ClinicalTrials.gov Studies

VAP-Measured Lipid Subfractions and In-Stent Restenosis After PCI (NCT07533656)

NIH registered multicenter observational study NCT07533656 investigating association between VAP-measured lipid/lipoprotein subfractions and coronary in-stent restenosis after PCI. Includes retrospective cross-sectional component (patients with prior PCI undergoing repeat angiography) and prospective follow-up component (patients undergoing index PCI). No additional blood draws required; serum samples from routine clinical collection used for VAP testing. Target enrollment: 140 participants. Conditions: In-Stent Restenosis, Coronary Artery Disease. No intervention.

Phase 2 Clinical Trial Evaluating HSK55718 for Postoperative Pain in Abdominal Surgery

NIH registered a Phase 2 clinical trial (NCT07533786) evaluating the efficacy and safety of investigational drug HSK55718 for postoperative pain treatment. The multi-center, randomized, double-blind, placebo/active-controlled study plans to enroll 200 subjects undergoing abdominal surgery under general anesthesia, comparing three dose levels of HSK55718 against morphine and placebo.

AI Thai Food App and CGM Monitoring Pilot Study for Type 2 Diabetes

NIH's ClinicalTrials.gov has registered NCT07533604, an 8-week randomized controlled pilot study evaluating an AI-powered Thai food analysis application (SnapD) combined with continuous glucose monitoring (CGM) for glycemic control in 45 patients with Type 2 Diabetes and overweight/obesity. The study has three arms: SnapD alone, SnapD with CGM, or standard diabetes self-management education. Participants will be monitored over 8 weeks with HbA1c as the primary endpoint.

Potassium Channel Study in Chronic Cocaine Users

NIH registered a clinical trial (NCT07532460) on ClinicalTrials.gov investigating the role of potassium channels in working memory impairments among chronic cocaine users. The study will test 4-aminopyridine (4-AP) versus placebo as an intervention for cognitive impairments associated with cocaine use disorder. The trial is registered with an estimated start date of April 16, 2026.

Gas6 and Soluble MerTK Periodontal Biomarkers Study

NIH registered an observational clinical study (NCT07535177) investigating Gas6 and soluble MerTK biomarker levels in gingival crevicular fluid and serum samples across three groups: 30 patients with stage III grade B periodontitis, 30 with gingivitis, and 30 periodontally healthy individuals. The study will measure clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, and plaque index. Biomarker levels will be determined using enzyme-linked immunosorbent assay with non-parametric statistical analysis.

JZP3507 (ONC206) Phase 2 Trial for Recurrent Grade 2 or 3 Meningioma

NIH registered a Phase 2 clinical trial (NCT07533942) evaluating JZP3507 (ONC206) in patients with recurrent Grade 2 or 3 meningioma who have failed prior therapy. The single-arm study will administer oral JZP3507 and evaluate antitumor activity and safety. The trial is listed on ClinicalTrials.gov with an anticipated start date of April 16, 2026.

Short Fiber vs Injectable Resin Composite in Class I Restorations

NIH ClinicalTrials.gov registered a Phase 4 clinical trial (NCT07535086) comparing short fiber reinforced flowable bulk fill resin composite to conventional injectable flowable resin composite for restoring Class I carious molar cavities. The trial will evaluate clinical performance of these dental restoration materials. Estimated study completion date is April 16, 2026.

MINIMALLY INVASIVE SURGERY FOR GRADE III HEMORRHOIDS - Observational Study NCT07534761

NIH ClinicalTrials.gov registered a new observational study (NCT07534761) evaluating minimally invasive surgery (MIS) for Grade III hemorrhoids using a closed excisional hemorrhoidectomy technique. The IDEAL Phase 2a study aims to assess reproducibility and technical feasibility of MIS in anal surgery with approximately 50 participants.

Multicentre Retrospective Cohort Study of Palliative Care Pathways in Patients Who Died From Sarcoma

NIH ClinicalTrials.gov registered multicentre retrospective observational study NCT07532668 examining palliative care pathways in adult patients who died from sarcoma. The study aims to describe how sarcoma patients who died were followed by palliative care teams. No regulatory obligations or compliance requirements are imposed by this study registration.

Comparing Medial and Lateral Dissection Approaches to the Recurrent Laryngeal Nerve During a Thyroidectomy

NIH registered a new interventional clinical trial (NCT07532889) comparing medial versus lateral dissection approaches to the recurrent laryngeal nerve during thyroidectomy. The randomized study will evaluate length of hospital stay, surgical adverse events, and post-operative vocal cord function. Participants scheduled for thyroidectomy will be enrolled after informed consent.

Phase 1 KSD-101 Trial for EBV-Associated Hematological Malignancies

NIH ClinicalTrials.gov registered a Phase 1 study (NCT07532746) evaluating KSD-101 for relapsed or refractory EBV-associated hematological malignancies. The single-arm trial will assess safety, tolerability, preliminary efficacy, immune response, and quality of life in participants treated with KSD-101.

Fecal Microbiome Signature of Multi-Strain Probiotics Supplementation in Pediatric IBD

The NIH has registered a clinical trial (NCT07533890) to study fecal microbiome and metabolic profiles in children and adolescents with inflammatory bowel disease upon multi-strain probiotic supplementation. The study will enroll participants and begin interventions on April 16, 2026.

Leaf Expander vs Hyrax for Molar Distalization

NIH ClinicalTrials.gov registered a randomized controlled trial comparing skeletally anchored modified Leaf Expander versus conventional Hyrax Expander for maxillary molar distalization in 30 patients aged 15-18 years. The three-year study will evaluate skeletal, dental, and arch dimensional changes using lateral cephalometric radiographs and digital dental models.

Hungarian ICU Transfusion Practices Survey

NIH ClinicalTrials.gov registered observational study NCT07532772, a Hungarian nationwide survey assessing transfusion practices in intensive care units. The study will evaluate how physiological parameters recommended as transfusion triggers are used in daily clinical practice across Hungarian hospitals. No regulatory obligations or compliance requirements are imposed by this registration.

MPXV Viral Clearance, Transmission Dynamics, and Vaccine Effectiveness Study in Guinea

NIH's ClinicalTrials.gov registered an observational study (NCT07534267) in Guinea, West Africa examining Monkeypox virus (MPXV) elimination kinetics from infected individuals, transmission dynamics between cases and contacts, and effectiveness of the MVA-BN vaccine against MPXV infection and Mpox disease. The study has three components: MOVIE-West Africa, TRACE-West Africa, and VE-West Africa.

Ga-68 PSMA PET/CT vs mpMRI in Cognitive Prostate Biopsy (NCT07533344)

The NIH ClinicalTrials.gov registry has registered observational study NCT07533344, an NCI-affiliated trial conducted by Stanford University comparing Ga-68 PSMA PET/CT imaging with multiparametric MRI (mpMRI) in cognitive prostate biopsy for prostate cancer diagnosis. The single-arm study will enroll approximately 100 participants and is estimated to begin enrollment on April 16, 2026.