinal stabilization surgery. The study was registered on ClinicalTrials.gov and is listed as not yet recruiting with an estimated completion date of April 17, 2026.

Lullabies and White Noise Breastfeeding Study

NIH registered clinical trial NCT07537218 on ClinicalTrials.gov. The randomized controlled experimental study examines the effect of lullabies and white noise on breastfeeding success in newborns. The study enrolled 160 newborns divided into four groups: female voice lullaby, male voice lullaby, white noise, and control, with data collected using the LATCH Breastfeeding Assessment Scale.

Sleep Quality, Cognition, and Disease Severity in Parkinson's Disease - NCT07536490

The NIH National Library of Medicine registered an observational study (NCT07536490) on ClinicalTrials.gov investigating the relationship between sleep quality, cognitive function, and disease severity in individuals with Parkinson's disease. The single-session study will assess participants using standardized tools including the Stroop Test, Clock Drawing Test, Montreal Cognitive Assessment, Unified Parkinson's Disease Rating Scale, and Modified Hoehn and Yahr Scale. The study enrolls participants diagnosed with Parkinson Disease.

Ivonescimab With Dato-DXd or Osimertinib Phase 1

NIH ClinicalTrials.gov registered Phase 1 trial NCT07535437 evaluating ivonescimab in combination with Dato-DXd or osimertinib for treatment of EGFR-mutated non-small cell lung cancer. The dose-escalation study will assess safety and tolerability to determine optimal dosing. Participants with NSCLC harboring EGFR mutations will receive fixed-dose ivonescimab with escalating doses of either Dato-DXd or osimertinib.

Decision Aid Efficacy in Low Risk Thyroid Cancer

NIH ClinicalTrials.gov registered a clinical trial (NCT07536412) evaluating whether a decision aid pamphlet reduces decision anxiety and improves treatment decision readiness in low-risk thyroid cancer patients. The study will enroll patients diagnosed with differentiated thyroid cancer, papillary thyroid microcarcinoma, or papillary thyroid carcinoma to receive the decision aid before meeting with a surgeon. The intervention provides information about three treatment options (total thyroidectomy, partial thyroidectomy, or active surveillance) and questions for patients to ask their surgeon.

NAUTILUS Project Develops Mutation-Specific ASO for Syndromic Craniosynostoses

NIH ClinicalTrials.gov registered observational study NCT07535372 for the NAUTILUS project, developing ultra-personalized antisense oligonucleotide (ASO) therapeutics for syndromic craniosynostoses. The study targets rare genetic conditions including Crouzon, Saethre-Chotzen, Muenke, Pfeiffer, and Apert syndromes caused by FGFR1/2/3, TWIST1, and TCF12 variants. ASO design will be patient-tailored to silence gain-of-function alleles or restore expression in loss-of-function contexts.

Wildfire Smoke Lung Health Study, Canada, Asthma COPD

NIH registered a clinical trial (NCT07536178) titled 'Lungs on Fire' to study how wildfire smoke exposure contributes to long-term lung disease in susceptible populations. The controlled human exposure study will test varying concentrations of woodsmoke from Lodgepole Pine on participants with asthma, COPD, and lung cancer in Canada. The research aims to identify health impacts, vulnerable populations, and biological changes leading to chronic illness.

At-Home taVNS for Neurorehabilitation in Parkinson's Disease

NIH registered a new clinical trial (NCT07536022) evaluating at-home transcutaneous auricular vagus nerve stimulation (taVNS) for neurorehabilitation in approximately 40 adults with Parkinson's Disease. The 8-week study will assess feasibility, tolerability, and preliminary efficacy of self-administered daily 1-hour taVNS sessions using a threshold-based individual dosing protocol. Secondary objectives include measuring changes in motor and non-motor symptoms and examining neural network connectivity via MRI.

Observational Study of Language Reorganization in AVM Patients

NIH registered observational clinical trial NCT07537504 on ClinicalTrials.gov. The study investigates language function reorganization in patients with brain arteriovenous malformations (AVMs) involving language areas. Researchers will use multimodal MRI to examine functional remodeling, white matter pathway remodeling, and structural remodeling from multiple dimensions. The study aims to elaborate the role of the right cerebral hemisphere in reorganized language networks and interhemispheric interaction mechanisms.

Efficacy of Multi-Type Photolithography Flat Microstructure Lenses for Childhood Myopia Control

NIH ClinicalTrials.gov registered a clinical trial (NCT07535658) studying photolithography flat microstructure lenses for childhood myopia prevention and control. The randomized controlled trial will compare plano microstructure lenses with multi-point defocus design against Spectacle Lenses with Aspherical Lenslets (Essilor Stellest) in children over a 1-year period.

Monocyte Ratios, APRs, and Sepsis ICU Study

NIH's ClinicalTrials.gov registered a new observational study (NCT07537179) examining whether monocyte distribution, monocyte-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio can serve as biomarkers in sepsis patients in the ICU. The study will enroll patients admitted to the ICU for sepsis or those who develop sepsis during hospitalization, comparing these ratios with conventional acute phase response biomarkers.

Phase 2 Trial for Intestinal Fluid Reinfusion Prevention of Low Anterior Resection Syndrome

NIH registered a Phase 2 clinical trial (NCT07537998) on ClinicalTrials.gov to evaluate antegrade intestinal fluid reinfusion for prevention of low anterior resection syndrome in patients with prophylactic ileal stoma. The single-center, prospective randomized controlled trial will compare intestinal fluid infusion to potable water infusion in approximately 60 participants. Participants will receive the assigned intervention at 1 month post-rectal resection until ileostomy reversal and maintain symptom diaries.

HEARTS Implementation for Hypertension-Diabetes Multimorbidity, Guatemala, 1,440 Adults

NIH's ClinicalTrials.gov has registered a new clinical study (NCT07536919) evaluating the WHO-developed HEARTS implementation program for comorbid hypertension and Type 2 diabetes. The pragmatic cluster-randomized trial will enroll 1,440 adults across 36 public primary care clinics in Guatemala. Participants are randomized to HEARTS intervention or current standard care, with primary outcomes (blood pressure and hemoglobin A1c) assessed at 12 months.

Effect of Patient Education Program on Vitamin D Levels and Health Beliefs

NIH has registered a clinical trial (NCT07535671) evaluating whether a structured patient education program improves health beliefs and medication adherence in patients with Vitamin D deficiency. The 6-month trial will randomize 120 adult hypothyroid female patients with serum Vitamin D below 30 ng/dL to either face-to-face education with brochures and monthly phone follow-ups or standard care. The intervention's effectiveness will be measured using the Medication Possession Ratio and serum 25(OH)D levels.

Phase 2 Naxitamab Neuroblastoma Trial, 10 Patients, Apr 17

NIH ClinicalTrials.gov registered Phase 2 trial NCT07537400 evaluating Naxitamab and GM-CSF chemoimmunotherapy combined with COG-type induction chemotherapy in 10 newly diagnosed high-risk neuroblastoma patients aged 12 months to 21 years. The trial aims to assess safety over approximately 2 years. This registration adds to the publicly available record of pediatric oncology clinical research.

VR Learning Program for Sexual-and-gender-diversity Care

NIH registered Clinical Trial NCT07535216 on ClinicalTrials.gov to study the effectiveness of a virtual reality (VR) learning program designed to improve nursing students' care practices for sexual and gender-diversity patients. The clinical trial will evaluate both short-term and long-term effects on caring behaviors. The study is listed with conditions including sex difference, virtual care, and nursing care, with an expected completion date of April 17, 2026.

Phase 1 3D1015 Injection Trial for Metastatic Castration-Resistant Prostate Cancer

NIH registered a Phase 1 clinical trial (NCT07537010) investigating 3D1015 Injection (Lu 177-PSMA-3D1015) in adult males with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). The open-label study will evaluate safety, tolerability, and dosimetry of intravenous infusions with dynamically individualized treatment regimens. Secondary objectives include assessing preliminary anti-tumor efficacy and optimal dosing.

Phase 3 BMAC vs Corticosteroid for TMJ Pain

NIH registered a Phase 3 randomized clinical trial (NCT07536399) comparing Bone Marrow Aspirate Concentrate (BMAC) injection versus corticosteroid injection during TMJ arthroscopy for patients with temporomandibular joint pain unresponsive to conservative treatment. The trial will enroll participants randomized to receive either BMAC or corticosteroid injection, with 3 follow-up visits over 6 months and MRI imaging.

Ivonescimab, Chemotherapy, and SRS for Non-Small Cell Lung Cancer Brain Metastases

The NIH National Library of Medicine registered a Phase 1 clinical trial (NCT07535463) on ClinicalTrials.gov testing ivonescimab in combination with standard chemotherapy and stereotactic radiosurgery for patients with non-small cell lung cancer that has spread to the brain. The study aims to establish the safe dosage of ivonescimab in this combination regimen and evaluate its effectiveness in treating brain metastases. The trial is listed as Phase 1, indicating an early-stage safety and dosing study.

Microgreens on Sleep Architecture, Athletes

NIH registered clinical trial NCT07537140 on ClinicalTrials.gov investigating the effects of microgreen consumption on sleep architecture in athletes. The study will assess sleep onset latency, total sleep time, sleep efficiency, and NREM/REM distribution. The trial lists cabbage as the control intervention and an oral microgreen cocktail as the experimental intervention, with an anticipated completion date of April 17, 2026.

Food is Medicine in Pediatric Patients With Diabetes

The NIH ClinicalTrials.gov registry has published a randomized controlled trial (NCT07535502) evaluating Food is Medicine Programming through medically tailored pre-packaged meals for pediatric patients with Type 1 Diabetes. The study will assess whether medically-tailored meals combined with nutrition counseling improves clinical outcomes, decreases healthcare utilization, and improves health-related quality of life in children and adolescents with diabetes and potential food security concerns.

Low-Level Diode Laser Therapy for Osseointegration Around Delayed Dental Implants

NIH ClinicalTrials.gov has registered a new clinical study (NCT07536451) evaluating the efficacy of Low-Level Diode Laser Therapy (LLDLT) on enhancing osseointegration and peri-implant mucosal tissue around delayed dental implants. The study will compare dental implant placement with LLDL intervention against standard dental implant placement without laser therapy. No compliance obligations or regulatory actions are imposed by this registration.

CIRCLE-Asia Phase 3 Trial: Colchicine for Chronic Limb-Threatening Ischemia

The CIRCLE-Asia trial (NCT07536373) is a Phase 3 randomized, double-blind, placebo-controlled multicenter study evaluating colchicine 0.5mg daily versus placebo in 200 adult patients with chronic limb-threatening ischemia who have undergone successful revascularization. The trial will be conducted at five hospitals in Taiwan with treatment beginning within 7 days of the procedure. Participants will be monitored for reduction of complications and limb events.

NCT07536243: Emotion Regulation RCT for Eco Anxiety and Eating Concerns in Mexican Adults

The National Institutes of Health registered clinical trial NCT07536243, a randomized controlled trial evaluating a group-based emotion regulation intervention for eco-anxiety and eating-related eco-concerns in Mexican adults aged 18 and older. The six-week intervention will be assessed at baseline, post-intervention, and four-month follow-up, comparing the treatment group to a control group. Participants will attend weekly sessions and complete assessment instruments at three time points.

Comparative Efficacy of Electromagnetic Field Therapy and Tibial Nerve Stimulation in Urge Urinary Incontinence

NIH registered Clinical Trial NCT07536139 on ClinicalTrials.gov, a prospective, randomized, assessor-blinded clinical trial comparing pulsed electromagnetic field (PEMF) therapy and posterior tibial nerve stimulation (PTNS) for treatment of urge urinary incontinence in women. Eligible participants will be randomized to one of two intervention groups and assessed at baseline and post-treatment using validated instruments including the ICIQ-SF, bladder diaries, and quality-of-life scales. The primary objective is to compare efficacy of the two modalities in reducing urinary symptoms. No compliance obligations or deadlines are imposed by this registration record.

OCU500 ChAd36 Vector COVID-19 Vaccine Phase 1 Trial, 80 Participants

A Phase 1 randomized, open-label, dose-escalation clinical trial registered for OCU500, a ChAd36 vector vaccine encoding SARS-CoV-2 spike protein, administered via intranasal and inhalational routes. The trial enrolls 80 healthy adults (aged 18-64) previously vaccinated with a primary COVID-19 series and at least one booster. Participants will receive one of two dose levels (1×10^10 VP or 5×10^10 VP) across four study arms of 20 participants each, with the primary objective of evaluating safety and reactogenicity.

Methadone Perception Survey Targets Pediatric Surgical Caregivers

An observational survey study (NCT07537608) examining methadone perceptions among caregivers of pediatric outpatient surgical patients, orthopedic surgeons, and anesthesiologists has been registered on ClinicalTrials.gov. The study will investigate associations between social determinants of health and attitudes toward methadone use for postoperative pain. Healthcare providers and clinical researchers should monitor this registry for emerging evidence on potential disparities in pain management perceptions.

AI LSTM Forecasting Depth of Anesthesia Trial

The National Institutes of Health registered observational clinical trial NCT07536230 on ClinicalTrials.gov, investigating the use of Long Short-Term Memory (LSTM) deep learning networks to forecast depth of anesthesia. The study aims to deploy AI frameworks to predict patient-specific physiological states by processing time-series BIS-EEG data, moving beyond traditional PK/PD models like the Eleveld model for Propofol and Remifentanil. This trial involves adult patients undergoing procedures requiring general anesthesia and will evaluate the predictive accuracy of AI-driven forecasting versus standard concentration estimation models.

Observational Study of Pre-Anaesthesia Person-Centred Care in Danish Hospitals

The NIH ClinicalTrials.gov registry has published registration details for observational study NCT07535450, an observational study examining pre-anaesthesia practices and patient experiences in Danish public hospitals. The study will collect patient survey data on what matters to patients before anaesthesia and the degree of person-centredness in pre-anaesthesia consultations.

i-PRF Perfusion Trial for Moderate to Severe Intrauterine Adhesions

NIH's ClinicalTrials.gov registered a new prospective randomized controlled study (NCT07536971) evaluating the efficacy and safety of intrauterine i-PRF (injectable platelet-rich fibrin) perfusion in women with moderate to severe intrauterine adhesions after hysteroscopic adhesiolysis. The trial will compare i-PRF intrauterine perfusion against sodium hyaluronate intrauterine treatment, assessing endometrial regeneration and reproductive outcomes. The anticipated study start date is April 17, 2026.

SPSIP Block vs Rhomboid Block for Postoperative Analgesia in Breast Cancer Surgery: Randomized Controlled Trial

This ClinicalTrials.gov registry entry announces a randomized controlled trial (NCT07536867) comparing the analgesic efficacy of Serratus Posterior Superior Intercostal Plane (SPSIP) Block versus Rhomboid Intercostal Block for postoperative pain management following breast cancer surgery with axillary lymph node dissection. The primary outcome is Visual Analog Scale pain scores during the first 24 hours post-surgery. Secondary outcomes include opioid consumption, rescue analgesia requirements, block performance time, and patient satisfaction. The study is currently recruiting.

Phase 2 Auricular Point Stimulation Plus Dexamethasone for Chemotherapy-Induced Nausea and Vomiting (NCT07537699)

NIH ClinicalTrials.gov registered a Phase 2 clinical trial (NCT07537699) evaluating auricular point stimulation combined with dexamethasone for preventing chemotherapy-induced nausea and vomiting in breast cancer patients receiving docetaxel plus cyclophosphamide. The single-arm study will track nausea, vomiting, appetite, and gastrointestinal function from Day 1 through Day 5 of chemotherapy. Participating institutions and investigators must conduct the trial in accordance with the registered protocol, IRB oversight, and informed consent requirements.

Telerehabilitation in Patients With Elevated Pulmonary Artery Pressure

NIH registered clinical trial NCT07535398 on ClinicalTrials.gov studying whether synchronous telerehabilitation improves exercise capacity, dyspnea, fatigue, functional status, and quality of life in patients with elevated pulmonary artery pressure (systolic PAP ≥50 mmHg). The randomized controlled trial will compare an 8-week telerehabilitation program (3 sessions/week, 30 min/session) against breathing and posture exercises. Estimated completion date is April 17, 2026.

First-in-human SRP-1005 Huntington's Disease Phase 1 Trial

NIH ClinicalTrials.gov registered a first-in-human Phase 1 trial (NCT07536061) studying SRP-1005, an investigational treatment for Huntington's Disease. The multi-center trial will evaluate the safety and tolerability of SRP-1005 versus placebo in participants with Huntington's Disease. The trial has an anticipated start date of April 17, 2026.

IPG11406 Phase 2 UC Trial, 144 Patients, 12 Weeks

NIH has registered a Phase 2 clinical trial (NCT07535489) for IPG11406, an investigational oral drug targeting the GPR183 receptor for ulcerative colitis. The randomized, double-blind, placebo-controlled study will enroll 144 adult patients across three active dose groups (10 mg, 20 mg, 40 mg twice daily) and one placebo arm over 12 weeks. The primary endpoint is clinical remission measured by modified Mayo Score at week 12, with secondary endpoints including clinical response, endoscopic remission, histological improvement, and safety evaluation.

IBM Dietary Surveillance Study at Manchester Metropolitan University

The NIH ClinicalTrials.gov registry has added a new observational study (NCT07535996) titled 'IBM Dietary Surveillance Study' at Manchester Metropolitan University. The study will investigate how diet affects muscle health and functional ability in adults with inclusion body myositis (IBM) compared to healthy volunteers aged 40 and older. Participants will complete dietary records, physical activity monitoring, body composition assessments, and muscle function tests over a four-week home monitoring period plus two university visits.

Montelukast Phase 2 Trial for Acute Myocardial Infarction

NIH registered a Phase 2 randomized controlled trial (NCT07537868) evaluating Montelukast 10 mg oral tablets for acute myocardial infarction. The trial, sponsored by Mansoura University (Egypt), will enroll participants randomized to Montelukast or placebo to assess anti-inflammatory and cardioprotective effects via inflammatory markers and cardiac injury indicators. The study has an estimated start date of April 17, 2026.

First-in-man Trial TRICENTO G2 Transcatheter Valve for Tricuspid Regurgitation

The NIH ClinicalTrials.gov registry has posted a first-in-man trial for the TRICENTO G2 Transcatheter Valve System (TRICENTO G2 TVSTR) intended to treat severe tricuspid regurgitation in adult patients. The early feasibility study will assess safety, performance, and clinical benefit through 1-year follow-up. Participants will undergo minimally invasive valve implantation with clinic visits at baseline, 30 days, 3 months, 6 months, and 1 year post-procedure.

Evaluation of Serum Autophagic Biomarkers in Acute Response to Walking and Cycling in Healthy Males

NIH ClinicalTrials.gov registered observational study NCT07536659 evaluating serum autophagic biomarkers in healthy male individuals responding to walking and cycling exercises. The study aims to assess acute cellular responses to different physical exercise modalities through peripheral blood analysis, building on limited existing human data in this area.

Effect of Tai Chi and Multimodal Exercise in Overweight and Obese Women

NIH registered clinical trial NCT07536893 examines the effects of a 10-week Tai Chi and Multimodal exercise program on balance in overweight and obese women. The study found that both Tai Chi and multimodal exercise programs significantly improved balance parameters compared to baseline. The research addresses a gap in the literature regarding balance-focused interventions as a primary goal for improving physical mobility in overweight individuals.

Integrating Supports to Promote PrEP for Black Adolescents Working With Apps - Atlanta

NIH has registered a clinical trial (NCT07535346) evaluating the Health MPowerment app as a behavioral intervention to promote PrEP adherence among Black adolescents and young adults in Atlanta. The study applies Social Cognitive Theory to assess feasibility and acceptability of the enhanced HMP app as a support tool. The trial targets Black AYAs and adult supports as participants, with data collection anticipated through April 2026.

ctDNA-driven Anti-EGFR Retreatment Metastatic Colorectal Cancer Study

NIH's ClinicalTrials.gov registered NCT07536113, an observational, retrospective, international multicenter study evaluating anti-EGFR rechallenge regimens in the largest real-world cohort of MSS mCRC patients. The study, funded by Fondazione Oncologia Niguarda ETS, will screen patients for RAS/BRAF/PIK3CA ctDNA status via liquid biopsy within the MEN1611-02 C-PRECISE-01 trial and collect molecular, clinical, and outcome data already available at participating centers.

Phase 2 Leucine-Restricted Diet, Gastric Cancer Study

NIH's ClinicalTrials.gov has registered Phase 2 trial NCT07537361 evaluating the safety and efficacy of a leucine-restricted diet combined with neoadjuvant chemotherapy and immunotherapy in gastric cancer patients. The study aims to assess whether dietary leucine restriction is safe, well-tolerated, and capable of promoting immune cell activation within the tumor microenvironment to improve patient outcomes. Estimated study completion date is April 17, 2026.

Time to Healing in Displaced Pediatric Diaphyseal Forearm Fractures Treated With Bioabsorbable Compared to Titanium Intramedullary Nails

NIH has registered a new clinical trial (NCT07536581) comparing bioabsorbable intramedullary nails to titanium elastic intramedullary nails for treating displaced pediatric diaphyseal forearm fractures. The randomized controlled trial will assess fracture healing time on X-ray, complications, recovery, function, and family experience. Children requiring surgery will be randomly assigned to either treatment group.