ClinicalTrials.gov Studies

PGT-A Upgrade International Multicenter Observational Clinical Trial

The NIH ClinicalTrials.gov registry has recorded a new international multicenter observational clinical trial (NCT07533630) evaluating PGT-A upgrade testing for preimplantation genetic testing in assisted reproductive technology. The study will enroll patients from seven domestic and international centers to assess embryo utilization rates and clinical outcomes including birth defects following PGT-A upgrade testing. Patient enrollment is expected to be completed within one year.

Shouhui Tongbian Capsule Phase 3 OIC Trial in Cancer Patients

NIH ClinicalTrials.gov registered Phase 3 trial NCT07534995 for Shouhui Tongbian Capsule in treating opioid-induced constipation (OIC) in cancer patients. The prospective, multicenter, randomized, parallel-controlled superiority trial will evaluate symptom-relieving effects including defecation frequency, stool consistency, symptom scores, and quality of life. Primary efficacy endpoint is proportion of responders at week 2, defined as increase of at least 1 in average weekly spontaneous bowel movements. Safety endpoints include adverse event incidence and vital sign changes.

Dose-Response Effect of Phosphatidylserine on eSport Performance

NIH registered a new randomized, double-blind, placebo-controlled clinical trial (NCT07533032) evaluating daily phosphatidylserine supplementation at 100 mg or 200 mg doses in healthy adult gamers over 6 weeks. The study will measure electronic gaming performance, cognitive function, sleep quality, stress outcomes, and heart rate variability at baseline, Week 3, and Week 6. Enrollment includes approximately 75 participants assigned to three parallel groups.

Novel Infant Formula Randomized Trial, Ages 12-18 Months

NIH has registered a new randomized controlled clinical trial on ClinicalTrials.gov (NCT07534735) to evaluate the effects of investigational infant formulas on growth, gut health, immune function, and sleep in healthy infants aged 12-18 months. The three-arm study will compare two investigational formulas against a control.

Phase 4 Elagolix vs OCPs Endometriosis Pain Clinical Trial NCT07532876

NIH's ClinicalTrials.gov has registered a Phase 4 clinical trial (NCT07532876) comparing Elagolix to oral contraceptive pills (OCPs) for reducing endometriosis-associated pelvic pain. The randomized, open-label study aims to provide direct evidence on relative effectiveness and safety to help physicians make more tailored treatment decisions for patients with diagnosed endometriosis. Elagolix is an oral GnRH antagonist intervention.

Placebo-Induced Hypoalgesia During TENS Application in Low Back Pain

NIH's ClinicalTrials.gov registered a randomized controlled trial (NCT07535047) evaluating transcutaneous electrical nerve stimulation (TENS) combined with video-based education for acute low back pain. The study will enroll participants divided into control group (standard physical therapy with TENS and exercises) and experimental group (standard therapy plus video-based TENS educational explanation). The primary outcome measures are feasibility of conducting the full RCT, including recruitment, compliance, and adverse events. Secondary outcomes include pressure pain threshold, pain intensity, functional mobility, patient satisfaction, and quality of life.

Blood Flow Restriction Parameters and Lower Limb Function in Older Adults With Dynapenia

NIH registered clinical trial NCT07534150, a two-phase study examining limb occlusion pressure (LOP) measurements and muscle electrophysiology in older adults with dynapenia. Year one collects baseline LOP data and influencing factors; year two uses high-density surface electromyography to analyze motor unit recruitment under varying BFR pressures. No regulatory obligations imposed.

Effect of Different Volumes of Erector Spinae Plane Block on Postoperative Opioid Consumption After Total Abdominal Hysterectomy

NIH's ClinicalTrials.gov has registered a new observational study (NCT07533760) investigating the effects of different volumes of ultrasound-guided erector spinae plane block on postoperative pain and opioid consumption in patients undergoing total abdominal hysterectomy. The study will evaluate whether varying local anesthetic volume reduces morphine requirements and improves pain scores during the first 24 hours after surgery. No compliance obligations or regulatory actions are associated with this trial registration.

Fexuprazan 20mg Phase 4 Trial for NSAID-Induced Peptic Ulcer Prevention

NIH ClinicalTrials.gov registered a Phase 4 clinical trial (NCT07533266) for Fexuprazan 20mg as a preventive treatment for NSAID-induced peptic ulcers. The study will enroll participants using NSAIDs and compare the non-inferiority of Fexuprazan 20mg to Lansoprazole 15mg over 8 weeks. The trial is listed with an estimated start date and targets completion by April 2026.

Randomized Trial Comparing PTCD Catheter Removal vs Retention After Pancreaticoduodenectomy in Obstructive Jaundice

NIH registered a multicenter prospective randomized controlled trial (NCT07532759) comparing intraoperative PTCD catheter removal versus retention during pancreaticoduodenectomy in patients with obstructive jaundice. The trial will enroll participants with pancreatic head cancer, periampullary neoplasms, and biliary tract neoplasms to evaluate postoperative complications including bile leak and severe morbidity within 90 days.

Acute Amino Acid Response of Proprietary Beverages

The National Institutes of Health registered clinical trial NCT07534020 on ClinicalTrials.gov. The trial evaluates post-meal amino acid response to four proprietary protein beverage formulations (carbonated test protein beverage, standard protein beverage, control protein beverage, and Study Product D) in generally healthy adults.

Effect of Preoperative Sensory Modulation Room on Pain, Anxiety, and Sleep in Kidney Transplant Patients

NIH registered clinical trial NCT07533669 evaluating whether preoperative exposure to a sensory modulation room influences postoperative pain, anxiety, and sleep outcomes in adult living kidney donors and recipients. The prospective study compares participants receiving preoperative sensory modulation (intervention group) to those receiving standard preoperative care (control group). Estimated study completion date is April 16, 2026.

Phase 2 Study of LY4005130 for Severe Alopecia Areata

The National Institutes of Health has registered a Phase 2 clinical trial (NCT07533006) on ClinicalTrials.gov evaluating LY4005130, an investigational intravenous drug, in adults with severe alopecia areata. The approximately 48-week randomized controlled trial will assess efficacy, tolerability, safety, and pharmacokinetics of LY4005130 versus placebo. This registry entry provides public transparency on the clinical investigation but does not constitute regulatory approval, authorization, or impose compliance obligations.

Multicenter RCT: Laparoscopic Staging for Stage III Gastric Cancer

The NIH has registered a new multicenter randomized controlled trial (NCT07533825) on ClinicalTrials.gov investigating laparoscopic staging-guided therapy for patients with clinical stage III gastric cancer. The study will evaluate the impact on overall survival, surgical conversion rate, and peritoneal metastasis rate, comparing laparoscopic staging-guided therapy against treatment without laparoscopic exploration. Enrollment begins April 16, 2026.

Observational Trial of Unapproved/Uncleared FDA Device

NIH ClinicalTrials.gov registered observational trial NCT07533201 studying an unapproved or uncleared FDA device. The study is classified as observational, meaning researchers will collect data on device performance or safety outcomes without intervening. Registered April 16, 2026.

Primed to Thrive: Mindfulness and Meditation Trial for Workplace Well-Being

NIH registered an interventional clinical trial (NCT07534683) evaluating whether combining mindfulness education with daily guided meditation via smartphone application improves psychological well-being and workplace outcomes compared with education alone. Adult employees will be randomized to receive meditation plus educational materials or a waitlist control, with assessments over approximately 12 weeks using the Utrecht Work Engagement Scale (UWES-9) as the primary outcome.

Study Investigates IBS During Fertility Treatments

The NIH ClinicalTrials.gov registry has posted a new observational study (NCT07533968) investigating the impact of fertility treatments on irritable bowel syndrome (IBS) symptoms in women. The study focuses on two cohorts: women with polycystic ovary syndrome (PCOS) beginning their first IVF cycle and women undergoing social egg freezing. Researchers will use questionnaires to track changes in IBS prevalence, severity, and associated anxiety and depression scores across multiple subgroups.

Respiratory and Haemodynamic Effects of Conscious Sedation With Dexmedetomidine for a TAVI Procedure

NIH registered clinical trial NCT07532733 comparing dexmedetomidine versus propofol with remifentanil for conscious sedation during transcatheter aortic valve implantation (TAVI). The study aims to evaluate intraoperative respiratory and hemodynamic tolerance in elderly patients with severe aortic stenosis. Trial status dated April 16, 2026.

Phase 4 Suzetrigine Trial for Opioid-Free Cesarean Recovery

NIH registered Phase 4 clinical trial NCT07534709 to evaluate suzetrigine as an adjunctive analgesic for opioid-free recovery following cesarean delivery. The randomized, placebo-controlled study will assess whether suzetrigine added to standard multimodal analgesia increases the proportion of patients remaining opioid-free through 72 hours post-surgery. Participants receive standardized pain management with acetaminophen, NSAIDs, and neuraxial morphine, with opioid rescue medication available for breakthrough pain.

ACSS Surgical Approaches and Dysphagia Comparison Study

NIH registered an observational clinical study (NCT07533864) comparing two anterior cervical spine surgery (ACSS) approaches—Smith-Robinson versus strap-splitting—for their effects on dysphagia (swallowing difficulties) and voice changes. The study will enroll participants assigned to either approach based on surgeon preference, with follow-up questionnaires assessing swallowing and speaking outcomes. This registry entry documents an active clinical investigation on a common spinal procedure with known swallowing-related complications.

Effect of Oral Probiotics on Allergic Rhinitis Symptoms and Quality of Life

NIH registered a clinical trial (NCT07532837) examining oral probiotics versus placebo for treating allergic rhinitis symptoms and quality of life. The study will evaluate Lactobacillus rhamnosus F-1 and Lactobacillus reuteri GL-104 in patients with allergic rhinitis, an inflammatory nasal condition affecting sleep, work productivity, and concentration.

Comparison of Maxillary Dental Expansion Using Smartee Clear Aligner With and Without S11 Expander: A Randomized Clinical Trial

The NIH's ClinicalTrials.gov has registered a randomized clinical trial (NCT07533682) comparing maxillary dental expansion using Smartee Clear Aligners with and without the S11 expander. The trial will use cone beam computed tomography (CBCT) to evaluate orthodontic expansion and tooth movement in patients with posterior crossbite requiring maxillary arch expansion.

FMT for Advanced Tumor Cachexia, Phase 2

NIH has registered a prospective, multicenter, single-arm Phase 2 clinical study (NCT07533227) to evaluate the efficacy and safety of fecal microbiota transplantation (FMT) capsules in treating advanced tumor cachexia in cancer patients. The trial is listed on ClinicalTrials.gov as a reference document.

AI-Assisted 4-Week Psychodynamic and Cognitive Behavioral Therapy Via Smartphone for Social Anxiety: Randomized Pilot Study (STePS-Ai)

NIH's ClinicalTrials.gov registered a new randomized pilot study comparing AI-assisted psychodynamic therapy and cognitive behavioral therapy delivered via smartphone for social anxiety disorder. The study will enroll participants in three arms: AI-guided psychodynamic therapy, AI-guided cognitive behavioral therapy, or waitlist control. Participants will complete weekly online questionnaires to monitor anxiety and mood changes over the 4-week intervention period.

Tafenoquine Combinations for Improved Radical Cure Efficacy of Plasmodium Vivax

NIH registered ClinicalTrials.gov Study NCT07533136, a Phase 4 trial evaluating tafenoquine-based combination therapies for radical cure of uncomplicated Plasmodium vivax malaria in Thai adults. The study compares dihydroartemisinin-piperaquine or artemether-lumefantrine with tafenoquine against chloroquine plus tafenoquine over a 6-month follow-up period to assess recurrence prevention efficacy.

Web-Based Mindful Parenting RCT for Adoptive Parents

A pilot randomized controlled trial evaluating AdoptMindful2Care@Web, a 9-module web-based post-adoption psychological intervention grounded in mindful parenting principles for adoptive parents, has been registered on ClinicalTrials.gov (NCT07534111). The study targets parenting stress and positive mental health as primary outcomes using a web-based intervention delivery format. This registry entry documents the study design, conditions (Parenting Stress, Positive Mental Health), and intervention details for research transparency purposes.

Treatment of Cognitive and Sensorimotor Deficits in Parkinson's Disease With High Definition Transcranial Direct Current Stimulation

NIH ClinicalTrials.gov registered a Phase 1/2 interventional study (NCT07534397) evaluating high-definition transcranial direct current stimulation (tDCS) for treating cognitive and sensorimotor deficits in Parkinson's disease patients. The trial will enroll participants receiving either active tDCS or sham stimulation to assess effects on verbal retrieval, cognition, and motor control. Estimated start date is April 16, 2026.

Evaluation of the Effect of a PRECEDE-PROCEED Model-Based Laughter Yoga-Supported Education Program on Peer Bullying

NIH registered a clinical trial (NCT07534566) evaluating a laughter yoga-supported education program based on the PRECEDE-PROCEED Model to reduce peer bullying among adolescents. The study targets middle school students and examines effects on awareness of peer bullying and psychosocial well-being. The trial involves health education and laughter yoga interventions as comparators.

Early Pregnancy Behavioral Patterns and Gestational Diabetes Risk

NIH ClinicalTrials.gov has registered a prospective nested randomized pilot trial (NCT07534670) examining how early-pregnancy chronobehavioral patterns including sleep irregularity, physical activity, and meal timing influence continuous glucose dynamics and gestational diabetes mellitus risk. The TOFFFY substudy at KK Women's and Children's Hospital, Singapore will enroll 140 pregnant women without pre-existing diabetes at 13 weeks gestation or less.

Pediatric Persistent Hypoglycemia Risk Factors at Sohag University Hospital

NIH registered a new observational clinical trial (NCT07533318) at Sohag University Hospital in Egypt studying endocrine, metabolic, and genetic risk factors of pediatric persistent hypoglycemia. The study will enroll 24 pediatric patients experiencing hypoglycemia beyond the first 3 days of life. Clinical investigators conducting pediatric metabolic research should be aware of this registry entry as part of ongoing surveillance of active hypoglycemia studies.

PRECISE Phenotyping to Guide Therapies for Coronary Microvascular Dysfunction

NIH's ClinicalTrials.gov registered a new Phase 3 clinical trial (NCT07533747) evaluating Empagliflozin 10mg for Coronary Microvascular Dysfunction (CMD). The trial aims to study heart energy metabolism in patients with CMD, a condition causing chest pain and shortness of breath without arterial blockages. No widely available proven treatments currently exist for CMD, making this a significant research effort targeting an unmet medical need.

Technology Addiction Linked to Adolescent Activity and Attention

NIH ClinicalTrials.gov has registered a new observational study (NCT07532720) examining the relationship between technology addiction and physical activity and attention levels in adolescents. The study evaluates whether higher levels of technology addiction are associated with lower physical activity and reduced attention. Conditions include Technology Addiction, Adolescent Health, and Attendance Level.

Thermal Spa Programme for Knee Osteoarthritis, 3-Week Study (NCT07534189)

The NIH ClinicalTrials.gov registry has registered a prospective cohort study (NCT07534189) evaluating a 3-week thermal spa treatment programme for patients with symptomatic knee osteoarthritis. The study will assess knee joint movement using wearable inertial sensors (Xsens), along with secondary outcomes including pain, physical function, quality of life, and blood transcriptomic profiles. Participants will be evaluated at baseline, post-treatment, and at 3- and 12-month follow-up visits.

Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients

NIH has registered a new clinical trial (NCT07532694) on ClinicalTrials.gov evaluating diode laser-assisted non-surgical periodontal therapy in 80 kidney transplant recipients with periodontitis. The randomized controlled trial will compare scaling and root planing (SRP) with adjunctive diode laser therapy versus SRP alone. The study will assess clinical periodontal parameters, blood biomarkers, radiographic findings, and subgingival microbiome profiles at baseline and during follow-up through April 2026.

Modular Neurological Examination for Early Risk Detection

NIH's ClinicalTrials.gov registered observational study NCT07533162 to validate a modular neurological screening tool for infants. The study evaluates the Hammersmith Infant Neurological Examination (HINE) and a novel modular tool requiring approximately 15 minutes to administer, aimed at early identification of infants requiring further neurological evaluation. The research focuses on infants from birth to 24 months across both low and high-risk populations for neurological damage.

Internet-Based CBT for Anxiety and Depression, Singapore, NCT07532551

NIH's ClinicalTrials.gov has registered a clinical trial (NCT07532551) in Singapore evaluating Internet-based Cognitive Behavioural Therapy (iCBT) for adults with mild-to-moderate anxiety and/or depression. The randomized controlled trial will compare guided iCBT to usual care (traditional CBT) to assess clinical effectiveness, cost-effectiveness, and acceptability. Participants will receive structured digital modules with therapist support. The trial is expected to complete in April 2026.

NECC Peer Support Observational Study for Neuroendocrine Cervical Cancer Patients

NIH registered an observational study (NCT07532954) titled 'The Impact Of A Patient Support Community On Patients With Neuroendocrine Cervical Cancer' on ClinicalTrials.gov. The study aims to learn about the effects of a participant support community on illness perception, emotional well-being, and feelings of isolation among participants with NECC using questionnaire-based interventions. No regulatory obligations or compliance requirements are imposed by this registry entry.

Kinesiophobia and Adhesive Capsulitis Observational Trial NCT07534527

NIH ClinicalTrials.gov registered observational study NCT07534527 investigating the relationship between kinesiophobia (fear of movement) and pain, range of motion, disability, and quality of life in patients with adhesive capsulitis (frozen shoulder). The study will involve physical examination and questionnaire-based assessment; no interventions are administered.

Holmium Laser Versus Conventional TURBT for Non-Muscle-Invasive Bladder Cancer: Randomized Controlled Trial, 100 Patients

NIH ClinicalTrials.gov registered a prospective randomized controlled trial (NCT07534631) comparing holmium laser en-bloc resection (HoLERBT) with conventional transurethral resection (cTURBT) for treatment of non-muscle-invasive bladder cancer. A total of 100 patients will be randomized 1:1. The primary outcome is quality of pathological specimen assessed by presence of detrusor muscle. Secondary outcomes include perioperative complications, operative time, obturator nerve reflex, bladder perforation, positive surgical margins, persistent disease at second-look TURBT, and recurrence rates at 3 and 12 months.

Therapeutic Touch and Acupressure on Depressive Symptoms (NCT07532512)

NIH ClinicalTrials.gov registered a new study (NCT07532512) investigating therapeutic touch and acupressure as interventions for mild-to-moderate depressive symptoms. The randomized controlled trial will enroll participants receiving either eight therapeutic touch sessions or eight acupressure sessions over four weeks. Acupressure points include Yintang (EX-HN3), Shenmen (HT7), and Neiguan (PC6).

ACOD1 Gene Expression as Sepsis Mortality Predictor

NIH has registered a new observational clinical study (NCT07533994) on ClinicalTrials.gov evaluating ACOD1 gene expression in peripheral blood mononuclear cells as a prognostic biomarker for predicting sepsis mortality. The single-center study will enroll septic ICU patients and correlate ACOD1 expression with clinical severity scores and in-hospital mortality outcomes.

Tpex Subsets in Negative Tumor Draining Lymph Nodes for Predicting Efficacy of PD-1 Inhibitors in Esophageal Squamous Cell Carcinoma

NIH registered an observational study (NCT07533357) examining Tpex subsets in negative tumor draining lymph nodes as predictors of PD-1 inhibitor efficacy in advanced or recurrent esophageal squamous cell carcinoma. The study aims to determine whether high proportions of precursor exhausted T cells correlate with longer overall survival and whether Tpex has better predictive efficacy for treatment response than PD-L1 CPS.

Observational Trial of Deep Learning Model for Head and Neck Cancer Prognosis

NIH registered NCT07532928, an observational study developing a dynamic deep learning model using multimodal patient data to assess prognostic risk and recommend individualized adjuvant treatment for locally advanced head and neck squamous cell carcinoma. The model aims to assist clinicians in precision therapy decisions. The study is observational with an estimated enrollment of 500 participants, registered April 16, 2026.

Preoperative Topical Lidocaine Versus Intravenous Fentanyl for Intubation Stress Reduction

NIH registered clinical trial NCT07533643 comparing preoperative topical lidocaine versus intravenous fentanyl for reducing stress response during endotracheal intubation under general anesthesia. The trial will evaluate hemodynamics after intubation using combined topical airway anesthesia (nebulized, mouth rinsing and gargling) against low-dose IV fentanyl. No compliance obligations are created by this trial registration.

ML/AI Model Predicts Head and Neck Cancerous Lesion Risk

NIH registered ClinicalTrials.gov study NCT07532538, an observational multi-center trial to develop and validate a deep learning/AI-based clinical prediction model for head and neck cancerous lesion risk. The study targets hypopharyngeal cancer, laryngeal cancer, and general head and neck cancer. The trial is registered as an observational study without stated enrollment or completion dates.

Congenital Ptosis Surgery Visual Function and Psychological Conditions Prospective Cohort Study

NIH ClinicalTrials.gov registered NCT07534436, an observational prospective cohort study evaluating 6-month outcomes of Levator Resection combined with Fascial Sheath Suspension surgery in patients with congenital ptosis. The study will assess improvements in best-corrected visual acuity, stereopsis, and patient-reported quality of life through standardized ophthalmological examinations at baseline and 1, 3, and 6 months post-operation. Enrollment includes patients already scheduled for this combined surgical procedure as part of their regular medical care.

IPEX Observational Study on Pancreatic Exocrine Insufficiency in IPMN Patients

NIH registered the IPEX study (NCT07535125), a multicenter prospective observational cohort study evaluating pancreatic exocrine insufficiency (PEI) prevalence in patients with intraductal papillary mucinous neoplasms (IPMN) under surveillance. The study will assess whether PEI correlates with morphologic disease progression and whether it can serve as a functional marker complementary to imaging criteria in IPMN surveillance.

Guselkumab High-Dose vs Standard-Dose Study in Chinese Moderate-to-Severe Plaque Psoriasis

NIH registered a clinical trial (NCT07532486) on ClinicalTrials.gov evaluating the efficacy, safety, tolerability, and drug survival of guselkumab at high-dose and extended-interval regimens versus standard-dose in Chinese participants with moderate-to-severe plaque psoriasis. The interventional study compares two guselkumab dosing approaches. This is an administrative registration entry with no regulatory compliance obligations.

Trial Comparing Ultrasound-guided vs Arthroscopic Guided PRF Injection for TMJ Disc Displacement

NIH registered a clinical trial (NCT07535073) comparing ultrasound-guided versus arthroscopic guided platelet rich fibrin injection for temporomandibular joint disc displacement. The trial will evaluate pain reduction, improvement of mandibular function, and patient-reported outcomes. No regulatory obligations or compliance requirements are created by this study registration.

Piloting a Generative Artificial Intelligence Chatbot in a Mobile Weight Loss Program

NIH has registered a new clinical trial (NCT07534254) evaluating the feasibility of integrating a generative AI chatbot into a 12-week smartphone-based behavioral weight loss program for young adults. The study will compare standard program delivery (1-2 brief daily messages) against the same program enhanced with an AI chatbot offering additional behavior change support. Participants will be assessed on program feasibility, acceptability, engagement, and weight change outcomes.