ClinicalTrials.gov Studies

Effect of Complete Suction-Induced Collapse of Renal Collecting System at End of RIRS on Early Postoperative Outcomes

NIH ClinicalTrials.gov has registered NCT07535281, a randomized controlled trial evaluating whether actively suctioning the renal collecting system to induce collapse at the end of retrograde intrarenal surgery (RIRS) reduces postoperative pain and infection in kidney stone patients. Participants will be randomly assigned to experimental group (suction-induced collapse) or control group (standard drainage). The study aims to determine if this surgical modification improves early recovery outcomes and patient satisfaction.

Relief Efficacy of Lidocaine Versus Morphine for Acute Renal Colic in the Emergency Department

NIH has registered a new clinical trial (NCT07536594) on ClinicalTrials.gov comparing intravenous lidocaine to morphine for acute renal colic pain management in emergency departments. The trial aims to address the opioid epidemic by investigating whether lidocaine can serve as an effective non-opioid alternative for pain management. Researchers plan to recruit a diverse population to build on preliminary evidence from a 2012 Iranian study.

Phase I/II Clinical Trial for HS_SW01 Cells Injection in Systemic Sclerosis

The National Institutes of Health registered a Phase I/II clinical trial (NCT07535931) on ClinicalTrials.gov to evaluate the safety, tolerability, pharmacokinetics, and immunological profile of HS_SW01 human umbilical cord mesenchymal stem cell injection in patients with systemic sclerosis. The single-arm, open-label trial will enroll participants who meet specified inclusion and exclusion criteria following informed consent. No regulatory approvals or compliance deadlines are established by this registration notice.

Phase 4 Dulaglutide Triple Therapy for T2DM Chronic Kidney Disease

A Phase 4 clinical trial (NCT07537088) has been registered on ClinicalTrials.gov evaluating dulaglutide as add-on therapy for Chinese adults with Type 2 Diabetes and Chronic Kidney Disease. The 26-week randomized study will assess whether adding dulaglutide to existing SGLT2 inhibitor plus finerenone therapy provides additional kidney protection. Participants must have been on stable combination therapy for at least 3 months before enrollment.

Effect of Low-Power Laser Therapy on Pain and Functional Outcomes in Patients With Thoracic Outlet Syndrome

NIH's ClinicalTrials.gov registered a new randomized controlled study (NCT07535853) evaluating low-power laser therapy combined with physical therapy versus conventional treatment alone for thoracic outlet syndrome patients. The trial aims to determine whether adding laser therapy provides superior pain relief and improves daily physical functions. The study carries an anticipated start date of April 17, 2026.

NCT07535723: Botulinum Toxin and GON Block for Chronic Migraine

A new randomized controlled trial (NCT07535723) was registered on ClinicalTrials.gov evaluating the combination of OnabotulinumtoxinA (Botox) injections with Greater Occipital Nerve (GON) block versus single therapy for chronic migraine patients. The trial will assess improvements in headache frequency, severity, and quality of life. Enrollment target and sponsor details were not specified in the registration record.

Phase 4 Adenosine Pre-Medication in Primary PCI Randomized Control Trial

NIH registered a Phase 4 clinical trial (NCT07536802) evaluating adenosine pre-medication versus standard care in primary percutaneous coronary intervention for ST-segment elevation myocardial infarction patients. The randomized controlled trial aims to assess impact on slow flow/no-reflow phenomenon incidence. The trial is registered on ClinicalTrials.gov.

Observational Falls Validation Study for Traumatic Brain Bleeding

NIH registered an observational study (NCT07536906) to validate a rapid bedside decision rule guiding emergency physicians on when older adults should receive brain scans to diagnose traumatic brain bleeding. The study addresses falls in adults over 65, which result in 500,000 Canadian emergency department visits annually. Researchers will assess whether the clinical decision rule effectively identifies patients requiring imaging for intracranial bleed detection.

Qualitative Study of Care Perceptions in Chemotherapy Patients

NIH registered an observational qualitative study (NCT07536945) on individualized care perceptions among outpatient chemotherapy patients at Yalova Training and Research Hospital in Turkey. The study will interview 10 to 20 participants over age 18 to understand how personalized nursing care affects symptom management and treatment adherence. Research will be conducted from May 2026 through April 2027.

Lidocaine Spray for Postoperative Shoulder Pain in Laparoscopic Surgery

ClinicalTrials.gov registered a randomized controlled trial (NCT07537127) at Peking Union Medical College Hospital evaluating 0.08% lidocaine spray for postoperative shoulder pain in 100 patients undergoing single-port laparoscopic gynecological surgery. The experimental group receives 50ml lidocaine sprayed on bilateral subdiaphragmatic regions; the control group receives standard ERAS protocol. Primary endpoint is NRS pain score at 6 hours postoperatively. Estimated primary completion date is April 17, 2026.

Prophylactic Anti-epileptic Regimen in Traumatic Brain Injury

NIH registered an observational clinical trial (NCT07535736) evaluating the effectiveness and safety of anti-epileptic drugs in preventing early and late post-traumatic seizures among patients with traumatic brain injury. The study will assess antiepileptic efficacy and safety outcomes in this patient population.

Prostate Cancer Hot Flashes ADT Smartwatch Feasibility Study

NIH ClinicalTrials.gov registered a new feasibility study (NCT07535541) titled 'A Feasibility Study of Biometric Measurements Via Wearable Smart Watch Technology for Evaluation of Vasomotor Symptoms in Patients Treated With Androgen Deprivation Therapy for Prostate Cancer.' The study will evaluate whether prostate cancer patients on ADT with vasomotor symptoms (hot flashes) consistently wear a smartwatch device to track health data and log hot flashes. Participants will wear the smartwatch for 4 weeks and complete surveys about their hot flash experiences. No compliance obligations are created for organizations.

Phase 4 Randomized Trial of Indomethacin and Paracetamol for Pain Management During IVF Oocyte Retrieval

NIH registered a Phase 4 randomized controlled trial (NCT07536425) evaluating preoperative Indomethacin (100 mg per rectum) and Paracetamol/Acamol (1,000 mg intravenously) for pain management during oocyte retrieval in women undergoing IVF or ICSI. The trial will study pain outcomes in women receiving these analgesic interventions. Conditions include Pain and Oocyte Retrieval. This is an informational clinical trial registration on ClinicalTrials.gov.

NCT07537569: Preoperative Oncogeriatric Assessment in Hepatectomy Patients

NIH registered clinical trial NCT07537569, a prospective study examining comprehensive geriatric assessment (CGA) in older adults scheduled for hepatectomy due to hepatic malignancies. The study aims to optimize perioperative care and improve surgical safety and recovery outcomes in elderly patients. Conditions include hepatic malignancies and comprehensive geriatric assessment with CGA as the sole intervention type.

Extended Time Window IV Thrombolysis Registry for Acute Ischemic Stroke

The NIH registered a new observational study (NCT07536074) titled EXTEND-IVT Registry on ClinicalTrials.gov. The study will evaluate the effectiveness and safety of intravenous thrombolysis administered beyond 4.5 hours after last known well in patients with acute ischemic stroke. The prospective, multicenter, observational cohort study will be conducted in routine clinical practice settings across China.

GEA Simultaneous to VSG Reduces Post-operative GERD

NIH registered a clinical trial (NCT07537244) to evaluate whether adding gastroenteroanastomosis (GEA) to vertical sleeve gastrectomy (VSG) reduces post-operative gastroesophageal reflux disease (GERD) in obese patients. The randomized study will compare Group A (VSG with GEA) versus Group B (VSG without GEA) using symptom questionnaires during follow-up visits. All exams are part of standard surgical or GERD follow-up routines, with an estimated start date of April 17, 2026.

Observational Study Recording Stress Biomarkers in Autism Spectrum Disorders

The National Institutes of Health registered an observational clinical trial (NCT07535801) studying how physiological stress signals differ between children and young people with autism spectrum disorder (ASD) and non-ASD participants. The study will monitor two biological stress systems — the autonomic nervous system and the hypothalamic-pituitary-adrenal axis — in real-life environments including schools, homes, and care institutions. Participants with ASD who also have intellectual deficiency will be compared against a control group of typically developing peers.

Auricular Point Stimulation Plus Dexamethasone for Chemotherapy Nausea

NIH registered a Phase 2 clinical trial (NCT07537660) on ClinicalTrials.gov evaluating auricular point stimulation combined with dexamethasone for preventing chemotherapy-induced nausea and vomiting in pancreatic cancer patients receiving gemcitabine plus paclitaxel protein-bound treatment. The trial aims to enroll participants who will receive auricular acupressure with bean seeds plus IV dexamethasone as an antiemetic, with a primary completion date of April 17, 2026.

Co-supplementation With Bifidobacterium Longum W11 and Colopectin for Maintenance Therapy in Children With Functional Constipation

The NIH ClinicalTrials.gov registry has recorded a new randomized, double-blind, placebo-controlled trial (NCT07536698) evaluating co-supplementation with Bifidobacterium longum W11 and Colopectin for maintenance therapy in children aged 2 to 6 years with functional constipation receiving macrogol. The study will enroll participants for 4 weeks of active treatment followed by 4 weeks of follow-up after treatment discontinuation, assessing constipation persistence, stool consistency, evacuation distress, soiling episodes, and treatment compliance.

Seven-Year Radiographic Retention Study, Four Implant Overdenture

NIH's ClinicalTrials.gov registered a retrospective observational study (NCT07536776) examining marginal bone loss and retention outcomes in 27 completely edentulous patients receiving four-implant LOCATOR-retained mandibular overdentures over a seven-year follow-up period. The study assesses bone loss and retention at baseline, one year, and seven years post-insertion. Enrollment opens April 17, 2026.

Phase 1/2a Trial of NWRD09 for Persistent HPV16 Infection in Female Participants

The NIH ClinicalTrials.gov registry has posted a new Phase 1/2a clinical trial (NCT07536282) evaluating NWRD09, an investigational drug, for the treatment of persistent HPV16 infection in female participants. The two-part study will assess safety, tolerability, immunogenicity, and efficacy while determining the maximum tolerated dose and recommended Phase 2 dose. Participants will receive either NWRD09 or placebo as part of the study design.

Williams Syndrome iPSC Oligodendrocyte Study

NIH's ClinicalTrials.gov has registered NCT07537374, a case-control observational study examining oligodendrocyte lineage development in children with Williams syndrome using peripheral blood-derived iPSC models. The study plans to enroll 3 children with Williams syndrome and 3 healthy controls, with samples induced into neural progenitor cells and oligodendrocyte lineage cells for in vitro studies of myelin-related gene programs and developmental trajectories.

Phase 4 Cardiac Surgery Ketamine Anti-inflammatory Trial NCT07536633

NIH ClinicalTrials.gov registered a Phase 4 clinical trial (NCT07536633) investigating the anti-inflammatory effect of ketamine in cardiac surgery patients. The randomized controlled study will evaluate intraoperative ketamine administration (1 mg/kg induction plus 2.4 mg/kg/h maintenance infusion) versus control on inflammatory markers including neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, and C-reactive protein. The trial targets adult cardiac surgery patients and will assess pain scores, hospital mortality, and morbidity outcomes.

Prospective Longitudinal EVOH Renal Embolization Study in ADPKD

NIH has registered a prospective longitudinal observational study (NCT07535385) evaluating the radiological and clinical outcomes of renal embolization using ethylene-vinyl alcohol copolymer (EVOH) in dialysis patients with autosomal dominant polycystic kidney disease (ADPKD). The study aims to assess renal volume changes, complications, and prognostic factors in affected patients. Results may inform treatment strategies for ADPKD-related renal failure.

Phase 4 Antihistamine Trial for HTR Prevention in 40 Children, NCT07536152

NIH registered a Phase 4 randomized, double-blinded, placebo-controlled clinical trial (NCT07536152) at a university hospital evaluating intravenous antihistamine (chlorpheniramine) versus placebo for prevention of blood transfusion-associated adverse reactions in 40 children undergoing elective congenital heart defect repair with blood-primed cardiopulmonary bypass. The study will randomly assign 20 patients per group to receive a single dose immediately after separation from bypass prior to protamine administration.

Quadro-Iliac Plane Block vs Erector Spinae Plane Block After Total Hip Arthroplasty

NIH's ClinicalTrials.gov registered a new comparative clinical study (NCT07537036) evaluating the analgesic efficacy of Quadro-Iliac Plane Block versus Erector Spinae Plane Block in patients undergoing total hip arthroplasty. The interventional study will assign participants to receive one of two regional anesthesia techniques. This trial registration provides public transparency on ongoing medical research but does not establish regulatory compliance obligations.

Trans-septal Quilting Suturing vs Intranasal Silicone Splinting in Septoplasty

NIH ClinicalTrials.gov registered a randomized controlled trial (NCT07537920) comparing trans-septal quilting suturing versus intranasal silicone splinting following septoplasty in patients with deviated nasal septum. The study aims to identify which post-operative technique results in fewer adverse effects. Participants will be enrolled with an estimated completion date of April 2026.

Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation

NIH registered clinical trial NCT07535892, a single-site pilot randomized controlled trial using a 2×2×2 factorial design to evaluate a multi-component behavioral intervention for weight loss maintenance following discontinuation of GLP-1 and anti-obesity medications. The trial will enroll participants randomized to a standardized 10-week foundational weight loss maintenance program combined with candidate support components including medically tailored meals, YMCA membership, and a structured mind-based program, with six-month follow-up.

Acute Medical Unit Study, Singapore, Apr 17

NIH's ClinicalTrials.gov registered observational study NCT07536035 evaluating Acute Medical Unit care models versus standard hospital care for patients with acute medical illnesses including falls, COPD, infection, asthma, pneumonia, UTI, and URTI. The 4-year study based in Singapore will measure hospital length of stay, emergency department utilization, health quality outcomes, and cost differences across care delivery models.

tDCS Stroke Rehabilitation Observational Study, Apr 17

This NIH ClinicalTrials.gov registry entry documents observational study NCT07535788 examining implementation of transcranial Direct Current Stimulation (tDCS) in inpatient and outpatient rehabilitation settings for stroke patients with aphasia. The study evaluates whether tDCS can be effectively integrated with routine speech therapy.

Ego-Tucking: Exploring Psychological Mechanisms of Fo-xi Phenomenon Among University Students

The NIH registered observational study NCT07536711 on ClinicalTrials.gov examining psychological mechanisms, stress, and mental fatigue among university students. The cross-sectional study uses a structured questionnaire to explore individual experiences, family dynamics, and macro-social environments contributing to behavioral changes in academic and professional competition contexts.

PD-1 Plus Lenvatinib vs Regorafenib for Unresectable Hepatocellular Carcinoma

NIH ClinicalTrials.gov registered a new Phase 2/3 clinical trial (NCT07537985) comparing the efficacy and safety of PD-1 inhibitor combined with Lenvatinib versus PD-1 inhibitor combined with Regorafenib for unresectable hepatocellular carcinoma (UHCC) after failure of first-line treatment with bevacizumab plus sintilimab. The study aims to provide evidence-based guidance for selecting optimal second-line treatment regimens. Estimated enrollment and completion date are listed in the registry.

High-flow Nasal Cannula Versus Conventional Oxygen Therapy in High-altitude Pulmonary Edema

NIH has registered Clinical Trial NCT07536477, a randomized controlled study evaluating High-flow Nasal Cannula Oxygen Therapy (HFNC) versus Conventional Oxygen Therapy (COT) in patients with High-Altitude Pulmonary Edema (HAPE). The single-center trial plans to enroll 168 participants, with an estimated completion date of April 17, 2026. HFNC is the sole intervention under investigation.

SBRT Followed by PD-1 Inhibitor, Bevacizumab and TAS-102 as Third-Line Therapy for Recurrent/Metastatic Colorectal Cancer

NIH's ClinicalTrials.gov has registered a new Phase 2 clinical trial (NCT07535632) at Zhongshan Hospital, Fudan University in China. The trial will study stereotactic body radiotherapy (SBRT) combined with sintilimab, bevacizumab, and TAS-102 as third-line therapy for 58 patients with recurrent or metastatic colorectal cancer. The 24-month study has a primary endpoint of progression-free survival.

Risk Factors and Prediction Model for Liver-Related Outcomes in Elderly Patients With Steatotic Liver Disease

NIH registered a retrospective cohort study (NCT07537829) on steatotic liver disease in elderly patients. The single-center observational study will analyze approximately 10,000 participants aged 60 and older from the Nanjing Elderly Steatotic Liver Disease Cohort to investigate liver-related and extrahepatic adverse outcomes. Risk prediction models will be developed using machine learning algorithms; no intervention is involved.

Serum GFAP, NfL, VEGF and Clinical Progression in Progressive MS

NIH registered an observational clinical trial (NCT07535242) investigating whether serum biomarkers GFAP, NfL, and VEGF serve as indicators of clinical progression in progressive multiple sclerosis. The study aims to better understand MS pathophysiology through biomarker analysis. This registry entry provides transparency on ongoing research but imposes no regulatory obligations on affected parties.

ESP Block Trial for Postoperative Spinal Pain Relief

NIH registered clinical trial NCT07537647, titled 'The Effect of Bilateral Erector Spina Plane Block on Postoperative Pain in Spinal Surgery.' The trial studies whether ultrasound-guided ESP block with bupivacaine reduces postoperative pain in patients undergoing lumbar spinal stabilization surgery. The study was registered on ClinicalTrials.gov and is listed as not yet recruiting with an estimated completion date of April 17, 2026.

Lullabies and White Noise Breastfeeding Study

NIH registered clinical trial NCT07537218 on ClinicalTrials.gov. The randomized controlled experimental study examines the effect of lullabies and white noise on breastfeeding success in newborns. The study enrolled 160 newborns divided into four groups: female voice lullaby, male voice lullaby, white noise, and control, with data collected using the LATCH Breastfeeding Assessment Scale.

Sleep Quality, Cognition, and Disease Severity in Parkinson's Disease - NCT07536490

The NIH National Library of Medicine registered an observational study (NCT07536490) on ClinicalTrials.gov investigating the relationship between sleep quality, cognitive function, and disease severity in individuals with Parkinson's disease. The single-session study will assess participants using standardized tools including the Stroop Test, Clock Drawing Test, Montreal Cognitive Assessment, Unified Parkinson's Disease Rating Scale, and Modified Hoehn and Yahr Scale. The study enrolls participants diagnosed with Parkinson Disease.

Ivonescimab With Dato-DXd or Osimertinib Phase 1

NIH ClinicalTrials.gov registered Phase 1 trial NCT07535437 evaluating ivonescimab in combination with Dato-DXd or osimertinib for treatment of EGFR-mutated non-small cell lung cancer. The dose-escalation study will assess safety and tolerability to determine optimal dosing. Participants with NSCLC harboring EGFR mutations will receive fixed-dose ivonescimab with escalating doses of either Dato-DXd or osimertinib.

Decision Aid Efficacy in Low Risk Thyroid Cancer

NIH ClinicalTrials.gov registered a clinical trial (NCT07536412) evaluating whether a decision aid pamphlet reduces decision anxiety and improves treatment decision readiness in low-risk thyroid cancer patients. The study will enroll patients diagnosed with differentiated thyroid cancer, papillary thyroid microcarcinoma, or papillary thyroid carcinoma to receive the decision aid before meeting with a surgeon. The intervention provides information about three treatment options (total thyroidectomy, partial thyroidectomy, or active surveillance) and questions for patients to ask their surgeon.

NAUTILUS Project Develops Mutation-Specific ASO for Syndromic Craniosynostoses

NIH ClinicalTrials.gov registered observational study NCT07535372 for the NAUTILUS project, developing ultra-personalized antisense oligonucleotide (ASO) therapeutics for syndromic craniosynostoses. The study targets rare genetic conditions including Crouzon, Saethre-Chotzen, Muenke, Pfeiffer, and Apert syndromes caused by FGFR1/2/3, TWIST1, and TCF12 variants. ASO design will be patient-tailored to silence gain-of-function alleles or restore expression in loss-of-function contexts.

Wildfire Smoke Lung Health Study, Canada, Asthma COPD

NIH registered a clinical trial (NCT07536178) titled 'Lungs on Fire' to study how wildfire smoke exposure contributes to long-term lung disease in susceptible populations. The controlled human exposure study will test varying concentrations of woodsmoke from Lodgepole Pine on participants with asthma, COPD, and lung cancer in Canada. The research aims to identify health impacts, vulnerable populations, and biological changes leading to chronic illness.

At-Home taVNS for Neurorehabilitation in Parkinson's Disease

NIH registered a new clinical trial (NCT07536022) evaluating at-home transcutaneous auricular vagus nerve stimulation (taVNS) for neurorehabilitation in approximately 40 adults with Parkinson's Disease. The 8-week study will assess feasibility, tolerability, and preliminary efficacy of self-administered daily 1-hour taVNS sessions using a threshold-based individual dosing protocol. Secondary objectives include measuring changes in motor and non-motor symptoms and examining neural network connectivity via MRI.

Observational Study of Language Reorganization in AVM Patients

NIH registered observational clinical trial NCT07537504 on ClinicalTrials.gov. The study investigates language function reorganization in patients with brain arteriovenous malformations (AVMs) involving language areas. Researchers will use multimodal MRI to examine functional remodeling, white matter pathway remodeling, and structural remodeling from multiple dimensions. The study aims to elaborate the role of the right cerebral hemisphere in reorganized language networks and interhemispheric interaction mechanisms.

Efficacy of Multi-Type Photolithography Flat Microstructure Lenses for Childhood Myopia Control

NIH ClinicalTrials.gov registered a clinical trial (NCT07535658) studying photolithography flat microstructure lenses for childhood myopia prevention and control. The randomized controlled trial will compare plano microstructure lenses with multi-point defocus design against Spectacle Lenses with Aspherical Lenslets (Essilor Stellest) in children over a 1-year period.

Monocyte Ratios, APRs, and Sepsis ICU Study

NIH's ClinicalTrials.gov registered a new observational study (NCT07537179) examining whether monocyte distribution, monocyte-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio can serve as biomarkers in sepsis patients in the ICU. The study will enroll patients admitted to the ICU for sepsis or those who develop sepsis during hospitalization, comparing these ratios with conventional acute phase response biomarkers.

Phase 2 Trial for Intestinal Fluid Reinfusion Prevention of Low Anterior Resection Syndrome

NIH registered a Phase 2 clinical trial (NCT07537998) on ClinicalTrials.gov to evaluate antegrade intestinal fluid reinfusion for prevention of low anterior resection syndrome in patients with prophylactic ileal stoma. The single-center, prospective randomized controlled trial will compare intestinal fluid infusion to potable water infusion in approximately 60 participants. Participants will receive the assigned intervention at 1 month post-rectal resection until ileostomy reversal and maintain symptom diaries.

HEARTS Implementation for Hypertension-Diabetes Multimorbidity, Guatemala, 1,440 Adults

NIH's ClinicalTrials.gov has registered a new clinical study (NCT07536919) evaluating the WHO-developed HEARTS implementation program for comorbid hypertension and Type 2 diabetes. The pragmatic cluster-randomized trial will enroll 1,440 adults across 36 public primary care clinics in Guatemala. Participants are randomized to HEARTS intervention or current standard care, with primary outcomes (blood pressure and hemoglobin A1c) assessed at 12 months.

Effect of Patient Education Program on Vitamin D Levels and Health Beliefs

NIH has registered a clinical trial (NCT07535671) evaluating whether a structured patient education program improves health beliefs and medication adherence in patients with Vitamin D deficiency. The 6-month trial will randomize 120 adult hypothyroid female patients with serum Vitamin D below 30 ng/dL to either face-to-face education with brochures and monthly phone follow-ups or standard care. The intervention's effectiveness will be measured using the Medication Possession Ratio and serum 25(OH)D levels.